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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Malocclusion Clear all
Completed Not applicable Interventional Results available

Clinical Performance of a New Esthetic, Self-ligating Orthodontic Bracket

NCT02959671
View directory record Official record
Conditions
Malocclusion
Interventions
Lower Anterior EXD-952 Self-ligating Brackets
Device
Lead sponsor
University of Minnesota
Other
Eligibility
10 Years and older
Enrollment
34 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Jan 13, 2021 · Synced Jun 10, 2026, 12:57 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Effect of AcceleDent® Aura on Orthodontic Tooth Movement With Aligners

NCT01962012
View directory record Official record
Conditions
Malocclusion
Interventions
AcceleDent Aura, Sham Device
Device
Lead sponsor
OrthoAccel Technologies Inc.
Industry
Eligibility
18 Years to 40 Years
Enrollment
46 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2016
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Sep 27, 2016 · Synced Jun 10, 2026, 12:57 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

A Comparison Between GUMMETAL and SS Orthodontic Wires in Space Closure

NCT04591080
View directory record Official record
Conditions
Malocclusion, Angle Class I
Interventions
GUMMETAL Orthodontic Wire, Stainless Steel (CrNi)
Device
Lead sponsor
State University of New York at Buffalo
Other
Eligibility
12 Years to 17 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated May 29, 2025 · Synced Jun 10, 2026, 12:57 PM EDT
Completed Phase 3 Interventional Results available

Effect of Cyclic Loading (Vibration) on Orthodontic Tooth Movement

NCT00830947
View directory record Official record
Conditions
Malocclusion
Interventions
OrthoAccel Device, Sham Device
Device
Lead sponsor
OrthoAccel Technologies Inc.
Industry
Eligibility
12 Years to 40 Years
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Dec 22, 2013 · Synced Jun 10, 2026, 12:57 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

A Comparison of the Alignment Achieved Using Computer-guided Indirect Bonding of Orthodontic Brackets to Conventional Appliance Placement

NCT02221856
View directory record Official record
Conditions
Malocclusion
Interventions
Motion View, Conventional Orthodontic Treatment
Procedure
Lead sponsor
Harvard School of Dental Medicine
Other
Eligibility
Up to 60 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 8, 2017 · Synced Jun 10, 2026, 12:57 PM EDT
Completed Not applicable Interventional Results available

Effect of Intra-Oral Photobiomodulation on Orthodontic Treatment Time

NCT02267850
View directory record Official record
Conditions
Malocclusion
Interventions
Fixed Orthodontic Appliance Treatment, OrthoPulse™, Non-Functional OrthoPulse™
Other · Device
Lead sponsor
Biolux Research Holdings, Inc.
Industry
Eligibility
12 Years to 40 Years
Enrollment
29 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
1
States / cities
Suwanee, Georgia
Source: ClinicalTrials.gov public record
Updated Sep 20, 2018 · Synced Jun 10, 2026, 12:57 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Pain and Activity Levels After Orthodontic Separators

NCT05615688
View directory record Official record
Conditions
Dental Malocclusion
Interventions
Pain Intensity following Placement of Orthodontic Separators
Procedure
Lead sponsor
Lina Sharab
Other
Eligibility
15 Years to 49 Years
Enrollment
94 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2025
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Oct 15, 2025 · Synced Jun 10, 2026, 12:57 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

One Week Aligner Evaluation

NCT02603289
View directory record Official record
Conditions
Malocclusion
Interventions
Invisalign
Device
Lead sponsor
Align Technology, Inc.
Industry
Eligibility
Not listed
Enrollment
287 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2020
U.S. locations
23
States / cities
Livermore, California • Napa, California • San Francisco, California + 20 more
Source: ClinicalTrials.gov public record
Updated Oct 19, 2020 · Synced Jun 10, 2026, 12:57 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Effect of Clear Aligner Attachment Design on Extrusion of Maxillary Lateral Incisors

NCT04968353
View directory record Official record
Conditions
Maxillary Lateral Incisor Malocclusion
Interventions
Incisally-beveled attachment, Gingivally-beveled attachment, Optimized attachment, Horizontal attachment
Device
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
16 Years and older
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Jun 27, 2023 · Synced Jun 10, 2026, 12:57 PM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Changes in Upper Airway Anatomy, Quality of Life Measures, and Polysomnographic Parameters Using A Functional Dental Appliance

NCT02805764
View directory record Official record
Conditions
Obstructive Sleep Apnea, Malocclusion
Interventions
Homeoblock
Device
Lead sponsor
Montefiore Medical Center
Other
Eligibility
18 Years to 65 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Feb 4, 2019 · Synced Jun 10, 2026, 12:57 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Precision Orthodontics: Virtual Treatment Planning for Orthodontic Braces

NCT04002999
View directory record Official record
Conditions
Malocclusion, Malocclusion, Angle's Class
Interventions
3D printed ceramic bracket and tray, Stock ceramic bracket + 3D printed tray, Stock bracket, no tray
Device
Lead sponsor
Harvard School of Dental Medicine
Other
Eligibility
11 Years to 65 Years
Enrollment
51 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 11, 2020 · Synced Jun 10, 2026, 12:57 PM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Exploration of the Utility of Dental-dedicated MRI for Dentistry

NCT06948162
View directory record Official record
Conditions
Dental Crowding, Dental Occlusion, Traumatic, Dental Pain, TMD/Orofacial Pain, TMD, Orthodontics, Endodontic Disease, Orthodontic Treatment
Interventions
dental-dedicated MRI (ddMRI)
Device
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years and older
Enrollment
300 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated May 19, 2026 · Synced Jun 10, 2026, 12:57 PM EDT
Completed Not applicable Interventional Results available

Alveolar Microperforation for Inflammation-Enhanced Tooth Movement During Orthodontic Treatment

NCT01720797
View directory record Official record
Conditions
Malocclusion
Interventions
Micro-osteoperforation, Anesthestic, Chlorhexidine
Device · Drug · Other
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 55 Years
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Jun 18, 2015 · Synced Jun 10, 2026, 12:57 PM EDT
Recruiting Not applicable Interventional

Bromelain for Post-surgery Facial Swelling

NCT07115212
View directory record Official record
Conditions
Malocclusion
Interventions
Bromelain
Dietary Supplement
Lead sponsor
Mohamed Bazina
Other
Eligibility
18 Years to 65 Years
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Jun 4, 2026 · Synced Jun 10, 2026, 12:57 PM EDT
Terminated No phase listed Observational Accepts healthy volunteers

Three-dimensional Assessment of Craniofacial Structures

NCT01210547
View directory record Official record
Conditions
Malocclusion
Interventions
Not listed
Lead sponsor
University of Minnesota
Other
Eligibility
Not listed
Enrollment
58 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2017
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Nov 5, 2017 · Synced Jun 10, 2026, 12:57 PM EDT
Not listed Not applicable Interventional

Orthodontic Archwire Comparison Trial

NCT02983084
View directory record Official record
Conditions
Malocclusion
Interventions
Orthodontic archwire
Device
Lead sponsor
Ormco Corporation
Industry
Eligibility
18 Years and older
Enrollment
105 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Jan 14, 2019 · Synced Jun 10, 2026, 12:57 PM EDT
Recruiting Not applicable Interventional

Hyrax Vs. Invisalign Palatal Expander Clinical Study

NCT06662279
View directory record Official record
Conditions
Malocclusions, Narrow Maxilla, Narrow Maxillary Arch, Crowding
Interventions
Removable Rapid Palatal Expander, Banded Palatal Expander
Device
Lead sponsor
Align Technology, Inc.
Industry
Eligibility
6 Years to 11 Years
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
4
States / cities
Laguna Hills, California • Warner Robins, Georgia • Naperville, Illinois + 1 more
Source: ClinicalTrials.gov public record
Updated Dec 3, 2024 · Synced Jun 10, 2026, 12:57 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Clinical Effectiveness of Late Maxillary Protraction for Cleft Lip and Palate

NCT02789787
View directory record Official record
Conditions
Cleft Lip and Palate
Interventions
Maxillary Protraction, Orthognathic Surgery
Procedure
Lead sponsor
University of Southern California
Other
Eligibility
11 Years to 21 Years
Enrollment
117 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2021
U.S. locations
2
States / cities
Los Angeles, California • Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Oct 10, 2021 · Synced Jun 10, 2026, 12:57 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

RCT Comparing Invisalign and Traditional Orthodontic Treatment

NCT04556448
View directory record Official record
Conditions
Malocclusion, Angle Class II
Interventions
Aligners, Clear braces
Other
Lead sponsor
Texas A&M University
Other
Eligibility
17 Years and older
Enrollment
78 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2019
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Sep 20, 2020 · Synced Jun 10, 2026, 12:57 PM EDT
Completed Not applicable Interventional Results available

The Effects of Extraoral Photobiomodulation on the Rate of Orthodontic Alignment

NCT02267824
View directory record Official record
Conditions
Malocclusion
Interventions
Extraoral OrthoPulse® PBM, Fixed Orthodontic Appliance Treatment
Device · Other
Lead sponsor
Biolux Research Holdings, Inc.
Industry
Eligibility
11 Years to 40 Years
Enrollment
101 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
2
States / cities
Birmingham, Alabama • Suwanee, Georgia
Source: ClinicalTrials.gov public record
Updated Aug 26, 2018 · Synced Jun 10, 2026, 12:57 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Carriere Motion Appliance* Versus In-office Sectional Appliance

NCT05204654
View directory record Official record
Conditions
Angle Class 2 Malocclusion
Interventions
In-office fabricated appliance, Carriere Motion Appliance
Other · Device
Lead sponsor
State University of New York at Buffalo
Other
Eligibility
12 Years to 17 Years
Enrollment
4 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Mar 16, 2025 · Synced Jun 10, 2026, 12:57 PM EDT
Completed No phase listed Observational

Focused Registry to Collect Clinical Data on the MatrixWAVE System

NCT03405389
View directory record Official record
Conditions
Mandibular Fractures
Interventions
MatrixWAVE MMF System
Procedure
Lead sponsor
AO Innovation Translation Center
Other
Eligibility
18 Years and older
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2025
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Sep 15, 2025 · Synced Jun 10, 2026, 12:57 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Primer Aligner Study

NCT02550938
View directory record Official record
Conditions
Malocclusion
Interventions
Invisalign
Device
Lead sponsor
Align Technology, Inc.
Industry
Eligibility
18 Years and older
Enrollment
253 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2020
U.S. locations
13
States / cities
Anthem, Arizona • Napa, California • Oakland, California + 10 more
Source: ClinicalTrials.gov public record
Updated Feb 2, 2021 · Synced Jun 10, 2026, 12:57 PM EDT
Completed Not applicable Interventional Results available

The Effect of OrthoPulse™ on the Rate of Orthodontic Tooth Movement

NCT02267811
View directory record Official record
Conditions
Malocclusion
Interventions
Orthodontic Treatment, OrthoPulse™
Other · Device
Lead sponsor
Biolux Research Holdings, Inc.
Industry
Eligibility
11 Years to 60 Years
Enrollment
33 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated May 20, 2019 · Synced Jun 10, 2026, 12:57 PM EDT