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ClinicalTrials.gov public records Last synced Nov 12, 2026, 8:42 PM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 25–48 of 354 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Joint Replacement Clear all

Conditions: Osteoarthritis
Interventions: Not listed
Lead sponsor: Brigham and Women's Hospital; Other
Eligibility: 45 Years and older
Enrollment: 248 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2019
U.S. locations: 1
States / cities: Chestnut Hill, Massachusetts

Conditions: Elbow Joint Destruction, Post-traumatic Lesions, Ankylosed Joints, Advanced Rheumatoid Arthritis, Joint Instability or Loss of Motion, Acute Comminuted Articular Fracture of Elbow Joint Surfaces, Bone Loss Contributing to Elbow Instability, Bilateral Ankylosis From Causes Other Than Active Sepsis, Post-traumatic Arthritis, Degenerative Arthritis
Interventions: Nexel Total Elbow; Device
Lead sponsor: Zimmer Biomet; Industry
Eligibility: 18 Years and older
Enrollment: 134 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2036
U.S. locations: 4
States / cities: Golden, Colorado • Charlotte, North Carolina • Philadelphia, Pennsylvania + 1 more

Conditions: Osteoarthritis
Interventions: Customized patient instruments, Traditional Metal Instruments; Device
Lead sponsor: Medacta USA; Industry
Eligibility: 18 Years to 75 Years
Enrollment: 32 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2022
U.S. locations: 5
States / cities: Marrero, Louisiana • Billings, Montana • Meadville, Pennsylvania + 2 more

Conditions: Lumbar Degenerative Disc Disease, Lower Back Pain, Chronic Lower Back Pain
Interventions: Not listed
Lead sponsor: The Foundation for Spinal Research, Education and Humanitarian Care, Inc.; Industry
Eligibility: 18 Years to 85 Years
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2018
U.S. locations: 1
States / cities: Odessa, Florida

Conditions: Pain, Postoperative
Interventions: Pre-operative Ultrasound FICB Group, Intra-operative FICB Group; Procedure
Lead sponsor: Randy Fayne, DO; Other
Eligibility: 18 Years to 65 Years
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2015
U.S. locations: 1
States / cities: Royal Oak, Michigan

Conditions: Delirium
Interventions: olanzapine, placebo; Drug
Lead sponsor: The New England Baptist Hospital; Other
Eligibility: 65 Years and older
Enrollment: 495 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2005 – 2007
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Osteo Arthritis Shoulders, Traumatic Arthritis, Rheumatoid Arthritis
Interventions: Integra Titan Modular Shoulder System 2.5; Device
Lead sponsor: Smith & Nephew, Inc.; Industry
Eligibility: 18 Years and older
Enrollment: 58 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2023
U.S. locations: 7
States / cities: Birmingham, Alabama • Columbia, Maryland • Starkville, Mississippi + 3 more

Conditions: Osteoarthritis, Knee, Knee Osteoarthritis
Interventions: ConforMIS iUni, iDuo, or iTotal (CR); Device
Lead sponsor: Restor3D; Industry
Eligibility: 18 Years and older
Enrollment: 950 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2019
U.S. locations: 1
States / cities: Boynton Beach, Florida

Conditions: Arthropathy of Knee, Arthropathy of Hip, Lower Extremity Fracture, Orthopedic Disorder
Interventions: Daily Inspiratory Muscle Training (dIMT), Acute Inspiratory Muscle Training (aIMT), Standard of Care (SOC); Behavioral · Other
Lead sponsor: University of Florida; Other
Eligibility: 18 Years to 100 Years
Enrollment: 36 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2026
U.S. locations: 1
States / cities: Jacksonville, Florida

Conditions: Obesity, Knee Osteoarthritis
Interventions: InBody Band 2; Device
Lead sponsor: University of Iowa; Other
Eligibility: 18 Years to 99 Years
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2024
U.S. locations: 1
States / cities: Iowa City, Iowa

Conditions: Hip Osteoarthritis, Avascular Necrosis, Rheumatoid Arthritis, Post-traumatic Osteoarthritis, Femoral Neck Fractures, Trochanteric Fractures, Surgery
Interventions: Insignia uncemented Hip Stem; Device
Lead sponsor: Stryker Orthopaedics; Industry
Eligibility: 18 Years and older
Enrollment: 313 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2034
U.S. locations: 11
States / cities: Phoenix, Arizona • San Francisco, California • Chicago, Illinois + 8 more

Conditions: Osteoarthritis, Knee, Arthroplasty, Replacement, Knee
Interventions: Stereotactic guidance system; Device
Lead sponsor: Ormonde M. Mahoney, MD; Other
Eligibility: 45 Years and older
Enrollment: 150 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2021
U.S. locations: 1
States / cities: Athens, Georgia

Conditions: Osteoarthritis, Rheumatoid Arthritis, Post-Traumatic Arthritis, Septic Arthritis, Prior Ankle Fusion
Interventions: Salto Talaris Ankle; Device
Lead sponsor: Smith & Nephew, Inc.; Industry
Eligibility: 18 Years and older
Enrollment: 76 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2023
U.S. locations: 2
States / cities: San Antonio, Texas • Milwaukee, Wisconsin

Conditions: Knee Injuries, Knee Osteoarthritis, Knee Arthritis
Interventions: B-FREE; Other
Lead sponsor: Michigan Technological University; Other
Eligibility: 40 Years to 75 Years
Enrollment: 30 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2027
U.S. locations: 1
States / cities: Houghton, Michigan

Conditions: Osteoarthritis, Arthritis, Rheumatoid, Avascular Necrosis of Bone, Post-traumatic Arthritis, Rheumatoid Arthritis
Interventions: Total knee replacement; Device
Lead sponsor: DePuy Orthopaedics; Industry
Eligibility: 18 Years to 75 Years
Enrollment: 399 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2001 – 2006
U.S. locations: 4
States / cities: La Jolla, California • Crystal River, Florida • Melbourne, Florida + 1 more

Conditions: Arthritis
Interventions: Total hip replacement; Procedure
Lead sponsor: Tennessee Orthopedic Alliance; Other
Eligibility: 18 Years and older
Enrollment: 100 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2007 – 2010
U.S. locations: 1
States / cities: Nashville, Tennessee

Conditions: Hemophilia A, Factor VIII
Interventions: Eloctate, Adynovate, Emicizumab; Drug
Lead sponsor: University of Texas Southwestern Medical Center; Other
Eligibility: Up to 17 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2027
U.S. locations: 1
States / cities: Dallas, Texas

Conditions: Osteoarthritis, Postoperative Pain
Interventions: Whole blood for genotyping; Genetic
Lead sponsor: University of Pittsburgh; Other
Eligibility: 18 Years and older
Enrollment: 156 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2012
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Total Knee Replacement
Interventions: Fondaparinux Sodium (Arixtra); Drug
Lead sponsor: Paul Di Cesare,MD; Other
Eligibility: 18 Years to 80 Years
Enrollment: 114 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009
U.S. locations: 1
States / cities: Sacramento, California

Conditions: Osteoarthritis, Knee
Interventions: Zero Degree Knee Positioner; Device
Lead sponsor: Prisma Health-Midlands; Other
Eligibility: 40 Years to 80 Years
Enrollment: 154 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2026
U.S. locations: 1
States / cities: Columbia, South Carolina

Conditions: Degenerative Joint Disease, Osteoarthritis, Rheumatoid Arthritis, Traumatic Arthritis
Interventions: 3DKnee™ System; Device
Lead sponsor: Encore Medical, L.P.; Industry
Eligibility: 18 Years and older
Enrollment: 229 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2018
U.S. locations: 8
States / cities: Scottsdale, Arizona • Fresno, California • Baltimore, Maryland + 5 more

Conditions: Lower Thighbone and Knee Joint Replacement
Interventions: ComPreSs Distal Femoral Replacement System.; Device
Lead sponsor: Memorial Sloan Kettering Cancer Center; Other
Eligibility: 10 Years and older
Enrollment: 26 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2000 – 2009
U.S. locations: 1
States / cities: New York, New York

Conditions: Arthropathy of Knee Joint
Interventions: Vancomycin; Drug
Lead sponsor: Mayo Clinic; Other
Eligibility: 18 Years and older
Enrollment: 22 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2015
U.S. locations: 1
States / cities: Phoenix, Arizona

Conditions: Arthroplasty, Replacement, Knee
Interventions: Triathlon PKR; Device
Lead sponsor: Stryker Orthopaedics; Industry
Eligibility: 21 Years to 75 Years
Enrollment: 111 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2023
U.S. locations: 6
States / cities: Jacksonville, Florida • Egg Harbor, New Jersey • Buffalo, New York + 3 more

Search by objective public record fields.

Prediction of Outcomes Following Total Knee Replacement

Clinical Outcomes Study of the Nexel Total Elbow

Single-use Efficiency Instruments With Patient Specific Technique (MyKnee®) Versus Traditional Metal Instruments With Conventional Surgical Technique

Human Autograft Mesenchymal Stem Cell Mediated Stabilization of The Degenerative Lumbar Spine

Efficacy of Fascia Iliaca Block Versus Intraoperative Nerve Infiltration During Anterior Hip Replacement Surgery

Prophylactic Olanzapine Versus Placebo for Prevention of Postoperative Delirium After Joint Replacement Surgery

Clinical Evaluation of the Integra® Titan™ Modular Shoulder System Generation 2.5 for Primary Shoulder Joint Replacement

A Retrospective Study to Evaluate the ConforMIS iUni, iDuo & iTotal® KRS

Pre-operative Inspiratory Muscle Strength Training in Total Joint Surgery

Wearable Bioimpedance Analyzer for Tracking Body Composition Changes

Insignia™ Hip Stem Outcomes Study

Total Knee Arthroplasty Guidance Systems Study

Ankle Joint Replacement Outcomes Study

Blood-Flow Restriction Exercise Following a Knee Replacement

Primary TKA Cruciate Retaining vs Cruciate Substituting With Rotating Platform Knee Prostheses

Restoration of Leg Length, Offset, and Center of Rotation in Total Hip Replacement

POCUS: Hemostatic Potential and Joint Health in Patients With Severe Hemophilia A on Novel Replacement Therapies

Acute Pain Genomic Study

The Effects of Arixtra on Wound Drainage Following Total Joint Arthroplasty

Zero Degree Knee Positioner for Improved Earley Knee Extension Following Total Knee Arthroplasty

Post-Market Study of the 3DKnee™ System

Evaluation of the Compress Distal Femoral Replacement System

Regional Prophylactic Vancomycin in Revision Total Knee Replacement

Triathlon® Partial Knee Replacement (PKR) Outcomes Study