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ClinicalTrials.gov public records Last synced Sep 10, 2026, 5:00 PM EDT

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Showing 1–24 of 740 matching trials from the live ClinicalTrials.gov search.
Local D1 index available.
Filters: Condition: Migrainous Headache Clear all
Not yet recruiting Phase 3 Interventional

0.5% Bupivacaine Lower Cervical Intramuscular Injection vs IV Medications for Headache Treatment

NCT06937385
View directory record Official record
Conditions
Headache, Migraine, Tension Headache, Occipital Neuralgia
Interventions
0.5% Bupivacaine HCl, standard IV treatment for headache
Drug
Lead sponsor
HCA Florida North Florida Hospital
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Apr 23, 2025 · Synced Sep 10, 2026, 5:00 PM EDT
Terminated Phase 4 Interventional Results available

Fremanezumab, Migraine and Sleep

NCT04693533
View directory record Official record
Conditions
Migraine Disorders, Sleep Disorder
Interventions
Fremanezumab Prefilled Syringe [Ajovy]
Drug
Lead sponsor
Beth Israel Deaconess Medical Center
Other
Eligibility
18 Years to 65 Years
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 26, 2026 · Synced Sep 10, 2026, 5:00 PM EDT
Recruiting Not applicable Interventional

A Comprehensive Digital Care Program for Migraine Management

NCT07642414
View directory record Official record
Conditions
Migraine, Migraine With Aura, Migraine Without Aura
Interventions
Neuromodulation Wearable Device, Migraine Digital Care Program
Device · Other
Lead sponsor
Hinge Health, Inc
Industry
Eligibility
18 Years and older
Enrollment
140 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jun 15, 2026 · Synced Sep 10, 2026, 5:00 PM EDT
Completed Phase 2Phase 3 Interventional Results available

Long-term Safety Study of BHV-3500 (Zavegepant*) for the Acute Treatment of Migraine

NCT04408794
View directory record Official record
Conditions
Acute Migraine
Interventions
Zavegepant (BHV-3500)
Drug
Lead sponsor
Pfizer
Industry
Eligibility
18 Years and older
Enrollment
974 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
67
States / cities
Huntsville, Alabama • Mobile, Alabama • Tucson, Arizona + 62 more
Source: ClinicalTrials.gov public record
Updated May 17, 2023 · Synced Sep 10, 2026, 5:00 PM EDT
Not listed No phase listed Observational

Validating a Modified COMPASS 31questionnaire for Treatment Outcomes

NCT05302479
View directory record Official record
Conditions
Headache, Migraine, Persistent Post Traumatic Headache, Cervicogenic Headache
Interventions
COMPASS 31 questionnaire
Other
Lead sponsor
Brooke Army Medical Center
Federal
Eligibility
18 Years to 64 Years
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jul 20, 2022 · Synced Sep 10, 2026, 5:00 PM EDT
Completed Phase 2 Interventional Results available

A Multicenter Assessment of LBR-101 in High Frequency Episodic Migraine

NCT02025556
View directory record Official record
Conditions
Episodic Migraine Headache
Interventions
LBR-101 High Dose, LBR-101 Low Dose, Placebo
Drug
Lead sponsor
Teva Branded Pharmaceutical Products R&D, Inc.
Industry
Eligibility
18 Years to 65 Years
Enrollment
297 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
63
States / cities
Gilbert, Arizona • Phoenix, Arizona • Scottsdale, Arizona + 56 more
Source: ClinicalTrials.gov public record
Updated Jan 23, 2022 · Synced Sep 10, 2026, 5:00 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Migraine and Body Composition

NCT01720862
View directory record Official record
Conditions
Migraine With and Without Aura, Chronic Migraine, Healthy Controls
Interventions
Not listed
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
300 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2015
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jan 27, 2016 · Synced Sep 10, 2026, 5:00 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Set Point Acupuncture for Migraines Using a Digital Assistant

NCT00714727
View directory record Official record
Conditions
Migraine Headaches
Interventions
acupuncture
Procedure
Lead sponsor
Memorial Medical Center
Other
Eligibility
21 Years to 65 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2011
U.S. locations
1
States / cities
Johnstown, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 11, 2013 · Synced Sep 10, 2026, 5:00 PM EDT
Completed Phase 4 Interventional

An Investigation of the Safety and Utility of Treximet in the Treatment of Menstrual Migraine

NCT01578941
View directory record Official record
Conditions
Menstrual Migraine
Interventions
Diary
Other
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
19 Years and older · Female only
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Oct 31, 2012 · Synced Sep 10, 2026, 5:00 PM EDT
Completed Not applicable Interventional

CBT Depression Intervention for Co-Occurring Chronic Headache

NCT02870725
View directory record Official record
Conditions
Depression, Headaches Chronic, Migraine Disorders
Interventions
CBT Individual Psychotherapy
Behavioral
Lead sponsor
University of Georgia
Other
Eligibility
18 Years to 75 Years
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
2
States / cities
Athens, Michigan • Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Jul 5, 2017 · Synced Sep 10, 2026, 5:00 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

A Study Investigating the Movement of Lu AG09222 Into, Through, and Out of the Body of Healthy Caucasian, Chinese, and Japanese Participants

NCT05304910
View directory record Official record
Conditions
Migraine
Interventions
Lu AG09222, Placebo
Drug
Lead sponsor
H. Lundbeck A/S
Industry
Eligibility
18 Years to 55 Years
Enrollment
52 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
Glendale, California
Source: ClinicalTrials.gov public record
Updated Nov 9, 2022 · Synced Sep 10, 2026, 5:00 PM EDT
Completed Phase 3 Interventional Results available

Migraine Study in Adolescent Patients

NCT00843024
View directory record Official record
Conditions
Migraine Disorders
Interventions
Sumatriptan and Naproxen Sodium, Placebo
Drug
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
12 Years to 17 Years
Enrollment
589 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
79
States / cities
Gilbert, Arizona • Litchfield Park, Arizona • Phoenix, Arizona + 71 more
Source: ClinicalTrials.gov public record
Updated Jan 17, 2017 · Synced Sep 10, 2026, 5:00 PM EDT
Completed Not applicable Interventional Results available

Evaluation of a Novel Device for Treatment of Migraine Headache

NCT03361423
View directory record Official record
Conditions
Migraine Without Aura, Migraine With Aura
Interventions
Nerivio Migra-1 active device, Nerivio Migra-1 Sham device
Device
Lead sponsor
Theranica
Industry
Eligibility
18 Years to 75 Years
Enrollment
296 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
7
States / cities
Hartford, Connecticut • Springfield, Missouri • St Louis, Missouri + 4 more
Source: ClinicalTrials.gov public record
Updated May 18, 2021 · Synced Sep 10, 2026, 5:00 PM EDT
Not listed Phase 2Phase 3 Interventional

MIST II PFO-Migraine Trial With BioSTAR® Bioabsorbable Septal Repair Implant

NCT00283738
View directory record Official record
Conditions
Migraine, Aura, Patent Foramen Ovale
Interventions
BioSTAR Septal Repair Implant System, Sham Procedure
Device · Procedure
Lead sponsor
NMT Medical
Industry
Eligibility
18 Years to 60 Years
Enrollment
610 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2008
U.S. locations
2
States / cities
Stamford, Connecticut • Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jan 24, 2008 · Synced Sep 10, 2026, 5:00 PM EDT
Completed Phase 3 Interventional Results available

Lasmiditan Compared to Placebo in the Acute Treatment of Migraine:

NCT02439320
View directory record Official record
Conditions
Acute Migraine
Interventions
Lasmiditan 100 mg, Lasmiditan 200 mg, Placebo (matches lasmiditan doses)
Drug
Lead sponsor
Eli Lilly and Company
Industry
Eligibility
18 Years and older
Enrollment
2,231 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
92
States / cities
Birmingham, Alabama • Chandler, Arizona • Fountain Hills, Arizona + 67 more
Source: ClinicalTrials.gov public record
Updated Dec 15, 2019 · Synced Sep 10, 2026, 5:00 PM EDT
Completed Phase 1 Interventional

Occipital Nerve Stimulation for the Treatment of Chronic Migraine Headache.

NCT00200109
View directory record Official record
Conditions
Chronic Migraine Headache
Interventions
Occipital Nerve Stimulation
Device
Lead sponsor
MedtronicNeuro
Industry
Eligibility
18 Years and older
Enrollment
110 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2011
U.S. locations
7
States / cities
Scottsdale, Arizona • Oceanside, California • Denver, Colorado + 4 more
Source: ClinicalTrials.gov public record
Updated Oct 11, 2011 · Synced Sep 10, 2026, 5:00 PM EDT
Completed Not applicable Interventional

Clinical Study Examining Use of an Over-the-Counter Supplement for the Prevention of Menstrually-Associated Migraine Headache

NCT00203255
View directory record Official record
Conditions
Migraine Headache
Interventions
Soy Isoflavones
Drug
Lead sponsor
Thomas Jefferson University
Other
Eligibility
Female only
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2005
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 22, 2009 · Synced Sep 10, 2026, 5:00 PM EDT
Completed Phase 3 Interventional Results available

A Safety Study of Galcanezumab in Participants With Migraine, With or Without Aura

NCT02614287
View directory record Official record
Conditions
Migraine
Interventions
Galcanezumab
Drug
Lead sponsor
Eli Lilly and Company
Industry
Eligibility
18 Years to 65 Years
Enrollment
270 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
13
States / cities
Santa Monica, California • Spring Valley, California • Stamford, Connecticut + 10 more
Source: ClinicalTrials.gov public record
Updated Jun 16, 2020 · Synced Sep 10, 2026, 5:00 PM EDT
Recruiting Not applicable Interventional

Investigation and Modulation of the Central Mu-Opioid Mechanism in Migraine (in Vivo)

NCT05769348
View directory record Official record
Conditions
Chronic Migraine
Interventions
HD-tDCS Active Protocol, HD-tDCS Sham Protocol
Device
Lead sponsor
University of Michigan
Other
Eligibility
18 Years to 65 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Feb 24, 2026 · Synced Sep 10, 2026, 5:00 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers Results available

A Study to Compare Zavegepant Concentration Using Samples Collected From the Vein Versus Patient-Centric Microsampling

NCT05948085
View directory record Official record
Conditions
Healthy
Interventions
Zavegepant 10 mg IN
Drug
Lead sponsor
Pfizer
Industry
Eligibility
18 Years and older
Enrollment
14 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jan 28, 2026 · Synced Sep 10, 2026, 5:00 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Osteopathic Manipulative Treatment and Migraine Headaches

NCT04976985
View directory record Official record
Conditions
Chronic Migraine, Migraine Disorders, Headache Disorders, Headache, Migraine
Interventions
Osteopathic Manipulative Therapy (OMT), Standard of care
Procedure · Other
Lead sponsor
St. Luke's Hospital, Pennsylvania
Other
Eligibility
18 Years to 50 Years
Enrollment
140 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2022
U.S. locations
1
States / cities
Bethlehem, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 2, 2021 · Synced Sep 10, 2026, 5:00 PM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Headache Ear Auditory Dizziness Sinus (HEADS) Registry

NCT07754266
View directory record Official record
Conditions
Headache Disorders, Dizziness, Vestibular Diseases, Sinus Disease, Vestibular Disorder, Migraine Disorders, Headache, Migraine, Facial Pain
Interventions
Not listed
Lead sponsor
Association of Migraine Disorders
Other
Eligibility
18 Years and older
Enrollment
10,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2033
U.S. locations
1
States / cities
North Kingstown, Rhode Island
Source: ClinicalTrials.gov public record
Updated Aug 9, 2026 · Synced Sep 10, 2026, 5:00 PM EDT
Completed No phase listed Observational

The Identification and Characterization of Autonomic Dysfunction in Migraineurs With and Without Auras

NCT01080287
View directory record Official record
Conditions
Migraine
Interventions
Not listed
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years to 65 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Feb 21, 2012 · Synced Sep 10, 2026, 5:00 PM EDT
Terminated Not applicable Interventional

Understanding the Pathophysiology of Migraine Pain

NCT03026101
View directory record Official record
Conditions
Migraine Disorders, Migraine, Classic, Migraine Without Aura
Interventions
Nitroglycerin
Other
Lead sponsor
Montefiore Medical Center
Other
Eligibility
18 Years to 80 Years
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2025
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Aug 19, 2025 · Synced Sep 10, 2026, 5:00 PM EDT