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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Insomnia, Primary Clear all
Completed Phase 2 Interventional

Efficacy Study of EVT 201 to Treat Insomnia

NCT00380003
View directory record Official record
Conditions
Sleep Initiation and Maintenance Disorders
Interventions
EVT 201
Drug
Lead sponsor
Evotec Neurosciences GmbH
Industry
Eligibility
21 Years to 64 Years
Enrollment
66 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2007
U.S. locations
5
States / cities
St. Petersburg, Florida • Atlanta, Georgia • Overland Park, Kansas + 2 more
Source: ClinicalTrials.gov public record
Updated Jan 29, 2008 · Synced Sep 24, 2026, 3:14 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Cereset Research Long-Term Healthcare Worker Study

NCT05994261
View directory record Official record
Conditions
Stress, Anxiety, Autonomic Dysregulation, Acoustic Stimulation, Hyperarousal, Health Personnel
Interventions
Cereset Research
Device
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years to 100 Years
Enrollment
94 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 20, 2026 · Synced Sep 24, 2026, 3:14 AM EDT
Completed No phase listed Observational Accepts healthy volunteers Results available

A High Density EEG Comparison of Sleep Patterns in Insomnia

NCT01960452
View directory record Official record
Conditions
Primary Insomnia
Interventions
Serial awakenings
Behavioral
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years to 45 Years
Enrollment
45 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2017
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Jan 8, 2025 · Synced Sep 24, 2026, 3:14 AM EDT
Not yet recruiting Phase 4 Interventional

Doxepin Alone or Combined With Ramelteon Versus Placebo for Improving Sleep Quality After Primary Total Knee Arthroplasty

NCT07598734
View directory record Official record
Conditions
Sleep Quality Post-TKA, Postoperative Knee Function, Quality of Life After Primary TKA
Interventions
Doxepin 6 mg, Ramelteon 8 mg, Placebo Tablets
Drug
Lead sponsor
University of Washington
Other
Eligibility
18 Years to 80 Years
Enrollment
129 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated May 19, 2026 · Synced Sep 24, 2026, 3:14 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers Results available

A 2-Part Single Dose Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of E2006

NCT01463098
View directory record Official record
Conditions
Insomnia
Interventions
E2006 1.0 mg, E2006 2.5 mg, E2006 5.0 mg, E2006 10.0 mg, E2006 25.0 mg, E2006 50.0 mg, E2006 100 mg, E2006 200 mg, Zolpidem 10 mg, E2006 Matched Placebo or Zolpidem Matched Placebo, E2006 Matched Placebo
Drug
Lead sponsor
Eisai Inc.
Industry
Eligibility
18 Years to 64 Years
Enrollment
122 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2012
U.S. locations
2
States / cities
New York, New York • Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Jan 17, 2020 · Synced Sep 24, 2026, 3:14 AM EDT
Completed Phase 2 Interventional

Subjective Study to Assess the Efficacy of APD125 in Patients With Sleep Maintenance Insomnia

NCT00664664
View directory record Official record
Conditions
Primary Insomnia
Interventions
APD125, Placebo
Drug
Lead sponsor
Arena Pharmaceuticals
Industry
Eligibility
18 Years to 65 Years
Enrollment
744 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Dec 23, 2020 · Synced Sep 24, 2026, 3:14 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Cereset Research In Healthcare Workers During COVID-19

NCT04682197
View directory record Official record
Conditions
Health Personnel, Stress, Anxiety, Insomnia, Hyperarousal, Corona Virus Infection, Covid19
Interventions
Cereset Research
Device
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older
Enrollment
144 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 18, 2024 · Synced Sep 24, 2026, 3:14 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

The Effects of Modafinil on Waking Function and on Sleep in Individuals With Primary Insomnia

NCT00124384
View directory record Official record
Conditions
Primary Insomnia
Interventions
CBT-I, modafinil
Behavioral · Drug
Lead sponsor
University of Rochester
Other
Eligibility
25 Years to 80 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2007
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Apr 22, 2008 · Synced Sep 24, 2026, 3:14 AM EDT
Completed Not applicable Interventional

Effects of Insomnia Treatment on Metabolism in Patients With Depression

NCT04719143
View directory record Official record
Conditions
Insomnia Chronic, Insomnia, Insomnia, Primary, Depression, Depressive Symptoms
Interventions
Cognitive Behavioral Therapy for Insomnia (CBT-I)
Behavioral
Lead sponsor
University of Pennsylvania
Other
Eligibility
21 Years to 60 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 16, 2023 · Synced Sep 24, 2026, 3:14 AM EDT
Completed No phase listed Observational Accepts healthy volunteers Results available

Impact of Hyperarousal on Simple and Complex Cognitive Task Performance Among Insomnia Sufferers

NCT02290405
View directory record Official record
Conditions
Insomnia, Primary Insomnia, Chronic Insomnia
Interventions
Multiple Sleep Latency Test (MSLT)
Behavioral
Lead sponsor
Jack Edinger, PhD
Other
Eligibility
21 Years to 80 Years
Enrollment
89 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2017
U.S. locations
1
States / cities
Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Mar 29, 2021 · Synced Sep 24, 2026, 3:14 AM EDT
Completed Phase 2 Interventional

Evaluation of A Morning Dosing Of A New Medicine And Its Effects On Sleep At Bedtime In Subjects With Primary Insomnia

NCT00354809
View directory record Official record
Conditions
Sleep Initiation and Maintenance Disorders, Insomnia
Interventions
GW679769
Drug
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
18 Years to 64 Years
Enrollment
68 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2007
U.S. locations
13
States / cities
Glendale, Arizona • Glendale, California • Hallandale, Florida + 10 more
Source: ClinicalTrials.gov public record
Updated Apr 15, 2015 · Synced Sep 24, 2026, 3:14 AM EDT
Completed Not applicable Interventional

30 Days in Home Use and Home Use Patterns Over 6 Months

NCT01882699
View directory record Official record
Conditions
Primary Insomnia
Interventions
Cereve Sleep System
Device
Lead sponsor
Cereve, Inc.
Industry
Eligibility
22 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013
U.S. locations
4
States / cities
Saint Petersburgh, Florida • Atlanta, Georgia • Crestview Hills, Kentucky
Source: ClinicalTrials.gov public record
Updated May 21, 2015 · Synced Sep 24, 2026, 3:14 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Comparison of Efficacy of Behavioral Approaches for Treatment of Insomnia

NCT03461666
View directory record Official record
Conditions
Primary Insomnia
Interventions
Cognitive Behavior Therapy-Insomnia, Focus of Attention, Combined-CBT-I and FOA Group, Sleep Hygiene
Behavioral
Lead sponsor
Pacific Institute of Medical Sciences
Other
Eligibility
18 Years to 72 Years
Enrollment
160 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2022
U.S. locations
2
States / cities
Bothell, Washington
Source: ClinicalTrials.gov public record
Updated Apr 4, 2023 · Synced Sep 24, 2026, 3:14 AM EDT
Not listed Not applicable Interventional

Integrating Behavioral Health and Primary Care for Comorbid Behavioral and Medical Problems

NCT02868983
View directory record Official record
Conditions
Arthritis, Asthma, Chronic Obstructive Lung Disease, Diabetes, Heart Failure, Hypertension, Anxiety, Chronic Pain, Depression, Fibromyalgia, Insomnia, Irritable Bowel Syndrome, Problem Drinking, Substance Use Disorder
Interventions
Integration
Other
Lead sponsor
University of Vermont
Other
Eligibility
18 Years and older
Enrollment
4,025 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2021
U.S. locations
1
States / cities
Burlington, Vermont
Source: ClinicalTrials.gov public record
Updated Oct 4, 2021 · Synced Sep 24, 2026, 3:14 AM EDT
Completed Phase 2 Interventional Results available

Almorexant (ACT-078573) in Elderly Subjects With Chronic Primary Insomnia

NCT00606593
View directory record Official record
Conditions
Chronic Primary Insomnia
Interventions
ACT-078573 oral capsules at 25 and 100 mg and matching placebo, ACT-078573 and matching placebo
Drug
Lead sponsor
Midnight Pharma, LLC
Industry
Eligibility
65 Years and older
Enrollment
112 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2008
U.S. locations
21
States / cities
Hot Springs, Arkansas • Los Angeles, California • San Diego, California + 16 more
Source: ClinicalTrials.gov public record
Updated Mar 13, 2016 · Synced Sep 24, 2026, 3:14 AM EDT
Not listed Not applicable Interventional

The Effect of Mindfulness Training Before Primary Total Joint Arthroplasty on Sleep Quality

NCT05295004
View directory record Official record
Conditions
Sleep Disturbance, Arthropathy
Interventions
Mindfulness Meditation Training
Behavioral
Lead sponsor
Colorado Joint Replacement
Other
Eligibility
18 Years to 90 Years
Enrollment
282 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Jul 9, 2023 · Synced Sep 24, 2026, 3:14 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Validating the Use of a Subjectively Reported Sleep Vital Sign

NCT03018912
View directory record Official record
Conditions
Obstructive Sleep Apnea (OSA), Insomnia, Restless Leg Syndrome (RLS), Hypersomnia Type; Sleep Disorder, Shift Work Sleep Disorders
Interventions
Sleep VS
Other
Lead sponsor
Kaiser Permanente
Other
Eligibility
18 Years and older
Enrollment
1,260 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Fontana, California
Source: ClinicalTrials.gov public record
Updated Jul 20, 2026 · Synced Sep 24, 2026, 3:14 AM EDT
Recruiting Not applicable Interventional

A Hybrid Effectiveness Implementation Trial Evaluating Behavioral Treatments for Insomnia for Socioeconomically Disadvantaged Adults in Primary Care

NCT05759065
View directory record Official record
Conditions
Insomnia
Interventions
Tele-Brief Behavioral Treatment for Insomnia, Tele-Cognitive-Behavioral Therapy for Insomnia
Behavioral
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years and older
Enrollment
350 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 6, 2026 · Synced Sep 24, 2026, 3:14 AM EDT
Completed Not applicable Interventional

Exercise and Insomnia Study: The Effects of 1 Week of Exercise Training on Insomnia Severity

NCT04402021
View directory record Official record
Conditions
Insomnia Chronic, Insomnia, Primary
Interventions
Outdoor Walking, Quiet Rest
Behavioral · Other
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years to 55 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 13, 2021 · Synced Sep 24, 2026, 3:14 AM EDT
Completed Phase 2 Interventional

Effects Of GW679769 On Sleep Onset And Maintenance,And Next Day Functioning In The Elderly And Non-elderly With Primary Insomnia

NCT00280436
View directory record Official record
Conditions
Sleep Initiation and Maintenance Disorders, Insomnia
Interventions
GW679769
Drug
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
18 Years and older
Enrollment
122 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2007
U.S. locations
26
States / cities
Phoenix, Arizona • Tucson, Arizona • Anaheim, California + 21 more
Source: ClinicalTrials.gov public record
Updated Apr 15, 2015 · Synced Sep 24, 2026, 3:14 AM EDT
Completed Not applicable Interventional

Infant Night Wakings in Pediatric Primary Care

NCT02780596
View directory record Official record
Conditions
Insomnia, Night Wakings
Interventions
Item1, Item2, Item3, Item4, Item5
Other
Lead sponsor
Indiana University
Other
Eligibility
5 Months to 20 Months
Enrollment
3,501 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Feb 21, 2018 · Synced Sep 24, 2026, 3:14 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Testing the Nocturnal Sleep Latency Profile in Primary Insomnia

NCT00167375
View directory record Official record
Conditions
Primary Insomnia, Sleep Initiation and Maintenance Disorders
Interventions
eszopiclone 3 mg qHS, General cognitive/behavioral interventions for insomnia
Drug · Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years to 60 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2007
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 14, 2008 · Synced Sep 24, 2026, 3:14 AM EDT
Completed Phase 2 Interventional

Efficacy Study of LY2422347 to Treat Insomnia

NCT00259311
View directory record Official record
Conditions
Sleep Initiation and Maintenance Disorders
Interventions
LY2422347, placebo
Drug
Lead sponsor
Eli Lilly and Company
Industry
Eligibility
24 Years to 75 Years
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2006
U.S. locations
22
States / cities
Phoenix, Arizona • Anaheim, California • Burbank, California + 19 more
Source: ClinicalTrials.gov public record
Updated Jan 25, 2007 · Synced Sep 24, 2026, 3:14 AM EDT