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Showing 25–43 of 19 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Impaired Driving Clear all
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Assess the Effect of Metaxalone 640 mg (M640) Compared to Tizanidine 8 mg on Truck Driving Ability and Cognition

NCT06382662
View directory record Official record
Conditions
Cognitive Impairment
Interventions
metaxalone m640 mg, tizanidine 8mg
Drug
Lead sponsor
Primus Pharmaceuticals
Industry
Eligibility
18 Years to 65 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Peoria, Arizona
Source: ClinicalTrials.gov public record
Updated Sep 10, 2026 · Synced Sep 14, 2026, 9:41 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Fire Fighter Fatigue Management Program: Operation Fight Fatigue

NCT01672502
View directory record Official record
Conditions
Shift-Work Sleep Disorder, Insomnia, Restless Leg Syndrome, Obstructive Sleep Apnea, Impaired Driving
Interventions
Sleep health education provided via a web-based program, Sleep disorder detection and treatment, Optimization of Sleep in Fire Station
Behavioral · Other
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years and older
Enrollment
620 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2014
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 16, 2016 · Synced Sep 14, 2026, 9:41 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Neuroscience of Marijuana Impaired Driving

NCT02757313
View directory record Official record
Conditions
Marijuana Impairment
Interventions
Low dose THC marijuana, High dose THC marijuana, Placebo marijuana
Drug
Lead sponsor
Yale University
Other
Eligibility
18 Years to 40 Years
Enrollment
62 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2021
U.S. locations
1
States / cities
Hartford, Connecticut
Source: ClinicalTrials.gov public record
Updated Jul 22, 2024 · Synced Sep 14, 2026, 9:41 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Increasing Seat Belt Wearing and Decreasing Handheld Phone Use While Driving

NCT05469477
View directory record Official record
Conditions
Distracted Driving, Impaired Driving, Driving Behaviors
Interventions
Persuasive education, WOOP (aka, mental contrasting with implementation intentions., Wish, Outcome, Obstacle, Plan), Customized Habit Tips, Raffle Financial Incentive, Shared Pot Financial Incentive, Weekly SMS Support text, Weekly SMS Encouragement
Behavioral
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
1,139 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 2, 2023 · Synced Sep 14, 2026, 9:41 AM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

High Confusion: Cannabis & Driving

NCT06236815
View directory record Official record
Conditions
Impairment, Cognitive, Impairment of Attention, Impairment, Psychomotor
Interventions
Delta-9-THC, Delta-8-THC, Placebo
Drug
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years to 49 Years
Enrollment
5 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Oct 9, 2025 · Synced Sep 14, 2026, 9:41 AM EDT
Completed Phase 1Phase 2 Interventional Accepts healthy volunteers Results available

The Impact and Detection of Driving Impairments Associated With Acute Cannabis Smoking

NCT02849587
View directory record Official record
Conditions
Cannabis Intoxication
Interventions
Cannabis
Drug
Lead sponsor
University of California, San Diego
Other
Eligibility
21 Years to 55 Years
Enrollment
199 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Jan 3, 2022 · Synced Sep 14, 2026, 9:41 AM EDT
Terminated No phase listed Observational Accepts healthy volunteers

The Rise of Ride Sharing Companies and Trends in Impaired Driving Accidents

NCT04564599
View directory record Official record
Conditions
Ride Sharing, Alcohol Drinking, Alcohol Intoxication, Drug Use, Motor Collision, Sexual Assault
Interventions
Not listed
Lead sponsor
Methodist Health System
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Mar 22, 2026 · Synced Sep 14, 2026, 9:41 AM EDT
Active, not recruiting No phase listed Observational Accepts healthy volunteers

Use of Driving Tests to Evaluate Patient Performance on Oral Opioids

NCT00659035
View directory record Official record
Conditions
Chronic Pain
Interventions
Not listed
Lead sponsor
Asokumar Buvanendran
Other
Eligibility
18 Years to 80 Years
Enrollment
450 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2026
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jan 7, 2026 · Synced Sep 14, 2026, 9:41 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

Validation of Driving Simulator to Blood Alcohol Concentration Standards for Impaired Driving

NCT00559819
View directory record Official record
Conditions
Driving, Intoxication, Impairment, Alcohol Impaired Driving
Interventions
placebo, Alcohol
Drug
Lead sponsor
Rush University Medical Center
Other
Eligibility
21 Years to 80 Years
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2022
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Dec 13, 2022 · Synced Sep 14, 2026, 9:41 AM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Examine the Feasibility of a Standardized Field Test for Marijuana and Alcohol Impairment: Laboratory Evaluations

NCT04856566
View directory record Official record
Conditions
Marijuana Impairment, Alcohol Impairment
Interventions
Low Marijuana, Hash, THC, or Grass, High Marijuana, Hash, THC, or Grass, Placebo, 0.05 BAC Alcohol, 0.08 BAC Alcohol
Drug
Lead sponsor
Yale University
Other
Eligibility
21 Years to 40 Years
Enrollment
41 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
Hartford, Connecticut
Source: ClinicalTrials.gov public record
Updated Jun 30, 2025 · Synced Sep 14, 2026, 9:41 AM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Examine the Feasibility of a Standardized Field Test for Marijuana Impairment: Laboratory Evaluations

NCT03191084
View directory record Official record
Conditions
Marijuana Impairment
Interventions
Low Dose THC Marijuana, High Dose THC Marijuana, Placebo Marijuana
Drug
Lead sponsor
Yale University
Other
Eligibility
20 Years to 40 Years
Enrollment
26 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2020
U.S. locations
1
States / cities
Hartford, Connecticut
Source: ClinicalTrials.gov public record
Updated Jul 22, 2024 · Synced Sep 14, 2026, 9:41 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Evaluation of an Interactive Mobile Phone-Based Brief Intervention to Reduce Substance-Impaired Driving

NCT05537116
View directory record Official record
Conditions
Driving Impaired
Interventions
Personalized feedback, Personalized feedback and text messages, Information Only
Behavioral
Lead sponsor
Western Kentucky University
Other
Eligibility
18 Years to 29 Years
Enrollment
149 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2026
U.S. locations
1
States / cities
Bowling Green, Kentucky
Source: ClinicalTrials.gov public record
Updated Aug 30, 2026 · Synced Sep 14, 2026, 9:41 AM EDT
Not listed Phase 1 Interventional Accepts healthy volunteers

Detection of Cannabis Impairment With ISBRG's SpotLight-THC

NCT05276232
View directory record Official record
Conditions
Cannabis
Interventions
Cannabis(THC) inhaled
Drug
Lead sponsor
ISBRG Corp
Other
Eligibility
18 Years and older
Enrollment
75 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Mar 10, 2022 · Synced Sep 14, 2026, 9:41 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Preventing Impaired Driving Among Adolescents

NCT04959461
View directory record Official record
Conditions
Substance-Related Disorders
Interventions
webCHAT, Usual Care
Behavioral
Lead sponsor
Stanford University
Other
Eligibility
15 Years to 17 Years
Enrollment
198 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2025
U.S. locations
2
States / cities
Denver, Colorado • Dearborn, Michigan
Source: ClinicalTrials.gov public record
Updated Mar 26, 2026 · Synced Sep 14, 2026, 9:41 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers Results available

Ability of Partial Inverse Agonist, Iomazenil, to Block Ethanol Effects in Humans

NCT01590277
View directory record Official record
Conditions
Active Ethanol and Active Iomazenil, Active Ethanol and Placebo Iomazenil, Placebo Ethanol and Active Iomazenil, Placebo Ethanol and Placebo Iomazenil, Alcohol Effect, Driving Under the Influence, Alcohol Impairment
Interventions
Active Ethanol, Active Iomazenil, Placebo
Drug
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
21 Years to 35 Years · Male only
Enrollment
33 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2018
U.S. locations
1
States / cities
West Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Oct 8, 2024 · Synced Sep 14, 2026, 9:41 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Reducing Cell Phone Use While Driving Among High Risk UBI Auto Policy Holders

NCT04587609
View directory record Official record
Conditions
Distracted Driving, Driving Impaired
Interventions
Free Phone Mounts, Commitment Contract, Personalized Habit Tips, Social Gamification Feedback, "Contest" Financial Incentives
Behavioral
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
1,668 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 1, 2021 · Synced Sep 14, 2026, 9:41 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

The Effects of Cannabidiol on the Driving Ability of Healthy Adults

NCT04590495
View directory record Official record
Conditions
Driving Performance, Cognitive Impairment, Sedation Complication, Mood
Interventions
300 mg Cannabidiol (CBD) oil, Placebo
Drug
Lead sponsor
West Virginia University
Other
Eligibility
18 Years to 30 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
Morgantown, West Virginia
Source: ClinicalTrials.gov public record
Updated Sep 14, 2022 · Synced Sep 14, 2026, 9:41 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Phenytoin and Driving Safety: A Randomized, Controlled Cross-Over Study

NCT00581893
View directory record Official record
Conditions
Cognitive Measures, Driving Simulator Performance
Interventions
Phenytoin, Placebo oral capsule
Drug
Lead sponsor
University of Iowa
Other
Eligibility
25 Years to 60 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2008
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Jun 30, 2021 · Synced Sep 14, 2026, 9:41 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Standardized Field Test for Marijuana Impairment II

NCT05115513
View directory record Official record
Conditions
Marijuana Impairment
Interventions
Medium THC, Placebo THC
Drug
Lead sponsor
Yale University
Other
Eligibility
18 Years to 55 Years
Enrollment
41 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Hartford, Connecticut
Source: ClinicalTrials.gov public record
Updated Oct 8, 2025 · Synced Sep 14, 2026, 9:41 AM EDT