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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Lower Limb Functions Clear all
Completed Phase 1Phase 2 Interventional Accepts healthy volunteers Results available

Effects of Caffeine and Intermittent Hypoxia on Leg Function in Human Spinal Cord Injury

NCT02323698
View directory record Official record
Conditions
Spinal Cord Injuries
Interventions
Caffeine, AIH, Placebo, SHAM
Drug · Other
Lead sponsor
Spaulding Rehabilitation Hospital
Other
Eligibility
18 Years to 75 Years
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2022
U.S. locations
1
States / cities
Cambridge, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 12, 2023 · Synced Sep 13, 2026, 9:33 PM EDT
Completed Phase 2 Interventional

Effects of Shock Absorbing Insoles on Knee Pain and Walking in Persons With Knee Osteoarthritis

NCT02018380
View directory record Official record
Conditions
Osteoarthritis
Interventions
Shock Absorbing Insole (SofSole Athletes Plus)
Other
Lead sponsor
Winston Salem State University
Other
Eligibility
50 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2008
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Dec 22, 2013 · Synced Sep 13, 2026, 9:33 PM EDT
Completed Phase 1Phase 2 Interventional

Extract of Ginkgo Biloba (EGB 761) and Vascular Function

NCT00029991
View directory record Official record
Conditions
Intermittent Claudication, Peripheral Vascular Disease
Interventions
Gingko Biloba (Herb)
Drug
Lead sponsor
National Center for Complementary and Integrative Health (NCCIH)
NIH
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2000 – 2005
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Aug 17, 2006 · Synced Sep 13, 2026, 9:33 PM EDT
Withdrawn Not applicable Interventional

Arthroscopic Assisted Open Reduction Internal Fixation Versus Open Reduction Internal Fixation in Ankle Fractures

NCT03084263
View directory record Official record
Conditions
Ankle Fractures
Interventions
Arthroscopic Assisted Open Reduction Internal Fixation, Open Reduction Internal Fixation
Procedure
Lead sponsor
Corewell Health West
Other
Eligibility
18 Years to 65 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Grand Rapids, Michigan
Source: ClinicalTrials.gov public record
Updated May 24, 2017 · Synced Sep 13, 2026, 9:33 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Ultrasound for Quantifying Muscle Activation Elicited by Spinal Cord Stimulation and Functional Electrical Stimulation

NCT07206797
View directory record Official record
Conditions
Neuromodulatory Effects of TSCS and FES in Lower Limbs
Interventions
Functional Electrical Stimulation, Transcutaneous (Non-Invasive) Spinal Cord Stimulation, Ultrasound
Device
Lead sponsor
North Carolina State University
Other
Eligibility
18 Years to 60 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Raleigh, North Carolina
Source: ClinicalTrials.gov public record
Updated Oct 13, 2025 · Synced Sep 13, 2026, 9:33 PM EDT
Enrolling by invitation Not applicable Interventional Accepts healthy volunteers

Examining the Effect of Acute Intermittent Hypoxia on Serum Blood Proteins and Lower Limb Function

NCT06906536
View directory record Official record
Conditions
INCOMPLETE SPINAL CORD INJURY (ASIA D), Able Bodied
Interventions
Acute Intermittent Hypoxia (AIH)
Other
Lead sponsor
University of Colorado, Boulder
Other
Eligibility
18 Years to 75 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
Boulder, Colorado
Source: ClinicalTrials.gov public record
Updated Apr 3, 2025 · Synced Sep 13, 2026, 9:33 PM EDT
Completed Not applicable Interventional Results available

Adherence and Perspiration While Wearing Lower Limb Prostheses

NCT03900845
View directory record Official record
Conditions
Lower Extremity Amputation
Interventions
Dynamic Air Exchange - Rising Edge Design (DAE-RED), Perforated elastomeric liner, As-prescribed prosthesis
Device
Lead sponsor
Seattle Institute for Biomedical and Clinical Research
Other
Eligibility
18 Years to 70 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jan 26, 2026 · Synced Sep 13, 2026, 9:33 PM EDT
Active, not recruiting Not applicable Interventional

Thromboelastography With Platelet Mapping to Guide Antiplatelet Therapy After Lower Extremity Revascularization

NCT07597239
View directory record Official record
Conditions
Thrombosis, Arterial Occlusive Diseases, Thromboelastography (TEG), Peripheral Arterial Disease(PAD), Stent Thrombosis, Platelet Inhibition, PRU(Platelet Reactivity Unit)
Interventions
Aspirin, Clopidogrel, Ticagrelor, Platelet Reactivity Testing, Thromboelastography with Platelet Mapping
Drug · Diagnostic Test
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
60 Years and older
Enrollment
514 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2026
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 8, 2026 · Synced Sep 13, 2026, 9:33 PM EDT
Withdrawn Not applicable Interventional

Comparison of Transcutaneous and Epidural Spinal Stimulation for Improving Function

NCT04043715
View directory record Official record
Conditions
Spinal Cord Injuries, Spinal Cord Diseases, Central Nervous System Diseases, Nervous System Diseases, Trauma, Nervous System, Wounds and Injuries
Interventions
Transcutaneous spinal stimulation, Epidural spinal stimulation
Device
Lead sponsor
University of Washington
Other
Eligibility
21 Years to 70 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Apr 25, 2024 · Synced Sep 13, 2026, 9:33 PM EDT
Completed Phase 3 Interventional

Improving Pain and Function in Hip Fracture

NCT00749489
View directory record Official record
Conditions
Pain, Hip Fractures
Interventions
Femoral Nerve Block
Procedure
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
60 Years and older
Enrollment
164 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2014
U.S. locations
3
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jun 24, 2014 · Synced Sep 13, 2026, 9:33 PM EDT
Terminated Not applicable Interventional

Tourniquet Use in Anterior Cruciate Ligament Repair

NCT05931627
View directory record Official record
Conditions
ACL - Anterior Cruciate Ligament Deficiency, ACL Injury, ACL Tear
Interventions
Patients undergoing ACL reconstruction with or without a tourniquet
Procedure
Lead sponsor
OrthoCarolina Research Institute, Inc.
Other
Eligibility
18 Years and older
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Charlotte, North Carolina
Source: ClinicalTrials.gov public record
Updated May 21, 2026 · Synced Sep 13, 2026, 9:33 PM EDT
Completed No phase listed Observational

Dual-tasking for Individuals With Lower Limb Amputation: Exploring the Relationship to Falls and Instrumental Activities of Daily Living

NCT05119192
View directory record Official record
Conditions
Amputation
Interventions
Not listed
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
50 Years to 89 Years
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Mar 14, 2024 · Synced Sep 13, 2026, 9:33 PM EDT
Terminated No phase listed Observational

Retrospective Study of the Linear™ Hip

NCT00764959
View directory record Official record
Conditions
Osteoarthritis, Rheumatoid Arthritis, Femoral Fracture, Correction of a Functional Deformity, Avascular Necrosis
Interventions
Encore Linear™ Hip System
Device
Lead sponsor
Encore Medical, L.P.
Industry
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2011
U.S. locations
1
States / cities
Vero Beach, Florida
Source: ClinicalTrials.gov public record
Updated Feb 8, 2011 · Synced Sep 13, 2026, 9:33 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

The Effect of Gait Training Using Virtual Reality and Real-Time Feedback on Physiological and Functional Gait Performance in Persons With a Traumatic Lower Extremity Amputation

NCT01225432
View directory record Official record
Conditions
Elevated Metabolic Cost
Interventions
Gait Training
Other
Lead sponsor
Brooke Army Medical Center
Federal
Eligibility
18 Years to 45 Years
Enrollment
66 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
Started 2007
U.S. locations
1
States / cities
Fort Sam Houston, Texas
Source: ClinicalTrials.gov public record
Updated Oct 20, 2010 · Synced Sep 13, 2026, 9:33 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Sensing of Leg Position and Movement

NCT00100919
View directory record Official record
Conditions
Proprioception
Interventions
Not listed
Lead sponsor
National Institutes of Health Clinical Center (CC)
NIH
Eligibility
21 Years to 40 Years
Enrollment
38 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2010
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 1, 2017 · Synced Sep 13, 2026, 9:33 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A Comparison of External Mechanical Work Between Different Prosthetic Feet

NCT01340807
View directory record Official record
Conditions
Traumatic Amputation of Lower Extremity
Interventions
Specialized Functional Prosthetic Training
Other
Lead sponsor
Miami VA Healthcare System
Federal
Eligibility
40 Years to 65 Years
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2011
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Apr 24, 2011 · Synced Sep 13, 2026, 9:33 PM EDT
Completed Not applicable Interventional

Conditioning Brain Responses to Improve Thigh Muscle Function After Anterior Cruciate Ligament Reconstruction

NCT03209531
View directory record Official record
Conditions
Anterior Cruciate Ligament Injury
Interventions
Operant Conditioning, Control, Single Pulse Transcranial Magnetic Stimulation
Behavioral · Device
Lead sponsor
University of Michigan
Other
Eligibility
18 Years to 45 Years
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2025
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Nov 25, 2025 · Synced Sep 13, 2026, 9:33 PM EDT
Completed Phase 3 Interventional

Evaluating Two Exercise Training Programs to Reduce Leg Pain in People With Peripheral Arterial Disease (The EXERT Study)

NCT00895635
View directory record Official record
Conditions
Intermittent Claudication, Peripheral Vascular Diseases
Interventions
Treadmill Exercise Training, Arm Ergometry Exercise Training, Usual Care
Behavioral
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years to 90 Years
Enrollment
104 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2014
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Oct 31, 2019 · Synced Sep 13, 2026, 9:33 PM EDT
Terminated Phase 2 Interventional Results available

Safety, Tolerability and Efficacy of ACZ885 on Leg Artery Structure in Patients With Peripheral Artery Disease

NCT01731990
View directory record Official record
Conditions
Peripheral Artery Disease
Interventions
Canakinumab (ACZ885), Placebo
Drug
Lead sponsor
Novartis Pharmaceuticals
Industry
Eligibility
18 Years to 85 Years
Enrollment
38 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
8
States / cities
Phoenix, Arizona • Jacksonville, Florida • Chicago, Illinois + 4 more
Source: ClinicalTrials.gov public record
Updated Apr 28, 2025 · Synced Sep 13, 2026, 9:33 PM EDT
Withdrawn Not applicable Interventional

The Effect of Balance Training on Unloading Reaction in Individuals With Functional Ankle Instability

NCT00703456
View directory record Official record
Conditions
Ankle Injury
Interventions
Balance Training
Behavioral
Lead sponsor
University of Kansas Medical Center
Other
Eligibility
18 Years to 45 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2009
U.S. locations
1
States / cities
Kansas City, Kansas
Source: ClinicalTrials.gov public record
Updated Apr 18, 2016 · Synced Sep 13, 2026, 9:33 PM EDT
Active, not recruiting Not applicable Interventional

At-Home Exercise Study for Veterans With Healed Diabetic Foot Ulcers

NCT06312579
View directory record Official record
Conditions
Diabetic Foot Ulcer
Interventions
12-week home based exercise, 12-week standard of care
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
50 Years and older
Enrollment
26 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Aug 16, 2026 · Synced Sep 13, 2026, 9:33 PM EDT
Completed Phase 2Phase 3 Interventional Results available

Mepivacaine Versus Low-Dose Bupivacaine For Primary Total Hip and Knee Arthroplasty

NCT03838874
View directory record Official record
Conditions
Knee Osteoarthritis, Hip Osteoarthritis
Interventions
Low-Dose Bupivacaine, Mepivacaine
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Days and older
Enrollment
154 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Aug 11, 2021 · Synced Sep 13, 2026, 9:33 PM EDT
Completed Not applicable Interventional

Electrical Stimulation Effect on Ankle Instability During Walking in Virtual Reality Setup

NCT06484712
View directory record Official record
Conditions
Ankle Sprains, Ankle Instability
Interventions
Stochastic Resonance (SR)
Device
Lead sponsor
University of Delaware
Other
Eligibility
18 Years to 39 Years
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Newark, Delaware
Source: ClinicalTrials.gov public record
Updated Apr 10, 2025 · Synced Sep 13, 2026, 9:33 PM EDT
Terminated Not applicable Interventional

Dry Needling and Functional Improvement

NCT02838394
View directory record Official record
Conditions
Myofascial Trigger Point Pain, Myofascial Pain Syndrome
Interventions
Dry needling, Sham dry needling
Procedure · Other
Lead sponsor
Brigham Young University
Other
Eligibility
18 Years to 65 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2023
U.S. locations
1
States / cities
Provo, Utah
Source: ClinicalTrials.gov public record
Updated Apr 24, 2024 · Synced Sep 13, 2026, 9:33 PM EDT