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ClinicalTrials.gov public records Last synced Oct 4, 2026, 10:15 AM EDT

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Showing 49–72 of 210 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Knee and Hip Clear all
Completed Not applicable Interventional Results available

Nurse Initiated Acupressure for Pain Management

NCT04044716
View directory record Official record
Conditions
Pain, Postoperative, Pain, Acute
Interventions
Auricular acupressure, Standard of care pain management
Device · Other
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years to 80 Years
Enrollment
65 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Bermuda Run, North Carolina
Source: ClinicalTrials.gov public record
Updated Dec 7, 2022 · Synced Oct 4, 2026, 10:15 AM EDT
Completed Phase 3 Interventional Results available

A Study to Evaluate Long-Term Safety of Multiple Doses of Tapentadol (CG5503) Prolonged-Release (PR) and Oxycodone Controlled-Release (CR) in Patients With Chronic Pain

NCT00361504
View directory record Official record
Conditions
Osteoarthritis, Hip, Osteoarthritis, Knee, Lower Back Pain, Pain
Interventions
Oxycodone CR, Tapentadol (CG5503) ER
Drug
Lead sponsor
Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Industry
Eligibility
18 Years and older
Enrollment
1,123 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2008
U.S. locations
40
States / cities
Mesa, Arizona • Tucson, Arizona • Anaheim, California + 37 more
Source: ClinicalTrials.gov public record
Updated Apr 29, 2014 · Synced Oct 4, 2026, 10:15 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Prophylaxis Against DVTs After Primary Hip and Knee Replacement Surgery

NCT00767559
View directory record Official record
Conditions
Pulmonary Embolism
Interventions
warfarin, Fondaparinux:
Drug
Lead sponsor
The New England Baptist Hospital
Other
Eligibility
20 Years and older
Enrollment
330 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2012
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 26, 2011 · Synced Oct 4, 2026, 10:15 AM EDT
Enrolling by invitation Not applicable Interventional

Treatment of Acute Periprosthetic Joint Infection Comparing Single and Planned Double-Debridement Antibiotics and Implant Retention Followed by Chronic Antibiotic Suppression

NCT05640336
View directory record Official record
Conditions
Periprosthetic Joint Infection
Interventions
Single Debridement, Antibiotics and Implant Retention, Planned Double Debridement, Antibiotics and Implant Retention
Procedure
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
490 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2032
U.S. locations
2
States / cities
Jacksonville, Florida • Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Dec 18, 2025 · Synced Oct 4, 2026, 10:15 AM EDT
Completed Phase 3 Interventional Results available

Safety and Efficacy of Buprenorphine Transdermal System in Subjects With Moderate to Severe Osteoarthritis of Hip or Knee

NCT00313846
View directory record Official record
Conditions
Osteoarthritis
Interventions
Buprenorphine transdermal patch, Placebo
Drug
Lead sponsor
Purdue Pharma LP
Industry
Eligibility
40 Years to 75 Years
Enrollment
529 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2004
U.S. locations
44
States / cities
Mesa, Arizona • Phoenix, Arizona • Tucson, Arizona + 38 more
Source: ClinicalTrials.gov public record
Updated Sep 3, 2012 · Synced Oct 4, 2026, 10:15 AM EDT
Recruiting No phase listed Observational

SportsPro: Post-Market Clinical Follow Up Study

NCT06320925
View directory record Official record
Conditions
Shoulder Injuries, Knee Injuries, Hip Injuries
Interventions
Standard of Care Treatment
Device
Lead sponsor
Stryker Endoscopy
Industry
Eligibility
18 Years and older
Enrollment
1,500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
3
States / cities
Phoenix, Arizona • Englewood, Colorado • San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated May 29, 2025 · Synced Oct 4, 2026, 10:15 AM EDT
Recruiting Not applicable Interventional

Effects of Microprocessor-controlled Prosthetic Knees on Fall-related Health Outcomes in Limited Community Ambulators

NCT06937242
View directory record Official record
Conditions
Amputation, Prosthesis User, Amputation; Traumatic, Leg: Thigh, Between Hip and Knee, Limb; Absence, Congenital, Lower, Lower Limb Amputation Above Knee (Injury), Lower Limb Amputation Above Knee
Interventions
Ottobock C-Leg 4 Microprocessor Knee, Ottobock Kenevo
Device
Lead sponsor
Hanger Institute for Clinical Research and Education, LLC
Industry
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Feb 5, 2026 · Synced Oct 4, 2026, 10:15 AM EDT
Recruiting Not applicable Interventional

Binaural Beats for Postoperative Pain and Anxiety Reduction

NCT07437469
View directory record Official record
Conditions
TKA, THA, Anxiety, Binaural Beats, Music Exposure, Total Hip Arthroplasty (THA), Total Knee Arthroplasty, Total Knee Replacement, Total Hip Replacement
Interventions
Binaural Beats Audio Intervention, Music of Choice
Other
Lead sponsor
University of Miami
Other
Eligibility
18 Years to 99 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Sep 30, 2026 · Synced Oct 4, 2026, 10:15 AM EDT
Completed Not applicable Interventional

Evaluation of DVD and Internet Decision Aids for Hip and Knee Osteoarthritis: Focus on Health Literacy

NCT01618097
View directory record Official record
Conditions
Osteoarthritis
Interventions
DVD Decision Aid, Internet Based Decision Aid
Behavioral
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
155 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Mar 5, 2015 · Synced Oct 4, 2026, 10:15 AM EDT
Recruiting No phase listed Observational

Prospective Case Series Evaluating 6-Month and 12-Month Outcomes After Cryoneurolysis for Chronic Pain

NCT07639060
View directory record Official record
Conditions
Chronic Pain, PERIPHERAL NEUROPATHY, Occipital Neuralgia, Chronic Hip Pain, Hip Osteoarthritis, Knee Osteoarthritis, Spasticity, Chronic Low Back Pain, Lumbar Spondylosis, Cervical Spondylosis, Shoulder Arthritis, Causalgia, Chronic Pain Syndrome, Chronic Neck Pain
Interventions
Not listed
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Old Saybrook, Connecticut
Source: ClinicalTrials.gov public record
Updated Aug 21, 2026 · Synced Oct 4, 2026, 10:15 AM EDT
Recruiting No phase listed Observational

Investigating Periprosthetic Fracture Cultures in Arthroplasty

NCT06952738
View directory record Official record
Conditions
Periprosthetic Fracture Around Prosthetic Joint Implant
Interventions
Not applicable- observational study
Other
Lead sponsor
University of Chicago
Other
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Dec 22, 2025 · Synced Oct 4, 2026, 10:15 AM EDT
Completed Not applicable Interventional Results available

Effect of Gabapentin Enacarbil on Opioid Consumption and Pain Scores

NCT02840240
View directory record Official record
Conditions
Pain
Interventions
Gabapentin enacarbil, Placebo
Drug
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years to 85 Years
Enrollment
107 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2021
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jan 9, 2024 · Synced Oct 4, 2026, 10:15 AM EDT
Completed Phase 2Phase 3 Interventional Results available

Mepivacaine Versus Low-Dose Bupivacaine For Primary Total Hip and Knee Arthroplasty

NCT03838874
View directory record Official record
Conditions
Knee Osteoarthritis, Hip Osteoarthritis
Interventions
Low-Dose Bupivacaine, Mepivacaine
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Days and older
Enrollment
154 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Aug 12, 2021 · Synced Oct 4, 2026, 10:15 AM EDT
Not yet recruiting Not applicable Interventional

Short-term and Intermediate-term Effects of Self-applied Joint Mobilization Versus Clinician-applied Joint Mobilization in Addition to Exercise in Patients With Knee Osteoarthritis: A Randomized Clinical Trial

NCT07020897
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
Clinician-administered joint mobilization, Self-administered joint mobilization, Exercise-based physical therapy
Other
Lead sponsor
Texas Woman's University
Other
Eligibility
45 Years and older
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
2
States / cities
Allen, Texas • Plano, Texas
Source: ClinicalTrials.gov public record
Updated Jun 13, 2025 · Synced Oct 4, 2026, 10:15 AM EDT
Completed Not applicable Interventional Results available

Improvement of Patient Satisfaction and Clinical Outcomes Using JointCOACH

NCT03499028
View directory record Official record
Conditions
Arthroplasty, Replacement, Hip, Arthroplasty, Replacement, Knee
Interventions
JointCOACH
Other
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years and older
Enrollment
446 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Apr 20, 2021 · Synced Oct 4, 2026, 10:15 AM EDT
Completed No phase listed Observational

CREATION Health Readmission Risk Assessment Tool

NCT03424382
View directory record Official record
Conditions
Heart Failure, COPD, Myocardial Infarction, Coronary Artery Bypass Graft, Pneumonia, Total Knee Replacement, Total Hip Replacement, Stroke
Interventions
Not listed
Lead sponsor
AdventHealth
Other
Eligibility
21 Years and older
Enrollment
1,218 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Orlando, Florida
Source: ClinicalTrials.gov public record
Updated Feb 7, 2020 · Synced Oct 4, 2026, 10:15 AM EDT
Completed Phase 1 Interventional

Tissue Distribution, Pharmacokinetics, Safety, and Tolerability After a Single Dose of TNP-2092 in Participants Undergoing Primary Total Hip or Knee Arthroplasty

NCT04294862
View directory record Official record
Conditions
Prosthetic Joint Infection
Interventions
TNP-2092
Drug
Lead sponsor
TenNor Therapeutics Limited
Industry
Eligibility
18 Years and older
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 19, 2022 · Synced Oct 4, 2026, 10:15 AM EDT
Completed Not applicable Interventional

Preoperative Pain Threshold and Rapid Recover Programs

NCT02740738
View directory record Official record
Conditions
Knee Arthritis, Hip Arthritis
Interventions
Wagner Pain Algometer, Dynamometer
Device
Lead sponsor
Duke University
Other
Eligibility
18 Years to 90 Years
Enrollment
201 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 8, 2019 · Synced Oct 4, 2026, 10:15 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Continuous Postoperative Pulse Oximetry in Patients Presenting for Total Hip and Total Knee Replacement

NCT01189565
View directory record Official record
Conditions
Total Knee Replacement
Interventions
Not listed
Lead sponsor
Medical University of South Carolina
Other
Eligibility
19 Years and older
Enrollment
150 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
Started 2010
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated May 22, 2013 · Synced Oct 4, 2026, 10:15 AM EDT
Terminated Not applicable Interventional

Total Joint Arthroplasty (TJA) Weight Loss Study

NCT05156762
View directory record Official record
Conditions
Osteoarthritis, Hip, Osteoarthritis, Knee, Obesity, Morbid
Interventions
Bariatric surgery, Medical weight loss, Patient research surveys, Total joint arthroplasty (TJA), Usual standard of care
Procedure · Behavioral · Other
Lead sponsor
Boston Medical Center
Other
Eligibility
18 Years and older
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 14, 2025 · Synced Oct 4, 2026, 10:15 AM EDT
Completed Not applicable Interventional

Yeahhh Baby! Ointment on Hip and/or Knee Pain in Men and Women

NCT04764552
View directory record Official record
Conditions
Joint Pain
Interventions
Yeahhh Baby Ointment, Coconut oil ointment
Dietary Supplement · Other
Lead sponsor
University of Memphis
Other
Eligibility
35 Years to 65 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021
U.S. locations
1
States / cities
Memphis, Tennessee
Source: ClinicalTrials.gov public record
Updated Dec 29, 2021 · Synced Oct 4, 2026, 10:15 AM EDT
Completed No phase listed Observational

Coach2Move: Physical Therapy to Improve Physical Activity in Individuals With Chronic MSK Conditions

NCT07806318
View directory record Official record
Conditions
Osteoarthritis,Knee, Osteoarthritis Knees Both, Osteoarthritis Hip, Low Back Pain, Chronic Pain, Hip Pain Chronic, Knee Pain Chronic
Interventions
motivational enhancement and planning
Behavioral
Lead sponsor
University of Utah
Other
Eligibility
50 Years and older
Enrollment
94 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Sep 8, 2026 · Synced Oct 4, 2026, 10:15 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Does Fluid Replacement From Preoperative NPO Status Improve Postoperative Recovery

NCT02638623
View directory record Official record
Conditions
Osteoarthritis
Interventions
Lactated Ringer, Placebo
Drug
Lead sponsor
West Virginia University
Other
Eligibility
18 Years and older
Enrollment
52 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2016
U.S. locations
1
States / cities
Morgantown, West Virginia
Source: ClinicalTrials.gov public record
Updated Nov 20, 2020 · Synced Oct 4, 2026, 10:15 AM EDT
Completed Not applicable Interventional Results available

Development of an Osteoarthritis (OA) Care Plan to Improve Process and Quality of OA Treatment Decisions

NCT03102580
View directory record Official record
Conditions
Osteo Arthritis Knee, Osteoarthritis, Hip
Interventions
OA Care Plan
Other
Lead sponsor
University of Massachusetts, Worcester
Other
Eligibility
40 Years to 99 Years
Enrollment
5,713 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2023
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Feb 2, 2026 · Synced Oct 4, 2026, 10:15 AM EDT