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ClinicalTrials.gov public records Last synced Oct 27, 2026, 3:04 AM EDT

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Showing 1009–1032 of 1,036 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Leg Injuries Clear all
Completed Not applicable Interventional Results available

A Trial To Assess Risk of Delirium in Older Adults Undergoing Hip Fracture Surgery With Spinal or General Anesthesia

NCT02190903
View directory record Official record
Conditions
Postoperative Complications, Hip Fracture, Delirium
Interventions
General endotracheal anesthesia, Regional (spinal) Anesthesia
Other
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 30, 2018 · Synced Oct 27, 2026, 3:04 AM EDT
Suspended No phase listed Observational Accepts healthy volunteers

Non-Invasive Testing to Evaluate Wound Healing in Diabetes

NCT04232631
View directory record Official record
Conditions
Diabetic Foot Ulcer
Interventions
SnapshotNIR, Kent Imaging
Device
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years to 89 Years
Enrollment
700 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2026
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Sep 23, 2026 · Synced Oct 27, 2026, 3:04 AM EDT
Active, not recruiting Phase 4 Interventional

PVI to Prevent S. Aureus SSI After Fixation of HELEF (POTENT Study)

NCT05763602
View directory record Official record
Conditions
Surgical Site Infection
Interventions
povidone-iodine topical ointment
Drug
Lead sponsor
Loreen Herwaldt
Other
Eligibility
18 Years and older
Enrollment
2,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
6
States / cities
Atlanta, Georgia • Indianapolis, Indiana • Iowa City, Iowa + 3 more
Source: ClinicalTrials.gov public record
Updated Feb 4, 2026 · Synced Oct 27, 2026, 3:04 AM EDT
Completed Not applicable Interventional Results available

Efficacy, Safety and Economic Benefits of Topical Wound Oxygen Therapy in the Treatment of Chronic Diabetic Foot Ulcers

NCT02326337
View directory record Official record
Conditions
Diabetic Foot Ulcer
Interventions
TWO2 Device, Placebo Device
Device
Lead sponsor
AOTI Ltd.
Industry
Eligibility
18 Years to 89 Years
Enrollment
73 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2018
U.S. locations
10
States / cities
Phoenix, Arizona • Vacaville, California • Washington D.C., District of Columbia + 6 more
Source: ClinicalTrials.gov public record
Updated Oct 27, 2025 · Synced Oct 27, 2026, 3:04 AM EDT
Completed Phase 3 Interventional

Evaluation of CureXcell® in Treating Lower Extremity Chronic Ulcers in Adults With Diabetes

NCT01421966
View directory record Official record
Conditions
Lower Extremity Chronic Ulcers in Diabetics
Interventions
CureXcell®, Sham injection
Biological
Lead sponsor
Macrocure Ltd.
Industry
Eligibility
18 Years and older
Enrollment
285 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2015
U.S. locations
31
States / cities
Glendale, Arizona • Mesa, Arizona • Phoenix, Arizona + 28 more
Source: ClinicalTrials.gov public record
Updated Dec 7, 2015 · Synced Oct 27, 2026, 3:04 AM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Hip Fracture Exercise and Rehabilitation Post Hip Fracture Study

NCT03247205
View directory record Official record
Conditions
Hip Fractures, Cognitive Impairment
Interventions
HipERS
Behavioral
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
65 Years and older
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 10, 2022 · Synced Oct 27, 2026, 3:04 AM EDT
Active, not recruiting Not applicable Interventional

Maximizing Patient Goal Attainment

NCT05652270
View directory record Official record
Conditions
Knee Osteoarthritis, Knee Injuries, Knee Pain Chronic, Knee Injuries and Disorders
Interventions
Goal Attainment, Goal Development, Goal Tracking
Behavioral
Lead sponsor
Dartmouth-Hitchcock Medical Center
Other
Eligibility
21 Years and older
Enrollment
258 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Lebanon, New Hampshire
Source: ClinicalTrials.gov public record
Updated Aug 31, 2026 · Synced Oct 27, 2026, 3:04 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Virtual Reality Treatment for Phantom Limb Pain

NCT03338842
View directory record Official record
Conditions
Lower Limb Amputation Above Knee (Injury), Lower Limb Amputation Below Knee (Injury), Phantom Limb Pain
Interventions
Distractor and Lower limb VR
Device
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
14 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 16, 2020 · Synced Oct 27, 2026, 3:04 AM EDT
Completed Phase 4 Interventional

Efficacy of Hematoma Block on Postoperative Pain After Femoral Intramedullary Rodding: A Randomized Trial

NCT04860856
View directory record Official record
Conditions
Femur Fracture
Interventions
0.5% ropivacaine, Normal Saline
Drug
Lead sponsor
University of Cincinnati
Other
Eligibility
18 Years and older
Enrollment
88 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Feb 16, 2023 · Synced Oct 27, 2026, 3:04 AM EDT
Enrolling by invitation Not applicable Interventional

Dual Implant Versus Single Implant Distal End of Femur

NCT05292313
View directory record Official record
Conditions
Distal Femur Fracture
Interventions
Single distal femur implant, Dual distal femur implants
Procedure
Lead sponsor
University of Utah
Other
Eligibility
60 Years to 100 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
5
States / cities
Rochester, Minnesota • New York, New York • Portland, Oregon + 2 more
Source: ClinicalTrials.gov public record
Updated Apr 13, 2026 · Synced Oct 27, 2026, 3:04 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Multisegmented Foot Motion in Patients With Lateral Ankle Sprains and Chronic Ankle Instability

NCT02697461
View directory record Official record
Conditions
Injuries, Ankle, Sprain of Foot
Interventions
Intrinsic Foot Strengthening, Joint Mobilization
Other
Lead sponsor
University of Virginia
Other
Eligibility
18 Years to 50 Years
Enrollment
115 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated May 3, 2017 · Synced Oct 27, 2026, 3:04 AM EDT
Not listed Not applicable Interventional

Randomized Controlled Trial Comparing Suture Button Versus Fibulink Fixation for Acute Ankle Syndesmosis Injuries

NCT05626036
View directory record Official record
Conditions
Syndesmotic Injuries
Interventions
Arthrex Tightrope, Synthes Fibulink
Device
Lead sponsor
United States Naval Medical Center, San Diego
Federal
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated May 6, 2024 · Synced Oct 27, 2026, 3:04 AM EDT
Active, not recruiting Not applicable Interventional

PENG vs FICB for Hip Fracture in ED Patients

NCT05505604
View directory record Official record
Conditions
Femoral Neck Fractures, Intertrochanteric Fractures
Interventions
PENG, FICB
Procedure
Lead sponsor
University of Virginia
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Jun 3, 2026 · Synced Oct 27, 2026, 3:04 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Internal Brace Augmented Anterior Inferior Tibiofibular Ligament Repair: Post-operative Syndesmotic Volumes.

NCT05062265
View directory record Official record
Conditions
Syndesmotic Injuries, Ligament Rupture, Bimalleolar Fractures, Trimalleolar Fractures
Interventions
Tight rope fixation, Tight rope fixation with an anterior inferior tibiofibular ligament (AITFL) repair augmentation with an internal brace
Device
Lead sponsor
Vann Virginia Center for Orthopaedics dba Atlantic Orthopaedic Specialists
Other
Eligibility
18 Years to 80 Years
Enrollment
23 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Virginia Beach, Virginia
Source: ClinicalTrials.gov public record
Updated Feb 19, 2025 · Synced Oct 27, 2026, 3:04 AM EDT
Completed Not applicable Interventional

Impact of Hyperarch Fascia Training on Ankle Health and Exercise Performance

NCT06959472
View directory record Official record
Conditions
Ankle Injuries, Sprains and Strains, Joint Instability
Interventions
Hyperarch Fascia Training
Behavioral
Lead sponsor
Applied Science & Performance Institute
Industry
Eligibility
20 Years to 45 Years
Enrollment
62 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Mar 2, 2026 · Synced Oct 27, 2026, 3:04 AM EDT
Completed Not applicable Interventional Results available

Single-Use Negative Pressure Wound Therapy System vs. Traditional Negative Pressure Wound Therapy System (tNPWT)

NCT02470806
View directory record Official record
Conditions
Venous Leg Ulcers, Diabetic Foot Ulcers
Interventions
PICO System, tNPWT System
Device
Lead sponsor
Smith & Nephew, Inc.
Industry
Eligibility
18 Years and older
Enrollment
164 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
15
States / cities
Carlsbad, California • Fresno, California • Martinez, California + 12 more
Source: ClinicalTrials.gov public record
Updated Apr 6, 2020 · Synced Oct 27, 2026, 3:04 AM EDT
Recruiting Not applicable Interventional

A Proprioceptive Training Program Using an Uneven Terrain Treadmill for Patients With Ankle Instability

NCT04999904
View directory record Official record
Conditions
Instability; Ankle (Ligaments) (Old Injury), Sprain of Ankle
Interventions
Uneven Treadmill Intervention, Standard of Care Physical Therapy
Other
Lead sponsor
Henry M. Jackson Foundation for the Advancement of Military Medicine
Other
Eligibility
18 Years to 49 Years
Enrollment
312 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
2
States / cities
Oceanside, California • San Diego, California
Source: ClinicalTrials.gov public record
Updated Jul 18, 2025 · Synced Oct 27, 2026, 3:04 AM EDT
Completed Phase 2 Interventional

Pilot Study of the Safety and Clinical Efficacy of Topical Dermacyn™ Wound Care to Treat Mild Diabetic Foot Infections

NCT00516958
View directory record Official record
Conditions
Foot Ulcer, Diabetic
Interventions
Topical Dermacyn, Topical Dermacyn and Levofloxacin, Topical Saline and Levofloxacin
Drug
Lead sponsor
Oculus Innovative Sciences, Inc.
Industry
Eligibility
18 Years and older
Enrollment
65 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007
U.S. locations
16
States / cities
Tucson, Arizona • La Jolla, California • Los Angeles, California + 13 more
Source: ClinicalTrials.gov public record
Updated Jan 14, 2008 · Synced Oct 27, 2026, 3:04 AM EDT
Completed Early Phase 1 Interventional Results available

IV Steroids Versus Steroids Included in Block for Orthopedic Lower Limb Surgery

NCT03855059
View directory record Official record
Conditions
Lower Limb Injury
Interventions
Placebos, Dexamethasone Sodium Phosphate
Drug
Lead sponsor
University of Arizona
Other
Eligibility
5 Years to 25 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Tucson, Arizona
Source: ClinicalTrials.gov public record
Updated Jul 21, 2021 · Synced Oct 27, 2026, 3:04 AM EDT
Completed Not applicable Interventional Results available

Comparison of Three Surgical Techniques to Achieve Patella Symmetry During Resection

NCT01822574
View directory record Official record
Conditions
Arthroplasty, Replacement, Knee, Injuries, Knee
Interventions
Cutting Guide Technique, Haptic Feedback Technique, Four Quadrant Technique
Procedure
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 99 Years
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Mar 2, 2016 · Synced Oct 27, 2026, 3:04 AM EDT
Terminated Not applicable Interventional Results available

Blood Flow Restriction After Meniscus Repair

NCT04436523
View directory record Official record
Conditions
Meniscus Disorder, Meniscus, Torn Tibial, Meniscus Lesion, Meniscus Tear, Tibial, Atrophy, Muscular
Interventions
Blood flow restriction (Delfi Personalized Tourniquet System), Standard rehabilitation
Device · Other
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years to 60 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Feb 20, 2026 · Synced Oct 27, 2026, 3:04 AM EDT
Completed Not applicable Interventional Results available

Split Thickness Donor Site Healing With MIST Study

NCT01214980
View directory record Official record
Conditions
Burns, Trauma, Venous Ulcers
Interventions
MIST Therapy, Standard of care
Device · Other
Lead sponsor
Celleration, Inc.
Industry
Eligibility
18 Years and older
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Dec 19, 2014 · Synced Oct 27, 2026, 3:04 AM EDT
Completed Not applicable Interventional

The Environment's Impact on Thinking When Added to Leg Cycling in People With TBI: VITAL

NCT04901286
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
Exercise Only, Exercise + Non-Immersive Virtual Reality, Exercise + Immersive Virtual Reality
Behavioral
Lead sponsor
Kessler Foundation
Other
Eligibility
18 Years to 65 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
East Hanover, New Jersey
Source: ClinicalTrials.gov public record
Updated Sep 2, 2025 · Synced Oct 27, 2026, 3:04 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Iterative Design of Custom Dynamic Orthoses to Reduce Articular Contact Stress

NCT04562896
View directory record Official record
Conditions
Ankle Fractures, Post-traumatic Osteoarthritis, Osteoarthritis Ankle
Interventions
Custom Carbon Fiber Dynamic Orthosis (CDO)
Device
Lead sponsor
University of Iowa
Other
Eligibility
18 Years to 65 Years
Enrollment
22 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Jan 30, 2026 · Synced Oct 27, 2026, 3:04 AM EDT