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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Lumbar Disease Clear all
Completed Early Phase 1 Interventional

Improving Pain and Reducing Opioid Use (IPaRO) in Lumbar Spine Surgery Patients

NCT03088306
View directory record Official record
Conditions
Lumbar Spinal Stenosis, Lumbar Spinal Instability, Lumbar Spine Degeneration
Interventions
Standard analgesia use [Oxygen], Standard analgesia use [Hydromorphone], Standard analgesia use [Volatile Anesthesia], Standard analgesia use [Fentanyl], Multi-modal pain management [Acetaminophen + Gabapentin], Multi-modal pain management [Fentanyl], Multi-modal pain management [Intravenous Ketamine], Multi-modal pain management [Valium + Gabapentin]
Drug
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 100 Years
Enrollment
49 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Oct 15, 2018 · Synced Jul 24, 2026, 7:45 AM EDT
Not listed No phase listed Observational

NOC2 Spine Registry

NCT02187666
View directory record Official record
Conditions
Spinal Disease
Interventions
Not listed
Lead sponsor
DC2 Healthcare
Industry
Eligibility
Not listed
Enrollment
10,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2011
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Jul 10, 2014 · Synced Jul 24, 2026, 7:45 AM EDT
Not listed No phase listed Observational

PMCFU of an Annular Closure System

NCT05467072
View directory record Official record
Conditions
Lumbar Disc Herniation
Interventions
Annular closure
Device
Lead sponsor
Intrinsic Therapeutics
Industry
Eligibility
Not listed
Enrollment
250 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Paducah, Kentucky
Source: ClinicalTrials.gov public record
Updated Sep 28, 2023 · Synced Jul 24, 2026, 7:45 AM EDT
Withdrawn Phase 4 Interventional Accepts healthy volunteers

Quadratus Lumborum vs Erector Spinae Supplementary Blocks With Lumbar Plexus Blocks for Hip PAO

NCT04481451
View directory record Official record
Conditions
Pain, Postoperative, Regional Anesthesia, Hip Dysplasia
Interventions
Erector spinae block with ropivacaine 0.2%, Quadratus lumborum block with ropivacaine 0.2%, Ropivacaine
Procedure · Drug
Lead sponsor
Boston Children's Hospital
Other
Eligibility
15 Years to 30 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2025
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 11, 2025 · Synced Jul 24, 2026, 7:45 AM EDT
Completed Not applicable Interventional

Studying a New Piece of Equipment That Can Help Plan Radiation Therapy of the Spine

NCT04227717
View directory record Official record
Conditions
Thoracic Cancer, Spine Cancer, Thoracic Diseases, Spine Disease, Thoracic Neoplasms, Spine Metastases
Interventions
MRI with custom MRI spine coil
Diagnostic Test
Lead sponsor
Memorial Sloan Kettering Cancer Center
Other
Eligibility
18 Years and older
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 17, 2025 · Synced Jul 24, 2026, 7:45 AM EDT
Active, not recruiting No phase listed Observational

Comparison of Complication Rates Between Initial and Re-operative Anterior Lumbar Interbody Fusion Surgery: Is There a Difference?

NCT05945550
View directory record Official record
Conditions
Lumbar Spondylolisthesis, Lumbar Spine Degeneration
Interventions
Not listed
Lead sponsor
Methodist Health System
Other
Eligibility
18 Years to 85 Years
Enrollment
3,500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2028
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Mar 19, 2026 · Synced Jul 24, 2026, 7:45 AM EDT
Completed No phase listed Observational

Sagittal Plane Correction With Pass-LP Device in Adult Deformity Patients

NCT01635322
View directory record Official record
Conditions
Lumbar or Thoraco-lumbar Adult Deformity
Interventions
Polyaxial posterior spinal fusion system
Device
Lead sponsor
Medicrea International
Industry
Eligibility
21 Years and older
Enrollment
54 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
1
States / cities
Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Mar 27, 2017 · Synced Jul 24, 2026, 7:45 AM EDT
Completed Not applicable Interventional Results available

Post-op Acetaminophen vs NSAID Use on Lumbar Spinal Fusion Outcomes

NCT02700451
View directory record Official record
Conditions
Lumbar Osteoarthritis, Spondylosis, Lumbar Disc Disease, Spinal Stenosis
Interventions
Ketorolac, Acetaminophen, Placebo
Drug
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
18 Years to 75 Years
Enrollment
178 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2023
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 9, 2023 · Synced Jul 24, 2026, 7:45 AM EDT
Completed No phase listed Observational

Osteocel® Plus in Transforaminal Lumbar Interbody Fusion (TLIF)

NCT00947583
View directory record Official record
Conditions
Degenerative Disc Disease
Interventions
Osteocel Plus
Biological
Lead sponsor
NuVasive
Industry
Eligibility
18 Years to 70 Years
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Dec 23, 2025 · Synced Jul 24, 2026, 7:45 AM EDT
Not listed Not applicable Interventional

Supine vs. Upright Weight Bearing MRI in the Evaluation of Patients With Lumbar Spondylolisthesis

NCT02958241
View directory record Official record
Conditions
Spondylolisthesis
Interventions
MRI
Other
Lead sponsor
Texas Back Institute
Other
Eligibility
18 Years and older
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Plano, Texas
Source: ClinicalTrials.gov public record
Updated Nov 7, 2016 · Synced Jul 24, 2026, 7:45 AM EDT
Completed No phase listed Observational Results available

Patient Registry to Observe Outcomes Following Implantation of the VariLift Interbody Fusion Device

NCT01944345
View directory record Official record
Conditions
Prolapsed Lumbar Disc, Prolapsed Cervical Disc, Intervertebral Disc Degeneration, Spondylolisthesis, Grade 1, Intervertebral Disc Displacement
Interventions
Not listed
Lead sponsor
Wenzel Spine
Industry
Eligibility
18 Years to 99 Years
Enrollment
69 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
3
States / cities
Boston, Massachusetts • San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated May 16, 2016 · Synced Jul 24, 2026, 7:45 AM EDT
Recruiting Not applicable Interventional

Examining the Feasibility of Using Pressure Gradient Regulated Automated Cerebral Spinal Fluid Drainage During External Lumbar Drain Trials

NCT07494812
View directory record Official record
Conditions
NPH (Normal Pressure Hydrocephalus)
Interventions
Intellidrop Automated CSF Drainage System
Device
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
60 Years to 99 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Jun 1, 2026 · Synced Jul 24, 2026, 7:45 AM EDT
Completed Not applicable Interventional

Lumbar Manipulation for Hip and Muscle Strength

NCT03101956
View directory record Official record
Conditions
Patellofemoral Pain Syndrome, Anterior Knee Pain Syndrome
Interventions
Lumbar Spine Manipulation, Lumbar Spine Manipulation Placebo
Procedure
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years to 65 Years
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Nov 2, 2020 · Synced Jul 24, 2026, 7:45 AM EDT
Terminated No phase listed Observational

The Effectiveness of Anti-Gravity Treadmill Training

NCT01689922
View directory record Official record
Conditions
Lumbar Degenerative Disc Disease
Interventions
AlterG
Other
Lead sponsor
Justin Parker Neurological Institute
Other
Eligibility
18 Years to 65 Years
Enrollment
27 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
1
States / cities
Boulder, Colorado
Source: ClinicalTrials.gov public record
Updated Feb 28, 2017 · Synced Jul 24, 2026, 7:45 AM EDT
Recruiting Not applicable Interventional

Lumbar Drain vs Extraventricular Drain to Prevent Vasospasm in Subarachnoid Hemorrhage

NCT03065231
View directory record Official record
Conditions
Vasospasm, Intracranial, Subarachnoid Hemorrhage
Interventions
Extraventricular Drain, Lumbar Drain
Device
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years to 110 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2027
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Mar 3, 2025 · Synced Jul 24, 2026, 7:45 AM EDT
Not listed No phase listed Observational

Human Autograft Mesenchymal Stem Cell Mediated Stabilization of The Degenerative Lumbar Spine

NCT02529566
View directory record Official record
Conditions
Lumbar Degenerative Disc Disease, Lower Back Pain, Chronic Lower Back Pain
Interventions
Not listed
Lead sponsor
The Foundation for Spinal Research, Education and Humanitarian Care, Inc.
Industry
Eligibility
18 Years to 85 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2018
U.S. locations
1
States / cities
Odessa, Florida
Source: ClinicalTrials.gov public record
Updated Feb 14, 2017 · Synced Jul 24, 2026, 7:45 AM EDT
Completed Phase 3 Interventional

Titanium Surgical Mesh and MOSS-Miami Screws for Lumbar Fusion.

NCT00215319
View directory record Official record
Conditions
Degenerative Disc Disease
Interventions
Lumbar I/F with cage and pedicle screws
Device
Lead sponsor
DePuy Spine
Industry
Eligibility
18 Years to 79 Years
Enrollment
139 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2000 – 2006
U.S. locations
2
States / cities
Dothan, Alabama • Fort Wayne, Indiana
Source: ClinicalTrials.gov public record
Updated May 22, 2014 · Synced Jul 24, 2026, 7:45 AM EDT
Completed Phase 3 Interventional Results available

A Study of SI-6603 in Patients With Lumbar Disc Herniation

NCT02421601
View directory record Official record
Conditions
Intervertebral Disc Disease, Lumbar Disc Disease
Interventions
Condoliase
Drug
Lead sponsor
Seikagaku Corporation
Industry
Eligibility
30 Years to 70 Years
Enrollment
1,011 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
30
States / cities
Mobile, Alabama • Phoenix, Arizona • Gold River, California + 27 more
Source: ClinicalTrials.gov public record
Updated Mar 22, 2023 · Synced Jul 24, 2026, 7:45 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Epidural Clonidine for Lumbosacral Radiculopathy

NCT00588354
View directory record Official record
Conditions
Lumbar and Other Intervertebral Disc Disorders With Radiculopathy
Interventions
Clonidine, Triamcinolone hexacetonide, Lidocaine HCl
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
26 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2009
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Jan 10, 2012 · Synced Jul 24, 2026, 7:45 AM EDT
Completed Not applicable Interventional Results available

A Multicenter Prospective Study of Quality of Life in Adult Scoliosis

NCT00854828
View directory record Official record
Conditions
Scoliosis
Interventions
Surgical intervention, Non-operative intervention
Procedure · Other
Lead sponsor
Washington University School of Medicine
Other
Eligibility
40 Years to 80 Years
Enrollment
286 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2017
U.S. locations
7
States / cities
Chicago, Illinois • Louisville, Kentucky • Baltimore, Maryland + 3 more
Source: ClinicalTrials.gov public record
Updated Sep 13, 2021 · Synced Jul 24, 2026, 7:45 AM EDT
Completed Not applicable Interventional Results available

Spineology Clinical Outcomes Trial: An IDE Investigation

NCT02347410
View directory record Official record
Conditions
Lumbar Degenerative Disc Disease
Interventions
SIFS graft containment device
Device
Lead sponsor
Spineology, Inc
Industry
Eligibility
21 Years to 80 Years
Enrollment
102 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2020
U.S. locations
10
States / cities
DeLand, Florida • Shreveport, Louisiana • Thibodaux, Louisiana + 7 more
Source: ClinicalTrials.gov public record
Updated Oct 19, 2021 · Synced Jul 24, 2026, 7:45 AM EDT
Terminated Phase 1 Interventional

Autologous, Culture-Expanded Mesenchymal Stromal Cells for Degenerative Disc Disease

NCT03461458
View directory record Official record
Conditions
Degenerative Disc Disease
Interventions
Autologous Adipose-Derived Mesenchymal Stromal Cells
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Jan 24, 2022 · Synced Jul 24, 2026, 7:45 AM EDT
Completed Phase 1 Interventional Results available

Transition From Alendronate to Romosozumab (AMG 785)

NCT01588509
View directory record Official record
Conditions
Osteoporosis
Interventions
Romosozumab
Drug
Lead sponsor
Amgen
Industry
Eligibility
55 Years to 85 Years · Female only
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012
U.S. locations
9
States / cities
Tucson, Arizona • Walnut Creek, California • Gainesville, Georgia + 6 more
Source: ClinicalTrials.gov public record
Updated Mar 25, 2019 · Synced Jul 24, 2026, 7:45 AM EDT
Terminated Not applicable Interventional

Low Back Study to Compare Traditional Physical Therapy With Combined Therapy Protocol

NCT01236092
View directory record Official record
Conditions
Radiculopathy, Low Back Pain
Interventions
conservative therapy - traction, vibration, exercise
Other
Lead sponsor
Michael Wilson & Associates Health Care Consulting, LLC
Industry
Eligibility
25 Years to 65 Years
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
1
States / cities
Spokane, Washington
Source: ClinicalTrials.gov public record
Updated Apr 7, 2015 · Synced Jul 24, 2026, 7:45 AM EDT