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Showing 1–24 of 156 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Melatonin Clear all
Recruiting Not applicable Interventional Accepts healthy volunteers

Disease Modifying Potential of 5mg of Melatonin on Cognition and Brain Health in Aging

NCT03954899
View directory record Official record
Conditions
Mild Cognitive Impairment, Cognitive Decline, Healthy Aging
Interventions
melatonin, placebo
Dietary Supplement · Other
Lead sponsor
Natalie Denburg
Other
Eligibility
56 Years to 85 Years
Enrollment
230 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2025
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Mar 3, 2025 · Synced Jul 23, 2026, 3:39 PM EDT
Terminated Phase 2 Interventional Accepts healthy volunteers Results available

Melatonin and Ulcerative Colitis: A Pilot Clinical Trial

NCT00790478
View directory record Official record
Conditions
Ulcerative Colitis
Interventions
Melatonin, Placebo
Drug · Other
Lead sponsor
Emory University
Other
Eligibility
18 Years to 69 Years
Enrollment
3 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2010
U.S. locations
2
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Feb 11, 2021 · Synced Jul 23, 2026, 3:39 PM EDT
Terminated Not applicable Interventional Results available

Blind Child Melatonin Treatment Study

NCT00691444
View directory record Official record
Conditions
Blindness
Interventions
Melatonin, Melatonin
Dietary Supplement · Biological
Lead sponsor
Oregon Health and Science University
Other
Eligibility
5 Years to 20 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2015
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Nov 26, 2019 · Synced Jul 23, 2026, 3:39 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers Results available

Multiple Dose Study Of BIIB118 (PF-05251749) In Healthy Volunteers

NCT02691702
View directory record Official record
Conditions
Healthy Adult Subjects, Healthy Elderly Subjects
Interventions
BIIB118, Melatonin
Drug
Lead sponsor
Biogen
Industry
Eligibility
18 Years to 85 Years
Enrollment
97 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
2
States / cities
South Miami, Florida
Source: ClinicalTrials.gov public record
Updated Feb 16, 2021 · Synced Jul 23, 2026, 3:39 PM EDT
Withdrawn Phase 4 Interventional

Melatonin for Prevention of Post- Operative Delirium Pilot Study Protocol

NCT02903901
View directory record Official record
Conditions
Delirium
Interventions
Melatonin, Placebo
Drug
Lead sponsor
Loyola University
Other
Eligibility
65 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
1
States / cities
Maywood, Illinois
Source: ClinicalTrials.gov public record
Updated Sep 15, 2016 · Synced Jul 23, 2026, 3:39 PM EDT
Recruiting Early Phase 1 Interventional Accepts healthy volunteers

Effect of Melatonin on Sleep Patterns of Resident Trainees During Night Float Shift

NCT05701969
View directory record Official record
Conditions
Sleep Disorders, Circadian Rhythm
Interventions
Melatonin, Placebo
Dietary Supplement · Other
Lead sponsor
University of Virginia
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2028
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated May 3, 2026 · Synced Jul 23, 2026, 3:39 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Functional Melatonin Replacement for Sleep Disruptions in Individuals With Tetraplegia

NCT00507546
View directory record Official record
Conditions
Insomnia, Spinal Cord Injury, Tetraplegia, Sleep Disorders
Interventions
Ramelteon, Placebo
Drug
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
18 Years to 65 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2011
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated May 21, 2014 · Synced Jul 23, 2026, 3:39 PM EDT
Completed Early Phase 1 Interventional Results available

Melatonin Versus Placebo in Breast Cancer

NCT01805089
View directory record Official record
Conditions
Breast Cancer
Interventions
Melatonin 3 mg
Drug
Lead sponsor
Dana-Farber Cancer Institute
Other
Eligibility
18 Years and older · Female only
Enrollment
95 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2009
U.S. locations
2
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 22, 2015 · Synced Jul 23, 2026, 3:39 PM EDT
Completed Phase 2 Interventional Results available

Pilot Study of Melatonin and Epilepsy

NCT00965575
View directory record Official record
Conditions
Epilepsy
Interventions
Melatonin, Placebos
Drug
Lead sponsor
Children's Hospital Medical Center, Cincinnati
Other
Eligibility
6 Years to 11 Years
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 30, 2020 · Synced Jul 23, 2026, 3:39 PM EDT
Completed Phase 2 Interventional

Effects of Hydrocortisone, Melatonin, and Placebo on Jet Lag

NCT00097474
View directory record Official record
Conditions
Jet Lag
Interventions
Hydrocortisone, Melatonin, Placebo
Drug
Lead sponsor
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NIH
Eligibility
18 Years to 65 Years
Enrollment
57 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2007
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 16, 2026 · Synced Jul 23, 2026, 3:39 PM EDT
Terminated Phase 3 Interventional Results available

Prevention of Delirium in Inpatients Utilizing Melatonin

NCT02654314
View directory record Official record
Conditions
Delirium
Interventions
Melatonin, Placebo
Drug · Other
Lead sponsor
Yale University
Other
Eligibility
65 Years and older
Enrollment
277 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Mar 20, 2022 · Synced Jul 23, 2026, 3:39 PM EDT
Completed Phase 3 Interventional

Study of Melatonin: Sleep Problems in Alzheimer's Disease

NCT00000171
View directory record Official record
Conditions
Alzheimer Disease, Dyssomnias
Interventions
Melatonin
Drug
Lead sponsor
National Institute on Aging (NIA)
NIH
Eligibility
55 Years and older
Healthy volunteers
Healthy volunteers not accepted
U.S. locations
31
States / cities
Tucson, Arizona • Irvine, California • La Jolla, California + 26 more
Source: ClinicalTrials.gov public record
Updated Jun 23, 2005 · Synced Jul 23, 2026, 3:39 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Individually Tailored Lighting System to Improve Sleep in Older Adults

NCT01855126
View directory record Official record
Conditions
Sleep Disturbances
Interventions
Blue light, Red light
Other
Lead sponsor
Rensselaer Polytechnic Institute
Other
Eligibility
65 Years and older
Enrollment
46 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2017
U.S. locations
1
States / cities
Troy, New York
Source: ClinicalTrials.gov public record
Updated Jan 28, 2019 · Synced Jul 23, 2026, 3:39 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Exploratory Study of Melatonin Induced Sleep Regularization in Severe Brain Injury

NCT02732288
View directory record Official record
Conditions
Disorders of Consciousness
Interventions
melatonin
Dietary Supplement
Lead sponsor
Rockefeller University
Other
Eligibility
18 Years to 65 Years
Enrollment
1 participant
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2018
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated May 29, 2023 · Synced Jul 23, 2026, 3:39 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Investigating the Effects of Evening Light Exposure on Melatonin Suppression, Alertness and Nocturnal Sleep

NCT01586039
View directory record Official record
Conditions
Non-visual Photoreception
Interventions
Visible light
Device
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years to 30 Years
Enrollment
33 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2014
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 13, 2021 · Synced Jul 23, 2026, 3:39 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Melatonin-Micronutrients for Osteopenia Treatment Study

NCT01870115
View directory record Official record
Conditions
Osteoporosis, Osteopenia
Interventions
Fiber Pill, Melatonin, Strontium citrate, Vitamins D3 and K2
Dietary Supplement
Lead sponsor
Duquesne University
Other
Eligibility
Female only
Enrollment
23 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2017
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 13, 2018 · Synced Jul 23, 2026, 3:39 PM EDT
Recruiting Phase 4 Interventional

Buspirone and Melatonin for Depression Following Traumatic Brain Injury

NCT04400266
View directory record Official record
Conditions
Depression, Brain Injuries, Traumatic
Interventions
Buspirone, Mealatonin
Drug
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 64 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2028
U.S. locations
2
States / cities
Boston, Massachusetts • Charlestown, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 5, 2026 · Synced Jul 23, 2026, 3:39 PM EDT
Recruiting Not applicable Interventional

Melatonin Adolescent Research Study

NCT04588233
View directory record Official record
Conditions
Sleep Disorders in Children
Interventions
Melatonin, Placebo
Dietary Supplement · Other
Lead sponsor
Loma Linda University
Other
Eligibility
13 Years to 17 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2027
U.S. locations
2
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Jul 9, 2026 · Synced Jul 23, 2026, 3:39 PM EDT
Terminated Phase 2 Interventional Accepts healthy volunteers Results available

Effects of Melatonin Supplementation on Renal Physiology in a Habitual Sleep Restricted Population.

NCT02631148
View directory record Official record
Conditions
Obesity, Prediabetic State
Interventions
Melatonin, Placebo
Drug
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years and older
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 29, 2021 · Synced Jul 23, 2026, 3:39 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Interaction of Melatonin With MTNR1B Genotype on Glucose Control - Study 2

NCT03464084
View directory record Official record
Conditions
Glucose, Circadian Rhythm, Melatonin, Genes, Light
Interventions
placebo, melatonin, bright light, dim light
Drug · Dietary Supplement · Other
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
21 Years to 55 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2022
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 25, 2022 · Synced Jul 23, 2026, 3:39 PM EDT
Completed No phase listed Observational

Fatigue, Sleep and Cytokines in Primary Brain Tumor (PBT) Patients

NCT00876499
View directory record Official record
Conditions
Brain Cancer
Interventions
Questionnaire
Behavioral
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2013
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jan 8, 2015 · Synced Jul 23, 2026, 3:39 PM EDT
Not listed Phase 2Phase 3 Interventional Accepts healthy volunteers

Different Doses of Oral Melatonin Supplements in Chronic Kidney Disease (CKD)-Associated Sleep Disorders

NCT01922999
View directory record Official record
Conditions
End Stage Renal Disease, Chronic Kidney Disease, Sleep Disorder
Interventions
Melatonin
Drug
Lead sponsor
Southeast Renal Research Institute
Other
Eligibility
18 Years to 85 Years
Enrollment
53 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2017
U.S. locations
1
States / cities
Chattanooga, Tennessee
Source: ClinicalTrials.gov public record
Updated Jan 23, 2017 · Synced Jul 23, 2026, 3:39 PM EDT
Terminated Phase 1 Interventional Results available

Melatonin Postoperative Sleep Study in Breast Cancer Patients

NCT00506064
View directory record Official record
Conditions
Breast Cancer
Interventions
Melatonin, Placebo, Questionnaire
Drug · Behavioral
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
40 Years and older
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2008
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Dec 4, 2012 · Synced Jul 23, 2026, 3:39 PM EDT
Withdrawn Phase 2 Interventional

Melatonin Supplementation to Improve Sleep in Patients With Heart Failure

NCT00869869
View directory record Official record
Conditions
Heart Failure, Sleep Disorders
Interventions
melatonin, placebo
Drug
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
35 Years to 75 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 18, 2018 · Synced Jul 23, 2026, 3:39 PM EDT