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ClinicalTrials.gov public records Last synced Oct 23, 2026, 12:38 PM EDT

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Showing 385–408 of 455 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Malaise Clear all
Completed Phase 1 Interventional Results available

Pilot Study of the Safety of a Daily Ethanol Lock for Urinary Catheters in Critically Ill Children

NCT01865708
View directory record Official record
Conditions
Complication of Urinary Catheter
Interventions
Ethanol Lock
Drug
Lead sponsor
Children's Healthcare of Atlanta
Other
Eligibility
6 Months to 17 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Jun 28, 2018 · Synced Oct 23, 2026, 12:38 PM EDT
Completed No phase listed Observational

Prospective Cohort Study of Intravenous Lipid Emulsion for Resuscitating Critically-ill Poisoned Patients

NCT03107689
View directory record Official record
Conditions
Overdose
Interventions
administration of intravenous lipid emulsion
Other
Lead sponsor
University of Southern California
Other
Eligibility
Not listed
Enrollment
134 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2018
U.S. locations
2
States / cities
Phoenix, Arizona • Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Mar 1, 2024 · Synced Oct 23, 2026, 12:38 PM EDT
Completed Not applicable Interventional

Retrospective Data Analysis of VitalCare Targeted Population Management on Scott and White Chronically Ill Beneficiaries

NCT01912430
View directory record Official record
Conditions
Chronic Illness
Interventions
ICC (Integrated Care Coaching) Intervention Group
Behavioral
Lead sponsor
Scott & White Health Plan
Industry
Eligibility
18 Years and older
Enrollment
17,559 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012
U.S. locations
1
States / cities
Temple, Texas
Source: ClinicalTrials.gov public record
Updated Aug 1, 2013 · Synced Oct 23, 2026, 12:38 PM EDT
Completed Phase 4 Interventional Results available

Pharmacokinetics of Tamiflu® (Oseltamivir) in Patients Receiving Extracorporeal Membrane Oxygenation (ECMO)and or Continuous Venovenous Hemodialysis (CVVHD)

NCT01048879
View directory record Official record
Conditions
Critically Ill Renal Failure Requiring CVVHD and Oseltamivir, Critically Ill Requiring ECMO and Oseltamivir
Interventions
pharmacokinetic blood sampling, pharmacokinetic blood and dialysate sampling
Procedure
Lead sponsor
University of Michigan
Other
Eligibility
Not listed
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Aug 21, 2012 · Synced Oct 23, 2026, 12:38 PM EDT
Completed Not applicable Interventional Results available

Genomic Medicine for Ill Neonates and Infants (The GEMINI Study)

NCT03890679
View directory record Official record
Conditions
Pediatric: Genetic Syndrome
Interventions
rapid whole genomic sequencing (rWGS)
Diagnostic Test
Lead sponsor
Tufts Medical Center
Other
Eligibility
1 Day to 1 Year
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
6
States / cities
San Diego, California • Boston, Massachusetts • New York, New York + 3 more
Source: ClinicalTrials.gov public record
Updated Aug 6, 2025 · Synced Oct 23, 2026, 12:38 PM EDT
Withdrawn Not applicable Interventional

Optimal Protein Supplementation for Critically Ill Patients

NCT01934595
View directory record Official record
Conditions
Critical Illness
Interventions
Beneprotein
Dietary Supplement
Lead sponsor
University of Oklahoma
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
1
States / cities
Oklahoma City, Oklahoma
Source: ClinicalTrials.gov public record
Updated Jun 7, 2017 · Synced Oct 23, 2026, 12:38 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Gluconeogenesis Rates and Its Precursors in Pediatric Sepsis

NCT01890928
View directory record Official record
Conditions
Sepsis, Hyperglycemia, Critical Illness
Interventions
Not listed
Lead sponsor
The Cleveland Clinic
Other
Eligibility
5 Years to 19 Years
Enrollment
19 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2013
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Apr 28, 2016 · Synced Oct 23, 2026, 12:38 PM EDT
Not yet recruiting Not applicable Interventional

Abstinence Reinforcement Therapy for Veterans Who Smoke Tobacco and Are Experiencing Homelessness

NCT07714200
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
Cognitive Behavioral Therapy for Smoking Cessation, Nicotine Replacement Therapy, Bupropion, Varenicline, Mobile Contingency Management, Clinic-Based Smoking Cessation Counseling
Behavioral · Drug
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2027 – 2030
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 20, 2026 · Synced Oct 23, 2026, 12:38 PM EDT
Completed Not applicable Interventional Results available

Clinical Effectiveness of the "PICU Up!" Multifaceted Early Mobility Intervention for Critically Ill Children

NCT04989790
View directory record Official record
Conditions
Child, Intensive Care Unit Acquired Weakness, Critical Illness, Hospital Acquired Pressure Ulcer
Interventions
PICU Up!
Other
Lead sponsor
Johns Hopkins University
Other
Eligibility
Not listed
Enrollment
1,470 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
11
States / cities
Madera, California • Orlando, Florida • Louisville, Kentucky + 8 more
Source: ClinicalTrials.gov public record
Updated Oct 1, 2026 · Synced Oct 23, 2026, 12:38 PM EDT
Completed Phase 4 Interventional

Study of the Use of Coated Venous Catheters in the Critically Ill Child

NCT00202813
View directory record Official record
Conditions
Children in the Pediatric Intensive Care Unit or General Pediatric Care Unit Requiring a Central Venous Catheter
Interventions
Cook Spectrum Pediatric Central Venous Catheter Anti-microbial Impregnated Polyurethane and Arrow Pediatric Central Venous Catheter
Device
Lead sponsor
Corewell Health West
Other
Eligibility
Up to 18 Years
Enrollment
500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2005
U.S. locations
1
States / cities
Grand Rapids, Michigan
Source: ClinicalTrials.gov public record
Updated Apr 8, 2024 · Synced Oct 23, 2026, 12:38 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Quetiapine for Delirium Prophylaxis in High-risk Critically Ill Patients

NCT02612948
View directory record Official record
Conditions
Psychomotor Agitation
Interventions
Quetiapine
Drug
Lead sponsor
University of Tennessee Graduate School of Medicine
Other
Eligibility
18 Years to 100 Years
Enrollment
82 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2014
U.S. locations
1
States / cities
Knoxville, Tennessee
Source: ClinicalTrials.gov public record
Updated Nov 24, 2015 · Synced Oct 23, 2026, 12:38 PM EDT
Completed Not applicable Interventional

Family Support Intervention in Intensive Care Units (The Four Supports Study)

NCT01107704
View directory record Official record
Conditions
Physician-Family Communication in Intensive Care Units, Surrogate Decision-making for Critically Ill Patients
Interventions
Family Support Intervention
Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
50 Years and older
Enrollment
159 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 27, 2014 · Synced Oct 23, 2026, 12:38 PM EDT
Completed Phase 4 Interventional Results available

Effects of Intravenous Acetaminophen on Body Temperature and Hemodynamic Responses in Febrile Critically Ill Adults

NCT01869699
View directory record Official record
Conditions
Fever, Critical Illness
Interventions
Acetaminophen, Placebo
Drug
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
41 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
2
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Aug 9, 2017 · Synced Oct 23, 2026, 12:38 PM EDT
Completed Not applicable Interventional

Feasibility Trial of the Early Psychological Support for the Critically Ill

NCT02739022
View directory record Official record
Conditions
PICS
Interventions
Early Psychological Support for the Critically Ill (EPSCI)
Behavioral
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 99 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Mar 1, 2023 · Synced Oct 23, 2026, 12:38 PM EDT
Completed Not applicable Interventional Results available

Enhanced Protein-Energy Provision Via the Enteral Route in Critically Ill Patients

NCT01167595
View directory record Official record
Conditions
Critically Ill
Interventions
PEP uP Protocol
Other
Lead sponsor
Clinical Evaluation Research Unit at Kingston General Hospital
Other
Eligibility
18 Years and older
Enrollment
1,059 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
9
States / cities
Phoenix, Arizona • Loveland, Colorado • Washington D.C., District of Columbia + 6 more
Source: ClinicalTrials.gov public record
Updated Apr 28, 2021 · Synced Oct 23, 2026, 12:38 PM EDT
Completed No phase listed Interventional Results available

Validation of Noninvasive Hemoglobin, Comparison of PVI to Standard Methods, and Validation of Clinical Efficacy of ORI

NCT02841397
View directory record Official record
Conditions
Surgery
Interventions
Masimo Pulse CO-Oximeter
Device
Lead sponsor
Masimo Corporation
Industry
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Oct 21, 2021 · Synced Oct 23, 2026, 12:38 PM EDT
Terminated Phase 1 Interventional Results available

DOSE Trial of Opioid Sparing Effect

NCT03938857
View directory record Official record
Conditions
Dexmedetomidine, Mechanical Ventilation Complication, Critically Ill
Interventions
Fentanyl, Dexmedetomidine
Drug
Lead sponsor
Duke University
Other
Eligibility
Up to 18 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
19
States / cities
Little Rock, Arkansas • Gainesville, Florida • Indianapolis, Indiana + 15 more
Source: ClinicalTrials.gov public record
Updated Nov 5, 2021 · Synced Oct 23, 2026, 12:38 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Testing of a New Therapeutic Vibration Device to Reduce Neuromuscular Weakness in Hospitalized Patients

NCT03479008
View directory record Official record
Conditions
Critically Ill, Post Intensive Care Syndrome
Interventions
Therapeutic Vibration Device
Diagnostic Test
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated May 30, 2024 · Synced Oct 23, 2026, 12:38 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Developing and Testing a Nurse-Led Technology-Enhanced Family Engagement Program

NCT06128655
View directory record Official record
Conditions
Critical Illness
Interventions
Participation in PFCC-IR
Other
Lead sponsor
Rutgers, The State University of New Jersey
Other
Eligibility
18 Years to 80 Years
Enrollment
29 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Camden, New Jersey
Source: ClinicalTrials.gov public record
Updated Mar 7, 2025 · Synced Oct 23, 2026, 12:38 PM EDT
Completed Phase 1 Interventional

Effect of Stellate Ganglion Block on ME/CFS

NCT05664711
View directory record Official record
Conditions
Encephalomyelitis, Myalgic, Chronic Fatigue Syndrome, Chronic Fatigue Disorder, Chronic Fatigue and Immune Dysfunction Syndrome, Myalgic Encephalomyelitis, Postviral Fatigue Syndrome, Systemic Exertion Intolerance Disease, Infectious Mononucleosis-Like Syndrome, Chronic, Chronic Fatigue-Fibromyalgia Syndrome
Interventions
Bupivacaine Injection
Drug
Lead sponsor
Neuroversion, Inc.
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Anchorage, Alaska
Source: ClinicalTrials.gov public record
Updated Dec 6, 2024 · Synced Oct 23, 2026, 12:38 PM EDT
Completed Not applicable Interventional

Study of High Blood Sugars and Insulin in Hospitalized, Critically Ill Children

NCT00487006
View directory record Official record
Conditions
Critical Illness, Hyperglycemia
Interventions
Serum Lab testing
Other
Lead sponsor
Children's Healthcare of Atlanta
Other
Eligibility
2 Years to 12 Years
Enrollment
209 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2015
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Jun 16, 2015 · Synced Oct 23, 2026, 12:38 PM EDT
Completed Phase 4 Interventional

Olanzapine Versus Aripiprazole in the Treatment of Acutely Ill Patients With Schizophrenia

NCT00103571
View directory record Official record
Conditions
Schizophrenia
Interventions
Olanzapine, Aripiprazole
Drug
Lead sponsor
Eli Lilly and Company
Industry
Eligibility
18 Years to 55 Years
Enrollment
600 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2006
U.S. locations
4
States / cities
Saint Charles, Missouri • Beachwood, Ohio • Canton, Ohio + 1 more
Source: ClinicalTrials.gov public record
Updated Nov 6, 2007 · Synced Oct 23, 2026, 12:38 PM EDT
Withdrawn Phase 2 Interventional

Polypharmacy-related Adverse Events in Critically Ill Children

NCT03293927
View directory record Official record
Conditions
Delirium
Interventions
Fentanyl, Dexmedetomidine
Drug
Lead sponsor
Duke University
Other
Eligibility
2 Years to 17 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 18, 2019 · Synced Oct 23, 2026, 12:38 PM EDT
Not listed Phase 2 Interventional

Selenium as a Potential Treatment for Moderately-ill, Severely-ill, and Critically-ill COVID-19 Patients.

NCT04869579
View directory record Official record
Conditions
Covid19
Interventions
Selenium (as Selenious Acid), Placebo
Drug · Other
Lead sponsor
CHRISTUS Health
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021
U.S. locations
1
States / cities
Longview, Texas
Source: ClinicalTrials.gov public record
Updated Aug 3, 2021 · Synced Oct 23, 2026, 12:38 PM EDT