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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Menthol Cigarettes Clear all
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Correcting Disinformation About Menthol Cigarettes and Flavored Cigars

NCT07543081
View directory record Official record
Conditions
Disinformation, Menthol Cigarettes, Flavored Cigars
Interventions
Individual delivery of anti-disinformation messaging, Community delivery of anti-disinformation messaging
Behavioral
Lead sponsor
Rutgers, The State University of New Jersey
Other
Eligibility
18 Years and older
Enrollment
1,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2028
U.S. locations
1
States / cities
New Brunswick, New Jersey
Source: ClinicalTrials.gov public record
Updated May 4, 2026 · Synced Sep 14, 2026, 8:09 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Reduced Exposure Study Using THS 2.2 Menthol With 5 Days in a Confinement Setting Followed by 86 Days in an Ambulatory Setting

NCT01989156
View directory record Official record
Conditions
Smoking
Interventions
THS 2.2 Menthol (mTHS 2.2), Menthol Conventional Cigarette (mCC), Smoking Abstinence (SA)
Other
Lead sponsor
Philip Morris Products S.A.
Industry
Eligibility
22 Years and older
Enrollment
160 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2015
U.S. locations
2
States / cities
Daytona Beach, Florida • Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Mar 23, 2020 · Synced Sep 14, 2026, 8:09 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Menthol Flavored E-cigarette Use During a Simulated Ban of Menthol Cigarettes

NCT03164668
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
menthol flavored e-cigarette, tobacco flavored e-cigarette
Other
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years to 64 Years
Enrollment
37 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Jul 9, 2024 · Synced Sep 14, 2026, 8:09 PM EDT
Completed Not applicable Interventional Results available

Effect of Different E-cigarette Cooling Flavors on Adults' Sensory Experience TCORS 3.0

NCT05932693
View directory record Official record
Conditions
E-Cig Use
Interventions
E-liquid coolant (WS-3, 0.05%), E-liquid coolant (WS-3, 0.1%), E-liquid coolant (WS-3, 0.5%), E-liquid coolant (WS-3, 1.0%), E-liquid coolant (WS-3, 2.0%), E-liquid coolant (menthol, 0.05%), E-liquid coolant (menthol, 0.1%), E-liquid coolant (menthol, 0.5%), E-liquid coolant (menthol, 1.0%), E-liquid coolant (menthol, 2.0%), E-liquid coolant (WS-23, 0.05%), E-liquid coolant (WS-23, 0.1%), E-liquid coolant (WS-23, 0.5%), E-liquid coolant (WS-23, 1.0%), E-liquid coolant (WS-23, 2.0%), E-liquid coolant (WS-23, 4.0%)
Other
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Enrollment
31 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Feb 17, 2026 · Synced Sep 14, 2026, 8:09 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Menthol and Mint Experimental Tobacco Marketplace (ETM) Study

NCT04879225
View directory record Official record
Conditions
Cigarette Smoking, Vaping
Interventions
Tobacco e-liquids, Menthol and Tobacco e-liquids, Mint, Menthol and Tobacco e-liquids, All e-liquid flavors
Behavioral
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
21 Years and older
Enrollment
66 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 25, 2024 · Synced Sep 14, 2026, 8:09 PM EDT
Completed Not applicable Interventional Results available

Feasibility of Conducting a Pilot Telehealth Study Assessing the Removal of Filter Ventilation on Smoking Behavior and Biomarkers in Menthol Smokers Switched to Non-menthol Cigarettes

NCT04514471
View directory record Official record
Conditions
Smoking
Interventions
Minimally Ventilated non-menthol cigarettes, Ventilated non-menthol cigarettes
Other
Lead sponsor
Masonic Cancer Center, University of Minnesota
Other
Eligibility
21 Years and older
Enrollment
46 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Sep 8, 2026 · Synced Sep 14, 2026, 8:09 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Sex Differences in E-Cigarette Perception

NCT07398976
View directory record Official record
Conditions
Nicotine Dependence, E-cigarette Use
Interventions
Nicotine Level 1 (0mg/ml), Nicotine Level 2 (36mg/ml), Nicotine Level 3 (59mg/ml)
Other
Lead sponsor
Yale University
Other
Eligibility
21 Years to 44 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Sep 1, 2026 · Synced Sep 14, 2026, 8:09 PM EDT
Recruiting Not applicable Interventional

Effects of E-cigs vs Pouches on Cigarette Smoking and Addiction

NCT06077240
View directory record Official record
Conditions
Smoking, Smoking Behaviors, Nicotine Dependence
Interventions
E-cigarette with 2.4% Nicotine with Menthol and Tobacco Flavors, E-cigarette with 2.4% Nicotine with Tobacco Flavor Only, E-cigarette with 5% Nicotine with Menthol and Tobacco Flavors, E-cigarette with 5% Nicotine with Tobacco Flavor Only, Tobacco Pouches with 3mg Nicotine with Menthol and Tobacco Flavors, Tobacco Pouches with 3mg Nicotine with Tobacco Flavor Only, Tobacco Pouches with 6mg Nicotine with Menthol and Tobacco Flavors, Tobacco Pouches with 6mg Nicotine with Tobacco Flavor Only
Behavioral
Lead sponsor
Yale University
Other
Eligibility
21 Years and older
Enrollment
256 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Mar 18, 2026 · Synced Sep 14, 2026, 8:09 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Cooling Agent Pilot Among Adult Menthol Smokers

NCT06477601
View directory record Official record
Conditions
Tobacco Dependence
Interventions
Assigning cooling agent type cigarettes, Assigning traditional tobacco type cigarettes, Assigning menthol type cigarettes
Other
Lead sponsor
University of Kansas Medical Center
Other
Eligibility
21 Years and older
Enrollment
21 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Kansas City, Missouri
Source: ClinicalTrials.gov public record
Updated Apr 5, 2025 · Synced Sep 14, 2026, 8:09 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Use Behavior, Nicotine Uptake, and Subjective Effects Comparison of Tobacco and Menthol e-Liquids by ENDS Consumers

NCT05134415
View directory record Official record
Conditions
Electronic Cigarette Use
Interventions
RELX ENDS Tobacco Flavor 1, RELX ENDS Tobacco Flavor 2, RELX ENDS Menthol Flavor 1, RELX ENDS Menthol Flavor 2
Other
Lead sponsor
Cheerain HK Limited
Industry
Eligibility
22 Years to 65 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
Burbank, California
Source: ClinicalTrials.gov public record
Updated Dec 12, 2021 · Synced Sep 14, 2026, 8:09 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Effect of Banning Menthol Flavorant on Cigarette and E-Cigarette Use

NCT03402243
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
Menthol ban on cigarettes, Menthol ban on cigarettes and e-cigarettes, No menthol ban
Other
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years to 64 Years
Enrollment
47 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Aug 9, 2021 · Synced Sep 14, 2026, 8:09 PM EDT
Completed Not applicable Interventional

Evaluation of Cessation Preferences of Menthol Smoker

NCT02020005
View directory record Official record
Conditions
Smoking Cessation
Interventions
Non-flavored 2mg nicotine gum, Non-flavored 4mg nicotine gum, Mint-flavored 2mg nicotine gum, Mint-flavored 4mg nicotine gum, Non-flavored nicotine inhaler, Mint-flavored nicotine ihaler
Other
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Oct 2, 2025 · Synced Sep 14, 2026, 8:09 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Effective Ads for Quitting Smoking

NCT06485479
View directory record Official record
Conditions
Smoking Behaviors
Interventions
Intervention ads, Control ads
Behavioral
Lead sponsor
UNC Lineberger Comprehensive Cancer Center
Other
Eligibility
21 Years and older
Enrollment
1,236 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Nov 2, 2025 · Synced Sep 14, 2026, 8:09 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

CSD1602: A Crossover Study to Evaluate the Exposure to "Tar" and Nicotine From Two King Size Menthol Cigarette Products

NCT03063034
View directory record Official record
Conditions
Smoking
Interventions
PD21864AA, PD21864AB
Other
Lead sponsor
RAI Services Company
Industry
Eligibility
21 Years and older
Enrollment
39 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017
U.S. locations
1
States / cities
Lakewood, Colorado
Source: ClinicalTrials.gov public record
Updated Mar 13, 2017 · Synced Sep 14, 2026, 8:09 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Assessing Tobacco Product Choice When the Cost of Menthol Cigarettes Increases

NCT03612349
View directory record Official record
Conditions
Tobacco Use, Cigarette Smoking
Interventions
Experimental Tobacco Marketplace Task
Behavioral
Lead sponsor
Brown University
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Sep 27, 2018 · Synced Sep 14, 2026, 8:09 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Impact of Cigarette and E-cigarette Menthol Regulation on Current Smokers of Menthol Cigarettes

NCT05896033
View directory record Official record
Conditions
Smoking Prevention and Control
Interventions
Non-Menthol Cigarettes, Tobacco Flavored E-cigarettes, Menthol Cigarettes, Menthol Flavored E-cigarettes
Behavioral
Lead sponsor
Medical University of South Carolina
Other
Eligibility
21 Years and older
Enrollment
240 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Jul 20, 2026 · Synced Sep 14, 2026, 8:09 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Perceptions of Cigarette Smoking in Young Adults

NCT03953508
View directory record Official record
Conditions
Smoking, Cigarette
Interventions
Cigarette flavor type
Other
Lead sponsor
University of Oklahoma
Other
Eligibility
18 Years to 26 Years
Enrollment
199 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
1
States / cities
Oklahoma City, Oklahoma
Source: ClinicalTrials.gov public record
Updated Dec 15, 2024 · Synced Sep 14, 2026, 8:09 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Evaluating Selected Constituents in the Exhaled Breath Samples

NCT04143256
View directory record Official record
Conditions
Electronic Cigarette Use, Cigarette Use, Electronic, Tobacco Use, Tobacco Smoking
Interventions
JUUL ENDS 5% Virginia Tobacco, JUUL 3% Virginia Tobacco ENDS, JUUL 5% Mint ENDS, JUUL 3% Mint ENDS, JUUL 5% Menthol ENDS, JUUL 3% Menthol ENDS, JUUL 5% Mango ENDS, JUUL 3% Mango ENDS, US Cigarette, Non-menthol - Marlboro Gold King Size, US Cigarette, Menthol - Newport King Size
Other
Lead sponsor
Juul Labs, Inc.
Industry
Eligibility
21 Years to 65 Years
Enrollment
135 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
3
States / cities
Secaucus, New Jersey • Charlotte, North Carolina • Raleigh, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 10, 2020 · Synced Sep 14, 2026, 8:09 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Experimental Tobacco Marketplace in Regulating Flavored Tobacco Products in Menthol Cigarette Smokers

NCT03897530
View directory record Official record
Conditions
Cigarette Smoking
Interventions
Smoking Cessation Intervention, Functional Assessment, Questionnaire Administration
Behavioral · Other
Lead sponsor
Roswell Park Cancer Institute
Other
Eligibility
18 Years and older
Enrollment
103 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2023
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Apr 2, 2024 · Synced Sep 14, 2026, 8:09 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Flavors and E-cigarette Effects in Adolescent Smokers- STUDY 1

NCT02179034
View directory record Official record
Conditions
Nicotine Dependence, Other Tobacco Product
Interventions
Nicotine, Low Dose Menthol, High Dose Menthol
Drug · Other
Lead sponsor
Yale University
Other
Eligibility
18 Years to 20 Years
Enrollment
59 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2017
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated May 3, 2020 · Synced Sep 14, 2026, 8:09 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

CSD1601: A Study to Evaluate the Exposure to Tar and Nicotine From Two Cigarette Products That Contain a Menthol Capsule in the Filter

NCT04529551
View directory record Official record
Conditions
Smoking, Tobacco Smoking, Tobacco Use
Interventions
1601A, 1601B
Other
Lead sponsor
RAI Services Company
Industry
Eligibility
21 Years and older
Enrollment
55 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016
U.S. locations
1
States / cities
High Point, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 26, 2022 · Synced Sep 14, 2026, 8:09 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Nicotine Pharmacokinetic Profile and Safety of the Tobacco Heating System 2.2 Menthol (THS 2.2 Menthol)

NCT01967719
View directory record Official record
Conditions
Smoking
Interventions
mTHS 2.2, mCC, NNS
Other
Lead sponsor
Philip Morris Products S.A.
Industry
Eligibility
22 Years to 65 Years
Enrollment
64 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2014
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Mar 17, 2020 · Synced Sep 14, 2026, 8:09 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Comparison of Pharmacokinetic Parameters Between Adopters of Electronic Cigarettes and a Historical Sample of Combustible Cigarette Smokers

NCT02730676
View directory record Official record
Conditions
Smoking
Interventions
Electronic Cigarette #1, Electronic Cigarette #2
Other
Lead sponsor
R.J. Reynolds Vapor Company
Industry
Eligibility
21 Years to 60 Years
Enrollment
44 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016
U.S. locations
1
States / cities
Lakewood, Colorado
Source: ClinicalTrials.gov public record
Updated May 31, 2018 · Synced Sep 14, 2026, 8:09 PM EDT
Completed No phase listed Observational Results available

Brain Nicotine Receptor Density in Veteran Smokers

NCT01721473
View directory record Official record
Conditions
Positron Emission Tomography
Interventions
positron emission tomography scan
Other
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 65 Years
Enrollment
184 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
2
States / cities
San Diego, California • West Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Oct 6, 2019 · Synced Sep 14, 2026, 8:09 PM EDT