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ClinicalTrials.gov public records Last synced Oct 19, 2026, 3:13 PM EDT

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Showing 361–384 of 1,861 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Mental Disorders, Severe Clear all

Conditions: Major Depressive Disorder
Interventions: LY2216684, Placebo; Drug
Lead sponsor: Eli Lilly and Company; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 24 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2011
U.S. locations: 2
States / cities: St Louis, Missouri • Austin, Texas

Conditions: Major Depressive Disorder
Interventions: CYB003; Drug
Lead sponsor: Cybin IRL Limited; Industry
Eligibility: 18 Years to 85 Years
Enrollment: 468 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2028
U.S. locations: 42
States / cities: Phoenix, Arizona • Glendale, California • La Jolla, California + 32 more

Conditions: Depressive Disorder, Major
Interventions: vilazodone; Drug
Lead sponsor: Genaissance Pharmaceuticals; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 410 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2007
U.S. locations: 15
States / cities: Los Alamitos, California • Newport Beach, California • Northridge, California + 12 more

Conditions: Major Depressive Disorder (MDD)
Interventions: Cognitive therapy for depression; Behavioral
Lead sponsor: University of California, Berkeley; Other
Eligibility: 18 Years and older
Enrollment: 48 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2015
U.S. locations: 1
States / cities: Berkeley, California

Conditions: Psychosis, Substance Use Disorders
Interventions: Clozapine, Olanzapine; Drug
Lead sponsor: Augusta University; Other
Eligibility: 18 Years to 60 Years
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2021
U.S. locations: 1
States / cities: Evans, Georgia

Conditions: Major Depression
Interventions: SAGE-217, Placebo; Drug
Lead sponsor: Biogen; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 102 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2017
U.S. locations: 8
States / cities: Garden Grove, California • Orlando, Florida • Atlanta, Georgia + 5 more

Conditions: Major Depressive Disorder
Interventions: Not listed
Lead sponsor: National Institute of Mental Health (NIMH); NIH
Eligibility: 18 Years to 50 Years
Enrollment: 100 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2004 – 2008
U.S. locations: 1
States / cities: Bethesda, Maryland

Conditions: HIV Infections, Central Nervous System Diseases
Interventions: Not listed
Lead sponsor: National Cancer Institute (NCI); NIH
Eligibility: Not listed
Enrollment: 21 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2005 – 2014
U.S. locations: 1
States / cities: Bethesda, Maryland

Conditions: Major Depression
Interventions: cognitive behavioral therapy, culturally adapted cognitive behavioral therapy; Behavioral
Lead sponsor: Claremont McKenna College; Other
Eligibility: 18 Years to 65 Years
Enrollment: 61 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2011
U.S. locations: 1
States / cities: Claremont, California

Conditions: Major Depressive Disorder
Interventions: Duloxetine, Placebo; Drug
Lead sponsor: Eli Lilly and Company; Industry
Eligibility: 18 Years and older
Enrollment: 527 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2011
U.S. locations: 32
States / cities: Sherman Oaks, California • Cromwell, Connecticut • Fort Lauderdale, Florida + 29 more

Conditions: Major Depressive Disorder, Bipolar I and Bipolar II
Interventions: Diagnostic test (LDT); Other
Lead sponsor: Myriad Genetic Laboratories, Inc.; Industry
Eligibility: 18 Years to 70 Years
Enrollment: 261 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2018
U.S. locations: 5
States / cities: Iowa City, Iowa • Minneapolis, Minnesota • Mason, Ohio + 2 more

Conditions: Major Depressive Disorder (MDD), Treatment Resistant Depression (TRD)
Interventions: Ketamine, Midazolam; Drug
Lead sponsor: Baylor College of Medicine; Other
Eligibility: 21 Years to 80 Years
Enrollment: 73 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2012
U.S. locations: 2
States / cities: New York, New York • Houston, Texas

Conditions: Major Depressive Disorder (MDD), Major Depressive Disorder With Anxious Distress
Interventions: SPT-300; Drug
Lead sponsor: Seaport Therapeutics; Industry
Eligibility: 18 Years to 66 Years
Enrollment: 360 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 20
States / cities: Chino, California • Garden Grove, California • Glendale, California + 17 more

Conditions: Major Depressive Disorder
Interventions: Intermittent theta burst repetitive transcranial magnetic stimulation (iTBS); Device
Lead sponsor: National Institute of Mental Health (NIMH); NIH
Eligibility: 13 Years to 17 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026
U.S. locations: 1
States / cities: Bethesda, Maryland

Conditions: Schizoaffective Disorder, Schizophrenia, Bipolar Disorder, Major Depressive Disorder
Interventions: Mobile Interventionist; Other
Lead sponsor: University of Washington; Other
Eligibility: 18 Years to 99 Years
Enrollment: 49 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2020
U.S. locations: 2
States / cities: Chicago, Illinois • Spokane, Washington

Conditions: Treatment-resistant Depression
Interventions: Propofol, Electroencephalography (EEG), Slow-Wave Activity; Drug · Diagnostic Test
Lead sponsor: Washington University School of Medicine; Other
Eligibility: 60 Years and older
Enrollment: 16 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2025
U.S. locations: 1
States / cities: St Louis, Missouri

Conditions: Schizophrenia, Schizoaffective Disorder, Bipolar Disorder, Major Depression
Interventions: Health Care Management and Supported Rehabilitation; Behavioral
Lead sponsor: Dartmouth-Hitchcock Medical Center; Other
Eligibility: 50 Years and older · Female only
Enrollment: 180 participants
Timeline: 2001 – 2006
U.S. locations: 3
States / cities: Boston, Massachusetts • Nashua, New Hampshire

Conditions: Major Depressive Disorder
Interventions: (Condition 1) Behavioral Activation; (Condition 2) Behavioral Activation and Stress Innoculation; Behavioral
Lead sponsor: University of Chicago; Other
Eligibility: 18 Years to 58 Years
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2004 – 2006
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Major Depressive Disorder
Interventions: F2695 SR; Drug
Lead sponsor: Forest Laboratories; Industry
Eligibility: 18 Years to 80 Years
Enrollment: 828 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: Started 2009
U.S. locations: 68
States / cities: Dothan, Alabama • Scottsdale, Arizona • Beverly Hills, California + 57 more

Conditions: Severe Mental Illness
Interventions: Person Centered Care Planning; Other
Lead sponsor: New York University; Other
Eligibility: 18 Years and older
Enrollment: 570 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2019
U.S. locations: 1
States / cities: New York, New York

Conditions: Depression, Major Depressive Disorder
Interventions: fNIRS measurement; Other
Lead sponsor: Kernel; Industry
Eligibility: 18 Years to 75 Years
Enrollment: 540 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2026
U.S. locations: 10
States / cities: Costa Mesa, California • La Jolla, California • Los Angeles, California + 4 more

Conditions: Schizophrenia, Major Depressive Disorder, Bi-Polar Disorder, Schizo Affective Disorder
Interventions: ABILIFY MYCITE; Combination Product
Lead sponsor: Durham VA Medical Center; Federal
Eligibility: 18 Years and older
Enrollment: 46 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2021
U.S. locations: 2
States / cities: Durham, North Carolina • Houston, Texas

Conditions: Major Depressive Disorder
Interventions: duloxetine; Drug
Lead sponsor: Eli Lilly and Company; Industry
Eligibility: 18 Years and older
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2002 – 2003
U.S. locations: 23
States / cities: Carlsbad, California • Los Angeles, California • Stanford, California + 20 more

Conditions: Major Depressive Disorder
Interventions: tDCS; Device
Lead sponsor: Hebrew SeniorLife; Other
Eligibility: 50 Years and older
Enrollment: 5 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2021
U.S. locations: 1
States / cities: Boston, Massachusetts