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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Isolation, Social Clear all
Completed Not applicable Interventional Accepts healthy volunteers

The Development and Effectiveness of Museum-Based Experiences for Individuals With Chronic Pain

NCT04091893
View directory record Official record
Conditions
Chronic Pain
Interventions
Usual care/wait list, Art Rx, Artful Meditation
Behavioral
Lead sponsor
University of California, Davis
Other
Eligibility
18 Years and older
Enrollment
149 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated Dec 15, 2021 · Synced Jun 7, 2026, 4:58 PM EDT
Completed Not applicable Interventional

The Preliminary Effects of Empower@Home

NCT05593276
View directory record Official record
Conditions
Depression, Depressive Disorder, Behavioral Symptoms, Mood Disorders, Mental Disorder
Interventions
Empower@Home
Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
60 Years and older
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Jun 3, 2024 · Synced Jun 7, 2026, 4:58 PM EDT
Completed Not applicable Interventional

Management of Depression and Social Isolation in Older Adults With Dementia With Home-based Telehealth Delivered Behavioral Activation + Caregiver Facilitation.

NCT04915040
View directory record Official record
Conditions
Depression
Interventions
Behavioral Activation for Depression
Behavioral
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
65 Years and older
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Nov 29, 2023 · Synced Jun 7, 2026, 4:58 PM EDT
Enrolling by invitation Not applicable Interventional Accepts healthy volunteers

Keep Social Study for Young Adults

NCT07005817
View directory record Official record
Conditions
Social Isolation, Loneliness
Interventions
Experimental Health Communication, Simulated Social Media Platform Only
Behavioral
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 29 Years
Enrollment
1,900 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Mar 18, 2026 · Synced Jun 7, 2026, 4:58 PM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Effect of a Telephone Reminiscence Intervention on Mental Health

NCT07576855
View directory record Official record
Conditions
Mental Health
Interventions
Telephone Reminiscence Program
Behavioral
Lead sponsor
University of Connecticut
Other
Eligibility
60 Years and older
Enrollment
170 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Storrs, Connecticut
Source: ClinicalTrials.gov public record
Updated May 7, 2026 · Synced Jun 7, 2026, 4:58 PM EDT
Completed Not applicable Interventional Results available

Group-based Integrative Pain Management (IPMP+ Pilot)

NCT05906784
View directory record Official record
Conditions
Chronic Pain
Interventions
group acupuncture, Integrative Group Medical Visits
Other
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jan 29, 2025 · Synced Jun 7, 2026, 4:58 PM EDT
Completed Not applicable Interventional

E-Support Groups in Multiple Sclerosis

NCT03574961
View directory record Official record
Conditions
Multiple Sclerosis
Interventions
e-Support group, e-Journaling placebo
Behavioral
Lead sponsor
Columbia University
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 31, 2020 · Synced Jun 7, 2026, 4:58 PM EDT
Completed Not applicable Interventional

Impact of Covid-19 on Frequent Social Interaction Through Communication Technologies in the Cognitive Status of Socially-isolated Older Adults

NCT04480112
View directory record Official record
Conditions
Memory Disorders, Alzheimer Disease, Mild Cognitive Impairment
Interventions
Technology based social interactions, No research related technology based social interactions
Behavioral · Other
Lead sponsor
Boston University
Other
Eligibility
Not listed
Enrollment
196 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 29, 2021 · Synced Jun 7, 2026, 4:58 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Neurobehavioral Mechanisms of Social Isolation and Loneliness in Serious Mental Illness

NCT04940663
View directory record Official record
Conditions
Psychosis, Schizophrenia
Interventions
EMA
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 55 Years
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2026
U.S. locations
1
States / cities
Charlestown, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 10, 2026 · Synced Jun 7, 2026, 4:58 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

HARP-Project 1 Cognitive Training

NCT03293823
View directory record Official record
Conditions
Aging, Social Isolation
Interventions
VSOP training, MLA control
Behavioral
Lead sponsor
University of Rochester
Other
Eligibility
60 Years and older
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
4
States / cities
Fairport, New York • Pittsford, New York • Rochester, New York
Source: ClinicalTrials.gov public record
Updated Jul 4, 2019 · Synced Jun 7, 2026, 4:58 PM EDT
Recruiting Not applicable Interventional

Empower@Home: Community Implementation for Older Adults With Ambulatory Disabilities

NCT06721559
View directory record Official record
Conditions
Depression
Interventions
Empower@Home: An online cognitive-behavioral therapy self-care program for geriatric depression, Telephone friendly visits
Behavioral · Other
Lead sponsor
University of Michigan
Other
Eligibility
50 Years and older
Enrollment
64 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Nov 20, 2025 · Synced Jun 7, 2026, 4:58 PM EDT
Completed No phase listed Observational

Emotional, Social, Cognitive and Behavioral Sequalae of the COVID-19 Pandemic

NCT04823988
View directory record Official record
Conditions
Healthy Volunteer
Interventions
Not listed
Lead sponsor
National Institute of Mental Health (NIMH)
NIH
Eligibility
18 Years to 99 Years
Enrollment
2,086 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated May 30, 2025 · Synced Jun 7, 2026, 4:58 PM EDT
Completed No phase listed Observational

Discharge Functional Status and Rehospitalization in the Elderly

NCT02041585
View directory record Official record
Conditions
Social Isolation, Depression, Anxiety, Debility
Interventions
Not listed
Lead sponsor
Northwestern University
Other
Eligibility
65 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Mar 5, 2023 · Synced Jun 7, 2026, 4:58 PM EDT
Recruiting Not applicable Interventional

Empower@Home: Hybrid Effectiveness-Implementation Randomized Controlled Trial (RCT)

NCT06584422
View directory record Official record
Conditions
Depression
Interventions
Empower@Home: An online cognitive-behavioral therapy self-care program for geriatric depression, Telephone friendly visits
Behavioral · Other
Lead sponsor
University of Michigan
Other
Eligibility
50 Years and older
Enrollment
256 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2029
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Nov 20, 2025 · Synced Jun 7, 2026, 4:58 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Yoga for Seniors

NCT04889131
View directory record Official record
Conditions
Aging Well
Interventions
Yoga Program Immediately, Wait-Listed Control, Activity Monitor
Behavioral · Other
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
60 Years and older
Enrollment
88 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated May 16, 2021 · Synced Jun 7, 2026, 4:58 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Evaluating Risk Factors and Biomarkers for Adaptation and Resilience to Spaceflight

NCT03786016
View directory record Official record
Conditions
Resilience, Mood, Performance, Stress, Psychological
Interventions
8-Days in an Isolation, Confinement Unit
Behavioral
Lead sponsor
University of Pennsylvania
Other
Eligibility
30 Years to 55 Years
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2025
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 5, 2025 · Synced Jun 7, 2026, 4:58 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Telephone Calls for Health for Homebound Older Adults

NCT04595708
View directory record Official record
Conditions
Loneliness, Social Isolation, Depression
Interventions
Phone Call
Behavioral
Lead sponsor
University of Texas at Austin
Other
Eligibility
18 Years and older
Enrollment
240 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Mar 29, 2021 · Synced Jun 7, 2026, 4:58 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Impact of Community Exercise on Social Connectedness and Falls in Older Adults: Leveraging Exercise to Age in Place

NCT03624049
View directory record Official record
Conditions
Social Isolation, Fall
Interventions
Exercise, Health Class
Other
Lead sponsor
Cedars-Sinai Medical Center
Other
Eligibility
50 Years and older
Enrollment
671 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2023
U.S. locations
9
States / cities
Beverly Hills, California • Los Angeles, California • West Hollywood, California
Source: ClinicalTrials.gov public record
Updated Aug 21, 2024 · Synced Jun 7, 2026, 4:58 PM EDT
Recruiting Not applicable Interventional

Intervening on Opioid Use and Loneliness

NCT06458335
View directory record Official record
Conditions
Opioid Use Disorder, Loneliness, Social Isolation
Interventions
Cognitive-Behavioral Therapy for Perceived Social Isolation, Health Education
Behavioral
Lead sponsor
University of Rochester
Other
Eligibility
18 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2029
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Dec 8, 2025 · Synced Jun 7, 2026, 4:58 PM EDT
Recruiting Not applicable Interventional

Disclosure Intervention for People in Treatment for Opioid Use Disorder

NCT06458985
View directory record Official record
Conditions
Opioid Use Disorder
Interventions
Disclosing Recovery: A Decision Aid and Toolkit
Behavioral
Lead sponsor
University of Delaware
Other
Eligibility
18 Years and older
Enrollment
480 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
1
States / cities
Wilmington, Delaware
Source: ClinicalTrials.gov public record
Updated Jul 17, 2025 · Synced Jun 7, 2026, 4:58 PM EDT
Recruiting Not applicable Interventional

Fostering Agricultural Relationships and Meaning - Thriving on Kinship

NCT07218965
View directory record Official record
Conditions
Loneliness, Social Isolation, Rural Health
Interventions
Cognitive-Behavioral Therapy for Perceived Social Isolation, Health Education
Behavioral
Lead sponsor
Ohio State University
Other
Eligibility
18 Years and older
Enrollment
65 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Oct 20, 2025 · Synced Jun 7, 2026, 4:58 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Determining How Indoor Lighting Affects the Brain Health of Older Adults

NCT05978934
View directory record Official record
Conditions
Sleep, Physical Activity, Cognitive Function, Social Isolation
Interventions
Static Lighting Condition (L1), Dynamic Lighting Condition (L2), Dynamic Lighting Condition (L3)
Behavioral
Lead sponsor
Well Living Lab, Inc.
Industry
Eligibility
60 Years and older
Enrollment
70 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Aug 6, 2023 · Synced Jun 7, 2026, 4:58 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

The Emotional, Physical and Cognitive Benefits of Purposeful Green Space Activities on Seniors

NCT04913363
View directory record Official record
Conditions
Loneliness, Social Isolation, Mood, Well Aging, Physical Activity, Mobility Limitation
Interventions
Green space
Other
Lead sponsor
University of Virginia
Other
Eligibility
65 Years and older
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Oct 9, 2024 · Synced Jun 7, 2026, 4:58 PM EDT
Recruiting Not applicable Interventional

Increasing Veterans' Social Engagement and Connectedness

NCT06467214
View directory record Official record
Conditions
Social Isolation
Interventions
CONNECTED, VET BEFRIENDING
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
264 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Jul 17, 2025 · Synced Jun 7, 2026, 4:58 PM EDT