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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Isolation, Social Clear all
Completed Not applicable Interventional Accepts healthy volunteers

Combatting Social Isolation in Older Adults

NCT05426837
View directory record Official record
Conditions
Loneliness, Social Isolation
Interventions
Combatting Social Isolation, Health Education Training
Behavioral
Lead sponsor
Florida State University
Other
Eligibility
60 Years and older
Enrollment
70 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
Tallahassee, Florida
Source: ClinicalTrials.gov public record
Updated Feb 25, 2025 · Synced Sep 20, 2026, 10:15 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

A Personalized Reminder Information and Social Management System

NCT01497613
View directory record Official record
Conditions
Social Isolation, Social Support (Formal and Informal), Well-being/Quality of Life
Interventions
PRISM C: Computer Condition, PRISM B: Notebook Condition
Behavioral
Lead sponsor
University of Miami
Other
Eligibility
65 Years and older
Enrollment
300 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2014
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Jan 22, 2019 · Synced Sep 20, 2026, 10:15 PM EDT
Not yet recruiting Not applicable Interventional

Talk2gether Program for Social Connection in Older Adults

NCT07782905
View directory record Official record
Conditions
Social Isolation or Loneliness
Interventions
Talk2gether program
Behavioral
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
65 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Aug 23, 2026 · Synced Sep 20, 2026, 10:15 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Determining How Indoor Lighting Affects the Brain Health of Older Adults

NCT05978934
View directory record Official record
Conditions
Sleep, Physical Activity, Cognitive Function, Social Isolation
Interventions
Static Lighting Condition (L1), Dynamic Lighting Condition (L2), Dynamic Lighting Condition (L3)
Behavioral
Lead sponsor
Well Living Lab, Inc.
Industry
Eligibility
60 Years and older
Enrollment
70 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Aug 6, 2023 · Synced Sep 20, 2026, 10:15 PM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Social Disconnection Study

NCT06705348
View directory record Official record
Conditions
Social Disconnection
Interventions
Not listed
Lead sponsor
Yale University
Other
Eligibility
55 Years and older
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2028
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Aug 13, 2026 · Synced Sep 20, 2026, 10:15 PM EDT
Completed Not applicable Interventional

Bridging Community Gaps Photovoice

NCT03291717
View directory record Official record
Conditions
Mental Illness, Social Isolation
Interventions
Bridging Community Gaps Photovoice (BCGP)
Behavioral
Lead sponsor
Boston University Charles River Campus
Other
Eligibility
18 Years and older
Enrollment
197 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
4
States / cities
Denver, Colorado • Bridgeport, Connecticut • Boston, Massachusetts + 1 more
Source: ClinicalTrials.gov public record
Updated Sep 15, 2020 · Synced Sep 20, 2026, 10:15 PM EDT
Enrolling by invitation Not applicable Interventional Accepts healthy volunteers

Virtual Senior Center

NCT06946186
View directory record Official record
Conditions
Social Isolation in Older Adults, Quality of Life (QOL), Activities of Daily Living
Interventions
Virtual Senior Center - GrandPad, Virtual Senior Center - No GrandPad
Behavioral
Lead sponsor
Washington University School of Medicine
Other
Eligibility
65 Years and older
Enrollment
650 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2028
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Jul 16, 2026 · Synced Sep 20, 2026, 10:15 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

International Students Intervention

NCT04945902
View directory record Official record
Conditions
Social Isolation
Interventions
Synchronous Intervention, Asynchronous Intervention
Behavioral
Lead sponsor
Purdue University
Other
Eligibility
18 Years and older
Enrollment
77 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
West Lafayette, Indiana
Source: ClinicalTrials.gov public record
Updated Jun 29, 2021 · Synced Sep 20, 2026, 10:15 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of Arts Engagement on Physical Performance, Cognition, Social Isolation, and Self-Perception in Older Adults

NCT04281654
View directory record Official record
Conditions
Social Isolation, Mental Status Change, Cognitive Impairment, Physical Activity, Quality of Life, Self-Perception
Interventions
Active Social Conversation
Other
Lead sponsor
George Mason University
Other
Eligibility
65 Years to 100 Years
Enrollment
64 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Manassas, Virginia
Source: ClinicalTrials.gov public record
Updated Mar 3, 2022 · Synced Sep 20, 2026, 10:15 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

A Personalized Health Behavior System

NCT03538158
View directory record Official record
Conditions
Social Isolation, Aging, Physical Activity
Interventions
Intervention Condition, Control Condition
Behavioral
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
60 Years and older
Enrollment
181 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2021
U.S. locations
2
States / cities
Miami, Florida • New York, New York
Source: ClinicalTrials.gov public record
Updated Oct 11, 2022 · Synced Sep 20, 2026, 10:15 PM EDT
Not listed Not applicable Interventional

The Impact of Social Phone Calls With Isolated Older Adults Receiving Protective Services for Abuse, Neglect and/or Exploitation

NCT05026762
View directory record Official record
Conditions
Senior Abuse
Interventions
Treatment
Other
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
65 Years and older
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Aug 29, 2021 · Synced Sep 20, 2026, 10:15 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Building Wealth and Health Network: A Microfinance/TANF Demonstration Project

NCT02577705
View directory record Official record
Conditions
Hunger, Child Development, Social Isolation
Interventions
Self Empowerment Groups, Financial Empowerment, Matched Savings
Behavioral
Lead sponsor
Center for Hunger-Free Communities
Other
Eligibility
18 Years and older
Enrollment
145 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2015
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 31, 2017 · Synced Sep 20, 2026, 10:15 PM EDT
Completed Not applicable Interventional Results available

Engage Psychotherapy to Promote Connectedness in Caregivers

NCT04176601
View directory record Official record
Conditions
Loneliness, Social Isolation, Caregiver Burnout
Interventions
Engage coaching
Behavioral
Lead sponsor
University of Rochester
Other
Eligibility
50 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Feb 24, 2025 · Synced Sep 20, 2026, 10:15 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Enhancing Quality of Life for Older Adults With and Without Mild Cognitive Impairment (MCI) Through Social Engagement Over Video Technology

NCT05380180
View directory record Official record
Conditions
Aging, Mild Cognitive Impairment, Aging Well
Interventions
OneClick Social Engagement Intervention, OneClick Social Engagement Intervention Extension
Other
Lead sponsor
University of Illinois at Urbana-Champaign
Other
Eligibility
65 Years and older
Enrollment
99 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
2
States / cities
Champaign, Illinois • Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated May 18, 2026 · Synced Sep 20, 2026, 10:15 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Discrimination and the Brain-Gut-Microbiome (BGM) Axis

NCT05120908
View directory record Official record
Conditions
Discrimination, Racial, Social Isolation, Stress
Interventions
Not listed
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
266 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2024
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jan 9, 2025 · Synced Sep 20, 2026, 10:15 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Mobilizing Community Networks to Optimize Child Well-being

NCT02622399
View directory record Official record
Conditions
Social Isolation
Interventions
Project NOW
Behavioral
Lead sponsor
Boston Medical Center
Other
Eligibility
18 Years to 64 Years
Enrollment
98 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2017
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 27, 2017 · Synced Sep 20, 2026, 10:15 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Neurobehavioral Mechanisms of Social Isolation and Loneliness in Serious Mental Illness

NCT04940663
View directory record Official record
Conditions
Psychosis, Schizophrenia
Interventions
EMA
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 55 Years
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2027
U.S. locations
1
States / cities
Charlestown, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 15, 2026 · Synced Sep 20, 2026, 10:15 PM EDT
Completed Not applicable Interventional

Social Prescribing and Relationship Cognitive Strategies (SPARCS)

NCT06656975
View directory record Official record
Conditions
Social Isolation, Suicidal Ideation
Interventions
Brief Cognitive Therapy, Social Prescribing, Enhanced Usual Care
Behavioral · Other
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
2
States / cities
Brighton, Michigan • Canton, Michigan
Source: ClinicalTrials.gov public record
Updated Jun 22, 2026 · Synced Sep 20, 2026, 10:15 PM EDT
Terminated Phase 2 Interventional Accepts healthy volunteers Results available

Effects of Pregnenolone on Perceived Social Isolation

NCT02826577
View directory record Official record
Conditions
Perceived Social Isolation
Interventions
Pregnenolone 175mg, Pregnenolone 400mg, Placebo
Drug
Lead sponsor
University of Chicago
Other
Eligibility
21 Years to 80 Years
Enrollment
34 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2022
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated May 15, 2024 · Synced Sep 20, 2026, 10:15 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Rural Dementia Caregiver Project

NCT04428112
View directory record Official record
Conditions
Depression, Stress, Psychological, Self Efficacy, Loneliness, Social Isolation, Health Care Utilization, Dementia, Dementia Alzheimers, Dementia of Alzheimer Type, Dementia, Vascular, Dementia Frontal, Dementia, Lewy Body, Dementia, Mixed, Dementia in Parkinsons Disease, Dementia, HIV, Dementia Frontotemporal, Dementia, Multi-Infarct
Interventions
Building Better Caregivers Workshop, Attention Control
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
418 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jul 16, 2025 · Synced Sep 20, 2026, 10:15 PM EDT
Not listed Not applicable Interventional

Virtual Yoga for Social Isolation and Loneliness in Rural Veterans

NCT05431166
View directory record Official record
Conditions
Loneliness, Social Isolation
Interventions
Virtual Yoga at First 8 weeks, Virtual Yoga at Second 8 weeks
Behavioral
Lead sponsor
Oregon Health and Science University
Other
Eligibility
18 Years to 88 Years
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Sep 21, 2023 · Synced Sep 20, 2026, 10:15 PM EDT
Not yet recruiting Not applicable Interventional

AI-CONECT: A Conversational AI for Early Dementia Prevention in Socially-Isolated Older Adults

NCT07701668
View directory record Official record
Conditions
Mild Cognitive Impairment (MCI), Social Isolation
Interventions
AI-based conversational intervention
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
75 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 24, 2026 · Synced Sep 20, 2026, 10:15 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

LEAPTogether: An Intergenerational Intervention to Address Loneliness and Social Isolation

NCT05831475
View directory record Official record
Conditions
Social Isolation, Loneliness, Intergenerational Relations
Interventions
Intergenerational Virtual Paired Exercise, Peer Virtual Paired Exercise
Behavioral
Lead sponsor
Cedars-Sinai Medical Center
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Beverly Hills, California
Source: ClinicalTrials.gov public record
Updated Aug 21, 2024 · Synced Sep 20, 2026, 10:15 PM EDT
Completed Not applicable Interventional

Impact of Covid-19 on Frequent Social Interaction Through Communication Technologies in the Cognitive Status of Socially-isolated Older Adults

NCT04480112
View directory record Official record
Conditions
Memory Disorders, Alzheimer Disease, Mild Cognitive Impairment
Interventions
Technology based social interactions, No research related technology based social interactions
Behavioral · Other
Lead sponsor
Boston University
Other
Eligibility
Not listed
Enrollment
196 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 29, 2021 · Synced Sep 20, 2026, 10:15 PM EDT