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Conditions: Peripheral Arterial Disease, Peripheral Vascular Disease, Amputation, Lower Limb Amputation Knee, Lower Limb Amputation Above Knee (Injury), Lower Limb Amputation Below Knee (Injury)
Interventions: Ischemic Conditioning Low - Sham Comparator, Ischemic Conditioning High - Active Comparator; Procedure
Lead sponsor: University of Illinois at Chicago; Other
Eligibility: 18 Years and older
Enrollment: 21 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2024
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Coronary Heart Disease
Interventions: Intermittent pneumatic compression of the lower extremities; Device
Lead sponsor: Johns Hopkins University; Other
Eligibility: 21 Years to 90 Years
Enrollment: 10 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2009 – 2014
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Diabetes Mellitus, Critical Limb Ischemia, Lower Limb Amputation Knee, Peripheral Arterial Disease
Interventions: Active Arm N-acetyl cysteine (NAC), Placebo Arm; Drug
Lead sponsor: Washington University School of Medicine; Other
Eligibility: 30 Years to 90 Years
Enrollment: 33 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2022
U.S. locations: 1
States / cities: St Louis, Missouri

Conditions: Critical Limb Ischemia
Interventions: Oxygenesys(TM) Dissolved Oxygen Dressing; Device
Lead sponsor: Halyard Health; Industry
Eligibility: 21 Years and older
Enrollment: 7 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2014
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Diabetic Foot Ulcer (DFU)
Interventions: FoundationDRS Solo, Standard of Care; Other
Lead sponsor: Samaritan Biologics; Industry
Eligibility: 18 Years and older
Enrollment: 124 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Hollywood, Florida

Conditions: Atherosclerosis, Lower Extremity Ischemia, Claudication, Rest Pain
Interventions: Femoral-popliteal Bypass, Angioplasty and stent placement with Viabahn covered stent-graft(W.L. Gore & Associates, Flagstff, Arizona) of superficial femoral artery; Procedure · Device
Lead sponsor: Texas Vascular Associates; Other
Eligibility: 18 Years and older
Enrollment: 86 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2003 – 2008
U.S. locations: 1
States / cities: Dallas, Texas

Conditions: Coronary Heart Disease, Stroke, Breast Cancer, Ovarian Cancer, Cancer, Hip Fracture, Death
Interventions: Not listed
Lead sponsor: Parker, William H., M.D.; Other
Eligibility: 30 Years to 55 Years · Female only
Enrollment: 32,175 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 1980 – 2004
U.S. locations: 1
States / cities: Santa Monica, California

Conditions: Critical Limb Ischemia
Interventions: treprostinil dienthanolmine sustained release, Placebo; Drug
Lead sponsor: Ochsner Health System; Other
Eligibility: 18 Years and older
Enrollment: 7 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2010
U.S. locations: 1
States / cities: New Orleans, Louisiana

Conditions: Chronic Critical Limb Ischemia, Peripheral Vascular Diseases
Interventions: Xpert(TM) Self-expanding Transhepatic Biliary Stent System feasibility in treating chronic critical limb ischemia; Device
Lead sponsor: VIVA Physicians; Other
Eligibility: 18 Years to 89 Years
Enrollment: 120 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2011
U.S. locations: 1
States / cities: San Jose, California

Conditions: Peripheral Artery Disease
Interventions: Rivaroxaban (Xarelto, BAY59-7939), Rivaroxaban-Placebo; Drug
Lead sponsor: Bayer; Industry
Eligibility: 50 Years and older
Enrollment: 6,564 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2020
U.S. locations: 105
States / cities: Alexander City, Alabama • Birmingham, Alabama • Fort Payne, Alabama + 91 more

Conditions: Peripheral Vascular Disease
Interventions: Paclitaxel; Drug
Lead sponsor: Patrick Kelly; Other
Eligibility: 18 Years to 90 Years
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2015
U.S. locations: 1
States / cities: Sioux Falls, South Dakota

Conditions: Peripheral Artery Disease, Coronary Artery Disease
Interventions: Coronary computed topography (CT) angiography with FFR-CT; Diagnostic Test
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 50 Years to 85 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024
U.S. locations: 7
States / cities: Aurora, Colorado • Gainesville, Florida • Cleveland, Ohio + 4 more

Conditions: Leukodystrophy, White Matter Disease, 4H Syndrome, Adrenoleukodystrophy, AMN, ALD, ALD (Adrenoleukodystrophy), X-linked Adrenoleukodystrophy, X-ALD, Adrenomyeloneuropathy, Aicardi Goutieres Syndrome, AGS, Alexander Disease, Alexanders Leukodystrophy, AxD, ADLD, Canavan Disease, CTX, Cerebrotendinous Xanthomatoses, Krabbe Disease, GALC Deficiency, Globoid Leukodystrophy, TUBB4A-Related Leukodystrophy, H-ABC - Hypomyelination, Atrophy of Basal Ganglia and Cerebellum, HBSL, HBSL - Hypomyelination, Brain Stem, Spinal Cord, Leg Spasticity, LBSL, Leukoencephalopathy With Brain Stem and Spinal Cord Involvement and High Lactate Syndrome (Disorder), Leukoencephalopathy With Brainstem and Spinal Cord Involvement and Lactate Elevation, ALSP, CSF1R Gene Mutation, HCC - Hypomyelination and Congenital Cataract, MLC1, Megalencephalic Leukoencephalopathy With Subcortical Cysts 1, MLD, Metachromatic Leukodystrophy, PMD, Pelizaeus-Merzbacher Disease, PLP1 Null Syndrome, PLP1 Gene Duplication &#X7C; Blood or Tissue &#X7C; Mutations, Pelizaeus-Merzbacher-Like Disease, 1, Peroxisomal Biogenesis Disorder, Zellweger Syndrome, Refsum Disease, Salla Disease, Sialic Storage Disease, Sjögren, Sjogren-Larsson Syndrome, Van Der Knapp Disease, Vanishing White Matter Disease, Charcot-Marie-Tooth, CMT, Mct8 (Slc16A2)-Specific Thyroid Hormone Cell Transporter Deficiency, Allan-Herndon-Dudley Syndrome, Cadasil, Cockayne Syndrome, Multiple Sulfatase Deficiency, Gangliosidoses, GM2 Gangliosidosis, BPAN, Labrune Syndrome, LCC, Mucopolysaccharidoses, TBCK-Related Intellectual Disability Syndrome
Interventions: Not listed
Lead sponsor: Children's Hospital of Philadelphia; Other
Eligibility: Up to 18 Years
Enrollment: 236 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2024
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Critical Limb Ischemia, Peripheral Vascular Disease, Foot Ulcers, Rest Leg Pain
Interventions: Remodulin® (treprostinil sodium) Injection; Drug
Lead sponsor: United Therapeutics; Industry
Eligibility: 18 Years to 85 Years
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2003 – 2004
U.S. locations: 7
States / cities: Tampa, Florida • Worcester, Massachusetts • Minneapolis, Minnesota + 4 more

Conditions: Lower Extremity Acute Limb Ischemia, LE ALI
Interventions: Indigo Aspiration System; Device
Lead sponsor: Penumbra Inc.; Industry
Eligibility: 18 Years and older
Enrollment: 300 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2029
U.S. locations: 32
States / cities: Scottsdale, Arizona • San Diego, California • Ventura, California + 28 more

Conditions: Acute Lower Limb Arterial Occlusion
Interventions: Artix Thrombectomy System; Device
Lead sponsor: Inari Medical; Industry
Eligibility: 18 Years and older
Enrollment: 250 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2029
U.S. locations: 17
States / cities: New Haven, Connecticut • Washington D.C., District of Columbia • Pensacola, Florida + 14 more

Conditions: Lower Extremity Acute Limb Ischemia, LE ALI
Interventions: Indigo Aspiration System; Device
Lead sponsor: Penumbra Inc.; Industry
Eligibility: 18 Years and older
Enrollment: 119 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2023
U.S. locations: 14
States / cities: Stanford, California • Danbury, Connecticut • Bradenton, Florida + 11 more

Conditions: Critical Limb Ischemia, Ischemia, Leg Ulcer
Interventions: pVGI.1 (VEGF-2); Genetic
Lead sponsor: Losordo, Douglas, M.D.; Individual
Eligibility: 21 Years and older
Timeline: Ends 2008
U.S. locations: 3
States / cities: Birmingham, Alabama • Boston, Massachusetts • Minneapolis, Minnesota

Conditions: Hip Fracture, Myocardial Ischemia, Inflammation
Interventions: Atorvastatin, Placebo; Drug
Lead sponsor: Hospital for Special Surgery, New York; Other
Eligibility: 65 Years to 99 Years
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2017
U.S. locations: 2
States / cities: New York, New York

Conditions: Peripheral Vascular Disease
Interventions: Ecraprost in lipid emulsion; Drug
Lead sponsor: Tanabe Pharma Corporation; Industry
Eligibility: 40 Years and older
Enrollment: 280 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2001 – 2005
U.S. locations: 15
States / cities: Phoenix, Arizona • Tucson, Arizona • Glendale, California + 12 more

Conditions: Peripheral Vascular Diseases
Interventions: NightHawk; Device
Lead sponsor: FoxHollow Technologies; Industry
Eligibility: Not listed
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007
U.S. locations: 1
States / cities: Austin, Texas

Conditions: Critical Limb Ischemia
Interventions: BMAC injection, Placebo injection; Device
Lead sponsor: Harvest Technologies; Industry
Eligibility: 18 Years and older
Enrollment: 97 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2015
U.S. locations: 34
States / cities: Birmingham, Alabama • El Dorado, Arkansas • Los Angeles, California + 30 more

Conditions: Critical Limb Ischemia, Peripheral Vascular Disease
Interventions: Mesendo; Biological
Lead sponsor: TCA Cellular Therapy; Industry
Eligibility: 18 Years and older
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2009
U.S. locations: 1
States / cities: Covington, Louisiana

Conditions: Stroke, Ischemic, Stroke Hemorrhagic, Stroke, Hemiparesis, Cerebral Vascular Accident
Interventions: Keeogo™ Dermoskeleton; Device
Lead sponsor: B-Temia, Inc.; Industry
Eligibility: 18 Years and older
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2020
U.S. locations: 3
States / cities: Chicago, Illinois • West Orange, New Jersey • The Bronx, New York

Search by objective public record fields.

The Effect of Ischemic Conditioning on Strength and Ambulation in Subjects with PAD

Global Vascular Effects of Intermittent Pneumatic Compression-Pilot Study

N-Acetyl-Cysteine (NAC) for Healing of Amputation Stumps in the Setting of Diabetes

Dissolved Oxygen Dressing to Improve Chronic Wound Healing After Revascularization for Critical Limb Ischemia

Evaluating the Efficacy of FoundationDRS Solo in Addition to Standard of Care for the Treatment of Non-healing Diabetic Foot Ulcers

Comparison of Prosthetic Femoropopliteal Bypass Versus Viabahn Endoprosthesis for Treatment of Symptomatic Femoral Artery Occlusive Disease

Examining the Long-Term Risks of Oophorectomy

Safety Study of UT-15C SR (Oral Treprostinil) in Patients Undergoing a Lower Limb Endovascular Procedure

Study to Evaluate the Safety & Performance of the Xpert(TM) Stent in Treating Below-the-knee Lesions in Patients Undergoing Percutaneous Intervention for Chronic CLI.

Efficacy and Safety of Rivaroxaban in Reducing the Risk of Major Thrombotic Vascular Events in Subjects With Symptomatic Peripheral Artery Disease Undergoing Peripheral Revascularization Procedures of the Lower Extremities

Effects of Paclitaxel on Intimal Hyperplasia

Diagnosis and Treatment of CAD in Severe PAD After Lower Extremity Revascularization

LeukoSEQ: Whole Genome Sequencing as a First-Line Diagnostic Tool for Leukodystrophies

Study of Remodulin in Patients With Critical Limb Ischemia With No Planned Revascularization Procedures

A Study of Patients With Lower Extremity Acute Limb Ischemia to Remove Thrombus With the Indigo™ Aspiration System (STRIDE II)

The ArtixASCEND Study

A Study of Patients With Lower Extremity Acute Limb Ischemia to Remove Thrombus With the Indigo Aspiration System

VEGF Gene Transfer for Critical Limb Ischemia

Pilot Study of Atorvastatin for Orthopedic Surgery Patients

Efficacy/Safety of Ecraprost in Lipid Emulsion for Treatment of Critical Leg Ischemia Due to Peripheral Arterial Disease

A Non-Randomized Study of the NightHawk Peripheral Plaque Excision System During Plaque Excision of Peripheral Arterial Disease

Bone Marrow Aspirate Concentrate (BMAC) for Treatment of Critical Limb Ischemia (CLI)

Combination Stem Cell Therapy for the Treatment of Severe Leg Ischemia

Evaluation of the Effectiveness and Safety of Keeogo™ Dermoskeleton in Subjects With Mobility Impairments Due to Stroke