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ClinicalTrials.gov public records Last synced Oct 13, 2026, 5:50 PM EDT

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Showing 289–312 of 861 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Knee Replacement Arthroplasty Clear all
Completed Early Phase 1 Interventional

Pain Control After Total Knee Arthroplasty: Benefit In Adding Single Shot Adductor Canal Block to Existing Pain Regimen Protocol?

NCT02740192
View directory record Official record
Conditions
Pain
Interventions
Adductor Canal Block, Periarticular Injection, Ropivacaine, Bupivacaine
Procedure · Drug
Lead sponsor
Henry Ford Health System
Other
Eligibility
18 Years and older
Enrollment
128 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Oct 30, 2023 · Synced Oct 13, 2026, 5:50 PM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

A Randomized Controlled Trial for Partial Knee Arthroplasty

NCT05037734
View directory record Official record
Conditions
Degenerative Joint Disease of Knee, Osteoarthritis, Traumatic Arthritis, Varus Deformity, Knee Pain Chronic
Interventions
Persona Partial Knee System
Device
Lead sponsor
Zimmer Biomet
Industry
Eligibility
Not listed
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2030
U.S. locations
1
States / cities
Jackson, Mississippi
Source: ClinicalTrials.gov public record
Updated Jun 5, 2023 · Synced Oct 13, 2026, 5:50 PM EDT
Withdrawn Not applicable Interventional

Acute Nerve Decompression Versus Non-operative Treatment for Peroneal Nerve Palsy Following Primary Total Knee Arthroplasty

NCT02856958
View directory record Official record
Conditions
Peroneal Palsy (Foot Drop)
Interventions
Nerve decompression, Non-operative
Procedure · Other
Lead sponsor
Rush University Medical Center
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Apr 11, 2018 · Synced Oct 13, 2026, 5:50 PM EDT
Enrolling by invitation Phase 4 Interventional

Comparison of Suzetrigine and Oxycodone for Postoperative Pain After Primary Total Knee Arthroplasty

NCT07219888
View directory record Official record
Conditions
Osteoarthritis (OA) of the Knee
Interventions
oral suzetrigine, oral Oxycodone
Drug
Lead sponsor
University of Louisville
Other
Eligibility
21 Years to 89 Years
Enrollment
140 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Louisville, Kentucky
Source: ClinicalTrials.gov public record
Updated May 4, 2026 · Synced Oct 13, 2026, 5:50 PM EDT
Not listed No phase listed Observational

Outcome Study of Highly-cross Linked Polyethylene vs. Standard Polyethylene for Primary Posterior Stabilized (PS) Total Knee

NCT02178020
View directory record Official record
Conditions
Arthroplasty, Replacement, Knee
Interventions
knee arthroplasty, standard polyethylene, knee arthroplasty, XLP polyethylene
Device
Lead sponsor
Chapel Hill Orthopedics Surgery & Sports Medicine
Other
Eligibility
Not listed
Enrollment
500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2019
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 1, 2017 · Synced Oct 13, 2026, 5:50 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Incidence of Fat Embolism With Computer Assisted Total Knee Arthroplasty

NCT00656877
View directory record Official record
Conditions
Fat Embolism Syndrome
Interventions
Not listed
Lead sponsor
Marshall University
Other
Eligibility
Not listed
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2008
U.S. locations
1
States / cities
Huntington, West Virginia
Source: ClinicalTrials.gov public record
Updated Apr 11, 2008 · Synced Oct 13, 2026, 5:50 PM EDT
Enrolling by invitation Not applicable Interventional

The Use of Smart Glasses for Saphenous Nerve Adductor Canal Block

NCT07213622
View directory record Official record
Conditions
Total Knee Arthroplasty
Interventions
Smartglasses
Procedure
Lead sponsor
MetroHealth Medical Center
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Oct 9, 2025 · Synced Oct 13, 2026, 5:50 PM EDT
Not listed Phase 4 Interventional

Comparing Ropivacaine Adductor Canal Blockade by Surgeon Versus Anesthesiologist

NCT03864588
View directory record Official record
Conditions
Pain, Postoperative, Satisfaction
Interventions
Ropivacaine
Drug
Lead sponsor
Rothman Institute Orthopaedics
Other
Eligibility
18 Years to 80 Years
Enrollment
164 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 6, 2019 · Synced Oct 13, 2026, 5:50 PM EDT
Completed Not applicable Interventional

Minimally Invasive Knee Replacement Outcomes (MIKRO) Study

NCT00633113
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
MPPA, SV
Procedure
Lead sponsor
Dartmouth-Hitchcock Medical Center
Other
Eligibility
35 Years to 85 Years
Enrollment
131 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2012
U.S. locations
1
States / cities
Lebanon, New Hampshire
Source: ClinicalTrials.gov public record
Updated Apr 29, 2013 · Synced Oct 13, 2026, 5:50 PM EDT
Withdrawn Not applicable Interventional

Using Peripheral Nerve Stimulation (PNS) to Treat Chronic Post-surgical Pain (CPSP) After Knee Surgery

NCT04670042
View directory record Official record
Conditions
Injury; Nerve, Peripheral, Multiple, Chronic Post-Procedural Pain, Total Knee Arthroplasty, Surgery, Knee Injuries, Knee Pain Chronic, Postoperative Pain, Chronic Postoperative Pain
Interventions
SPRINT® Peripheral Nerve Stimulation (PNS) System (510k Cleared)
Device
Lead sponsor
Stanford University
Other
Eligibility
21 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
Redwood City, California
Source: ClinicalTrials.gov public record
Updated Oct 20, 2022 · Synced Oct 13, 2026, 5:50 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Enhanced Recovery After Surgery (ERAS) Total Knee Replacement (TKR) With a Transitional Pain Service

NCT03747146
View directory record Official record
Conditions
Anesthesia
Interventions
Continuous Adductor Canal Catheter (ACC), Adductor Canal block with sham catheter
Device
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
18 Years to 65 Years
Enrollment
94 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2026
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 28, 2026 · Synced Oct 13, 2026, 5:50 PM EDT
Withdrawn Phase 2 Interventional

Phase IIa Venous Thromboembolism (VTE) Prevention Study In Total Knee Replacement (TKR)

NCT00541320
View directory record Official record
Conditions
Venous Thromboembolism
Interventions
GW813893
Drug
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
18 Years to 85 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2007
U.S. locations
8
States / cities
Birmingham, Alabama • Phoenix, Arizona • Yuba City, California + 4 more
Source: ClinicalTrials.gov public record
Updated Apr 4, 2013 · Synced Oct 13, 2026, 5:50 PM EDT
Completed Not applicable Interventional Results available

Comparison of Alignment Achieved Using the VELYS Robotic-Assisted Solution Versus Manual Instrumentation in Total Knee Arthroplasty

NCT04730271
View directory record Official record
Conditions
Osteo Arthritis Knee, Osteoarthritis
Interventions
Total Knee Replacement
Device
Lead sponsor
DePuy Orthopaedics
Industry
Eligibility
22 Years to 85 Years
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
5
States / cities
Baltimore, Maryland • Crosby, Minnesota • Charlotte, North Carolina + 2 more
Source: ClinicalTrials.gov public record
Updated Apr 27, 2025 · Synced Oct 13, 2026, 5:50 PM EDT
Recruiting Phase 2 Interventional

Yale Steroid Enhanced Versus Exparel Nerveblock TKA RCT Study

NCT05279092
View directory record Official record
Conditions
Total Knee Replacement, Knee Arthroplasty
Interventions
Bupivacaine-Liposomal Bupivacaine, Bupivacaine -Dexamethasone Sodium Phosphate-Methylprednisolone Acetate
Drug
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Enrollment
250 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2028
U.S. locations
2
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jul 23, 2026 · Synced Oct 13, 2026, 5:50 PM EDT
Completed Phase 4 Interventional Results available

Does Duloxetine Reduce Sub-Acute Pain After Knee Arthroplasty?

NCT02005601
View directory record Official record
Conditions
Total Knee Arthroplasty
Interventions
Placebo, Duloxetine 60mg
Drug
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
25 Years to 75 Years
Enrollment
106 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 29, 2017 · Synced Oct 13, 2026, 5:50 PM EDT
Terminated Phase 4 Interventional Results available

Steroids in Total Knee Arthroplasty

NCT02219581
View directory record Official record
Conditions
Postoperative Pain, Inflammation, Osteoarthritis
Interventions
Dexamethasone 10 mg, Dexamethasone 20 mg, Standard multimodal pain management regimen, Placebo
Drug
Lead sponsor
Thomas L Bradbury
Other
Eligibility
18 Years to 100 Years
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Tucker, Georgia
Source: ClinicalTrials.gov public record
Updated Oct 4, 2022 · Synced Oct 13, 2026, 5:50 PM EDT
Completed Phase 2 Interventional

Study to Evaluate Safety/Efficacy of a Single Preop Dose of AYX1 Injection to Treat Pain After Knee Replacement Surgery

NCT02807428
View directory record Official record
Conditions
Post-surgical Pain
Interventions
AYX1 Injection 660 mg/6 mL, Placebo Injection 6 mL
Drug
Lead sponsor
Adynxx, Inc.
Industry
Eligibility
40 Years and older
Enrollment
210 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017
U.S. locations
9
States / cities
Birmingham, Alabama • Sheffield, Alabama • Phoenix, Arizona + 6 more
Source: ClinicalTrials.gov public record
Updated Oct 17, 2018 · Synced Oct 13, 2026, 5:50 PM EDT
Active, not recruiting No phase listed Observational Accepts healthy volunteers

Performance of MOTO Medial® Unicompartmental Knee Arthroplasty

NCT03211663
View directory record Official record
Conditions
Knee Osteoarthritis, Knee Arthritis, Knee Pain Chronic
Interventions
MOTO Medial® UKA
Device
Lead sponsor
Medacta USA
Industry
Eligibility
18 Years and older
Enrollment
269 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2025
U.S. locations
5
States / cities
Lady Lake, Florida • Louisville, Kentucky • Billings, Montana + 2 more
Source: ClinicalTrials.gov public record
Updated Sep 25, 2025 · Synced Oct 13, 2026, 5:50 PM EDT
Enrolling by invitation No phase listed Observational

Exactech Knee Systems Post Market Clinical Follow-up

NCT07107581
View directory record Official record
Conditions
Knee Arthroplasty, Total, Partial Knee Replacement
Interventions
Prospective / Subjects Knee Arthroplasty, Retrospective to Prospective, Retrospective Only Subjects
Device
Lead sponsor
Exactech
Industry
Eligibility
18 Years and older
Enrollment
1,879 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2036
U.S. locations
1
States / cities
DeLand, Florida
Source: ClinicalTrials.gov public record
Updated Aug 6, 2025 · Synced Oct 13, 2026, 5:50 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Preanalgesic Effect of Gabapentin in Total Knee Repair

NCT00279487
View directory record Official record
Conditions
Pain
Interventions
Gabapentin, Placebos
Drug
Lead sponsor
Texas Health Resources
Other
Eligibility
18 Years and older
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
Ends 2007
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Oct 26, 2016 · Synced Oct 13, 2026, 5:50 PM EDT
Not listed Not applicable Interventional

Post-Market Study of Robotic-Arm Assisted Total Knee Arthroplasty

NCT03106558
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
Total Knee Arthroplasty using Manual Instrumentation, Total Knee Arthroplasty using Robotic Arm
Device
Lead sponsor
Rothman Institute Orthopaedics
Other
Eligibility
18 Years and older
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
4
States / cities
Athens, Georgia • Egg Harbor, New Jersey • Cleveland, Ohio + 1 more
Source: ClinicalTrials.gov public record
Updated Apr 10, 2017 · Synced Oct 13, 2026, 5:50 PM EDT
Completed Phase 2 Interventional

Pilot Study of the Efficacy and Safety of Q8003 in Patients Who Have Undergone Total Knee Arthroplasty or Total Hip Arthroplasty

NCT00818493
View directory record Official record
Conditions
Postoperative Pain
Interventions
Q8003 (morphine sulfate and oxycodone hydrochloride), Low dose Q8003 (morphine sulfate and oxycodone hydrochloride), Percocet (oxycodone and acetaminophen)
Drug
Lead sponsor
QRxPharma Inc.
Industry
Eligibility
18 Years and older
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009
U.S. locations
4
States / cities
Birmingham, Alabama • Phoenix, Arizona • Royal Oak, Michigan + 1 more
Source: ClinicalTrials.gov public record
Updated May 17, 2012 · Synced Oct 13, 2026, 5:50 PM EDT
Recruiting Not applicable Interventional

Mechanical Alignment vs Kalipered Kinematic Alignment Total Knee Arthroplasty

NCT06617871
View directory record Official record
Conditions
Knee Osteoarthritis, Knee Arthropathy
Interventions
Mechanical Alignment (MA), Kinematic Alignment (KA) Interventions:
Procedure
Lead sponsor
Northwestern University
Other
Eligibility
21 Years to 79 Years
Enrollment
95 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Mar 24, 2026 · Synced Oct 13, 2026, 5:50 PM EDT
Active, not recruiting Not applicable Interventional

Prophylactic Infrapatellar Saphenous Neurectomy in Primary Total Knee Arthroplasty

NCT04028947
View directory record Official record
Conditions
Knee Pain Chronic
Interventions
Prophylactic Infrapatellar Saphenous Neurectomy in Primary Total Knee Arthroplasty
Procedure
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 85 Years
Enrollment
178 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2026
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Jan 14, 2026 · Synced Oct 13, 2026, 5:50 PM EDT