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ClinicalTrials.gov public records Last synced Nov 1, 2026, 5:57 AM EST

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Showing 673–696 of 1,755 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Major Depressive Disorders Clear all
Completed Phase 1 Interventional

Use of a Generative AI (Gen-AI) Chatbot for Anxiety and Depression Among Persons With Cannabis Use

NCT06920238
View directory record Official record
Conditions
Cannabis Use Disorder, Anxiety, Depression, Anxiety, Depression - Major Depressive Disorder
Interventions
Therabot-CALM
Device
Lead sponsor
Trustees of Dartmouth College
Other
Eligibility
18 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Lebanon, New Hampshire
Source: ClinicalTrials.gov public record
Updated Jul 6, 2026 · Synced Nov 1, 2026, 5:57 AM EST
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Creatine Augmentation for Adolescent Females With Treatment-Resistant Major Depressive Disorder

NCT02134808
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
Creatine, Placebo
Drug
Lead sponsor
Perry Renshaw
Other
Eligibility
12 Years to 21 Years · Female only
Enrollment
71 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2017
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Jul 3, 2024 · Synced Nov 1, 2026, 5:57 AM EST
Completed Phase 2 Interventional

A Randomized, Double-Blind, Placebo-Controlled, Sequential Parallel Study of CERC-301 in the Adjunctive Treatment of Subjects With Severe Depression and Recent Active Suicidal Ideation Despite Antidepressant Treatment

NCT01941043
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
CERC-301, Placebo
Drug · Other
Lead sponsor
Avalo Therapeutics, Inc.
Industry
Eligibility
18 Years to 70 Years
Enrollment
1,357 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
24
States / cities
Birmingham, Alabama • Phoenix, Arizona • Culver City, California + 21 more
Source: ClinicalTrials.gov public record
Updated Dec 21, 2017 · Synced Nov 1, 2026, 5:57 AM EST
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Testing a Non-Deceptive Placebo Intervention for Subclinical Depressive Symptoms

NCT07889908
View directory record Official record
Conditions
Depression - Major Depressive Disorder, Psychological Distress, Depression / Major Depressive Disorder
Interventions
Non-deceptive placebo (NDP)
Other
Lead sponsor
Miami University
Other
Eligibility
18 Years to 30 Years
Enrollment
330 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Oxford, Ohio
Source: ClinicalTrials.gov public record
Updated Oct 22, 2026 · Synced Nov 1, 2026, 5:57 AM EST
Terminated Phase 4 Interventional Results available

Effectiveness of Nimodipine Plus Antidepressant Medication in Treating Vascular Depression

NCT00781326
View directory record Official record
Conditions
Depression
Interventions
Nimodipine, Placebo
Drug
Lead sponsor
University of Pittsburgh
Other
Eligibility
50 Years and older
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2009
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 29, 2016 · Synced Nov 1, 2026, 5:57 AM EST
Not yet recruiting Not applicable Interventional

Electrical Vestibular Nerve Stimulation (VeNS) as a Treatment for Major Depressive Disorder (MDD)

NCT06470035
View directory record Official record
Conditions
Major Depressive Disorder \(MDD, Depressive Disorder, Major
Interventions
Active VeNS Device, Sham VeNS Device
Device
Lead sponsor
Neurovalens Ltd.
Industry
Eligibility
18 Years to 80 Years
Enrollment
170 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Aug 9, 2024 · Synced Nov 1, 2026, 5:57 AM EST
Completed Phase 3 Interventional Results available

A Trial of AXS-05 in Patients With Major Depressive Disorder

NCT04019704
View directory record Official record
Conditions
Depression, Major Depressive Disorder
Interventions
AXS-05, Placebo
Drug
Lead sponsor
Axsome Therapeutics, Inc.
Industry
Eligibility
18 Years to 65 Years
Enrollment
327 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019
U.S. locations
43
States / cities
Phoenix, Arizona • Little Rock, Arkansas • Bellflower, California + 39 more
Source: ClinicalTrials.gov public record
Updated Oct 12, 2022 · Synced Nov 1, 2026, 5:57 AM EST
Completed Phase 2Phase 3 Interventional

A Stepped Care Model of Adolescent Depression Treatment in Primary Care

NCT01443715
View directory record Official record
Conditions
Major Depressive Disorder, Dysthymia
Interventions
Stepped Care IPT-A (SCIPT-A), Treatment as Usual
Behavioral
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
13 Years to 20 Years
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Sep 4, 2014 · Synced Nov 1, 2026, 5:57 AM EST
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Brain GABA Levels and Treatment Response in Major Depressive Disorder

NCT00464711
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
Escitalopram
Drug
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2009
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 4, 2017 · Synced Nov 1, 2026, 5:57 AM EST
Completed Phase 3 Interventional

Safety & Efficacy Study of Quetiapine Fumarate (SEROQUEL®) vs. Placebo in Major Depressive Disorder

NCT00320268
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
Quetiapine fumarate
Drug
Lead sponsor
AstraZeneca
Industry
Eligibility
18 Years to 65 Years
Enrollment
600 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2007
U.S. locations
37
States / cities
Little Rock, Arkansas • Newport Beach, California • Northridge, California + 34 more
Source: ClinicalTrials.gov public record
Updated Mar 25, 2009 · Synced Nov 1, 2026, 5:57 AM EST
Completed Phase 2 Interventional Results available

An Efficacy and Safety Study of Sirukumab in Participants With Major Depressive Disorder

NCT02473289
View directory record Official record
Conditions
Depressive Disorder, Major
Interventions
Sirukumab 50 mg, Placebo
Drug
Lead sponsor
Janssen Research & Development, LLC
Industry
Eligibility
21 Years to 64 Years
Enrollment
193 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
24
States / cities
Birmingham, Alabama • Little Rock, Arkansas • Bellflower, California + 21 more
Source: ClinicalTrials.gov public record
Updated Apr 29, 2025 · Synced Nov 1, 2026, 5:57 AM EST
Completed No phase listed Observational Accepts healthy volunteers

Evaluating Brain Responses to Facial Expressions in Major Depressive Disorder

NCT00071123
View directory record Official record
Conditions
Current Major Depressive Disorder, Healthy, Remitted Major Depressive Disorder
Interventions
Not listed
Lead sponsor
National Institute of Mental Health (NIMH)
NIH
Eligibility
18 Years to 55 Years
Enrollment
172 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2003 – 2010
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 2, 2017 · Synced Nov 1, 2026, 5:57 AM EST
Completed Not applicable Interventional

Storytelling Video Intervention for Depressed Primary Care Patients - Open Trial

NCT02309060
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
Storytelling Video Intervention (sTVi)
Behavioral
Lead sponsor
Butler Hospital
Other
Eligibility
18 Years and older
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
2
States / cities
Pawtucket, Rhode Island • Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Jun 25, 2019 · Synced Nov 1, 2026, 5:57 AM EST
Completed Phase 1 Interventional Results available

A Study of LY2216684 in Major Depressive Disorder in Patients Taking Selective Serotonin Reuptake Inhibitors

NCT01263223
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
LY2216684, Placebo
Drug
Lead sponsor
Eli Lilly and Company
Industry
Eligibility
18 Years to 65 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
2
States / cities
St Louis, Missouri • Austin, Texas
Source: ClinicalTrials.gov public record
Updated Oct 23, 2018 · Synced Nov 1, 2026, 5:57 AM EST
Terminated Not applicable Interventional Results available

Effects of Low Dose Ketamine Given at Induction of Anesthesia on Postoperative Mood in Patients With Depressive Symptoms

NCT02422303
View directory record Official record
Conditions
Depression, Major Depressive Disorder
Interventions
ketamine
Drug
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
18 Years to 65 Years · Female only
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Feb 15, 2018 · Synced Nov 1, 2026, 5:57 AM EST
Completed Phase 1 Interventional

Photobiomodulation to Alter Cerebral Blood Flow and to Affect the Emotional Status of Patients With Major Depression

NCT00961454
View directory record Official record
Conditions
Major Depression, Anxiety Disorder, Post-Traumatic Stress Disorder, Substance Abuse Disorder
Interventions
Photobiomodulation with a super-luminous light emitting diode
Device
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 60 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 19, 2009 · Synced Nov 1, 2026, 5:57 AM EST
Withdrawn Phase 4 Interventional

Can Additional Drug Therapy Accelerate Response Time to Antidepressants

NCT00221494
View directory record Official record
Conditions
Depression
Interventions
citalopram + tiodothyronine, or + pindolol, or + placebo
Drug
Lead sponsor
Mark Frye
Other
Eligibility
18 Years to 65 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2004
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jun 1, 2015 · Synced Nov 1, 2026, 5:57 AM EST
Completed Not applicable Interventional

Comparative Effectiveness of Pharmacogenomics for Treatment of Depression

NCT03749629
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
GeneSight Psychotropic test, Canadian Network for Mood and Anxiety Treatment (CANMAT) Best Practice Guidelines
Other
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
201 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 7, 2022 · Synced Nov 1, 2026, 5:57 AM EST
Completed Not applicable Interventional Accepts healthy volunteers

Examining the Effects of Reduced Environmental Stimulation on Anxiety

NCT03051074
View directory record Official record
Conditions
Generalized Anxiety Disorder, Agoraphobia, Panic Disorder, PostTraumatic Stress Disorder, Social Anxiety Disorder, Major Depressive Disorder
Interventions
Floating, Comparison
Behavioral
Lead sponsor
Laureate Institute for Brain Research, Inc.
Other
Eligibility
18 Years to 55 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2019
U.S. locations
1
States / cities
Tulsa, Oklahoma
Source: ClinicalTrials.gov public record
Updated Oct 6, 2023 · Synced Nov 1, 2026, 5:57 AM EST
Recruiting Not applicable Interventional

Pain and Major Depressive Disorder

NCT04556890
View directory record Official record
Conditions
Major Depressive Disorder, Chronic Pain
Interventions
Active rTMS/Active iTBS DFPLC/Sham Pain M1, Active rTMS/Active iTBS
Device
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years to 75 Years
Enrollment
54 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Aug 11, 2026 · Synced Nov 1, 2026, 5:57 AM EST
Recruiting Phase 3 Interventional

A Phase 3 Trial of DT120 for Major Depressive Disorder (Ascend)

NCT07592689
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
Placebo, DT120
Other · Drug
Lead sponsor
Definium Therapeutics US, Inc.
Industry
Eligibility
18 Years to 74 Years
Enrollment
165 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
30
States / cities
Little Rock, Arkansas • Orange, California • San Diego, California + 25 more
Source: ClinicalTrials.gov public record
Updated Oct 23, 2026 · Synced Nov 1, 2026, 5:57 AM EST
Recruiting Not applicable Interventional

Home-Based tDCS Treatment Of Major Depressive Disorder

NCT06976697
View directory record Official record
Conditions
Major Depressive Disorder (MDD)
Interventions
Transcranial direct current stimulation, Sham transcranial direct current stimulation
Device
Lead sponsor
Sooma Medical Inc
Industry
Eligibility
22 Years to 70 Years
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 14, 2026 · Synced Nov 1, 2026, 5:57 AM EST
Completed Phase 4 Interventional

Adjunctive Transcranial Direct Current Stimulation for Cognition in Major Depression

NCT00760097
View directory record Official record
Conditions
Depression
Interventions
Transcranial direct stimulation
Device
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years to 75 Years
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2009
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Feb 6, 2013 · Synced Nov 1, 2026, 5:57 AM EST
Recruiting Phase 2 Interventional

JAK Signaling in Depression

NCT07003997
View directory record Official record
Conditions
Major Depressive Disorder
Interventions
Baricitinib, Placebo
Drug
Lead sponsor
Emory University
Other
Eligibility
25 Years to 55 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2030
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Sep 28, 2026 · Synced Nov 1, 2026, 5:57 AM EST