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ClinicalTrials.gov public records Last synced Jul 23, 2026, 5:01 PM EDT

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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
Local D1 index available.
Filters: Condition: Lens Diseases Clear all
Completed Not applicable Interventional Results available

Clinical Performance of Two Daily Disposable Toric Soft Contact Lenses

NCT04908488
View directory record Official record
Conditions
Refractive Errors, Ametropia, Astigmatism
Interventions
Verofilcon A toric contact lenses, Etafilcon A toric contact lenses
Device
Lead sponsor
Alcon Research
Industry
Eligibility
18 Years and older
Enrollment
115 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021
U.S. locations
8
States / cities
Los Angeles, California • Oakland, California • Orlando, Florida + 4 more
Source: ClinicalTrials.gov public record
Updated Oct 17, 2022 · Synced Jul 23, 2026, 5:01 PM EDT
Completed No phase listed Observational Results available

Evaluation of Binocular Visual Acuity and Refractive Stability in the Alcon Clareon Intraocular Lens

NCT04936256
View directory record Official record
Conditions
Cataract
Interventions
Clareon
Device
Lead sponsor
Gainesville Eye Associates
Other
Eligibility
50 Years and older
Enrollment
31 participants
Timeline
2021 – 2022
U.S. locations
1
States / cities
Gainesville, Georgia
Source: ClinicalTrials.gov public record
Updated Aug 6, 2024 · Synced Jul 23, 2026, 5:01 PM EDT
Recruiting Phase 3 Interventional

A Study to Evaluate Efficacy and Safety of MELT-300 for Procedural Sedation in Subjects Undergoing Cataract Extraction With Lens Replacement (CELR)

NCT06383273
View directory record Official record
Conditions
Cataract
Interventions
MELT-300 sublingual tablet, Midalozam sublingual tablet, Placebo sublingual tablet
Drug
Lead sponsor
Melt Pharmaceuticals
Industry
Eligibility
18 Years to 65 Years
Enrollment
528 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
12
States / cities
Chico, California • Grand Junction, Colorado • Jacksonville, Florida + 9 more
Source: ClinicalTrials.gov public record
Updated Aug 1, 2024 · Synced Jul 23, 2026, 5:01 PM EDT
Completed Not applicable Interventional Results available

A Contralateral Dispensing Clinical Trial of Study Test Sapphire Lens Against Enfilcon A Silicone Hydrogel Lens

NCT02518490
View directory record Official record
Conditions
Myopia
Interventions
Sapphire Lens, enfilcon A
Device
Lead sponsor
CooperVision, Inc.
Industry
Eligibility
18 Years and older
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015
U.S. locations
1
States / cities
Berkeley, California
Source: ClinicalTrials.gov public record
Updated Sep 21, 2020 · Synced Jul 23, 2026, 5:01 PM EDT
Enrolling by invitation Not applicable Interventional

Effectiveness of a Large Language Model-Based Educational Tool on Intraocular Lens Options

NCT07317661
View directory record Official record
Conditions
Eye Disorders, Cataract Extraction, Cataract and IOL Surgery, Cataract Surgery Experience, Cataract Surgery, Intraocular Lens
Interventions
LLM-based Education
Other
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Jan 4, 2026 · Synced Jul 23, 2026, 5:01 PM EDT
Terminated Phase 3 Interventional

Study Evaluating the Efficacy and Safety of OCS-01 Eye Drops in Subjects Following Cataract Surgery

NCT06128369
View directory record Official record
Conditions
Inflammation Eye, Pain, Postoperative, Cataract
Interventions
Dexamethasone Ophthalmic Suspension, Vehicle of OCS-01
Drug · Other
Lead sponsor
Oculis
Industry
Eligibility
18 Years and older
Enrollment
117 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
12
States / cities
Inglewood, California • Morrow, Georgia • Louisville, Kentucky + 9 more
Source: ClinicalTrials.gov public record
Updated Dec 9, 2024 · Synced Jul 23, 2026, 5:01 PM EDT
Enrolling by invitation No phase listed Observational

Binocular and Monocular Distance-Corrected Visual Performance and Defocus Characteristics of Clareon Truplus Intraocular Lens (IOL)

NCT07589894
View directory record Official record
Conditions
Cataract, Cataract Surgery, Cataract Bilateral, Cataract (Post-operative Cataract Surgery Follow-up)
Interventions
Clareon TruPlus IOL
Device
Lead sponsor
Colvard Kandavel Eye Center
Other
Eligibility
50 Years to 80 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Encino, California
Source: ClinicalTrials.gov public record
Updated May 25, 2026 · Synced Jul 23, 2026, 5:01 PM EDT
Terminated No phase listed Observational

Post-market Clinical Follow-up Study of Alcon PRECISION1™ Spherical and PRECISION1™ for Astigmatism Soft Contact Lenses

NCT06462456
View directory record Official record
Conditions
Refractive Errors
Interventions
Verofilcon A spherical soft contact lenses, Verofilcon A toric soft contact lenses
Device
Lead sponsor
Alcon Research
Industry
Eligibility
7 Years and older
Enrollment
140 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
12
States / cities
San Diego, California • Jacksonville, Florida • Orlando, Florida + 9 more
Source: ClinicalTrials.gov public record
Updated Jul 19, 2025 · Synced Jul 23, 2026, 5:01 PM EDT
Completed Not applicable Interventional Results available

Clinical Evaluation of the Long-Term Effects of Contact Lens Care Systems

NCT00813761
View directory record Official record
Conditions
Myopia
Interventions
O2Optix contact lens, Proclear contact lens, ReNu MultiPlus Multi-Purpose Solution, Clear Care Cleaning and Disinfecting Solution
Device
Lead sponsor
Johnson & Johnson Vision Care, Inc.
Industry
Eligibility
18 Years and older
Enrollment
473 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2009
U.S. locations
25
States / cities
North Little Rock, Arkansas • Campbell, California • Cupertino, California + 22 more
Source: ClinicalTrials.gov public record
Updated Jun 18, 2018 · Synced Jul 23, 2026, 5:01 PM EDT
Completed Phase 3 Interventional Results available

Study of T-PRED(TM) Compared to Pred Forte(R) II

NCT00854061
View directory record Official record
Conditions
Cataract
Interventions
T-Pred, Pred Forte
Drug
Lead sponsor
Bausch & Lomb Incorporated
Industry
Eligibility
18 Years and older
Enrollment
172 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009
U.S. locations
1
States / cities
Irvine, California
Source: ClinicalTrials.gov public record
Updated Oct 19, 2020 · Synced Jul 23, 2026, 5:01 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Comparing Optical Coherence Tomography (OCT) and Visual Acuity Outcomes in Subjects Undergoing Cataract Surgery, Who Receive Xibrom Ophthalmic Solution and Standard Presurgical Care vs. Xibrom Ophthalmic Solution Plus Prednisolone Acetate 1% and Standard Presurgical Care

NCT00698724
View directory record Official record
Conditions
Cataracts
Interventions
Xibrom, and Optive, Xibrom and Pred Forte
Drug
Lead sponsor
Bp Consulting, Inc
Network
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2009
U.S. locations
1
States / cities
Tarpon Springs, Florida
Source: ClinicalTrials.gov public record
Updated Jun 9, 2009 · Synced Jul 23, 2026, 5:01 PM EDT
Completed No phase listed Observational

User Acceptability Evaluation of Pseudophakic Patients Previously Implanted With the TECNIS Odyssey IOL

NCT06005675
View directory record Official record
Conditions
Cataracts
Interventions
Intervention
Device
Lead sponsor
Johnson & Johnson Surgical Vision, Inc.
Industry
Eligibility
Not listed
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
4
States / cities
Bakersfield, California • Venice, Florida • Mt. Pleasant, South Carolina + 1 more
Source: ClinicalTrials.gov public record
Updated Apr 24, 2025 · Synced Jul 23, 2026, 5:01 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Visual Outcomes of Subjects Bilaterally Implanted With ReSTOR Aspheric +4 vs. Tecnis or Acri.LISA

NCT00721253
View directory record Official record
Conditions
Cataract
Interventions
ReSTOR, Tecnis, Acri.LISA
Device
Lead sponsor
Alcon Research
Industry
Eligibility
18 Years and older
Enrollment
42 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2008
U.S. locations
1
States / cities
Fort Worth, Texas
Source: ClinicalTrials.gov public record
Updated Mar 15, 2010 · Synced Jul 23, 2026, 5:01 PM EDT
Completed Not applicable Interventional Results available

Evaluation of Deposits on Contact Lenses Worn Daily Wear

NCT00725153
View directory record Official record
Conditions
Refractive Error
Interventions
Balafilcon A contact lenses (PureVision), Etafilcon A contact lenses (Acuvue2)
Device
Lead sponsor
Alcon Research
Industry
Eligibility
18 Years and older
Enrollment
55 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008
U.S. locations
1
States / cities
Fort Worth, Texas
Source: ClinicalTrials.gov public record
Updated Aug 22, 2012 · Synced Jul 23, 2026, 5:01 PM EDT
Recruiting Phase 4 Interventional

Odyssey Evaluation in Post LASIK Patients

NCT07260695
View directory record Official record
Conditions
Cataract
Interventions
Odyssey intraocular lens
Device
Lead sponsor
Center For Sight
Other
Eligibility
50 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Venice, Florida
Source: ClinicalTrials.gov public record
Updated Dec 2, 2025 · Synced Jul 23, 2026, 5:01 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

High Refractive Index Material 510(k)

NCT00766168
View directory record Official record
Conditions
Myopia, Hyperopia
Interventions
HDS HI 1.54; pahrifocon A, FluoroPerm 30 RGP; paflufocon C
Other · Device
Lead sponsor
CooperVision International Limited (CVIL)
Industry
Eligibility
12 Years and older
Enrollment
76 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008
U.S. locations
8
States / cities
Lake Elsinore, California • Englewood, Colorado • East Lansing, Michigan + 5 more
Source: ClinicalTrials.gov public record
Updated Jun 13, 2012 · Synced Jul 23, 2026, 5:01 PM EDT
Completed Phase 3 Interventional Results available

Safety and Efficacy of OMS302 in Subjects Undergoing Intraocular Lens Replacement With Phacoemulsification

NCT01454063
View directory record Official record
Conditions
Intraocular Lens Replacement
Interventions
OMS302, Placebo
Drug
Lead sponsor
Omeros Corporation
Industry
Eligibility
18 Years and older
Enrollment
405 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
16
States / cities
Chandler, Arizona • Glendale, Arizona • Los Angeles, California + 13 more
Source: ClinicalTrials.gov public record
Updated Aug 20, 2014 · Synced Jul 23, 2026, 5:01 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Study of the Presence and Extent of Corneal Disturbance Associated With B+L Biotrue MPS Used With B+L PureVision Lenses

NCT01268306
View directory record Official record
Conditions
Keratitis
Interventions
B+L Biotrue MPS and B+L PureVision
Device
Lead sponsor
Epstein, Arthur B., OD, FAAO
Individual
Eligibility
18 Years and older
Enrollment
8 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010
U.S. locations
1
States / cities
Phoenix, Arizona
Source: ClinicalTrials.gov public record
Updated Aug 21, 2016 · Synced Jul 23, 2026, 5:01 PM EDT
Completed Phase 2 Interventional

Iontophoretic Delivery of EGP-437 in Patients Who Have Undergone Cataract Surgery

NCT03180255
View directory record Official record
Conditions
Cataract, Anterior Chamber Inflammation, Pain, Postoperative
Interventions
Dexamethasone phosphate, Placebo
Combination Product · Other
Lead sponsor
Eyegate Pharmaceuticals, Inc.
Industry
Eligibility
18 Years to 85 Years
Enrollment
101 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated May 20, 2018 · Synced Jul 23, 2026, 5:01 PM EDT
Completed Phase 2 Interventional Results available

Nepafenac 0.3% Two Study

NCT01318499
View directory record Official record
Conditions
Cataract
Interventions
Nepafenac Ophthalmic Suspension, 0.3%, Nepafenac Ophthalmic Suspension, 0.1%, Nepafenac Vehicle 0.3%
Drug · Other
Lead sponsor
Alcon Research
Industry
Eligibility
18 Years and older
Enrollment
1,342 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011
U.S. locations
1
States / cities
Fort Worth, Texas
Source: ClinicalTrials.gov public record
Updated Dec 16, 2012 · Synced Jul 23, 2026, 5:01 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Vivity Insight: A Study of Patient Satisfaction and Visual Performance

NCT04495049
View directory record Official record
Conditions
Cataract
Interventions
Alcon Vivity or Vivity Toric IOL
Device
Lead sponsor
Research Insight LLC
Industry
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
3
States / cities
Laguna Hills, California • Palm City, Florida • Edwardsville, Illinois
Source: ClinicalTrials.gov public record
Updated Jun 2, 2021 · Synced Jul 23, 2026, 5:01 PM EDT
Completed Not applicable Interventional

Endothelial Cell Loss and Induced Astigmatism After Wound-directed and Wound-assisted IOL Injection

NCT01250964
View directory record Official record
Conditions
Cataracts, Cataract Surgery
Interventions
Lens insertion during cataract surgery
Procedure
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years and older
Enrollment
72 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Nov 30, 2010 · Synced Jul 23, 2026, 5:01 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Visual Function After Implantation of Bilateral AcrySof ReSTOR Aspheric +3

NCT00719732
View directory record Official record
Conditions
Cataract
Interventions
ReSTOR
Device
Lead sponsor
Alcon Research
Industry
Eligibility
18 Years to 70 Years
Enrollment
218 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2009
U.S. locations
1
States / cities
Fort Worth, Texas
Source: ClinicalTrials.gov public record
Updated Mar 15, 2010 · Synced Jul 23, 2026, 5:01 PM EDT
Completed Not applicable Interventional Results available

A Bilateral Dispensing Clinical Trial of Sapphire Lens Against Senofilcon A Lens Over 2 Weeks

NCT02345811
View directory record Official record
Conditions
Myopia, Hyperopia
Interventions
Sapphire, senofilcon A
Device
Lead sponsor
CooperVision, Inc.
Industry
Eligibility
17 Years and older
Enrollment
34 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015
U.S. locations
1
States / cities
Berkeley, California
Source: ClinicalTrials.gov public record
Updated Sep 15, 2020 · Synced Jul 23, 2026, 5:01 PM EDT