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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Internal Fixation Clear all
Completed Not applicable Interventional Results available

Evaluation of Continuous Saphenous Nerve Block to Supplement a Continuous Sciatic Nerve Block After Ankle Surgery

NCT01167907
View directory record Official record
Conditions
Orthopedic Surgery of Lower Extremity
Interventions
0.2% ropivacaine, saline
Device · Drug
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years to 75 Years
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2017
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 30, 2018 · Synced Jul 23, 2026, 2:16 PM EDT
Recruiting Phase 4 Interventional

Nonopioid Pain Control Regimen After Open Reduction and Internal Fixation of Traumatic Fractures

NCT06113211
View directory record Official record
Conditions
Opioid Use, Fractures, Bone, Trauma
Interventions
Narcotic pain medication, Nonnarcotic pain medications
Drug
Lead sponsor
Henry Ford Health System
Other
Eligibility
18 Years to 80 Years
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Apr 12, 2026 · Synced Jul 23, 2026, 2:16 PM EDT
Recruiting Not applicable Interventional

Early Internal Fixation Versus NonOperative Care With Early Rehabilitation for LC1 Fragility Fractures of the Pelvis

NCT06496867
View directory record Official record
Conditions
Multiple Closed Pelvic Fractures With Disruption of Pelvic Ring, Fragility Fracture, Internal Fixation, Nonoperative Care
Interventions
Early Internal Fixation, Nonoperative Care with Early Rehabilitation
Procedure · Other
Lead sponsor
University of Southern California
Other
Eligibility
60 Years and older
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
12
States / cities
Phoenix, Arizona • Los Angeles, California • Sacramento, California + 7 more
Source: ClinicalTrials.gov public record
Updated Oct 14, 2025 · Synced Jul 23, 2026, 2:16 PM EDT
Recruiting Phase 1 Interventional Accepts healthy volunteers

Impact of Early ADL Education on Outcomes Post DRF ORIF

NCT06251206
View directory record Official record
Conditions
Distal Radius Fractures
Interventions
ADL/Postoperative Instruction, Postoperative Instruction
Behavioral
Lead sponsor
George Washington University
Other
Eligibility
18 Years to 110 Years
Enrollment
64 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
Washington, Virginia
Source: ClinicalTrials.gov public record
Updated Aug 27, 2025 · Synced Jul 23, 2026, 2:16 PM EDT
Withdrawn Phase 1Phase 2 Interventional

A Study of Postsurgical Pain Control for Lower Extremity Fractures

NCT02214810
View directory record Official record
Conditions
Lower Extremity Fractures.
Interventions
Bupivacaine/Exparel
Drug
Lead sponsor
Broward Health
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015
U.S. locations
1
States / cities
Fort Lauderdale, Florida
Source: ClinicalTrials.gov public record
Updated Feb 18, 2016 · Synced Jul 23, 2026, 2:16 PM EDT
Completed Phase 3 Interventional Results available

Liposomal Bupivacaine With Bupivacaine in Ankle Fracture Open Reduction Internal Fixation (ORIF)

NCT02480621
View directory record Official record
Conditions
Ankle Fracture
Interventions
Liposomal Bupivacaine with Bupivacaine
Drug
Lead sponsor
Jamaica Hospital Medical Center
Other
Eligibility
18 Years and older
Enrollment
84 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Jamaica, New York
Source: ClinicalTrials.gov public record
Updated Oct 19, 2017 · Synced Jul 23, 2026, 2:16 PM EDT
Not listed No phase listed Observational

Use of a Sustained Dynamic Compression Intramedullary Nail for Subtalar Arthrodesis

NCT04784156
View directory record Official record
Conditions
Foot Arthritis
Interventions
Subtalar (Talocalcaneal) Arthrodesis, DynaNail Mini
Procedure · Device
Lead sponsor
MedShape, Inc
Industry
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated May 24, 2021 · Synced Jul 23, 2026, 2:16 PM EDT
Terminated No phase listed Observational

Safety Study of Treatment of Leg Fractures

NCT03881241
View directory record Official record
Conditions
Tibial Fractures
Interventions
Not listed
Lead sponsor
Smith & Nephew, Inc.
Industry
Eligibility
18 Years and older
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
2
States / cities
Athens, Georgia • Fort Worth, Texas
Source: ClinicalTrials.gov public record
Updated Apr 9, 2020 · Synced Jul 23, 2026, 2:16 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Pediatric Femur Research Project

NCT00943332
View directory record Official record
Conditions
Femur Fracture
Interventions
femur fracture repair
Procedure
Lead sponsor
Washington University School of Medicine
Other
Eligibility
2 Years to 6 Years
Enrollment
48 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2018
U.S. locations
3
States / cities
Columbia, Missouri • Kansas City, Missouri • St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Apr 25, 2019 · Synced Jul 23, 2026, 2:16 PM EDT
Withdrawn Phase 2 Interventional

Efficacy of Tranexamic Acid (TXA) in Humerus ORIF

NCT05802238
View directory record Official record
Conditions
Fracture Humerus
Interventions
Tranexamic acid (TXA), Saline
Drug · Other
Lead sponsor
Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)
Other
Eligibility
18 Years to 100 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Dec 12, 2024 · Synced Jul 23, 2026, 2:16 PM EDT
Active, not recruiting Not applicable Interventional

Minimally Displaced Femoral Neck Fracture Pilot Study

NCT05947058
View directory record Official record
Conditions
Femoral Neck Fractures
Interventions
Arthroplasty, Internal Fixation
Procedure
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
60 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
8
States / cities
Los Angeles, California • New Haven, Connecticut • Gainesville, Florida + 5 more
Source: ClinicalTrials.gov public record
Updated Feb 12, 2026 · Synced Jul 23, 2026, 2:16 PM EDT
Terminated Not applicable Interventional Results available

The Effect of Botulinum Toxin A Injections on Ankle Dorsiflexion Following Internal Fixation of Tibial Pilon Fractures

NCT02051933
View directory record Official record
Conditions
Equinus Contracture
Interventions
Botulinum toxin type A, sodium chloride
Drug
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
1
States / cities
Charlotte, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 20, 2022 · Synced Jul 23, 2026, 2:16 PM EDT
Completed Not applicable Interventional

Early Functional Outcomes After Closed Reduction With Pinning Versus Open Reduction Internal Fixation of Wrist Fractures

NCT00828685
View directory record Official record
Conditions
Wrist Fractures
Interventions
CRPP, ORIF
Procedure
Lead sponsor
Beth Israel Deaconess Medical Center
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 6, 2017 · Synced Jul 23, 2026, 2:16 PM EDT
Withdrawn Phase 4 Interventional

Duloxetine Tibial Plateau

NCT04639011
View directory record Official record
Conditions
Tibial Plateau Fracture, Pain, Postoperative
Interventions
Duloxetine, Placebo, Standard of care (SOC) for tibial plateau surgery
Drug · Other
Lead sponsor
Boston Medical Center
Other
Eligibility
18 Years to 80 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
2
States / cities
Boston, Massachusetts • Valhalla, New York
Source: ClinicalTrials.gov public record
Updated Nov 20, 2022 · Synced Jul 23, 2026, 2:16 PM EDT
Recruiting Not applicable Interventional

Proximal FEmur Reconstruction or Internal Fixation fOR Metastases (PERFORM) Trial

NCT06863129
View directory record Official record
Conditions
Metastatic Bone Disease
Interventions
Internal Fixation, Resection and reconstruction
Procedure
Lead sponsor
Michelle Ghert, MD
Other
Eligibility
18 Years and older
Enrollment
334 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2030
U.S. locations
7
States / cities
Aurora, Colorado • Fort Wayne, Indiana • Baltimore, Maryland + 4 more
Source: ClinicalTrials.gov public record
Updated Jul 7, 2026 · Synced Jul 23, 2026, 2:16 PM EDT
Terminated Not applicable Interventional

Reverse Total Shoulder Arthroplasty Versus Open Reduction Internal Fixation of 3&4 Part Proximal Humerus Fractures

NCT02597972
View directory record Official record
Conditions
Closed Fracture Proximal Humerus, Four Part
Interventions
Fracture repair, Fracture repair with joint replacement
Procedure
Lead sponsor
Mayo Clinic
Other
Eligibility
70 Years and older
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Jan 26, 2020 · Synced Jul 23, 2026, 2:16 PM EDT
Recruiting Phase 4 Interventional

A Clinical Trial on the Use of Lidocaine Infusion During Surgery for Pediatric Upper Extremity Fractures and Its Impact on Total Perioperative Opioid Requirements

NCT07552766
View directory record Official record
Conditions
Fracture Arm, Fracture Closed of Lower End of Forearm, Unspecified, Fracture Elbow, Fracture Fixation, Fracture Fixation, Internal, Fracture Forearm, Fracture Distal Radius
Interventions
Lidocaine Infusion, Standard of Care (SOC)
Drug · Other
Lead sponsor
Nemours Children's Clinic
Other
Eligibility
3 Years to 18 Years
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Wilmington, Delaware
Source: ClinicalTrials.gov public record
Updated Jul 5, 2026 · Synced Jul 23, 2026, 2:16 PM EDT
Withdrawn Not applicable Interventional

Auricular Acupuncture As Part Of A Multimodal Regimen After Distal Radius Open Reduction and Internal Fixation

NCT05974254
View directory record Official record
Conditions
Radius Fracture Distal, Pain, Postoperative
Interventions
Acupuncture
Device
Lead sponsor
Baylor College of Medicine
Other
Eligibility
18 Years to 64 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Mar 2, 2026 · Synced Jul 23, 2026, 2:16 PM EDT
Not listed No phase listed Observational Accepts healthy volunteers

Proximal Humerus Fractures: A Retrospective Analysis

NCT03637608
View directory record Official record
Conditions
Proximal Humeral Fracture
Interventions
Not listed
Lead sponsor
The Orthopaedic Research & Innovation Foundation
Other
Eligibility
18 Years and older
Enrollment
94 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2024
U.S. locations
1
States / cities
Edgewood, Kentucky
Source: ClinicalTrials.gov public record
Updated May 29, 2019 · Synced Jul 23, 2026, 2:16 PM EDT
Withdrawn Phase 4 Interventional

CBD for Pain Reduction and Opioid Use After Ankle and Tibia Fracture ORIF

NCT04768478
View directory record Official record
Conditions
Ankle Fractures, Tibia Fracture
Interventions
CBD, Placebo
Drug
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years to 75 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jan 27, 2022 · Synced Jul 23, 2026, 2:16 PM EDT
Completed Not applicable Interventional

A Clinical Trial for the Surgical Treatment of Elderly Distal Radius Fractures

NCT01589692
View directory record Official record
Conditions
Distal Radius Fracture
Interventions
Open Reduction and Internal Fixation, External Fixation, Percutaneous Pinning, Closed Reduction and casting
Procedure
Lead sponsor
University of Michigan
Other
Eligibility
60 Years and older
Enrollment
304 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2019
U.S. locations
20
States / cities
Farmington, Connecticut • Louisville, Kentucky • Baltimore, Maryland + 15 more
Source: ClinicalTrials.gov public record
Updated Feb 10, 2019 · Synced Jul 23, 2026, 2:16 PM EDT
Not listed Not applicable Interventional

Sinus Tarsi Versus Extensile Lateral Approach for Calcaneus Fractures

NCT02446470
View directory record Official record
Conditions
Intra-articular Fractures
Interventions
Sinus Tarsi approach, Extensile Lateral approach
Procedure
Lead sponsor
University of Tennessee
Other
Eligibility
18 Years and older
Enrollment
110 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2019
U.S. locations
1
States / cities
Chattanooga, Tennessee
Source: ClinicalTrials.gov public record
Updated Nov 28, 2018 · Synced Jul 23, 2026, 2:16 PM EDT
Terminated Not applicable Interventional Results available

Comparison of Subcutaneous INFIX and EXFIX for Anterior Pelvic Ring Fractures Requiring Stabilization

NCT02403154
View directory record Official record
Conditions
Anterior Pelvic Ring Fractures
Interventions
Internal Fixator, External fixator
Procedure
Lead sponsor
Indiana University
Other
Eligibility
18 Years to 120 Years
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Mar 12, 2018 · Synced Jul 23, 2026, 2:16 PM EDT
Withdrawn Phase 2 Interventional Accepts healthy volunteers

Effect of Palmitoylethanolamide on Reducing Opioid Consumption for Below Knee Fracture Fixation

NCT05317676
View directory record Official record
Conditions
Tibial Fractures, Fibula Fracture, Knee Fracture
Interventions
Palmitoylethanolamide, Placebo
Drug
Lead sponsor
University of California, Irvine
Other
Eligibility
18 Years and older
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Orange, California
Source: ClinicalTrials.gov public record
Updated May 8, 2023 · Synced Jul 23, 2026, 2:16 PM EDT