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ClinicalTrials.gov public records Last synced Nov 13, 2026, 10:52 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 145–168 of 354 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Joint Replacement Clear all

Conditions: Hemophilia A, Factor VIII
Interventions: Eloctate, Adynovate, Emicizumab; Drug
Lead sponsor: University of Texas Southwestern Medical Center; Other
Eligibility: Up to 17 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2027
U.S. locations: 1
States / cities: Dallas, Texas

Conditions: Osteo Arthritis Knee
Interventions: Cryoneurolysis (Iovera); Procedure
Lead sponsor: Fondren Orthopedic Group L.L.P.; Other
Eligibility: 18 Years to 90 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2020
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Hip Osteoarthritis, Hip Arthropathy
Interventions: Pericapsular Nerve Block, Fascia Iliaca Nerve Block; Drug
Lead sponsor: LifeBridge Health; Other
Eligibility: 18 Years to 80 Years
Enrollment: 78 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2025
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Osteoarthritis, Traumatic Arthritis, Rheumatoid Arthritis, Lower Limb Deformity, Complications, Arthroplasty
Interventions: Vanguard™ Complete Knee System, Vanguard™ Patient-Specific Femur; Device
Lead sponsor: Zimmer Biomet; Industry
Eligibility: 18 Years and older
Enrollment: 552 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2004 – 2024
U.S. locations: 8
States / cities: Cedar Rapids, Iowa • Rockville, Maryland • Cape Girardeau, Missouri + 5 more

Conditions: Arthroplasty, Replacement, Knee, Anesthesia, Conduction, Acute Pain
Interventions: adductor canal block, SPANK, Ropivacaine; Procedure · Drug
Lead sponsor: Bruce Ben-David; Other
Eligibility: 19 Years to 90 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Rheumatoid Arthritis, Osteoarthritis Shoulder, Fractures Humerus, Avascular Necrosis, Correction of Functional Deformity, Traumatic Arthritis, Revision of Other Devices if Sufficient Bone Stock Remains, Rotator Cuff Tears
Interventions: Tornier HRS (HUMERAL RECONSTRUCTION SYSTEM) shoulder system; Device
Lead sponsor: Stryker Trauma and Extremities; Industry
Eligibility: 18 Years and older
Enrollment: 110 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2036
U.S. locations: 4
States / cities: Denver, Colorado • Bradenton, Florida • Tampa, Florida + 1 more

Conditions: Arthroplasty
Interventions: Tapentadol IR (CG5503), Placebo, Oxycodone HCL IR; Drug
Lead sponsor: Johnson & Johnson Pharmaceutical Research & Development, L.L.C.; Industry
Eligibility: 18 Years to 80 Years
Enrollment: 367 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2007
U.S. locations: 45
States / cities: Birmingham, Alabama • Mobile, Alabama • Sheffield, Alabama + 42 more

Conditions: Postoperative Pain
Interventions: HTX-011, Saline Placebo, Bupivicaine HCl, Ropivacaine; Drug
Lead sponsor: Heron Therapeutics; Industry
Eligibility: 18 Years and older
Enrollment: 285 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2018
U.S. locations: 24
States / cities: Mobile, Alabama • Sheffield, Alabama • Phoenix, Arizona + 13 more

Conditions: Knee Pain Chronic, Rheumatoid Arthritis, Osteoarthritis, Traumatic Arthritis, Polyarthritis, Avascular Necrosis, Varus Deformity, Valgus Deformity, Flexion Deformity of Knee
Interventions: Cementless Persona Knee System, Cemented Persona Knee System; Device
Lead sponsor: Zimmer Biomet; Industry
Eligibility: 18 Years and older
Enrollment: 300 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2032
U.S. locations: 7
States / cities: Westminster, Colorado • Chicago, Illinois • Baltimore, Maryland + 4 more

Conditions: Arthroplasty, Replacement, Hip, Osteoarthritis, Hip
Interventions: Off Table Group, On Table Group; Procedure
Lead sponsor: Carilion Clinic; Other
Eligibility: 18 Years and older
Enrollment: 93 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2025
U.S. locations: 1
States / cities: Roanoke, Virginia

Conditions: Osteoarthritis
Interventions: Modafinil, Gabapentin, Placebo; Drug
Lead sponsor: Wake Forest University Health Sciences; Other
Eligibility: 18 Years to 80 Years
Enrollment: 30 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014 – 2017
U.S. locations: 1
States / cities: Winston-Salem, North Carolina

Conditions: Prosthetic-joint Infection
Interventions: PLG0206, Placebo; Drug
Lead sponsor: Peptilogics; Industry
Eligibility: 18 Years to 85 Years
Enrollment: 240 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 17
States / cities: Pensacola, Florida • Sarasota, Florida • Tamarac, Florida + 14 more

Conditions: Primary Arthrosis
Interventions: Scandinavian Total Ankle Replacement System (STAR Ankle); Device
Lead sponsor: Stryker Trauma and Extremities; Industry
Eligibility: 18 Years and older
Enrollment: 87 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2016
U.S. locations: 5
States / cities: Oakland, California • Temple Terrace, Florida • Boise, Idaho + 2 more

Conditions: Arthritis, Osteoarthritis, Knee, Osteoarthritis, Hip, Thromboembolism
Interventions: Rivaroxaban; Drug
Lead sponsor: Ortho-McNeil Janssen Scientific Affairs, LLC; Industry
Eligibility: 18 Years to 99 Years
Enrollment: 56 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010
U.S. locations: 5
States / cities: Denver, Colorado • Hollywood, Florida • Tamarac, Florida + 2 more

Conditions: Primary Arthrosis, Post Traumatic Arthritis, Rheumatoid Arthritis, Osteoarthritis
Interventions: Scandinavian Total Ankle Replacement System (STAR Ankle); Device
Lead sponsor: Encore Medical, L.P.; Industry
Eligibility: Not listed
Enrollment: 102 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2021
U.S. locations: 9
States / cities: Phoenix, Arizona • Los Angeles, California • Palo Alto, California + 6 more

Conditions: Osteoarthritis
Interventions: Investigational Medical Product (IMP) administered in parent study; Drug
Lead sponsor: Pfizer; Industry
Eligibility: 18 Years and older
Enrollment: 154 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2019
U.S. locations: 51
States / cities: Birmingham, Alabama • Tucson, Arizona • Little Rock, Arkansas + 36 more

Conditions: Osteoarthritis, Postoperative Pain
Interventions: pregabalin, Placebo; Drug
Lead sponsor: Pfizer's Upjohn has merged with Mylan to form Viatris Inc.; Industry
Eligibility: 18 Years to 80 Years
Enrollment: 307 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2008
U.S. locations: 27
States / cities: Northport, Alabama • Tuscaloosa, Alabama • Phoenix, Arizona + 21 more

Conditions: Osteoarthritis, Rheumatoid Arthritis, Other Inflammatory Arthritis, Post-Traumatic Arthritis, Juvenile Rheumatoid Arthritis, Avascular Necrosis
Interventions: Total Knee Arthroplasty, Total knee replacement; Device
Lead sponsor: DePuy Orthopaedics; Industry
Eligibility: 18 Years to 75 Years
Enrollment: 149 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2001 – 2007
U.S. locations: 3
States / cities: Greensboro, North Carolina • Austin, Texas • Lakewood, Washington

Conditions: Degenerative Arthritis, Rheumatoid Arthritis, Post Traumatic Arthritis
Interventions: Zimmer Trabecular Metal Total Ankle System; Device
Lead sponsor: Zimmer Biomet; Industry
Eligibility: 18 Years and older
Enrollment: 120 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2027
U.S. locations: 5
States / cities: Sacramento, California • Grand Rapids, Michigan • Charlotte, North Carolina + 2 more

Conditions: Osteoarthritis, Arthritis, Joint Diseases, Musculoskeletal Diseases, Rheumatic Diseases
Interventions: Hip Replacement with crosslinked Marathon polyethylene, Hip Replacement with noncrosslinked Enduron polyethylene; Device
Lead sponsor: Anderson Orthopaedic Research Institute; Other
Eligibility: Not listed
Enrollment: 230 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 1999 – 2017
U.S. locations: 1
States / cities: Alexandria, Virginia

Conditions: Joint Disease, Arthropathy
Interventions: Zipper surgical skin closure, Monocryl + Dermabond, Polyester mesh + Dermabond; Device · Other
Lead sponsor: NYU Langone Health; Other
Eligibility: 18 Years and older
Enrollment: 160 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2020
U.S. locations: 1
States / cities: New York, New York

Conditions: Partial Knee Replacement
Interventions: Cementless fixation; Procedure
Lead sponsor: Anderson Orthopaedic Research Institute; Other
Eligibility: 18 Years to 85 Years
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2026
U.S. locations: 1
States / cities: Alexandria, Virginia

Conditions: Knee Osteoarthristis
Interventions: Cognitive-Behavioral Therapy for Insomnia, Bright Light therapy via the Re-Timer®, Negative Ion exposure via IonMi Device, Sleep / Knee Osteoarthritis Education; Behavioral · Device
Lead sponsor: Johns Hopkins University; Other
Eligibility: 60 Years and older
Enrollment: 252 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2029
U.S. locations: 2
States / cities: Baltimore, Maryland • Chestnut Hill, Massachusetts

Conditions: Degenerative Arthritis, Osteoarthritis, Rheumatoid Arthritis, Knee Arthritis
Interventions: Duracon®, Vanguard™; Device
Lead sponsor: Biomet Orthopedics, LLC; Industry
Eligibility: 18 Years and older
Enrollment: 150 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2005 – 2008
U.S. locations: 1
States / cities: Warsaw, Indiana

Search by objective public record fields.

POCUS: Hemostatic Potential and Joint Health in Patients With Severe Hemophilia A on Novel Replacement Therapies

Pain Control With Pre-operative Cryoneurolysis Following TKA

The Pericapsular Nerve Block in Total Hip Arthroplasty

A Clinical Investigation of the Vanguard™ Complete Knee System

Adductor Canal Vs Adductor Canal Plus SPANK Block for Postoperative Pain in Knee Arthroplasty Surgery

Tornier HRS (Humeral Reconstruction System) Study (REVIVE)

A Study to Evaluate the Effectiveness and Safety of Tapentadol(CG5503) in the Treatment of Acute Pain After Hip Replacement Surgery Compared With Oxycodone and Placebo Followed by a Voluntary Open-Label Extension For Safety

Total Knee Arthroplasty Infiltration Study for Postoperative Analgesia

Cemented vs Cementless Persona Keel RCT

On-Table Versus Off-Table Total Hip Arthroplasty

Pain Expectations in Subjects With Osteoarthritis

Evaluation of PLG0206 in Prevention of Recurrent Infection in Patients Undergoing Debridement, Antibiotics, and Implant Retention (DAIR) for Treatment of a Periprosthetic Joint Infection (PJI) Following Knee Arthroplasty

Post-Approval Study to Investigate the Long Term (8 Year) Survivorship of STAR Ankle Among Continued Access Study Patients

Switching Drug Therapy for the Prevention of Blood Clot Formation From Enoxaparin to Rivaroxaban After Orthopedic Surgery for Either Total Hip or Total Knee Replacement

2-Year Post-Approval Study to Investigate the Scandinavian Total Ankle Replacement System (STAR) Ankle Under Actual Conditions of Use

Long-term Observational Study of Subjects From Tanezumab Studies Who Undergo a Total Knee, Hip or Shoulder Replacement

Efficacy And Safety Of Pregabalin For Pain Following Total Knee Replacement

Randomized Fixed Bearing vs Mobile Bearing Cruciate Substituting TKA

Zimmer Trabecular Metal Total Ankle PMCF

Marathon and Enduron Polyethylene at Long-Term Follow-up

A Study Investigating the Efficacy of Various Wound Closure Devices in Reducing Postoperative Wound Complications

Cemented vs. Cementless Unicompartmental Knee Arthroplasty

Sleep TO Prevent Post-surgical Pain

Total Knee Replacement With Duracon® and Vanguard™ Prostheses