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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Insulin Response Clear all
Completed Not applicable Interventional Accepts healthy volunteers

A Randomized, Crossover Study to Assess the Effects of Dietary Fiber-containing Bars on Glucose and Insulin Responses

NCT03796286
View directory record Official record
Conditions
Blood Glucose, Insulin Sensitivity, Dietary Fiber
Interventions
Medium-fiber bar, High-fiber bar, Control bar (0 g fiber)
Other
Lead sponsor
Midwest Center for Metabolic and Cardiovascular Research
Other
Eligibility
18 Years to 65 Years
Enrollment
41 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
2
States / cities
Boca Raton, Florida • Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jul 23, 2019 · Synced Jul 24, 2026, 1:19 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Racial Differences in the Natriuretic Peptide Response to Glucose Challenge

NCT03072602
View directory record Official record
Conditions
Healthy, Natriuretic Peptides, Metabolic Syndrome
Interventions
Study diet, Glucose Challenge
Dietary Supplement · Other
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years to 40 Years
Enrollment
81 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Jun 21, 2023 · Synced Jul 24, 2026, 1:19 AM EDT
Completed Phase 2Phase 3 Interventional Results available

Trial of Leptin Replacement Therapy in Patients With Lipodystrophy

NCT00896298
View directory record Official record
Conditions
Hypoleptinemia, Generalized Lipodystrophy, Partial Lipodystrophy, Insulin Resistance
Interventions
Leptin, Placebo
Drug
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
6 Years to 70 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2014
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Mar 26, 2024 · Synced Jul 24, 2026, 1:19 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Replacing Refined Carbohydrates With Healthy Fats on Cardio-metabolic Markers

NCT02695433
View directory record Official record
Conditions
Pre-diabetes, Metabolic Syndrome
Interventions
Active, Control
Dietary Supplement
Lead sponsor
Clinical Nutrition Research Center, Illinois Institute of Technology
Industry
Eligibility
25 Years to 60 Years
Enrollment
124 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2021
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jun 28, 2021 · Synced Jul 24, 2026, 1:19 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Effect of D-allulose in Addition to Oral Sucrose Load

NCT02714413
View directory record Official record
Conditions
Blood Glucose
Interventions
D-allulose, sucrose, Placebo
Dietary Supplement · Other
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 70 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Jul 10, 2017 · Synced Jul 24, 2026, 1:19 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Regulation of Branched-chain Amino Acid Metabolism in Pre-Diabetes

NCT01786941
View directory record Official record
Conditions
Branched-chain Amino Acid Metabolism, Insulin Sensitivity
Interventions
Pre-Diabetes Group - 6-mo Aerobic and Resistance combined exercise training, GBP Group - Non-diabetics intending to undergo Gastric Bypass surgery
Other
Lead sponsor
Duke University
Other
Eligibility
30 Years to 65 Years
Enrollment
132 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2013
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Oct 18, 2015 · Synced Jul 24, 2026, 1:19 AM EDT
Terminated Phase 1Phase 2 Interventional Results available

Glucagon Response to Prandial Insulin Administration in Persons With Type 1 Diabetes

NCT04079881
View directory record Official record
Conditions
Type 1 Diabetes, Hyperglycemia, Postprandial
Interventions
Insulin
Drug
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years to 90 Years
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Oct 6, 2022 · Synced Jul 24, 2026, 1:19 AM EDT
Completed Not applicable Interventional

Glycemic Response in Persons with Type 2 Diabetes

NCT04413357
View directory record Official record
Conditions
Diabetes Mellitus, Type 2
Interventions
Balanced Nutritional Drink, Diabetes Specific, Balanced Nutritional Drink (DMA), Diabetes Specific, Balanced Nutritional Drink DMB
Other
Lead sponsor
Société des Produits Nestlé (SPN)
Industry
Eligibility
20 Years to 75 Years
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020
U.S. locations
1
States / cities
Tustin, California
Source: ClinicalTrials.gov public record
Updated Oct 20, 2024 · Synced Jul 24, 2026, 1:19 AM EDT
Completed Phase 1 Interventional Results available

Characteristics of Glargine in Type 2 Diabetics

NCT00574912
View directory record Official record
Conditions
Type 2 Diabetes
Interventions
Placebo, Insulin Glargine 0.5 u/kg body wt SC, Insulin Glargine 1.0 u/kg body wt SC, Insulin Glargine 1.5 u/kg body wt SC, Insulin Glargine 2.0 u/kg body wt SC
Drug
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
18 Years to 70 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2010
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Apr 16, 2017 · Synced Jul 24, 2026, 1:19 AM EDT
Completed Not applicable Interventional

Glycemic Response to Six Meal Replacements in Persons With Type 2 Diabetes Mellitus

NCT03155867
View directory record Official record
Conditions
Diabetes
Interventions
Meal replacement
Other
Lead sponsor
Société des Produits Nestlé (SPN)
Industry
Eligibility
20 Years to 75 Years
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017
U.S. locations
1
States / cities
Tustin, California
Source: ClinicalTrials.gov public record
Updated Jul 1, 2017 · Synced Jul 24, 2026, 1:19 AM EDT
Completed Not applicable Interventional Results available

Assess the Efficacy of the Low Glucose Suspend (LGS) Feature in the MiniMed Paradigm® X54 System

NCT01148862
View directory record Official record
Conditions
Type 1 Diabetes Mellitus
Interventions
The MiniMed Paradigm® X54 System
Device
Lead sponsor
Medtronic MiniMed, Inc.
Industry
Eligibility
16 Years to 60 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
5
States / cities
Escondido, California • Stanford, California • Aurora, Colorado + 2 more
Source: ClinicalTrials.gov public record
Updated Mar 29, 2017 · Synced Jul 24, 2026, 1:19 AM EDT
Recruiting Not applicable Interventional

VR Stimulation of Exercise Response in Sedentary Humans

NCT07296991
View directory record Official record
Conditions
Prolonged Inactivity, Metabolic Syndrome
Interventions
20 minutes cycling exercise, Virtual Reality
Behavioral
Lead sponsor
Wayne State University
Other
Eligibility
25 Years to 40 Years
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Dec 22, 2025 · Synced Jul 24, 2026, 1:19 AM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers Results available

Transdermal Insulin Response In Healthy Volunteers

NCT04857320
View directory record Official record
Conditions
Pharmacodynamic Response to Small Doses of Insulin
Interventions
Human insulin
Combination Product
Lead sponsor
Transdermal Delivery Solutions Corp
Industry
Eligibility
20 Years to 60 Years · Male only
Enrollment
7 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
Palm Beach Gardens, Florida
Source: ClinicalTrials.gov public record
Updated Oct 22, 2023 · Synced Jul 24, 2026, 1:19 AM EDT
Terminated Not applicable Interventional

The Effect of Nighttime Dialysis on the Inflammation of Kidney Failure

NCT00234130
View directory record Official record
Conditions
End-Stage Renal Disease
Interventions
nocturnal vs conventional dialysis
Procedure
Lead sponsor
Rockefeller University
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2006
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jun 2, 2009 · Synced Jul 24, 2026, 1:19 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Impact of Prebiotic Sodas on Satiety and Metabolic Responses in Healthy Men

NCT07105826
View directory record Official record
Conditions
Olipop, Poppi, Coca Cola - Classic, Diet Coke
Interventions
Prebiotic Soda 1, Prebiotic Soda 2, Diet Soda, Regular Coke
Other
Lead sponsor
Texas Christian University
Other
Eligibility
18 Years to 40 Years · Male only
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Fort Worth, Texas
Source: ClinicalTrials.gov public record
Updated May 26, 2026 · Synced Jul 24, 2026, 1:19 AM EDT
Completed Phase 1Phase 2 Interventional Accepts healthy volunteers Results available

T-IR- Study to Understand the Effects of Testosterone and Estrogen on the Body's Response to the Hormone Insulin

NCT01686828
View directory record Official record
Conditions
Insulin Resistance, Type 2 Diabetes Mellitus, Obesity, Androgen Deficiency, Metabolic Disease
Interventions
Acyline, Testosterone 1.62% gel, Letrozole, Placebo gel (for Testosterone 1.62% gel), Placebo pill (for Letrozole)
Drug
Lead sponsor
University of Washington
Other
Eligibility
25 Years to 55 Years · Male only
Enrollment
53 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2017
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated May 7, 2018 · Synced Jul 24, 2026, 1:19 AM EDT
Completed Not applicable Interventional

Obesity/Overweight in Persons With Early and Chronic Spinal Cord Injury (SCI)

NCT01467817
View directory record Official record
Conditions
Overweight, Obese, Spinal Cord Injury
Interventions
Lifestyle Intervention, Exercise Control
Behavioral
Lead sponsor
University of Miami
Other
Eligibility
18 Years to 65 Years
Enrollment
29 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2016
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Nov 29, 2016 · Synced Jul 24, 2026, 1:19 AM EDT
Completed Phase 3 Interventional Results available

Outpatient Study to Evaluate Safety and Effectiveness of the Low Glucose Suspend Feature

NCT01497938
View directory record Official record
Conditions
Type 1 Diabetes
Interventions
Medtronic MMT-754 Veo Insulin pump testing Low Glucose Suspend (LGS) feature, Medtronic (NO LGS FEATURE ) using Paradigm® Revel™2.0 Pump
Device
Lead sponsor
Medtronic MiniMed, Inc.
Industry
Eligibility
16 Years to 70 Years
Enrollment
247 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
17
States / cities
Little Rock, Arkansas • Escondido, California • San Mateo, California + 14 more
Source: ClinicalTrials.gov public record
Updated Mar 16, 2014 · Synced Jul 24, 2026, 1:19 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Effects of Two Days of Bedrest on Insulin Resistance in Type 2 Diabetics

NCT00508599
View directory record Official record
Conditions
Type 2 Diabetes, Insulin Resistance
Interventions
Study 2 (48 hours of complete bed rest)
Other
Lead sponsor
University of New Mexico
Other
Eligibility
21 Years to 75 Years
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2003 – 2006
U.S. locations
1
States / cities
Albuquerque, New Mexico
Source: ClinicalTrials.gov public record
Updated Mar 11, 2024 · Synced Jul 24, 2026, 1:19 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

A Study to Evaluate Glucose and Insulin Response to Nutralin

NCT01275820
View directory record Official record
Conditions
Diabetes
Interventions
Nutralin
Dietary Supplement
Lead sponsor
Avera McKennan Hospital & University Health Center
Other
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010
U.S. locations
1
States / cities
Sioux Falls, South Dakota
Source: ClinicalTrials.gov public record
Updated Jan 11, 2011 · Synced Jul 24, 2026, 1:19 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

The Effects of Vitamin E and Vitamin C and Exercise

NCT01369043
View directory record Official record
Conditions
Exercise and Non-exercise Effect Upon Vitamins E and C
Interventions
Vitamin E and Vitamin C
Dietary Supplement
Lead sponsor
USDA Grand Forks Human Nutrition Research Center
Federal
Eligibility
30 Years to 50 Years
Enrollment
1 participant
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2012
U.S. locations
1
States / cities
Grand Forks, North Dakota
Source: ClinicalTrials.gov public record
Updated Mar 8, 2015 · Synced Jul 24, 2026, 1:19 AM EDT
Completed Phase 2 Interventional Results available

Liquid Meal Study With Insulin Lispro With/Without Recombinant Human Hyaluronidase PH20 (rHuPH20) and Regular Human Insulin With rHuPH20 to Compare Pharmacokinetics, Postprandial Glycemic Response, and Optimal Insulin Dose in Participants With Type 2 Diabetes Mellitus (T2DM)

NCT00916357
View directory record Official record
Conditions
Diabetes Mellitus, Type 2
Interventions
Humalog, Humulin-R, Recombinant human hyaluronidase PH20 (rHuPH20)
Drug
Lead sponsor
Halozyme Therapeutics
Industry
Eligibility
18 Years to 70 Years
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009
U.S. locations
1
States / cities
Chula Vista, California
Source: ClinicalTrials.gov public record
Updated Aug 17, 2014 · Synced Jul 24, 2026, 1:19 AM EDT
Completed Not applicable Interventional

Glycemic Response to Three Oral Nutrition Supplements in Persons With Type 2 Diabetes Mellitus

NCT02856516
View directory record Official record
Conditions
Diabetes
Interventions
Boost Glucose Control (A), Boost Glucose Control (B), Boost Original
Other
Lead sponsor
Société des Produits Nestlé (SPN)
Industry
Eligibility
20 Years to 75 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016
U.S. locations
1
States / cities
Tustin, California
Source: ClinicalTrials.gov public record
Updated Oct 10, 2016 · Synced Jul 24, 2026, 1:19 AM EDT
Not yet recruiting Phase 4 Interventional Accepts healthy volunteers

Pharmacogenetics of Response to Sitagliptin (PRS)

NCT06813014
View directory record Official record
Conditions
Diabetes
Interventions
Oral Glucose Tolerance Test
Procedure
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
18 Years and older
Enrollment
400 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2032
U.S. locations
1
States / cities
Lancaster, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 17, 2026 · Synced Jul 24, 2026, 1:19 AM EDT