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ClinicalTrials.gov public records Last synced Oct 23, 2026, 7:37 PM EDT

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Showing 625–648 of 1,515 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Metabolism Changes Clear all
Recruiting Phase 2 Interventional Accepts healthy volunteers

Early Metabolic Effects of Antiretroviral Drugs in Healthy volUnteers: a Phase 2 Randomized Study

NCT05652478
View directory record Official record
Conditions
Healthy Volunteer, Weight Gain, Metabolic Effects, Integrase Strand Transfer Inhibitors
Interventions
Dolutegravir (DTG) AND Tenofovir alafenamide (TAF), Tenofovir Disoproxil Fumarate, Dolutegravir, Tenofovir alafenamide
Drug
Lead sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
NIH
Eligibility
18 Years to 55 Years
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2030
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Sep 29, 2026 · Synced Oct 23, 2026, 7:37 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Help Everyone Assess Risk Today: LEnten Nutrition Study (HEART-LENS)

NCT05057650
View directory record Official record
Conditions
Cardiovascular Morbidity, Risk Reduction, Nutrition Disorders
Interventions
Vegan diet
Dietary Supplement
Lead sponsor
Rush University Medical Center
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Oct 1, 2021 · Synced Oct 23, 2026, 7:37 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Using the Energy Gap to Prevent Weight Regain

NCT00429650
View directory record Official record
Conditions
Obesity
Interventions
increased exercise, diet, Exercise and Diet
Behavioral
Lead sponsor
University of Colorado, Denver
Other
Eligibility
19 Years to 45 Years
Enrollment
175 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2014
U.S. locations
1
States / cities
Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Jun 28, 2019 · Synced Oct 23, 2026, 7:37 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effect of Soy Protein and Colorado Diet on Weight Loss and Maintenance

NCT03248804
View directory record Official record
Conditions
Overweight, Obesity, Weight Loss
Interventions
Soy group, Non-soy group
Behavioral
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years to 55 Years
Enrollment
71 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2016
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Nov 7, 2018 · Synced Oct 23, 2026, 7:37 PM EDT
Completed Not applicable Interventional

Electrical Vestibular Nerve Stimulation (VeNS) Compared to Sham Control As a Means of Improving Glycemic Control in Adults with Type 2 Diabetes Mellitus

NCT04595968
View directory record Official record
Conditions
Type 2 Diabetes
Interventions
Vestal DM Active device, Lifestyle modification, Vestal DM Sham device
Device · Behavioral
Lead sponsor
Neurovalens Ltd.
Industry
Eligibility
22 Years to 70 Years
Enrollment
267 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
15
States / cities
Birmingham, Alabama • La Jolla, California • Sacramento, California + 12 more
Source: ClinicalTrials.gov public record
Updated Sep 19, 2024 · Synced Oct 23, 2026, 7:37 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Dietary Exchanges With Avocado and Mango in Pre-diabetes

NCT05353790
View directory record Official record
Conditions
Pre Diabetes, Vascular Stiffness, Vascular Dilation, Cognitive Change, Retinal Vascular
Interventions
Meals + snacks: control, Meals + snacks: Avocado mango
Other
Lead sponsor
Clinical Nutrition Research Center, Illinois Institute of Technology
Industry
Eligibility
25 Years to 70 Years
Enrollment
82 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2025
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jan 15, 2026 · Synced Oct 23, 2026, 7:37 PM EDT
Recruiting Phase 4 Interventional

Optimizing Portal Hypertension With TIPS and Interval Metabolic Surgery for Advanced Liver Disease

NCT07058155
View directory record Official record
Conditions
Liver Cirrhoses, Portal Hypertension Related to Cirrhosis, Severe Obesity, TIPS
Interventions
Transjugular Intrahepatic Portosystemic Shunt (TIPS), Sleeve Gastrectomy, Anti-Obesity Pharmacotherapy (Class Effect), Lifestyle Counseling - Diet & Physical-Activity Program
Procedure · Drug · Behavioral
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years to 70 Years
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2034
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Oct 22, 2026 · Synced Oct 23, 2026, 7:37 PM EDT
Completed Phase 2 Interventional

Study To Determine The Effects And Safety Of A Weight Loss Compound On Overweight, Otherwise Healthy, Volunteers

NCT00479492
View directory record Official record
Conditions
Obesity
Interventions
CP-866,087, placebo
Drug
Lead sponsor
Pfizer
Industry
Eligibility
18 Years to 65 Years
Enrollment
94 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2008
U.S. locations
4
States / cities
Orlando, Florida • Kalamazoo, Michigan • Portland, Oregon + 1 more
Source: ClinicalTrials.gov public record
Updated Oct 1, 2009 · Synced Oct 23, 2026, 7:37 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

Effect of Weight Loss and Exercise on Liver and Muscle Fat in Obese Elderly

NCT00779207
View directory record Official record
Conditions
Obesity
Interventions
weight loss and exercise, weight loss
Behavioral
Lead sponsor
Washington University School of Medicine
Other
Eligibility
65 Years to 85 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2008
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Oct 24, 2008 · Synced Oct 23, 2026, 7:37 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Metabolic Impact of Time Restricted Feeding

NCT03129581
View directory record Official record
Conditions
Obesity, Diet Modification
Interventions
Dietary Counseling
Behavioral
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years to 65 Years
Enrollment
47 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2022
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Sep 23, 2022 · Synced Oct 23, 2026, 7:37 PM EDT
Completed No phase listed Observational

Study of Effects From Gastric Bypass Weight Loss on Brain Tissue

NCT00357344
View directory record Official record
Conditions
Weight Loss
Interventions
Not listed
Lead sponsor
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NIH
Eligibility
18 Years to 45 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2008
U.S. locations
3
States / cities
Phoenix, Arizona • Scottsdale, Arizona
Source: ClinicalTrials.gov public record
Updated Jul 2, 2017 · Synced Oct 23, 2026, 7:37 PM EDT
Recruiting Phase 3 Interventional

A Study of Tirzepatide in Adolescents With Obesity and Weight-Related Comorbidities (SURMOUNT-ADOLESCENTS-2)

NCT06439277
View directory record Official record
Conditions
Obesity, Weight Gain
Interventions
Tirzepatide, Placebo
Drug
Lead sponsor
Eli Lilly and Company
Industry
Eligibility
12 Years to 17 Years
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2030
U.S. locations
14
States / cities
Los Angeles, California • Sacramento, California • Wilmington, Delaware + 11 more
Source: ClinicalTrials.gov public record
Updated Sep 24, 2026 · Synced Oct 23, 2026, 7:37 PM EDT
Not yet recruiting Not applicable Interventional

Reset: Enhancing Weight Loss in a Digital Intervention

NCT07032571
View directory record Official record
Conditions
Obesity, Overweight, Weight Loss, Health Behavior, Lifestyle Intervention
Interventions
Core Behavioral Weight Loss Intervention, Limit Red Zone Foods, Limit Eating Window, Increase Protein, Increase Fiber Intake
Behavioral
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older
Enrollment
208 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Aug 4, 2026 · Synced Oct 23, 2026, 7:37 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Hunger, Satiety, and Metabolic Responses to High-fat Meals of Varying Fatty Acid Composition

NCT02966444
View directory record Official record
Conditions
Body Weight Changes
Interventions
MUFA-rich HF Meal, PUFA-rich HF Meal, SFA-rich HF Meal
Other
Lead sponsor
Texas Christian University
Other
Eligibility
18 Years to 40 Years · Female only
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2018
U.S. locations
1
States / cities
Fort Worth, Texas
Source: ClinicalTrials.gov public record
Updated Jul 26, 2018 · Synced Oct 23, 2026, 7:37 PM EDT
Completed Phase 2 Interventional Results available

Liraglutide (Saxenda(R)) in Adolescents With Obesity After Sleeve Gastrectomy

NCT04883346
View directory record Official record
Conditions
Obesity, Status Post Sleeve Gastrectomy
Interventions
Liraglutide
Drug
Lead sponsor
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
NIH
Eligibility
12 Years to 20 Years
Enrollment
34 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Nov 20, 2024 · Synced Oct 23, 2026, 7:37 PM EDT
Completed Not applicable Interventional Results available

Physical Activity Behavior Change for Older Adults After Dysvascular Amputation

NCT02738086
View directory record Official record
Conditions
Amputation, Diabetes Mellitus, Type 2, Peripheral Artery Disease
Interventions
Physical Activity Behavior Change (PABC)
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
50 Years to 85 Years
Enrollment
31 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Feb 18, 2020 · Synced Oct 23, 2026, 7:37 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Impact of the Use of FeelWell™ Compression Garment on Individuals With a BMI ≥35

NCT03798873
View directory record Official record
Conditions
Obesity, Obesity, Abdominal, Mobility Limitation, Quality of Life, Back Pain, Pain, Chronic, Weight Change, Body, Inactivity, Exercise, Body Composition, Redundant Skin
Interventions
FeelWell™ Compression garment, Increase Mobility
Device · Behavioral
Lead sponsor
Feelwell Compression
Industry
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Shirlington, Virginia
Source: ClinicalTrials.gov public record
Updated Feb 19, 2019 · Synced Oct 23, 2026, 7:37 PM EDT
Completed Not applicable Interventional Results available

Implementing Effective, Collaborative Care for Schizophrenia (EQUIP-2)

NCT00137280
View directory record Official record
Conditions
Schizophrenia, Chronic Illness, Weight Gain, Psychotic Disorder
Interventions
Collaborative Chronic Illness Care Model
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
1,067 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2011
U.S. locations
8
States / cities
Long Beach, California • West Los Angeles, California • Shreveport, Louisiana + 5 more
Source: ClinicalTrials.gov public record
Updated Feb 22, 2018 · Synced Oct 23, 2026, 7:37 PM EDT
Recruiting Phase 2 Interventional

Modifying Metabolic Syndrome and Cardiovascular Risk for Prostate Cancer Patients on ADT Using a Risk Factor Modification Program and Continuous Fitbit Monitoring

NCT05054296
View directory record Official record
Conditions
Biochemically Recurrent Prostate Carcinoma, Metastatic Prostate Adenocarcinoma, Stage IV Prostate Cancer AJCC v8, Stage IVA Prostate Cancer AJCC v8, Stage IVB Prostate Cancer AJCC v8
Interventions
Educational Intervention, Exercise Intervention, FitBit, Quality-of-Life Assessment, Questionnaire Administration
Behavioral · Device · Other
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
18 Years and older · Male only
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2027
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Mar 29, 2023 · Synced Oct 23, 2026, 7:37 PM EDT
Active, not recruiting Phase 1 Interventional

Semaglutide (SEMA) for Alcohol Use Disorder (AUD) After Metabolic and Bariatric Surgery (MBS)

NCT07223983
View directory record Official record
Conditions
Alcohol Use Disorder, Weight Loss, Bariatric Surgery Patients
Interventions
Semaglutide 1.0 mg
Drug
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Sep 10, 2026 · Synced Oct 23, 2026, 7:37 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Sweet Kids Study (Stevia on Weight and Energy Effect Over Time)

NCT05992688
View directory record Official record
Conditions
Adiposity, Insulin Sensitivity, Weight Gain, Blood Pressure, Lipoproteins
Interventions
Sucrose sweetened beverage, Stevia sweetened beverages, Calorie free flavored water beverage
Other
Lead sponsor
Arkansas Children's Hospital Research Institute
Other
Eligibility
8 Years to 12 Years
Enrollment
106 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2026
U.S. locations
1
States / cities
Little Rock, Arkansas
Source: ClinicalTrials.gov public record
Updated Oct 15, 2026 · Synced Oct 23, 2026, 7:37 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

ACTION PAC: Adolescents Committed to Improvement of Nutrition & Physical Activity

NCT02502383
View directory record Official record
Conditions
Overweight, Obesity
Interventions
ACTION PAC, Communication with parents
Behavioral
Lead sponsor
University of New Mexico
Other
Eligibility
13 Years to 20 Years
Enrollment
991 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2017
U.S. locations
1
States / cities
Albuquerque, New Mexico
Source: ClinicalTrials.gov public record
Updated Jun 26, 2024 · Synced Oct 23, 2026, 7:37 PM EDT
Terminated No phase listed Observational

Studies of Biological Changes Related to Weight Loss After Gastric Bypass Surgery

NCT00120562
View directory record Official record
Conditions
Obesity, Morbid Obesity, Weight Loss
Interventions
Gastric Bypass Surgery
Procedure
Lead sponsor
Rockefeller University
Other
Eligibility
18 Years to 65 Years
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2007
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 28, 2009 · Synced Oct 23, 2026, 7:37 PM EDT
Completed No phase listed Observational

Redistribution of Fat and Metabolic Change in HIV Infection: Protocol 2 (FRAM Fat 2)

NCT00244803
View directory record Official record
Conditions
Human Immunodeficiency Virus
Interventions
Not listed
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 65 Years
Enrollment
101 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2007
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Aug 31, 2016 · Synced Oct 23, 2026, 7:37 PM EDT