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ClinicalTrials.gov public records Last synced Nov 14, 2026, 9:40 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 25–48 of 82 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Knee Prosthesis Clear all

Conditions: Osteoarthritis
Interventions: Patient record review, Radiographs, and questionaires.; Other
Lead sponsor: Medacta USA; Industry
Eligibility: Not listed
Enrollment: 24 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2022
U.S. locations: 1
States / cities: Boise, Idaho

Conditions: Noninflammatory Degenerative Joint Disease
Interventions: Attune Primary Total Knee Replacement; Device
Lead sponsor: DePuy International; Industry
Eligibility: 22 Years to 75 Years
Enrollment: 1,542 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2030
U.S. locations: 9
States / cities: Scottsdale, Arizona • Orange, California • DeLand, Florida + 6 more

Conditions: Lower Limb Amputation Below Knee
Interventions: Fixed stiffness prosthesis, Automatic stiffness prosthesis; Device
Lead sponsor: Seattle Institute for Biomedical and Clinical Research; Other
Eligibility: 18 Years to 79 Years
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Knee Prosthesis
Interventions: Stryker posterior cruciat retaining (PCR) total knee arthroplasty (TKA), Zimmer PCR TKA; Device
Lead sponsor: The University of Tennessee, Knoxville; Other
Eligibility: 40 Years to 70 Years
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2014
U.S. locations: 4
States / cities: Knoxville, Tennessee

Conditions: Amputation, Prosthesis User
Interventions: Standard-of-care prosthetic foot, Standard-of-care prosthetic foot with heel-stiffening wedge, Standard-of-care prosthetic foot of one category greater stiffness, Dual keel prosthetic foot, Powered ankle-foot; Device
Lead sponsor: VA Puget Sound Health Care System; Federal
Eligibility: 18 Years to 70 Years
Enrollment: 13 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2025
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Osteoarthritis
Interventions: Latella Knee Implant System; Device
Lead sponsor: Cotera, Inc.; Industry
Eligibility: 30 Years to 70 Years
Enrollment: 1 participant
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2017
U.S. locations: 2
States / cities: Washington D.C., District of Columbia • Chicago, Illinois

Conditions: Transfemoral Amputation
Interventions: MIT Powered Knee; Device
Lead sponsor: Massachusetts Institute of Technology; Other
Eligibility: 22 Years to 65 Years
Enrollment: 7 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2026
U.S. locations: 1
States / cities: Cambridge, Massachusetts

Conditions: Amputation, Amputation; Traumatic, Leg, Lower, Limb; Absence, Congenital, Lower, Prosthesis User, Lower Limb Amputation Above Knee (Injury), Amputation; Traumatic, Leg: Thigh, Between Hip and Knee
Interventions: Power Knee; Device
Lead sponsor: Liberating Technologies, Inc.; Industry
Eligibility: 18 Years and older
Enrollment: 13 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2024
U.S. locations: 2
States / cities: Holliston, Massachusetts • Austin, Texas

Conditions: Knee Arthroplasty, Total
Interventions: ConforMIS custom total knee; Device
Lead sponsor: University of Missouri-Columbia; Other
Eligibility: 18 Years and older
Enrollment: 28 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2016
U.S. locations: 1
States / cities: Columbia, Missouri

Conditions: Prosthesis-Related Infections
Interventions: Oral Antibiotics; Other
Lead sponsor: Rush University Medical Center; Other
Eligibility: 18 Years to 90 Years
Enrollment: 185 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2020
U.S. locations: 4
States / cities: Chicago, Illinois • Winfield, Illinois • Philadelphia, Pennsylvania + 1 more

Conditions: Total Knee Arthroplasty, Osteoarthritis
Interventions: NexGen LPS-Flex Fixed Bearing Knee, NexGen Legacy Posterior Stabilized Knee; Device
Lead sponsor: Zimmer Biomet; Industry
Eligibility: 21 Years to 80 Years
Enrollment: 331 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2001 – 2010
U.S. locations: 14
States / cities: Birmingham, Alabama • Decatur, Georgia • Springfield, Illinois + 11 more

Conditions: Staphylococcal Infections, Methicillin-resistant Staphylococcus Aureus
Interventions: Daptomycin, Vancomycin; Drug
Lead sponsor: Mountain Home Research & Education Corporation; Other
Eligibility: 18 Years to 90 Years
Enrollment: 28 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2014
U.S. locations: 2
States / cities: Johnson City, Tennessee • Mountain Home, Tennessee

Conditions: Transfemoral Amputation, Artificial Limbs
Interventions: Assist-Knee, Habitual Prosthesis; Device
Lead sponsor: Orthocare Innovations, LLC; Industry
Eligibility: 21 Years to 80 Years
Enrollment: 3 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2020
U.S. locations: 1
States / cities: Edmonds, Washington

Conditions: Arthritis, Osteoarthritis, Knee, Osteoarthritis, Hip, Thromboembolism
Interventions: Rivaroxaban; Drug
Lead sponsor: Ortho-McNeil Janssen Scientific Affairs, LLC; Industry
Eligibility: 18 Years to 99 Years
Enrollment: 56 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010
U.S. locations: 5
States / cities: Denver, Colorado • Hollywood, Florida • Tamarac, Florida + 2 more

Conditions: Amputation, Transfemoral Amputation
Interventions: Power Knee Firmware Update, Power Knee Current Marketed Firmware; Device
Lead sponsor: Össur Iceland ehf; Industry
Eligibility: 18 Years and older
Enrollment: 6 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024
U.S. locations: 1
States / cities: Bay City, Michigan

Conditions: Osteoarthritis, Rheumatoid Arthritis, Other Inflammatory Arthritis, Post-Traumatic Arthritis, Juvenile Rheumatoid Arthritis, Avascular Necrosis
Interventions: Total Knee Arthroplasty, Total knee replacement; Device
Lead sponsor: DePuy Orthopaedics; Industry
Eligibility: 18 Years to 75 Years
Enrollment: 149 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2001 – 2007
U.S. locations: 3
States / cities: Greensboro, North Carolina • Austin, Texas • Lakewood, Washington

Conditions: Degenerative Arthritis, Osteoarthritis, Rheumatoid Arthritis, Knee Arthritis
Interventions: Duracon®, Vanguard™; Device
Lead sponsor: Biomet Orthopedics, LLC; Industry
Eligibility: 18 Years and older
Enrollment: 150 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2005 – 2008
U.S. locations: 1
States / cities: Warsaw, Indiana

Conditions: Prosthesis-related Infections, Wound Complications, Joint Diseases, Musculoskeletal Diseases
Interventions: Prevena; Device
Lead sponsor: The Cleveland Clinic; Other
Eligibility: 18 Years and older
Enrollment: 160 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2017
U.S. locations: 1
States / cities: Cleveland, Ohio

Conditions: Amputation, Prosthesis User, Amputation; Traumatic, Leg: Thigh, Between Hip and Knee, Limb; Absence, Congenital, Lower, Lower Limb Amputation Above Knee (Injury), Lower Limb Amputation Above Knee
Interventions: Ottobock C-Leg 4 Microprocessor Knee, Ottobock Kenevo; Device
Lead sponsor: Hanger Institute for Clinical Research and Education, LLC; Industry
Eligibility: 18 Years and older
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: Austin, Texas

Conditions: Amputation
Interventions: META-Arc foot locked, META-Arc foot unlocked; Device
Lead sponsor: University of Washington; Other
Eligibility: 16 Years and older
Enrollment: 96 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2027
U.S. locations: 3
States / cities: Tampa, Florida • Mount Sterling, Ohio • Seattle, Washington

Conditions: Lower Limb Amputation Below Knee (Injury)
Interventions: Not listed
Lead sponsor: University of Washington; Other
Eligibility: 18 Years and older
Enrollment: 9 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2014
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Amputation
Interventions: Active Knee Prosthesis; Device
Lead sponsor: Providence VA Medical Center; Federal
Eligibility: 18 Years to 50 Years
Enrollment: 10 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2008 – 2009
U.S. locations: 2
States / cities: Cambridge, Massachusetts • North Andover, Massachusetts

Conditions: Lower Limb Amputation Below Knee (Injury), Lower Limb Amputation Above Knee (Injury)
Interventions: Questionnaire; Other
Lead sponsor: Minneapolis Veterans Affairs Medical Center; Federal
Eligibility: 18 Years to 80 Years
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2023
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Transfemoral Amputation, Limb Loss, Limb Absence
Interventions: College Park ICON, Conventional NMPK; Other
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 45 Years to 85 Years
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2027 – 2028
U.S. locations: 2
States / cities: Chicago, Illinois • Hines, Illinois

Search by objective public record fields.

A Post-Market Retrospective Study on Revision Total Knee Arthroplasty Using Medacta GMK® Revision Prosthesis

Survivorship of Attune Primary Total Knee Prosthesis

Automatic Prosthetic Foot Stiffness Modulation to Improve Balance in the Real World

In Vivo Kinematics Comparison of Stryker or Zimmer Total Knee Arthroplasty

Lower Limb Prostheses for Individuals Who Carry Infants, Toddlers, and Other Loads

Evaluation of the Latella™ Knee Implant System for Medial Osteoarthritis Pain Reduction

Active Knee Prosthesis Study

Clinical Outcomes With Passive MPKs vs. Powered Prosthetic Knees

iTotal Pilot Study of ConforMIS Custom Total Knee Implant

Oral Antibiotics After 2-Stage Revision for Infected Total Hip Arthroplasty and Total Knee Arthroplasty

A Study to Compare the NexGen LPS and LPS-Flex Knee Implants

Daptomycin Use for Antimicrobial Prophylaxis in Methicillin Resistant Staphylococcus Aureus (MRSA) Colonized Adult Patients Undergoing Primary Elective Hip, Knee, or Shoulder Arthroplasty

Assist-Knee: Energy-Harvesting Knee Prosthesis

Switching Drug Therapy for the Prevention of Blood Clot Formation From Enoxaparin to Rivaroxaban After Orthopedic Surgery for Either Total Hip or Total Knee Replacement

Investigation on a New Power Knee Firmware Update on Gait and Daily Life Activities for Transfemoral Amputees

Randomized Fixed Bearing vs Mobile Bearing Cruciate Substituting TKA

Total Knee Replacement With Duracon® and Vanguard™ Prostheses

Evaluation of Wound Management With Negative Pressure Dressing Versus Standard Dressing After Revision Arthroplasty.

Effects of Microprocessor-controlled Prosthetic Knees on Fall-related Health Outcomes in Limited Community Ambulators

Effectiveness of Frontal Plane Adaptability in a Novel Foot Prosthesis

Influence of Socket Volume on Prosthesis Performance

Active Knee Prosthesis Study for Improvement of Locomotion for Above Knee Amputees

Women's-Specific Footwear With Prosthetic Feet

Effect of a Microprocessor-controlled Prosthetic Knee Joint on K2 Level Ambulators