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Showing 1–24 of 955 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Insomnia Disorder Clear all
Completed Phase 3 Interventional

Safety and Efficacy of Ramelteon in Elderly Subjects With Chronic Insomnia

NCT00671255
View directory record Official record
Conditions
Chronic Insomnia
Interventions
Ramelteon, Placebo
Drug
Lead sponsor
Takeda
Industry
Eligibility
65 Years and older
Enrollment
829 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2004
U.S. locations
102
States / cities
Columbiana, Alabama • Mobile, Alabama • Muscle Shoals, Alabama + 99 more
Source: ClinicalTrials.gov public record
Updated Feb 27, 2012 · Synced Jun 11, 2026, 2:44 AM EDT
Completed Phase 3 Interventional

Long-Term Efficacy and Safety of Ramelteon in Adults With Chronic Insomnia.

NCT00247390
View directory record Official record
Conditions
Chronic Insomnia
Interventions
Ramelteon, Placebo
Drug
Lead sponsor
Takeda
Industry
Eligibility
18 Years and older
Enrollment
451 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2006
U.S. locations
19
States / cities
Birmingham, Alabama • Hot Springs, Arkansas • Los Angeles, California + 16 more
Source: ClinicalTrials.gov public record
Updated Jun 2, 2010 · Synced Jun 11, 2026, 2:44 AM EDT
Completed Phase 3 Interventional Results available

Treatment of Insomnia in Elderly Sleep Apnea Patients With Ramelteon (TAK 375)

NCT01048242
View directory record Official record
Conditions
Insomnia, Obstructive Sleep Apnea
Interventions
rozerem, Placebo
Drug
Lead sponsor
University of Pennsylvania
Other
Eligibility
60 Years and older
Enrollment
27 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2009
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 24, 2023 · Synced Jun 11, 2026, 2:44 AM EDT
Completed Not applicable Interventional Results available

Non-Pharmacological Treatments for Insomnia in Chronic Traumatic Brain Injury

NCT03261674
View directory record Official record
Conditions
Insomnia, Traumatic Brain Injury
Interventions
CBT-I, ABT-I
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
Not listed
Enrollment
110 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2024
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Oct 30, 2024 · Synced Jun 11, 2026, 2:44 AM EDT
Recruiting Not applicable Interventional

Multi-center Trial to Improve Nocturia and Sleep in Older Adults

NCT06110091
View directory record Official record
Conditions
Nocturia, Insomnia
Interventions
Integrated Behavioral Therapy Program, Health Education Program
Behavioral
Lead sponsor
Atlanta VA Medical Center
Federal
Eligibility
60 Years and older
Enrollment
192 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2028
U.S. locations
2
States / cities
Los Angeles, California • Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Sep 29, 2025 · Synced Jun 11, 2026, 2:44 AM EDT
Completed Not applicable Interventional Results available

Reducing Cannabis Use for Sleep Among Adults Using Medical Cannabis

NCT03964974
View directory record Official record
Conditions
Insomnia Chronic, Cannabis Use
Interventions
Cognitive Behavioral Therapy for Insomnia in Cannabis Users (CBTi-CB), Sleep Hygiene Education (SHE)
Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
21 Years and older
Enrollment
57 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
2
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Sep 13, 2022 · Synced Jun 11, 2026, 2:44 AM EDT
Completed Phase 2 Interventional

Comparison of MMFS Dosages in Older Adults

NCT03601169
View directory record Official record
Conditions
Anxiety, Depression, Sleep Quality, Cognitive Impairment
Interventions
Low Dose MMFS-205-SR, High Dose MMFS-205-SR, Placebo
Dietary Supplement
Lead sponsor
Neurocentria, Inc.
Industry
Eligibility
60 Years to 85 Years
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Springfield, Missouri
Source: ClinicalTrials.gov public record
Updated Sep 8, 2020 · Synced Jun 11, 2026, 2:44 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Computerized Cognitive Behavioral Treatment for Insomnia: Improving Rural Veteran Access to Evidence-Based Treatment to Reduce Suicide Risk (R-Vets Sleep)

NCT03365024
View directory record Official record
Conditions
Insomnia, Mental Health Functioning, Physical Health Functioning
Interventions
Computerized Cognitive Behavioral Therapy for Insomnia, Sleep Education
Behavioral
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years to 89 Years
Enrollment
93 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Jul 27, 2021 · Synced Jun 11, 2026, 2:44 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Morning Bright Light to Improve Sleep Quality in Veterans

NCT03578003
View directory record Official record
Conditions
Brain Injuries, Traumatic, Post-traumatic Stress Disorder
Interventions
Morning Bright Light Therapy
Other
Lead sponsor
Portland VA Medical Center
Federal
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2026
U.S. locations
1
States / cities
Portand, Oregon
Source: ClinicalTrials.gov public record
Updated Nov 13, 2025 · Synced Jun 11, 2026, 2:44 AM EDT
Not listed Not applicable Interventional

An ACT Website for College Students With Insomnia

NCT06094751
View directory record Official record
Conditions
Insomnia
Interventions
ACT Guide for Insomnia
Behavioral
Lead sponsor
Utah State University
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Logan, Utah
Source: ClinicalTrials.gov public record
Updated Oct 23, 2023 · Synced Jun 11, 2026, 2:44 AM EDT
Completed No phase listed Observational Accepts healthy volunteers Results available

The Psychoneuroimmunology of Insomnia

NCT00680771
View directory record Official record
Conditions
Primary Insomnia
Interventions
Not listed
Lead sponsor
University of Rochester
Other
Eligibility
30 Years to 50 Years · Female only
Enrollment
28 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2010
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Oct 16, 2012 · Synced Jun 11, 2026, 2:44 AM EDT
Completed Not applicable Interventional

The Effect of Family History on Insomnia During Sobriety in Alcoholics

NCT01603381
View directory record Official record
Conditions
Insomnia
Interventions
Cognitive Behavioral Therapy for Insomnia (CBT-I)
Behavioral
Lead sponsor
Corporal Michael J. Crescenz VA Medical Center
Federal
Eligibility
18 Years to 65 Years · Male only
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 3, 2016 · Synced Jun 11, 2026, 2:44 AM EDT
Terminated Not applicable Interventional

Prospective Study Evaluating the Use of PROSPECT to Reduce Insomnia in Patients With Early Stage Breast Cancer

NCT02712437
View directory record Official record
Conditions
Breast Cancer, Insomnia
Interventions
PROSPECT
Behavioral
Lead sponsor
University of Michigan Rogel Cancer Center
Other
Eligibility
18 Years and older · Female only
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Sep 7, 2017 · Synced Jun 11, 2026, 2:44 AM EDT
Completed Not applicable Interventional

Improving Sleep Quality in Flap Patients in the SICU

NCT03957317
View directory record Official record
Conditions
Sleep Deprivation
Interventions
Eye mask and ear plugs
Other
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years and older · Female only
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Oct 13, 2019 · Synced Jun 11, 2026, 2:44 AM EDT
Completed Not applicable Interventional

Internet-guided Cognitive Behavioral Therapy for Insomnia in Military Service Members With History of TBI

NCT04377009
View directory record Official record
Conditions
Insomnia Chronic, Mild Traumatic Brain Injury
Interventions
Sleep Healthy Using the Internet (SHUTi), Education Control Program
Device · Other
Lead sponsor
Henry M. Jackson Foundation for the Advancement of Military Medicine
Other
Eligibility
18 Years to 64 Years
Enrollment
125 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Aug 20, 2023 · Synced Jun 11, 2026, 2:44 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A Clinical Trial to Evaluate the Effects of a Supplement on Energy and Mood

NCT07398521
View directory record Official record
Conditions
Mood, Stress
Interventions
Liposomal Magnesium Complex
Dietary Supplement
Lead sponsor
Cymbiotika, LLC
Industry
Eligibility
18 Years to 60 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
Las Vegas, Nevada
Source: ClinicalTrials.gov public record
Updated Feb 9, 2026 · Synced Jun 11, 2026, 2:44 AM EDT
Not listed Not applicable Interventional

Treatment of Insomnia and Depression in Elders (TIDE)

NCT01648049
View directory record Official record
Conditions
Depression, Insomnia
Interventions
Integrated Cognitive Behavioral Therapy (CBT), Treatment as usual
Behavioral
Lead sponsor
University of Alabama, Tuscaloosa
Other
Eligibility
50 Years to 100 Years
Enrollment
46 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2012
U.S. locations
1
States / cities
Tuscaloosa, Alabama
Source: ClinicalTrials.gov public record
Updated Dec 1, 2015 · Synced Jun 11, 2026, 2:44 AM EDT
Recruiting Phase 2 Interventional

Efficacy of Cognitive Behavioral Therapy for Insomnia to Treat Insomnia Symptoms in Individuals With Multiple Sclerosis

NCT06428006
View directory record Official record
Conditions
Multiple Sclerosis, Insomnia
Interventions
Cognitive behavioral therapy for insomnia, Sleep and lifestyle education
Behavioral
Lead sponsor
University of Kansas Medical Center
Other
Eligibility
18 Years to 65 Years
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Kansas City, Kansas
Source: ClinicalTrials.gov public record
Updated Jul 19, 2025 · Synced Jun 11, 2026, 2:44 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Sleep as a Mechanism of Change in Alcohol Use

NCT06286774
View directory record Official record
Conditions
Insomnia, Alcohol; Harmful Use
Interventions
Cognitive Behavioral Therapy for Insomnia
Behavioral
Lead sponsor
University of Missouri-Columbia
Other
Eligibility
18 Years to 49 Years
Enrollment
256 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2028
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Jul 21, 2025 · Synced Jun 11, 2026, 2:44 AM EDT
Completed Not applicable Interventional

Cognitive-Behavioral Therapy for Chronic Insomnia After Breast Cancer Treatment

NCT00672217
View directory record Official record
Conditions
Breast Cancer
Interventions
Cognitive Behavioral Therapy for Insomnia (CBTI), Behavioral Placebo Treatment
Behavioral
Lead sponsor
University of Colorado, Denver
Other
Eligibility
21 Years to 65 Years · Female only
Enrollment
64 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2013
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated May 26, 2015 · Synced Jun 11, 2026, 2:44 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Efficacy of Wholetones® 2Sleep Music on Health and Sleep Behaviors of Healthy Adults With Insomnia Symptoms

NCT03928301
View directory record Official record
Conditions
Insomnia, Sleeplessness
Interventions
Wholetones Music, Classical Music
Behavioral
Lead sponsor
Jacksonville University
Other
Eligibility
25 Years to 65 Years
Enrollment
44 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Apr 25, 2019 · Synced Jun 11, 2026, 2:44 AM EDT
Terminated Not applicable Interventional Results available

Direct Noise Reduction in the Intensive Care Units (ICU) Using Earplugs and Noise Canceling Headphones

NCT01343095
View directory record Official record
Conditions
Delirium, Sleep Fragmentation
Interventions
Foam Earplugs, Noise Canceling Headphones
Device
Lead sponsor
Wake Forest University
Other
Eligibility
18 Years and older
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2015
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 11, 2018 · Synced Jun 11, 2026, 2:44 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Noradrenergic Dysregulation, Sleep and Cognition in Older Adults With Insomnia

NCT06694441
View directory record Official record
Conditions
Insomnia
Interventions
Light Exposure, Placebo
Other
Lead sponsor
Northwestern University
Other
Eligibility
55 Years and older
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2029
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Mar 29, 2026 · Synced Jun 11, 2026, 2:44 AM EDT
Not yet recruiting Phase 1 Interventional Accepts healthy volunteers

Evaluating the Efficacy and Safety of PROSOMNIA Sleep Therapy™ in Patients With Sleep Deprivation and Chronic Insomnia

NCT06644573
View directory record Official record
Conditions
Chronic Insomnia, Sleep Deprivation, REM Behavior Disorder, REM Sleep Behavior Disorder, REM Sleep Measurement, Insomnia, Insomnia Related to Specified Disorder, Insomnia Due to Other Mental Disorder, Insomnia Comorbid to Psychiatric Disorder, Insomnia Due to Anxiety and Fear, Insomnia Related to Another Mental Condition, Insomnia Disorders, Idiopathic Hypersomnia, Sleep Disorders, Circadian Rhythm, Post Trauma Nightmares, PTSD - Post Traumatic Stress Disorder, Sleep Quality, Anesthesia, Anxiety, Depression, Mental Health, Alzheimer Disease or Associated Disorder, Parkinsons, Circadian Rhythm, Circadian Dysregulation, PTSD, Post-Traumatic, Post-Traumatic Stress Disorder Complex, Military Combat Stress Reaction, Sleep, Military Activity, Veterans, Shift Work Sleep Disorder, Menopause Related Conditions, Pain, Cancer Pain, Athletes
Interventions
PROSOMNIA Sleep Therapy™ (PSTx), Anesthesia-Induced Sleep Therapy, Diprivan (propofol), Astra-Zeneca, Continuous EEG Monitoring
Procedure · Drug · Device
Lead sponsor
Nyree Penn
Industry
Eligibility
18 Years to 65 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Aventura, Florida
Source: ClinicalTrials.gov public record
Updated May 27, 2025 · Synced Jun 11, 2026, 2:44 AM EDT