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Showing 1–24 of 27 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Joint Stiffness Clear all
Completed Phase 3 Interventional Results available

To Study Generic Diclofenac Sodium Topical Gel 1% in the Treatment of Osteoarthritis of the Knee (Degenerative Joint Disease Presented as Joint Pain, Stiffness, Swelling and Restricted Motion).

NCT02596451
View directory record Official record
Conditions
Osteoarthritis
Interventions
Diclofenac Sodium gel, 1%, Voltaren® Gel, Placebo
Drug
Lead sponsor
Glenmark Pharmaceuticals Ltd. India
Industry
Eligibility
35 Years and older
Enrollment
1,164 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
44
States / cities
Mesa, Arizona • Anaheim, California • Canoga Park, California + 32 more
Source: ClinicalTrials.gov public record
Updated Jun 27, 2017 · Synced Jul 23, 2026, 12:42 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Impact of 'Recovery' Footwear on Lower Extremity Comfort and Biomechanics

NCT04830540
View directory record Official record
Conditions
Arthralgia, Joint Stiffness, Gait Mechanics
Interventions
OOFOS Recovery Footwear
Device
Lead sponsor
University of Massachusetts, Amherst
Other
Eligibility
18 Years to 30 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Amherst, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 4, 2021 · Synced Jul 23, 2026, 12:42 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

NEM® + BIOCURC® Versus Placebo in Exercised-induced Joint Pain, Stiffness, & Cartilage Turnover in Healthy Men & Women

NCT03769857
View directory record Official record
Conditions
Exercise-induced Joint Pain, Exercise-induced Joint Stiffness, Exercise-induced Joint Cartilage Turnover
Interventions
NEM® + BIOCURC®, Placebo
Dietary Supplement
Lead sponsor
ESM Technologies, LLC
Industry
Eligibility
40 Years to 75 Years
Enrollment
84 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
1
States / cities
Springfield, Missouri
Source: ClinicalTrials.gov public record
Updated Jul 17, 2019 · Synced Jul 23, 2026, 12:42 PM EDT
Not listed Not applicable Interventional

Bio-mechanical Reasoning and Lateral Specificity of Upper Cervical Joint Mobilization

NCT04054869
View directory record Official record
Conditions
Neck Pain
Interventions
Bio-mechanically correct manual therapy at the cervical atlanto-axial joints, Bio-mechanically in-correct manual therapy at the cervical atlanto-axial joints
Other
Lead sponsor
Andrews University
Other
Eligibility
18 Years to 80 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Avon, Indiana
Source: ClinicalTrials.gov public record
Updated Nov 28, 2019 · Synced Jul 23, 2026, 12:42 PM EDT
Not listed Not applicable Interventional

Study of the Use of Laser Light to Treat Osteoarthritis of the Hand.

NCT00254111
View directory record Official record
Conditions
Osteoarthritis
Interventions
Ultra Probe Laser System
Device
Lead sponsor
TriTech Manufacturing
Industry
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2006
U.S. locations
3
States / cities
Phoenix, Arizona • Long Beach, California • Bloomington, Minnesota
Source: ClinicalTrials.gov public record
Updated Nov 14, 2005 · Synced Jul 23, 2026, 12:42 PM EDT
Terminated No phase listed Observational Results available

Using Intraoperative Sensing Technology to Evaluate Revision Total Knee Arthroplasty

NCT03023410
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
VERASENSE
Procedure
Lead sponsor
Orthosensor, Inc.
Industry
Eligibility
18 Years and older
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018
U.S. locations
1
States / cities
Fort Lauderdale, Florida
Source: ClinicalTrials.gov public record
Updated Jan 28, 2025 · Synced Jul 23, 2026, 12:42 PM EDT
Completed Not applicable Interventional Results available

Yoga for Managing Knee Osteoarthritis in Older Women: a Feasibility Study

NCT01832155
View directory record Official record
Conditions
Osteoarthritis, Knee, Quality of Life, Poor Quality Sleep, Physical Impairment
Interventions
Hatha Yoga
Behavioral
Lead sponsor
University of Minnesota
Other
Eligibility
65 Years to 86 Years · Female only
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Oct 31, 2019 · Synced Jul 23, 2026, 12:42 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

NEM® + KD PUR® Fish Oil Versus Placebo in Exercised-induced Joint Pain, Stiffness, & Cartilage Turnover in Healthy Men & Women

NCT04215198
View directory record Official record
Conditions
Exercise-induced Joint Pain, Exercise-induced Joint Stiffness, Exercise-induced Joint Cartilage Turnover
Interventions
Move3™ (NEM® brand eggshell membrane + KD PUR® brand fish oil), Placebo
Dietary Supplement
Lead sponsor
ESM Technologies, LLC
Industry
Eligibility
40 Years to 75 Years
Enrollment
85 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Springfield, Missouri
Source: ClinicalTrials.gov public record
Updated Apr 29, 2024 · Synced Jul 23, 2026, 12:42 PM EDT
Not listed No phase listed Observational

Finding Early Rheumatoid Arthritis

NCT01341314
View directory record Official record
Conditions
Joint Pain, Stiffness
Interventions
Not listed
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 23, 2012 · Synced Jul 23, 2026, 12:42 PM EDT
Completed Phase 3 Interventional Results available

Safety and Efficacy Study of Xyrem® (Sodium Oxybate) in Subjects With Fibromyalgia.

NCT00423605
View directory record Official record
Conditions
Fibromyalgia
Interventions
Xyrem®
Drug
Lead sponsor
Jazz Pharmaceuticals
Industry
Eligibility
18 Years and older
Enrollment
560 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2010
U.S. locations
66
States / cities
Anniston, Alabama • Auburn, Alabama • Phoenix, Arizona + 60 more
Source: ClinicalTrials.gov public record
Updated Mar 29, 2012 · Synced Jul 23, 2026, 12:42 PM EDT
Completed Phase 2 Interventional Results available

Vitamin D Deficiency, Muscle Pain, Joint Pain, and Joint Stiffness in Postmenopausal Women Receiving Letrozole For Stage I-III Breast Cancer

NCT00416715
View directory record Official record
Conditions
Arthralgia, Musculoskeletal Complications, Pain, Recurrent Breast Cancer, Stage I Breast Cancer, Stage II Breast Cancer, Stage IIIA Breast Cancer, Stage IIIB Breast Cancer, Stage IIIC Breast Cancer
Interventions
letrozole, calcium carbonate, laboratory biomarker analysis, calcium citrate, calcium glucarate, calcium gluconate, cholecalciferol, assessment of therapy complications, musculoskeletal complications management/prevention
Drug · Dietary Supplement · Other + 1 more
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older · Female only
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2010
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jul 10, 2017 · Synced Jul 23, 2026, 12:42 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Instaflex and Joint Pain in Community Adults

NCT01956500
View directory record Official record
Conditions
Joint Pain, Stiffness, Function
Interventions
Instaflex, Placebo
Dietary Supplement
Lead sponsor
Appalachian State University
Other
Eligibility
50 Years to 75 Years
Enrollment
110 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013
U.S. locations
1
States / cities
Kannapolis, North Carolina
Source: ClinicalTrials.gov public record
Updated Oct 7, 2013 · Synced Jul 23, 2026, 12:42 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

NEM® Versus Placebo in Exercised-induced Joint Pain, Stiffness, & Cartilage Turnover in Healthy Men & Women

NCT03679923
View directory record Official record
Conditions
Exercise-induced Joint Pain, Exercise-induced Joint Stiffness, Exercise-induced Joint Cartilage Turnover
Interventions
NEM® brand eggshell membrane, Placebo
Dietary Supplement
Lead sponsor
ESM Technologies, LLC
Industry
Eligibility
40 Years to 75 Years
Enrollment
84 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
1
States / cities
Springfield, Missouri
Source: ClinicalTrials.gov public record
Updated Sep 18, 2024 · Synced Jul 23, 2026, 12:42 PM EDT
Recruiting Not applicable Interventional

Does Joint Immobilization Following Revision Total Knee Arthroplasty Improve Range of Motion Following Surgery?

NCT07552415
View directory record Official record
Conditions
Aseptic Revision Knee Arthroplasty, Stiffness Following Revision Knee Arthroplasty
Interventions
Knee immobilizer, No Knee Immobilizer
Device
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
18 Years and older
Enrollment
170 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 26, 2026 · Synced Jul 23, 2026, 12:42 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Atherosclerosis in Rheumatoid Arthritis

NCT00990730
View directory record Official record
Conditions
Rheumatoid Arthritis, Endothelial Dysfunction
Interventions
Not listed
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years to 80 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2011
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jan 24, 2012 · Synced Jul 23, 2026, 12:42 PM EDT
Completed No phase listed Observational Results available

Persistent Postoperative Pain and Joint Stiffness After Total Knee Arthroplasty Performed for Osteoarthritis

NCT02626533
View directory record Official record
Conditions
Pain, Joint Stiffness
Interventions
Total Knee Arthroplasty
Procedure
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
18 Years and older
Enrollment
179 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Dec 26, 2024 · Synced Jul 23, 2026, 12:42 PM EDT
Recruiting Not applicable Interventional

Pilot Study on The Effectiveness of Relative Motion Orthosis in Finger Motion

NCT06646029
View directory record Official record
Conditions
Proximal Interphalangeal Joint Stiffness
Interventions
RMO flexion orthosis (splint), Standard of care
Device · Other
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years to 80 Years
Enrollment
64 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 26, 2026 · Synced Jul 23, 2026, 12:42 PM EDT
Completed Phase 2 Interventional Results available

A Pilot Study Assessing the Treatment Responsiveness of a Novel Osteoarthritis Stiffness Scale

NCT03570554
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
Naproxen Sodium (Aleve, BAY117031), Acetaminophen ER, Celecoxib, Placebo
Drug
Lead sponsor
Bayer
Industry
Eligibility
40 Years to 80 Years
Enrollment
41 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
5
States / cities
Chandler, Arizona • Pinellas Park, Florida • Chicago, Illinois + 2 more
Source: ClinicalTrials.gov public record
Updated Jun 18, 2020 · Synced Jul 23, 2026, 12:42 PM EDT
Completed Phase 3 Interventional Results available

A Safety and Efficacy Study of Xyrem® in Subjects With Fibromyalgia

NCT00371137
View directory record Official record
Conditions
Fibromyalgia
Interventions
Xyrem®, Placebo
Drug
Lead sponsor
Jazz Pharmaceuticals
Industry
Eligibility
18 Years and older
Enrollment
548 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2008
U.S. locations
70
States / cities
Anniston, Alabama • Huntsville, Alabama • Phoenix, Arizona + 60 more
Source: ClinicalTrials.gov public record
Updated Dec 28, 2011 · Synced Jul 23, 2026, 12:42 PM EDT
Completed Phase 3 Interventional Results available

S0927:Omega3-Fatty Acid Supp in Treating Muscle&Bone Pain&Stiffness in Pts W/Stg I,II,III Brst Canc Rec'v Hormone Thpy

NCT01385137
View directory record Official record
Conditions
Arthralgia, Breast Cancer, Pain
Interventions
omega-3 fatty acid, placebo
Dietary Supplement · Other
Lead sponsor
SWOG Cancer Research Network
Network
Eligibility
18 Years to 120 Years · Female only
Enrollment
262 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
292
States / cities
Mobile, Alabama • Anchorage, Alaska • Fairbanks, Alaska + 215 more
Source: ClinicalTrials.gov public record
Updated Apr 6, 2017 · Synced Jul 23, 2026, 12:42 PM EDT
Completed Phase 3 Interventional Results available

A Safety and Efficacy Study of Xyrem® (Sodium Oxybate) to Treat Fibromyalgia.

NCT00423813
View directory record Official record
Conditions
Fibromyalgia
Interventions
placebo, Xyrem®
Drug
Lead sponsor
Jazz Pharmaceuticals
Industry
Eligibility
18 Years and older
Enrollment
573 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2009
U.S. locations
71
States / cities
Auburn, Alabama • Birmingham, Alabama • Montgomery, Alabama + 61 more
Source: ClinicalTrials.gov public record
Updated Jan 23, 2012 · Synced Jul 23, 2026, 12:42 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

JDS-HF3.0 Supplementation on Menopause Related Quality of Life Outcomes in Postmenopausal Women

NCT07238478
View directory record Official record
Conditions
Joint Discomfort, Joint Pain, Stiffness, Function, Joint Pain, Hot Flashes, Hot Flash, Night Sweats, Vasomotor Symptoms
Interventions
JDS-HF3.0, Placebo
Dietary Supplement · Other
Lead sponsor
Bonafide Health
Industry
Eligibility
50 Years to 70 Years · Female only
Enrollment
250 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Harrison, New York
Source: ClinicalTrials.gov public record
Updated Nov 19, 2025 · Synced Jul 23, 2026, 12:42 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Study of Febuxostat Effect on Blood Pressure in Patients With High Normal Blood Pressure

NCT01472692
View directory record Official record
Conditions
Prehypertension, Gout, Pulse Wave Velocity, Hypertension, 24 Hour Blood Pressure
Interventions
Febuxostat
Drug
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years to 50 Years
Enrollment
47 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2014
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Dec 15, 2019 · Synced Jul 23, 2026, 12:42 PM EDT
Completed Phase 3 Interventional Results available

A Study of the Effect of Tocilizumab on Markers of Atherogenic Risk in Patients With Moderate to Severe Rheumatoid Arthritis

NCT00535782
View directory record Official record
Conditions
Rheumatoid Arthritis
Interventions
Tocilizumab, Placebo, Methotrexate
Drug
Lead sponsor
Hoffmann-La Roche
Industry
Eligibility
18 Years to 75 Years
Enrollment
132 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2011
U.S. locations
26
States / cities
Anniston, Alabama • Huntsville, Alabama • Scottsdale, Arizona + 22 more
Source: ClinicalTrials.gov public record
Updated Jul 25, 2017 · Synced Jul 23, 2026, 12:42 PM EDT