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Showing 1–24 of 146 matching trials from the live ClinicalTrials.gov search.
Local D1 index available.
Filters: Condition: Lumbar Disc Degeneration Clear all
Withdrawn Phase 2 Interventional

Analgesic Effects of Perioperative Propranolol Administration for Spine Surgery

NCT04421209
View directory record Official record
Conditions
Lumbar Disc Disease, Spinal Fusion, Degenerative Disc Disease
Interventions
Propranolol Hcl 40mg Tab, Placebo oral tablet
Drug
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Mar 15, 2021 · Synced Jul 21, 2026, 9:51 AM EDT
Terminated Phase 3 Interventional Results available

Treatment of Symptomatic Lumbar Internal Disc Disruption (IDD) With the Biostat® System

NCT01011816
View directory record Official record
Conditions
Back Pain, Chronic Low Back Pain, Internal Disc Disruption, Degenerative Disc Disease
Interventions
BIOSTAT BIOLOGX, Saline
Biological · Drug
Lead sponsor
Spinal Restoration, Inc.
Industry
Eligibility
18 Years and older
Enrollment
220 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
20
States / cities
Birmingham, Alabama • Phoenix, Arizona • Chula Vista, California + 17 more
Source: ClinicalTrials.gov public record
Updated May 15, 2014 · Synced Jul 21, 2026, 9:51 AM EDT
Enrolling by invitation No phase listed Observational

Virtuos Bone Graft in Lumbar Fusion

NCT06686017
View directory record Official record
Conditions
Degenerative Disc Disease
Interventions
Not listed
Lead sponsor
Orthofix Inc.
Industry
Eligibility
18 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
9
States / cities
South Bend, Indiana • Southfield, Michigan • Missoula, Montana + 5 more
Source: ClinicalTrials.gov public record
Updated Nov 27, 2025 · Synced Jul 21, 2026, 9:51 AM EDT
Completed No phase listed Observational

MLX/XLX ACR Expandable Lumbar Interbody Implants

NCT04420143
View directory record Official record
Conditions
Degenerative Disc Disease, Spondylolisthesis, Degenerative Scoliosis
Interventions
Not listed
Lead sponsor
NuVasive
Industry
Eligibility
18 Years and older
Enrollment
109 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020
U.S. locations
4
States / cities
Orange, California • Jacksonville, Florida • Charlotte, North Carolina
Source: ClinicalTrials.gov public record
Updated Dec 21, 2025 · Synced Jul 21, 2026, 9:51 AM EDT
Completed Not applicable Interventional

A Prospective Pilot Study of the OP-1 Putty in Uninstrumented Posterolateral Fusions

NCT00679107
View directory record Official record
Conditions
Degenerative Lumbar Spondylolisthesis
Interventions
Use of OP-1 Putty in Uninstrumented posterolateral fusion
Device
Lead sponsor
Olympus Biotech Corporation
Industry
Eligibility
18 Years to 81 Years
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1999 – 2005
U.S. locations
5
States / cities
New Haven, Connecticut • Chicago, Illinois • Royal Oak, Michigan + 2 more
Source: ClinicalTrials.gov public record
Updated Jun 9, 2011 · Synced Jul 21, 2026, 9:51 AM EDT
Completed Phase 2 Interventional

Safety and Preliminary Efficacy Study of NeoFuse in Subjects Requiring Lumbar Interbody Fusion

NCT00996073
View directory record Official record
Conditions
Degenerative Disc Disease, Degenerative Spondylolisthesis, Spinal Stenosis
Interventions
Lumbar Interbody Fusion with Autograft, Lumbar Interbody Fusion with NeoFuse
Biological
Lead sponsor
Mesoblast, Ltd.
Industry
Eligibility
18 Years to 70 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2014
U.S. locations
5
States / cities
Santa Monica, California • Greenwood Village, Colorado • Loveland, Colorado + 2 more
Source: ClinicalTrials.gov public record
Updated Jun 28, 2020 · Synced Jul 21, 2026, 9:51 AM EDT
Completed Not applicable Interventional Results available

Prospective Study of Thoracolumbar Spinal Fusion Graft

NCT02297256
View directory record Official record
Conditions
Lumbar Degenerative Disc Disease
Interventions
BMAC & Allograft, Iliac Crest Bone Graft
Procedure
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years and older
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2020
U.S. locations
3
States / cities
New York, New York • Westbury, New York
Source: ClinicalTrials.gov public record
Updated Apr 29, 2026 · Synced Jul 21, 2026, 9:51 AM EDT
Not listed Phase 2 Interventional

KUR-113 Bone Graft Versus Local Autograft for the Treatment of Single-level Transforaminal Lumbar Interbody Fusion

NCT04294004
View directory record Official record
Conditions
Degenerative Disc Disease, Spinal Fusion
Interventions
TGplPTH1-34 in fibrin, Autologous Bone Graft
Combination Product · Other
Lead sponsor
Kuros Biosurgery AG
Industry
Eligibility
25 Years to 75 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
15
States / cities
La Jolla, California • Boulder, Colorado • Washington D.C., District of Columbia + 11 more
Source: ClinicalTrials.gov public record
Updated Aug 8, 2023 · Synced Jul 21, 2026, 9:51 AM EDT
Not listed No phase listed Observational

Human Autograft Mesenchymal Stem Cell Mediated Stabilization of The Degenerative Lumbar Spine

NCT02529566
View directory record Official record
Conditions
Lumbar Degenerative Disc Disease, Lower Back Pain, Chronic Lower Back Pain
Interventions
Not listed
Lead sponsor
The Foundation for Spinal Research, Education and Humanitarian Care, Inc.
Industry
Eligibility
18 Years to 85 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2018
U.S. locations
1
States / cities
Odessa, Florida
Source: ClinicalTrials.gov public record
Updated Feb 14, 2017 · Synced Jul 21, 2026, 9:51 AM EDT
Completed Not applicable Interventional

Comparison of nanOss Bioactive With Autograft and Bone Marrow Aspirate to Autograft in the Posterolateral Spine

NCT01968993
View directory record Official record
Conditions
Degenerative Disc Disease, Spinal Stenosis, Spondylolisthesis
Interventions
nanOss Bioactive - posterolateral gutter
Device
Lead sponsor
Pioneer Surgical Technology, Inc.
Industry
Eligibility
18 Years and older
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2015
U.S. locations
3
States / cities
La Jolla, California • San Francisco, California • Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Nov 7, 2016 · Synced Jul 21, 2026, 9:51 AM EDT
Withdrawn Not applicable Interventional

Single Center Study Comparing MOBIS II ST vs MOBIS PEEK

NCT02852187
View directory record Official record
Conditions
Lumbar Disc Disease
Interventions
SIGNUS MOBIS PEEK Cage, SIGNUS MOBIS II ST Cage
Device
Lead sponsor
Signus Medizintechnik GmbH
Industry
Eligibility
18 Years to 89 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
East Syracuse, New York
Source: ClinicalTrials.gov public record
Updated Mar 18, 2020 · Synced Jul 21, 2026, 9:51 AM EDT
Withdrawn Phase 4 Interventional Accepts healthy volunteers

Efficacy of Using Solum IV and BMC With GFC in TLIF

NCT03223701
View directory record Official record
Conditions
Degenerative Disc Disease, Isthmic-lytic Spondylolisthesis, Degenerative Spondylolisthesis, Spinal Stenosis
Interventions
Solum IV, Bone Marrow Concentrate with general fluid concentrate (GFC) in Transforaminal Lumbar Interbody Fusion
Combination Product
Lead sponsor
Seton Healthcare Family
Other
Eligibility
18 Years and older
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Apr 17, 2018 · Synced Jul 21, 2026, 9:51 AM EDT
Completed Phase 2 Interventional Results available

TXA in Spinal Fusion

NCT04272606
View directory record Official record
Conditions
Degenerative Disc Disease
Interventions
Tranexamic Acid, Saline Solution, Visual Acuity Exam, 3 Minute Diagnostic Interview for Confusion Assessment Method (3D-CAM)
Drug · Diagnostic Test
Lead sponsor
Catherine R. Olinger
Other
Eligibility
18 Years to 90 Years
Enrollment
123 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Dec 11, 2024 · Synced Jul 21, 2026, 9:51 AM EDT
Not listed Not applicable Interventional

OSTEOAMP Lumbar Fusion Intra-Patient Controlled Study

NCT05405374
View directory record Official record
Conditions
Lumbar Spine Disease, Lumbar Spondylolisthesis, Lumbar Spine Instability, Lumbar Spondylosis, Degenerative Disc Disease
Interventions
OSTEOAMP, Infuse
Other · Device
Lead sponsor
Bioventus LLC
Industry
Eligibility
21 Years to 80 Years
Enrollment
101 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
9
States / cities
New Haven, Connecticut • Wichita, Kansas • Paducah, Kentucky + 6 more
Source: ClinicalTrials.gov public record
Updated Aug 27, 2023 · Synced Jul 21, 2026, 9:51 AM EDT
Not listed Not applicable Interventional

Freedom Lumbar Disc in the Treatment of Lumbar Degenerative Disc Disease

NCT00775801
View directory record Official record
Conditions
Degenerative Disc Disease (DDD)
Interventions
FLD, Control
Device
Lead sponsor
AxioMed Spine Corporation
Industry
Eligibility
21 Years to 65 Years
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2018
U.S. locations
12
States / cities
Los Angeles, California • San Diego, California • Loveland, Colorado + 9 more
Source: ClinicalTrials.gov public record
Updated Jan 22, 2018 · Synced Jul 21, 2026, 9:51 AM EDT
Not listed No phase listed Observational

Injection of Autologous Bone Marrow Aspirate in Patients With Degenerative Disc Disease.

NCT05146583
View directory record Official record
Conditions
Lumbar Disc Disease
Interventions
Autologous bone marrow aspirate injected intradiscal after microdiscectomy, Discectomy only
Procedure
Lead sponsor
New York Presbyterian Hospital
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Dec 20, 2021 · Synced Jul 21, 2026, 9:51 AM EDT
Recruiting Phase 4 Interventional

Regional Anesthesia in Minimally Invasive Lumbar Spine Surgery

NCT05029726
View directory record Official record
Conditions
Lumbar Spinal Stenosis, Lumbar Disc Herniation, Lumbar Spondylolisthesis, Lumbar Spondylosis, Lumbar Radiculopathy, Lumbar Spine Instability, Synovial Cyst, Degenerative Disc Disease, Degenerative Spondylolisthesis, Degenerative Intervertebral Discs
Interventions
Bupivacaine-Epinephrine 0.25%-1:200,000 Injectable Solution plus clonidine, normal saline
Drug
Lead sponsor
John O'Toole
Other
Eligibility
18 Years to 80 Years
Enrollment
125 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Feb 16, 2026 · Synced Jul 21, 2026, 9:51 AM EDT
Completed No phase listed Observational Accepts healthy volunteers Results available

Retrospective Review of Integrity Implants FlareHawk® for Lumbar Fusion

NCT04057235
View directory record Official record
Conditions
Degenerative Disc Disease
Interventions
FlareHawk Interbody Fusion System
Device
Lead sponsor
Integrity Implants Inc.
Industry
Eligibility
18 Years and older
Enrollment
129 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
3
States / cities
Savannah, Georgia • Charlotte, North Carolina • Akron, Ohio
Source: ClinicalTrials.gov public record
Updated Apr 20, 2020 · Synced Jul 21, 2026, 9:51 AM EDT
Completed Phase 1Phase 2 Interventional

Study of 3 Doses of NeoFuse Combined With MasterGraft Granules in Subjects Requiring Posterolateral Lumbar Fusion (PLF)

NCT00549913
View directory record Official record
Conditions
Degenerative Disc Disease, Spondylolisthesis, Spinal Stenosis
Interventions
NeoFuse, posterolateral spinal fusion with instrumentation
Biological · Procedure
Lead sponsor
Mesoblast, Ltd.
Industry
Eligibility
18 Years and older
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2013
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jun 28, 2020 · Synced Jul 21, 2026, 9:51 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

ISOVUE Comparative Trial

NCT07363759
View directory record Official record
Conditions
Lumbar Degenerative Disease, Lumbar Degenerative Disc Disease, Degenerative Spine
Interventions
ISOVUE 300 Observation, ISOVUE 300 Feedback
Procedure
Lead sponsor
Rush University Medical Center
Other
Eligibility
18 Years to 100 Years
Enrollment
56 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2023
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jan 22, 2026 · Synced Jul 21, 2026, 9:51 AM EDT
Completed Phase 3 Interventional Results available

Placebo-controlled Study to Evaluate Rexlemestrocel-L Alone or Combined With Hyaluronic Acid in Participants With Chronic Low Back Pain

NCT02412735
View directory record Official record
Conditions
Degenerative Disc Disease
Interventions
Rexlemestrocel-L, Rexlemestrocel-L + HA Mixture, Placebo
Drug
Lead sponsor
Mesoblast, Ltd.
Industry
Eligibility
18 Years and older
Enrollment
404 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2021
U.S. locations
47
States / cities
Birmingham, Alabama • Huntsville, Alabama • Scottsdale, Arizona + 42 more
Source: ClinicalTrials.gov public record
Updated Oct 18, 2022 · Synced Jul 21, 2026, 9:51 AM EDT
Completed Phase 3 Interventional

rhBMP-2/CRM/CD HORIZON® Spinal System Pivotal Study

NCT00707265
View directory record Official record
Conditions
Degenerative Disc Disease
Interventions
rhBMP-2/CRM/CD HORIZON® Spinal System, Autograft/CD HORIZON® Spinal System
Device
Lead sponsor
Medtronic Spinal and Biologics
Industry
Eligibility
18 Years and older
Enrollment
463 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2010
U.S. locations
28
States / cities
Phoenix, Arizona • Orange, California • Santa Monica, California + 25 more
Source: ClinicalTrials.gov public record
Updated May 9, 2023 · Synced Jul 21, 2026, 9:51 AM EDT
Enrolling by invitation No phase listed Observational

Natural Matrix Protein™ (NMP™) Fibers in Cervical and Lumbar Interbody Fusion

NCT06000319
View directory record Official record
Conditions
Degenerative Disc Disease, Degenerative Spondylolisthesis, Spinal Stenosis
Interventions
Natural Matrix Protein (NMP) Fibers, Lumbar interbody fusion, Cervical interbody fusion
Biological · Procedure
Lead sponsor
Induce Biologics USA Inc.
Industry
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Jasper, Alabama
Source: ClinicalTrials.gov public record
Updated Nov 17, 2025 · Synced Jul 21, 2026, 9:51 AM EDT
Completed No phase listed Observational

An Evaluation of Interlaminar Lumbar Instrumented (ILIF™)

NCT01019057
View directory record Official record
Conditions
Degenerative Disc Disease
Interventions
ILIF
Procedure
Lead sponsor
NuVasive
Industry
Eligibility
40 Years and older
Enrollment
77 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2014
U.S. locations
8
States / cities
Phoenix, Arizona • Santa Monica, California • Gainesville, Florida + 5 more
Source: ClinicalTrials.gov public record
Updated Dec 23, 2025 · Synced Jul 21, 2026, 9:51 AM EDT