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Showing 1–24 of 120 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Loose Skin Clear all
Not listed Not applicable Interventional

Feasibility Study to Collect and Assess Safety Data for a Radiofrequency Microneedling Device for Electrocoagulation and Hemostasis of Soft Tissues for Dermatologic Conditions

NCT05987319
View directory record Official record
Conditions
Wrinkle, Fine Lines, Crepey Skin, Acne Scars, Active Acne, Enlarged Pores, Stretch Mark, Loose Skin
Interventions
RadioFrequency Microneedling Device
Device
Lead sponsor
Cynosure, Inc.
Industry
Eligibility
22 Years to 65 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Westford, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 6, 2024 · Synced Sep 12, 2026, 2:15 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Pivotal Study to Evaluate the Safety and Efficacy of a Micro-coring Device Treating Moderate to Severe Facial Wrinkles

NCT03573271
View directory record Official record
Conditions
Laxity; Skin
Interventions
MCD
Device
Lead sponsor
Cytrellis Biosystems, Inc.
Industry
Eligibility
40 Years to 70 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
5
States / cities
Sacramento, California • Miami, Florida • New York, New York + 2 more
Source: ClinicalTrials.gov public record
Updated Apr 8, 2026 · Synced Sep 12, 2026, 2:15 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

SofWave Treatment to Lift Lax Tissue in the Submental and Neck Zones and to Lift the Eyebrow

NCT04969380
View directory record Official record
Conditions
Skin Laxity
Interventions
Sofwave
Device
Lead sponsor
Sofwave Medical LTD
Industry
Eligibility
35 Years to 80 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
1
States / cities
Irvine, California
Source: ClinicalTrials.gov public record
Updated Nov 17, 2023 · Synced Sep 12, 2026, 2:15 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Clinical Assessment of Skin Tightening and Contour Change of Submental Tissue Using Bipolar Radiofrequency Microneedling

NCT04477187
View directory record Official record
Conditions
Skin Laxity
Interventions
Dermal Handpiece
Device
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
21 Years to 70 Years
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Dec 18, 2023 · Synced Sep 12, 2026, 2:15 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Evaluation of Fractional Ablative Laser Treatment for Skin Conditions

NCT05750901
View directory record Official record
Conditions
Skin Laxity
Interventions
Fractional ablative laser
Device
Lead sponsor
Sciton
Industry
Eligibility
18 Years to 85 Years
Enrollment
1,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2027
U.S. locations
1
States / cities
Boca Raton, Florida
Source: ClinicalTrials.gov public record
Updated Apr 22, 2026 · Synced Sep 12, 2026, 2:15 PM EDT
Active, not recruiting No phase listed Observational

Pathogenetic Basis of Aortopathy and Aortic Valve Disease

NCT03440697
View directory record Official record
Conditions
Aortopathies, Thoracic Aortic Aneurysm, Aortic Valve Disease, Thoracic Aortic Disease, Thoracic Aortic Dissection, Thoracic Aortic Rupture, Ascending Aortic Disease, Descending Aortic Disease, Ascending Aortic Aneurysm, Descending Aortic Aneurysm, Marfan Syndrome, Loeys-Dietz Syndrome, Vascular Ehlers-Danlos Syndrome, Shprintzen-Goldberg Syndrome, Turner Syndrome, PHACE Syndrome, Autosomal Recessive Cutis Laxa, Congenital Contractural Arachnodactyly, Arterial Tortuosity Syndrome, Bicuspid Aortic Valve-Associated Aortopathy, Bicuspid Aortic Valve, Familial Thoracic Aortic Aneurysm and Aortic Dissection
Interventions
Not listed
Lead sponsor
Yale University
Other
Eligibility
Not listed
Enrollment
3,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2030
U.S. locations
2
States / cities
Atlanta, Georgia • Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Feb 12, 2026 · Synced Sep 12, 2026, 2:15 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Feasibility Study: Compare the Effectiveness Between Two Pain Medications When Used Prior to Ultherapy™ Treatments

NCT01708473
View directory record Official record
Conditions
Skin Laxity
Interventions
Advil, Lortab, Ulthera System Treatment
Drug · Device
Lead sponsor
Ulthera, Inc
Industry
Eligibility
30 Years to 65 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2012
U.S. locations
1
States / cities
Rockville, Maryland
Source: ClinicalTrials.gov public record
Updated Nov 23, 2017 · Synced Sep 12, 2026, 2:15 PM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers Results available

Application of the Apsara Thermal Wand System

NCT00662389
View directory record Official record
Conditions
Tightening of Skin Laxity
Interventions
Apsara Thermal Wand System
Device
Lead sponsor
Apsara Medical Corporation
Industry
Eligibility
40 Years to 65 Years
Enrollment
4 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2009
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Aug 27, 2009 · Synced Sep 12, 2026, 2:15 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Feasibility Study: Evaluate the Effectiveness of Using a Topical Anesthetic Prior to Ultherapy™ Treatment

NCT01708447
View directory record Official record
Conditions
Skin Laxity
Interventions
L.M.X.4.® cream, A placebo cream, Ulthera System Treatment
Drug · Other · Device
Lead sponsor
Ulthera, Inc
Industry
Eligibility
30 Years to 65 Years
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2012
U.S. locations
1
States / cities
Phoenix, Arizona
Source: ClinicalTrials.gov public record
Updated Nov 23, 2017 · Synced Sep 12, 2026, 2:15 PM EDT
Completed Phase 4 Interventional

Suture Granuloma in Body Contouring Surgery

NCT00223132
View directory record Official record
Conditions
Skin Laxity of Abdomen, Thighs, Chest, Back, and Neck
Interventions
Absorbable sutures
Device
Lead sponsor
Medtronic - MITG
Industry
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2007
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 24, 2012 · Synced Sep 12, 2026, 2:15 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Feasibility Study: Higher Density Ulthera® System Treatment With Vectoring for Treatment of the Face and Neck

NCT01708512
View directory record Official record
Conditions
Skin Laxity
Interventions
Ulthera System Treatment
Device
Lead sponsor
Ulthera, Inc
Industry
Eligibility
25 Years to 60 Years
Enrollment
21 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2013
U.S. locations
1
States / cities
Spokane, Washington
Source: ClinicalTrials.gov public record
Updated Nov 23, 2017 · Synced Sep 12, 2026, 2:15 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Feasibility Study: Evaluation of the Ulthera® System for Treatment of the Knees

NCT01708434
View directory record Official record
Conditions
Skin Laxity
Interventions
Ulthera® System
Device
Lead sponsor
Ulthera, Inc
Industry
Eligibility
30 Years to 65 Years · Female only
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2012
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Nov 23, 2017 · Synced Sep 12, 2026, 2:15 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Evaluation of the Immediate Effect and Safety of DMA™ Novel Muscle Stimulation Technology

NCT04296201
View directory record Official record
Conditions
Skin Laxity, Muscle Contracture
Interventions
DMA treatment
Device
Lead sponsor
Lumenis Be Ltd.
Industry
Eligibility
25 Years to 45 Years
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Charlotte, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 16, 2021 · Synced Sep 12, 2026, 2:15 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Radiofrequency and Pulsed Electromagnetic Field Treatment of Skin Laxity of the Mon Pubis, Labia and Vaginal Introitus

NCT02770287
View directory record Official record
Conditions
Skin Laxity
Interventions
Venus Freeze Diamond Polar
Device
Lead sponsor
Venus Concept
Industry
Eligibility
25 Years to 65 Years · Female only
Enrollment
11 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
Torrance, California
Source: ClinicalTrials.gov public record
Updated Apr 16, 2020 · Synced Sep 12, 2026, 2:15 PM EDT
Completed Not applicable Interventional

Restorative Eye Treatment and INhance in Upper Eyelid Blepharoplasty Surgery

NCT05007288
View directory record Official record
Conditions
Eyelid Dermatochalasis, Dermatochalasis
Interventions
Restorative Eye Treatment (RET) cream, INhance with Trihex Technology
Other
Lead sponsor
University of Miami
Other
Eligibility
18 Years and older
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Apr 10, 2023 · Synced Sep 12, 2026, 2:15 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Measuring Renuvion Soft Tissue Contraction Using Ultrasound

NCT05968495
View directory record Official record
Conditions
Skin Laxity
Interventions
Renuvion APR Handpiece
Device
Lead sponsor
Apyx Medical
Industry
Eligibility
18 Years to 65 Years
Enrollment
5 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Olympia, Washington
Source: ClinicalTrials.gov public record
Updated Feb 2, 2025 · Synced Sep 12, 2026, 2:15 PM EDT
Withdrawn Phase 4 Interventional Accepts healthy volunteers

Brimonidine for Intraoperative Hemostasis

NCT05480098
View directory record Official record
Conditions
Dermatochalasis of Eyelid, Ptosis, Eyelid, Ectropion, Entropion
Interventions
Brimonidine Topical
Drug
Lead sponsor
University of Louisville
Other
Eligibility
18 Years and older
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
Louisville, Kentucky
Source: ClinicalTrials.gov public record
Updated Jan 14, 2025 · Synced Sep 12, 2026, 2:15 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A Comparison of the Effect of Suture Material on Blepharoplasty Incision

NCT04585217
View directory record Official record
Conditions
Dermatochalasis, Ptosis, Eyelid
Interventions
Randomized laterality of suture materials for closure (6-0 polypropylene monofilament suture vs fast absorbing gut suture on right eyelid)
Procedure
Lead sponsor
Massachusetts Eye and Ear Infirmary
Other
Eligibility
18 Years to 89 Years
Enrollment
23 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 22, 2023 · Synced Sep 12, 2026, 2:15 PM EDT
Completed Not applicable Interventional Results available

Evaluation of the Ulthera® System and Efficacy Correlation to Morphological Differences

NCT03599349
View directory record Official record
Conditions
Facial and Neck Skin Laxity
Interventions
Microfocused ultrasound w/ visualization
Device
Lead sponsor
Ulthera, Inc
Industry
Eligibility
30 Years to 55 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
Beverly Hills, California
Source: ClinicalTrials.gov public record
Updated Jun 10, 2019 · Synced Sep 12, 2026, 2:15 PM EDT
Completed Not applicable Interventional

Feasibility of Dynamic Muscle Stimulation + Radiofrequency for Improving Blink Quality in Subjects with Dry Eye Disease

NCT05945069
View directory record Official record
Conditions
Eyelid Diseases, Eyelid Movement Disorders, Dry Eye, Dry Eye Syndromes, Skin Laxity
Interventions
TriLift device
Device
Lead sponsor
Lumenis Be Ltd.
Industry
Eligibility
22 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Mar 9, 2025 · Synced Sep 12, 2026, 2:15 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Evaluating Procedure Pairing of a Post-Procedure Cream Versus a Comparator in Patients Treated With Fractional Ablative CO2 Laser for Facial Rejuvenation

NCT06366503
View directory record Official record
Conditions
Photoaging, Wrinkle, Skin Laxity
Interventions
Fractional Ablative CO2 Laser, Facial Cleanser, Facial Moisturizer, Sunscreen, Basic Ointment
Procedure · Other
Lead sponsor
Revision Skincare
Industry
Eligibility
35 Years to 65 Years · Female only
Enrollment
23 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Blue Ash, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 2, 2025 · Synced Sep 12, 2026, 2:15 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Injectable Poly-L-Lactic Acid for Volumization and Adipogenesis of the Hip Dell

NCT05269654
View directory record Official record
Conditions
Skin Laxity
Interventions
injectable poly-L-lactic acid, Normal Saline
Device · Other
Lead sponsor
Goldman, Butterwick, Fitzpatrick and Groff
Other
Eligibility
30 Years to 60 Years · Female only
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Mar 7, 2022 · Synced Sep 12, 2026, 2:15 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

CCH Treatment of Cellulite in the Presence of Dermal Laxity With Comparison Between Two (2) Different Injection Techniques

NCT04580303
View directory record Official record
Conditions
Edematous Fibrosclerotic Panniculopathy, Cellulite, Laxity; Skin
Interventions
collagenase clostridium histolyticum
Drug
Lead sponsor
Endo USA Inc., a Keenova Therapeutics Company
Industry
Eligibility
18 Years to 55 Years · Female only
Enrollment
35 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
3
States / cities
Coral Gables, Florida • Metairie, Louisiana • New York, New York
Source: ClinicalTrials.gov public record
Updated Sep 27, 2022 · Synced Sep 12, 2026, 2:15 PM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Bipolar RF Microneedling for Improved Laxity and Lift of the Submental and Neck Tissue and Effect on Elastin

NCT04245696
View directory record Official record
Conditions
Skin Laxity
Interventions
Dermal Handpiece / SubQ Handpiece
Device
Lead sponsor
Candela Corporation
Industry
Eligibility
21 Years to 70 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Marlborough, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 5, 2021 · Synced Sep 12, 2026, 2:15 PM EDT