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ClinicalTrials.gov public records Last synced Oct 12, 2026, 7:55 AM EDT

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Showing 145–168 of 861 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Knee Replacement Arthroplasty Clear all
Recruiting Phase 2 Interventional

Cannabidiol for Postoperative Opioid Reduction in Primary Total Knee Arthroplasty

NCT06234631
View directory record Official record
Conditions
Knee Replacement Surgery, Osteoarthritis, Knee
Interventions
Epidiolex oral solution, Placebo
Drug · Other
Lead sponsor
Chad Brummett
Other
Eligibility
18 Years to 80 Years
Enrollment
380 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2029
U.S. locations
2
States / cities
Ann Arbor, Michigan • Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Apr 15, 2026 · Synced Oct 12, 2026, 7:55 AM EDT
Active, not recruiting No phase listed Observational Accepts healthy volunteers

Performance of MOTO Medial® Unicompartmental Knee Arthroplasty

NCT03211663
View directory record Official record
Conditions
Knee Osteoarthritis, Knee Arthritis, Knee Pain Chronic
Interventions
MOTO Medial® UKA
Device
Lead sponsor
Medacta USA
Industry
Eligibility
18 Years and older
Enrollment
269 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2025
U.S. locations
5
States / cities
Lady Lake, Florida • Louisville, Kentucky • Billings, Montana + 2 more
Source: ClinicalTrials.gov public record
Updated Sep 25, 2025 · Synced Oct 12, 2026, 7:55 AM EDT
Completed Not applicable Interventional Results available

Educational Intervention for Knee Pain

NCT00324857
View directory record Official record
Conditions
Osteoarthritis
Interventions
Decision Aid Video, Motivational Interviewing, MI plus Decision aid, Attention control
Behavioral · Other
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
50 Years and older
Enrollment
663 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2011
U.S. locations
3
States / cities
Cleveland, Ohio • Philadelphia, Pennsylvania • Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 10, 2018 · Synced Oct 12, 2026, 7:55 AM EDT
Completed Not applicable Interventional

Prediction of Outcomes Following Total Knee Replacement- Pilot

NCT04328701
View directory record Official record
Conditions
Osteoarthritis, Knee, Knee Replacement
Interventions
Mindfulness-based Cognitive Behavioral Therapy
Behavioral
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
45 Years to 100 Years
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2023
U.S. locations
1
States / cities
Chestnut Hill, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 20, 2026 · Synced Oct 12, 2026, 7:55 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Comparative Effectiveness of an Activity-specific Monitoring Device- StepRite

NCT02900781
View directory record Official record
Conditions
Osteoarthritis, Degenerative Joint Disease
Interventions
Steprite™, Standard of care
Device · Other
Lead sponsor
Texas Tech University Health Sciences Center
Other
Eligibility
45 Years to 75 Years
Enrollment
9 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
Lubbock, Texas
Source: ClinicalTrials.gov public record
Updated Aug 9, 2019 · Synced Oct 12, 2026, 7:55 AM EDT
Completed Phase 2Phase 3 Interventional Results available

Femoral Nerve Block With Liposome Bupivacaine for Postsurgical Analgesia Following Total Knee Arthroplasty

NCT01683071
View directory record Official record
Conditions
Postoperative Pain
Interventions
Placebo, EXPAREL 67 mg, EXPAREL 133 mg, EXPAREL 266 mg
Drug
Lead sponsor
Pacira Pharmaceuticals, Inc
Industry
Eligibility
18 Years and older
Enrollment
297 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
30
States / cities
Birmingham, Alabama • Mobile, Alabama • Sheffield, Alabama + 23 more
Source: ClinicalTrials.gov public record
Updated Dec 9, 2020 · Synced Oct 12, 2026, 7:55 AM EDT
Completed Not applicable Interventional

The Need for Compression Bandage Following Total Knee Arthroplasty A Prospective Randomized Controlled Trial Conducted in Simultaneous Bilateral Total Knee Replacements

NCT03521869
View directory record Official record
Conditions
Osteo Arthritis Knee
Interventions
Compression bandage, Gauze dressing
Device
Lead sponsor
Rothman Institute Orthopaedics
Other
Eligibility
18 Years and older
Enrollment
50 participants
Timeline
2014 – 2017
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 11, 2018 · Synced Oct 12, 2026, 7:55 AM EDT
Completed Not applicable Interventional Results available

TSolution One® Total Knee Arthroplasty

NCT03017261
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
TSolution One®
Device
Lead sponsor
Think Surgical Inc.
Industry
Eligibility
21 Years and older
Enrollment
115 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
6
States / cities
Hackensack, New Jersey • New York, New York • Roslyn, New York + 3 more
Source: ClinicalTrials.gov public record
Updated Jun 4, 2020 · Synced Oct 12, 2026, 7:55 AM EDT
Completed Not applicable Interventional

Articulating Versus Static Antibiotic Loaded Spacers for the Treatment of Prosthetic Knee Infection

NCT01373112
View directory record Official record
Conditions
Osteoarthritis, Knee Infection, Prosthetic Joint Infection, Complications; Arthroplasty, Infection or Inflammation, Complications; Arthroplasty
Interventions
Static Spacer, Articulating Spacer
Procedure
Lead sponsor
Rush University Medical Center
Other
Eligibility
18 Years to 100 Years
Enrollment
68 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2020
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Oct 8, 2020 · Synced Oct 12, 2026, 7:55 AM EDT
Withdrawn No phase listed Observational Accepts healthy volunteers

Sleep Patterns After Total Joint Replacement Surgery

NCT04896892
View directory record Official record
Conditions
Arthroplasty, Replacement, Knee, Arthroplasty, Replacement, Hip
Interventions
Not listed
Lead sponsor
Henry Ford Health System
Other
Eligibility
18 Years and older
Healthy volunteers
Accepts healthy volunteers
Timeline
2026
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Aug 11, 2026 · Synced Oct 12, 2026, 7:55 AM EDT
Withdrawn Not applicable Interventional

Comparison of Implant Positioning With Robotic Aided Surgery and Traditional Jig Positioning in Total Knee Arthroplasty

NCT03052790
View directory record Official record
Conditions
Knee Arthritis
Interventions
manually instrumented total knee arthroplasty, robotic assisted total knee arthroplasty
Procedure · Device
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
25 Years to 95 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Apr 4, 2019 · Synced Oct 12, 2026, 7:55 AM EDT
Completed Not applicable Interventional

Continuous Femoral Nerve Block Following Total Knee Replacement

NCT00135889
View directory record Official record
Conditions
Pain
Interventions
Femoral perineural infusion
Drug
Lead sponsor
National Institute of General Medical Sciences (NIGMS)
NIH
Eligibility
18 Years to 80 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2008
U.S. locations
2
States / cities
La Jolla, California • Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Oct 8, 2009 · Synced Oct 12, 2026, 7:55 AM EDT
Terminated Not applicable Interventional Results available

Oxford Signature vs. Conventional Global Study

NCT01763684
View directory record Official record
Conditions
Osteoarthritis, Osteoarthritis, Knee, Osteonecrosis
Interventions
Signature Custom Guides, Conventional Instrumentation
Device · Procedure
Lead sponsor
Zimmer Biomet
Industry
Eligibility
21 Years and older
Enrollment
266 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
7
States / cities
Elkhart, Indiana • Rockville, Maryland • Columbia, Missouri + 4 more
Source: ClinicalTrials.gov public record
Updated Apr 23, 2021 · Synced Oct 12, 2026, 7:55 AM EDT
Terminated Phase 4 Interventional Results available

Predicting, Understanding and Speeding Recovery After TKA

NCT02685735
View directory record Official record
Conditions
Pain, Total Knee Replacement, Total Hip Replacement
Interventions
Gabapentin, Placebo
Drug
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years to 70 Years
Enrollment
350 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2022
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 15, 2025 · Synced Oct 12, 2026, 7:55 AM EDT
Withdrawn Not applicable Interventional

Amniotic Umbilical Cord Particulate During Total Knee Arthroplasty

NCT03912116
View directory record Official record
Conditions
Osteoarthritis: Joint Replacement Surgery
Interventions
CLARIX FLO, Saline
Other
Lead sponsor
BioTissue Holdings, Inc
Industry
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019
U.S. locations
1
States / cities
Orange Park, Florida
Source: ClinicalTrials.gov public record
Updated Dec 18, 2019 · Synced Oct 12, 2026, 7:55 AM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

HealthEast Community Hip and Knee Replacement Registry

NCT02692092
View directory record Official record
Conditions
Bone Fracture
Interventions
Not listed
Lead sponsor
HealthEast Care System
Other
Eligibility
18 Years and older
Enrollment
200,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
1991 – 2091
U.S. locations
1
States / cities
Saint Paul, Minnesota
Source: ClinicalTrials.gov public record
Updated Feb 26, 2018 · Synced Oct 12, 2026, 7:55 AM EDT
Completed No phase listed Observational

Post-Market Study of the 3DKnee™ System

NCT00819481
View directory record Official record
Conditions
Degenerative Joint Disease, Osteoarthritis, Rheumatoid Arthritis, Traumatic Arthritis
Interventions
3DKnee™ System
Device
Lead sponsor
Encore Medical, L.P.
Industry
Eligibility
18 Years and older
Enrollment
229 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2018
U.S. locations
8
States / cities
Scottsdale, Arizona • Fresno, California • Baltimore, Maryland + 5 more
Source: ClinicalTrials.gov public record
Updated Mar 16, 2021 · Synced Oct 12, 2026, 7:55 AM EDT
Completed No phase listed Observational

10003 PRO Current Products

NCT01497730
View directory record Official record
Conditions
Osteoarthritis
Interventions
Total Knee Replacement
Device
Lead sponsor
DePuy Orthopaedics
Industry
Eligibility
22 Years to 80 Years
Enrollment
842 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2018
U.S. locations
11
States / cities
Orange, California • San Diego, California • Fort Collins, Colorado + 8 more
Source: ClinicalTrials.gov public record
Updated Apr 22, 2019 · Synced Oct 12, 2026, 7:55 AM EDT
Terminated Not applicable Interventional Results available

Economic and Functional Impact of Peri-Operative Bracing for Primary Total Knee Arthroplasty (TKA)

NCT03260699
View directory record Official record
Conditions
Arthropathy of Knee
Interventions
OCSI Rehabilitator brace
Device
Lead sponsor
The Cleveland Clinic
Other
Eligibility
50 Years and older
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Oct 9, 2019 · Synced Oct 12, 2026, 7:55 AM EDT
Not listed Not applicable Interventional

Outcomes of Rotating Platform Versus Mobile Bearing Total Knee Arthroplasty

NCT03731676
View directory record Official record
Conditions
Total Knee Arthroplasty
Interventions
Fixed bearing total knee arthroplasty, Rotating platform total knee arthroplasty
Device
Lead sponsor
William Hopkinson
Other
Eligibility
Not listed
Enrollment
250 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2000 – 2021
U.S. locations
1
States / cities
Maywood, Illinois
Source: ClinicalTrials.gov public record
Updated Apr 19, 2021 · Synced Oct 12, 2026, 7:55 AM EDT
Completed Not applicable Interventional

Evaluating the Effectiveness of 2 Surgical Skin Preparation Methods in Reducing Surgical Wound Drainage After Total Hip or Knee Replacement

NCT01097135
View directory record Official record
Conditions
Drainage
Interventions
Duraprep Surgical Solution
Drug
Lead sponsor
Rothman Institute Orthopaedics
Other
Eligibility
18 Years to 80 Years
Enrollment
600 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 17, 2013 · Synced Oct 12, 2026, 7:55 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Traditional vs Oral Fluid Management in Total Knee Arthroplasty

NCT03719378
View directory record Official record
Conditions
Arthroplasty, Replacement, Knee
Interventions
Pre Operative Oral Fluids
Other
Lead sponsor
Colorado Joint Replacement
Other
Eligibility
18 Years to 75 Years
Enrollment
150 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2018
U.S. locations
1
States / cities
Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Mar 16, 2021 · Synced Oct 12, 2026, 7:55 AM EDT
Active, not recruiting No phase listed Observational

Safety and Performance Using Legion™ CR Oxinium and CoCr Femoral Implants Combined With Legion™/Genesis™ II XLPE High Flex Tibial Inserts

NCT03687593
View directory record Official record
Conditions
Total Knee Arthroplasty
Interventions
Legion™ CR Oxinium and CoCr Femoral Implants combined with Legion™/Genesis™ II XLPE High Flex Tibial Inserts
Device
Lead sponsor
Smith & Nephew, Inc.
Industry
Eligibility
18 Years and older
Enrollment
126 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2028
U.S. locations
4
States / cities
Edina, Minnesota • Reno, Nevada • Greenville, South Carolina + 1 more
Source: ClinicalTrials.gov public record
Updated Jan 29, 2026 · Synced Oct 12, 2026, 7:55 AM EDT
Completed Not applicable Interventional Results available

Triathlon® Posteriorly Stabilized (PS) Total Knee System - Outcomes Study

NCT00957021
View directory record Official record
Conditions
Arthroplasty, Replacement, Knee
Interventions
Triathlon® PS Total Knee System
Device
Lead sponsor
Stryker Orthopaedics
Industry
Eligibility
21 Years to 80 Years
Enrollment
409 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2014
U.S. locations
11
States / cities
Columbus, Georgia • Indianapolis, Indiana • Boston, Massachusetts + 7 more
Source: ClinicalTrials.gov public record
Updated Jan 25, 2017 · Synced Oct 12, 2026, 7:55 AM EDT