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Conditions: Congenital Hand Deformities
Interventions: Not listed
Lead sponsor: University of Utah; Other
Eligibility: 6 Months to 6 Years
Enrollment: 14 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2004 – 2019
U.S. locations: 1
States / cities: Salt Lake City, Utah

Conditions: Syndactyly
Interventions: Hyalomatrix, Skin graft; Device · Other
Lead sponsor: Gillette Children's Specialty Healthcare; Other
Eligibility: Up to 17 Years
Enrollment: 19 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2022
U.S. locations: 1
States / cities: Saint Paul, Minnesota

Conditions: Charcot-Marie-Tooth Disease, Charcot-Marie-Tooth, Charcot-Marie-Tooth Disease, Type IA, Charcot-Marie-Tooth Disease Type 2A, Charcot-Marie-Tooth Disease Type 2, Charcot-Marie-Tooth Disease, Type 2C, Charcot-Marie-Tooth Disease Type 2A2B, Charcot-Marie-Tooth Disease Type 2B2, Charcot-Marie-Tooth Disease Type 2A1, Charcot-Marie-Tooth Disease Type 4B1, Charcot-Marie-Tooth Disease, Type IB, Charcot-Marie-Tooth Disease Type 2B1, Charcot-Marie-Tooth Disease Type 2U (Diagnosis), Charcot-Marie-Tooth Disease Type 4A, Charcot-Marie-Tooth Disease, Type 4A, Axonal Form, Charcot-Marie-Tooth Disease Type 2A2A, Charcot-Marie-Tooth Disease Type 2S (Disorder), Charcot-Marie-Tooth Disease and Deafness, Charcot-Marie-Tooth Disease Type 4B2, Charcot-Marie-Tooth Disease Type 4H, Charcot-Marie-Tooth Disease Type 1F, Charcot-Marie-Tooth Disease Type 4C, Charcot-Marie-Tooth Disease Type 4E, Charcot-Marie-Tooth Disease Type 1D, Charcot-Marie-Tooth Disease Type 2Q (Diagnosis), Charcot-Marie-Tooth Disease Type 2A2, Charcot-Marie-Tooth Disease Type 2N (Diagnosis), Charcot-Marie-Tooth Disease Type 2B5, Charcot-Marie-Tooth Disease Type 2D, Charcot-Marie-Tooth Disease Type 4D, Charcot-Marie-Tooth Disease Type 2K, Charcot-Marie-Tooth Disease Type 2L (Diagnosis), Charcot-Marie-Tooth Disease Type 2T, Charcot-Marie-Tooth Disease Type 2I, Charcot-Marie-Tooth Disease Type 2J, Charcot-Marie-Tooth Disease Type 2E, Charcot-Marie-Tooth Disease Type 2G, Charcot-Marie-Tooth Disease Type 1C, Charcot-Marie-Tooth Disease Type 2R, Charcot-Marie-Tooth Disease Type 2O (Diagnosis), Charcot-Marie-Tooth Disease Type 2M, Charcot-Marie-Tooth Disease Type 2P, Charcot-Marie-Tooth Disease Type 2Y, Charcot-Marie-Tooth Disease Type 4F (Diagnosis), Charcot-Marie-Tooth Disease Type 4B3, Charcot-Marie-Tooth Disease Type 2H, HNPP, X-Linked Charcot-Marie-Tooth Disease, Charcot Marie Tooth Disease (CMT)
Interventions: Not listed
Lead sponsor: Hereditary Neuropathy Foundation; Government
Eligibility: Not listed
Enrollment: 10,000 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2029
U.S. locations: 1
States / cities: New York, New York

Conditions: Type 2 Diabetes
Interventions: Exercise program, Ascorbic Acid (Vitamin C); Behavioral · Drug
Lead sponsor: University of Colorado, Denver; Other
Eligibility: 30 Years to 55 Years
Enrollment: 47 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2008 – 2011
U.S. locations: 1
States / cities: Aurora, Colorado

Conditions: Congenital Upper Limb Differences
Interventions: Adaptive Rock Climbing Program; Behavioral
Lead sponsor: Children's Hospital Los Angeles; Other
Eligibility: 6 Years to 16 Years
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2026
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Limb-Girdle Muscular Dystrophies, Facioscapulohumeral Muscular Dystrophy
Interventions: ATYR1940, Placebo; Biological
Lead sponsor: aTyr Pharma, Inc.; Industry
Eligibility: 18 Years to 75 Years
Enrollment: 18 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2016
U.S. locations: 3
States / cities: Irvine, California • Baltimore, Maryland • Columbus, Ohio

Conditions: Osteoarthritis, Rheumatoid Arthritis, Traumatic Arthritis, Post Traumatic Deformity, Complications; Arthroplasty, Deformity of Limb
Interventions: Vanguard SSK 360 with PS Bearing, Vanguard SSK 360 with PSC bearing, Vanguard DA 360, Vanguard 360 TiNbN Femur with PS bearing, Vanguard 360 TiNbN Femur with PSC bearing; Device
Lead sponsor: Zimmer Biomet; Industry
Eligibility: 18 Years and older
Enrollment: 255 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2031
U.S. locations: 4
States / cities: Morton Grove, Illinois • Henderson, Nevada • Salt Lake City, Utah + 1 more

Conditions: Breast Cancer, Breast Cyst, Microcalcification
Interventions: Imaging; Diagnostic Test
Lead sponsor: Johns Hopkins University; Other
Eligibility: 18 Years and older · Female only
Enrollment: 252 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2037
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Limb-Girdle Muscular Dystrophy ; Subtypes 2A, 2B, and 2I
Interventions: Not listed
Lead sponsor: The Emmes Company, LLC; Industry
Eligibility: 14 Years and older
Enrollment: 45 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022
U.S. locations: 1
States / cities: Kingston, Massachusetts

Conditions: Spinal Muscular Atrophy, Spinal Muscular Atrophy Type 3, Spinal Muscular Atrophy Type II, Spinal Muscular Atrophy 4, SMA
Interventions: Spinal Cord Stimulator (Octopolar Medtronic Vectris Leads); Device
Lead sponsor: Marco Capogrosso; Other
Eligibility: 16 Years to 65 Years
Enrollment: 3 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2029
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Smith Lemli Opitz Syndrome, CHILD Syndrome, Lathosterolosis, Desmosterolosis
Interventions: Not listed
Lead sponsor: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD); NIH
Eligibility: 1 Day to 100 Years
Enrollment: 250 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2031
U.S. locations: 1
States / cities: Bethesda, Maryland

Conditions: Limb Girdle Muscular Dystrophy, Limb-Girdle Muscular Dystrophy Type 2, LGMD2I, Muscular Dystrophy, LGMD2, LGMD, FKRP, FKRP Mutation, Fukutin Related Protein
Interventions: AB-1003 dose level 1, AB-1003 dose level 2, Placebo; Genetic · Drug
Lead sponsor: AskBio Inc; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 9 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2032
U.S. locations: 6
States / cities: Irvine, California • Iowa City, Iowa • Kansas City, Kansas + 3 more

Conditions: Duchenne Muscular Dystrophy
Interventions: Armon Ayura (Kinova), JAECO Wrex; Device
Lead sponsor: Roxanna Marie Bendixen; Other
Eligibility: 14 Years and older · Male only
Enrollment: 18 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2020
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Neonatal Brachial Plexus Palsy
Interventions: Tetra-grip; Device
Lead sponsor: University of Texas Southwestern Medical Center; Other
Eligibility: 3 Years to 7 Years
Enrollment: 2 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2022
U.S. locations: 1
States / cities: Dallas, Texas

Conditions: Clubfoot Deformity
Interventions: Surgical, Non-Surgical, Non-surgical + surgical; Procedure
Lead sponsor: Texas Scottish Rite Hospital for Children; Other
Eligibility: Up to 18 Years
Enrollment: 2,500 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2005 – 2029
U.S. locations: 1
States / cities: Dallas, Texas

Conditions: Advanced Cancer
Interventions: Lucitanib; Drug
Lead sponsor: Teresa Helsten, MD; Other
Eligibility: 18 Years and older
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2022
U.S. locations: 1
States / cities: La Jolla, California

Conditions: Muscular Dystrophies
Interventions: rAAV1.tMCK.human-alpha-sarcoglycan- First cohort, Genetic: rAAV1.tMCK.human-alpha-sarcoglycan- Second cohort; Genetic
Lead sponsor: Nationwide Children's Hospital; Other
Eligibility: 5 Years and older
Enrollment: 6 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2011
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Muscle Weakness, Problems Moving Their Arms and Legs
Interventions: Extension assist knee ankle foot orthosis (EA-KAFO); Device
Lead sponsor: National Institutes of Health Clinical Center (CC); NIH
Eligibility: 5 Years to 25 Years
Enrollment: 23 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Bethesda, Maryland

Conditions: Craniofacial Differences
Interventions: Not listed
Lead sponsor: National Human Genome Research Institute (NHGRI); NIH
Eligibility: 12 Years to 20 Years
Enrollment: 44 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2005 – 2014
U.S. locations: 1
States / cities: Bethesda, Maryland

Conditions: Unequal Length of Limbs; Congenital, Lower Extremity Deformities, Congenital
Interventions: Botulinum toxin A injection, saline injection; Drug
Lead sponsor: Shriners Hospitals for Children; Other
Eligibility: 5 Years to 21 Years
Enrollment: 125 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2012
U.S. locations: 4
States / cities: Wilmington, Delaware • Honolulu, Hawaii • Portland, Oregon + 1 more

Conditions: Congenital Vertical Talus, Familial Encephalopathy With Neuroserpin Inclusion Bodies, Idiopathic Generalised Epilepsy, Familial Dementia, X-linked Mental Retardation
Interventions: Not listed
Lead sponsor: State University of New York - Upstate Medical University; Other
Eligibility: 6 Months and older
Enrollment: 176 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2005 – 2015
U.S. locations: 1
States / cities: Syracuse, New York

Conditions: Plantar Fasciitis, Equinus Deformity
Interventions: Instep without gastrocnemius recession, Instep with gastrocnemius recession; Procedure
Lead sponsor: OhioHealth; Other
Eligibility: 18 Years and older
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2016
U.S. locations: 4
States / cities: Dublin, Ohio • Gahanna, Ohio • Grove City, Ohio + 1 more

Conditions: Neurologic Diseases, Hemiparesis, Quadriplegia, Muscular Dystrophies, Arthrogryposis, Spinal Cord Injuries, Charcot-Marie-Tooth, Stroke, Weakness of Extremities as Sequela of Stroke, Weakness Due to Upper Motor Neuron Dysfunction, Amyotrophic Lateral Sclerosis, Spinal Muscular Atrophy, Arm Paralysis, Cerebral Palsy
Interventions: Neurosleeve; Device
Lead sponsor: Thomas Jefferson University; Other
Eligibility: 4 Years and older
Enrollment: 20 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2026
U.S. locations: 2
States / cities: Wilmington, Delaware • Philadelphia, Pennsylvania

Conditions: Face Injuries, Hand Injuries, Craniofacial Injuries, Upper Extremity Injuries, Facial Injuries, Facial Deformity
Interventions: Combined Craniomaxillofacial and Upper Extremity Allotransplantation; Procedure
Lead sponsor: NYU Langone Health; Other
Eligibility: 18 Years to 64 Years
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2026
U.S. locations: 1
States / cities: New York, New York

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Syndactyly Repair: Comparison of Skin Graft and No Skin Graft Techniques

Comparison of Scar Formation in Syndactyly Release Surgery With Full Thickness Skin Graft Versus Skin Graft Substitute

Natural History Study for Charcot Marie Tooth Disease

Influence of Endothelial Function on Central and Peripheral Causes Of Exercise Impairment in Type 2 Diabetes

Adaptive Rock Climbing

Evaluate Safety and Biological Activity of ATYR1940 in Participants With Limb Girdle Muscular Dystrophy 2B (LGMD2B) and Facioscapulohumeral Muscular Dystrophy (FSHD)

A Prospective, Clinical Investigation of the Vanguard 360 Revision Knee

Advanced Ultrasound Signal Processing of Suspicious Breast Images

Limb-Girdle Video Assessment

Spinal Cord Stimulation for the Treatment of Motor Deficits in People With Spinal Muscular Atrophy - Upper Limb

Biochemical and Phenotypical Aspects of Smith-Lemli-Opitz Syndrome and Related Disorders of Cholesterol Metabolism

A Study to Evaluate the Safety of AB-1003 (Previously LION-101) in Subjects With Genetic Confirmation of LGMD2I/R9 (Part1)

Use of Dynamic Arm Supports to Promote Activities of Daily Living in Individuals With DMD

Does Wearing Tetra-Grip Improve Arm Function in Children Diagnosed With Neonatal Brachial Plexus Palsy?

Prospective Evaluation of Treatment for Clubfoot

Lucitanib (E3810) in Patients With Advanced Cancer and FGFR, VEGFR, or PDGFR Pathway Aberrations

Gene Transfer Therapy for Treating Children and Adults With Limb Girdle Muscular Dystrophy Type 2D (LGMD2D)

Toward Ubiquitous Lower Limb Exoskeleton Use in Children and Young Adults

Positive Exposure: A Photography and Video Intervention for Individuals With Craniofacial Differences

Botox Injection for Lower Extremity Lengthening and Deformity Correction Surgery

Genetic Disease Gene Identification

Instep Plantar Fasciotomy With and Without Gastrocnemius Recession

NuroSleeve Powered Brace & Stimulation System to Restore Arm Function

Craniomaxillofacial and Upper Extremity Allotransplantation