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ClinicalTrials.gov public records Last synced Oct 30, 2026, 2:48 AM EDT

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Showing 121–144 of 844 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Mild Cognitive Impairment Clear all
Recruiting Early Phase 1 Interventional

Psilocybin for Depression in People With Mild Cognitive Impairment or Early Alzheimer's Disease

NCT04123314
View directory record Official record
Conditions
Depressive Symptoms, Depression, Alzheimer Disease, Mild Cognitive Impairment
Interventions
Psilocybin
Drug
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 85 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2027
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Sep 4, 2026 · Synced Oct 30, 2026, 2:48 AM EDT
Not yet recruiting Phase 2 Interventional Accepts healthy volunteers

RQC for the Prevention of Alzheimer's Disease and Retinal Amyloid-β

NCT06470061
View directory record Official record
Conditions
Alzheimer Disease, Mild Cognitive Impairment, Cognitive Decline
Interventions
Resveratrol, Quercetin, and Curcumin (RQC), Curcumin
Drug
Lead sponsor
Zaparackas and Knepper LTD
Other
Eligibility
50 Years to 90 Years
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2027
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jun 26, 2024 · Synced Oct 30, 2026, 2:48 AM EDT
Not listed Phase 1 Interventional

Study for the Use of TKIs for Treatment of Cognitive Decline Due to Degenerative Dementias

NCT02921477
View directory record Official record
Conditions
Mild Cognitive Impairment, Dementia
Interventions
bosutinib
Drug
Lead sponsor
Neurological Associates of West Los Angeles
Other
Eligibility
45 Years to 89 Years
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2025
U.S. locations
1
States / cities
Santa Monica, California
Source: ClinicalTrials.gov public record
Updated Sep 28, 2022 · Synced Oct 30, 2026, 2:48 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Feasibility of Gamma Transcranial Alternating Current Stimulation to Reduce Beta-amyloid Load and Improve Memory

NCT04646499
View directory record Official record
Conditions
Mild Cognitive Impairment
Interventions
Transcranial alternating current stimulation
Device
Lead sponsor
University of California, San Francisco
Other
Eligibility
55 Years to 80 Years
Enrollment
14 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jul 27, 2023 · Synced Oct 30, 2026, 2:48 AM EDT
Completed No phase listed Observational

Effect of Cerefolin®/CerefolinNAC® on Biomarker Measurements

NCT01745198
View directory record Official record
Conditions
Mild Cognitive Impairment, Alzheimer's Disease, Alzheimer's Disease Related Disorders
Interventions
Not listed
Lead sponsor
Pamlab, Inc.
Industry
Eligibility
18 Years and older
Enrollment
121 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
1
States / cities
Newport Beach, California
Source: ClinicalTrials.gov public record
Updated Apr 28, 2015 · Synced Oct 30, 2026, 2:48 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Brain Health & the Microbiome

NCT06039267
View directory record Official record
Conditions
Mild Cognitive Impairment, Mild Dementia, Alzheimer Disease 1
Interventions
Gut Microbiome Testing
Other
Lead sponsor
George Washington University
Other
Eligibility
50 Years to 90 Years
Enrollment
44 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Jan 29, 2026 · Synced Oct 30, 2026, 2:48 AM EDT
Withdrawn No phase listed Observational

Imaging of Brain Structural/Functional Connectivity and Amyloid and Tau Lesions in APOE4 Carriers.

NCT03816228
View directory record Official record
Conditions
Alzheimer Disease
Interventions
F 18 T807 Flortaucipir
Drug
Lead sponsor
Tammie L. S. Benzinger, MD, PhD
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Mar 13, 2024 · Synced Oct 30, 2026, 2:48 AM EDT
Completed Not applicable Interventional

Use of an Internet-Based Insomnia Intervention to Prevent Cognitive Decline in Adults With Mild Cognitive Impairment

NCT04382365
View directory record Official record
Conditions
Mild Cognitive Impairment, Cognitive Impairment, Insomnia
Interventions
Sleep Health Using the Internet for Older Adult Sufferers of Insomnia and Sleeplessness
Other
Lead sponsor
University of Virginia
Other
Eligibility
55 Years and older
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Apr 27, 2021 · Synced Oct 30, 2026, 2:48 AM EDT
Recruiting Not applicable Interventional

Improve New Learning and Memory in Individuals With Mild Cognitive Impairment

NCT05396248
View directory record Official record
Conditions
Mild Cognitive Impairment
Interventions
Memory Retraining Exercises, Placebo Control Memory Exercises
Behavioral
Lead sponsor
Kessler Foundation
Other
Eligibility
60 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
2
States / cities
Ann Arbor, Michigan • West Orange, New Jersey
Source: ClinicalTrials.gov public record
Updated Jul 22, 2026 · Synced Oct 30, 2026, 2:48 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Using fMRI-guided TMS to Increase Central Executive Function in Older Adults (MCI_Sub)

NCT04176406
View directory record Official record
Conditions
Mild Cognitive Impairment
Interventions
rTMS, Sham rTMS
Device
Lead sponsor
Duke University
Other
Eligibility
55 Years to 80 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jan 27, 2021 · Synced Oct 30, 2026, 2:48 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Network-guided TMS in Early Alzheimer's Disease

NCT04549155
View directory record Official record
Conditions
Mild Cognitive Impairment
Interventions
Transcranial Magnetic Stimulation
Device
Lead sponsor
Duke University
Other
Eligibility
60 Years to 82 Years
Enrollment
37 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2025
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Oct 27, 2026 · Synced Oct 30, 2026, 2:48 AM EDT
Completed Phase 4 Interventional

The Evaluation of the Efficacy and Safety of Donepezil Hydrochloride in Subjects With Mild Cognitive Impairment (MCI)

NCT00293176
View directory record Official record
Conditions
Memory Loss
Interventions
Donepezil Hydrochloride, Placebo
Drug
Lead sponsor
Eisai Inc.
Industry
Eligibility
45 Years to 90 Years
Enrollment
821 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2007
U.S. locations
54
States / cities
Albaster, Alabama • Mesa, Arizona • Peoria, Arizona + 51 more
Source: ClinicalTrials.gov public record
Updated Apr 1, 2011 · Synced Oct 30, 2026, 2:48 AM EDT
Recruiting Not applicable Interventional

δ in Dementia Clinical Trials

NCT05592678
View directory record Official record
Conditions
Alzheimer's Disease (AD), Dementia, Cognitive Decline, Mild Cognitivie Impairment (MCI)
Interventions
Donepezil
Other
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
65 Years to 100 Years
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated May 5, 2026 · Synced Oct 30, 2026, 2:48 AM EDT
Completed Not applicable Interventional

Neurophysiological Benefits of Live Music for Early Alzheimer's Patients and Their Caregivers

NCT06940687
View directory record Official record
Conditions
Alzheimer Disease, Dementia, Mild Cognitive Impairment, Peer-bonded Caregiver, Caregiver
Interventions
Pre-recorded Music Session, Live Music Session
Behavioral
Lead sponsor
Yale University
Other
Eligibility
50 Years to 80 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
2
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Oct 19, 2026 · Synced Oct 30, 2026, 2:48 AM EDT
Terminated Early Phase 1 Interventional Results available

Pharmacokinetics Centella Asiatica Product (CAP) in Mild Cognitive Impairment

NCT03937908
View directory record Official record
Conditions
Cognitive Impairment, Elderly
Interventions
2g Centella asiatica water extract product, 4g Centella asiatica water extract product
Drug
Lead sponsor
Oregon Health and Science University
Other
Eligibility
65 Years to 85 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated May 4, 2022 · Synced Oct 30, 2026, 2:48 AM EDT
Completed Not applicable Interventional Results available

Repetitive Transcranial Magnetic Stimulation for Dementia

NCT02621424
View directory record Official record
Conditions
Dementia, Mild Cognitive Impairment
Interventions
RTMS, sham
Device
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
55 Years to 99 Years
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2025
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Sep 30, 2025 · Synced Oct 30, 2026, 2:48 AM EDT
Enrolling by invitation No phase listed Observational Accepts healthy volunteers

Biodistribution of [11C]PIB in Patients With Risk Factors for Alzheimer's Disease

NCT03089827
View directory record Official record
Conditions
Alzheimer Disease, Mild Cognitive Impairment
Interventions
Not listed
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
55 Years and older
Enrollment
800 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2031
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Dec 22, 2025 · Synced Oct 30, 2026, 2:48 AM EDT
Completed Not applicable Interventional Results available

A Policy Relevant US Trauma Care System Pragmatic Trial for PTSD and Comorbidity

NCT02655354
View directory record Official record
Conditions
Posttraumatic Stress Disorder, Depression, Alcohol-Related Disorders, Suicidal Ideation, Substance-Related Disorders, Mild Cognitive Impairment, Quality of Life, Pain, Wounds and Injury, Brain Injuries, Chronic Disease
Interventions
Motivational Interviewing, Cognitive Behavioral Therapy Elements, Care Management, Fluoxetine, Fluvoxamine, Paroxetine, Sertraline, Citalopram, Venlafaxine, Duloxetine, Mirtazapine, Diphenhydramine, Trazodone, Prazosin
Behavioral · Drug
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older
Enrollment
635 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2019
U.S. locations
24
States / cities
Scottsdale, Arizona • Beverly Hills, California • Sacramento, California + 20 more
Source: ClinicalTrials.gov public record
Updated Jul 2, 2021 · Synced Oct 30, 2026, 2:48 AM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Contributions of mTBI to Neurodegeneration Due to Chronic Traumatic Encephalopathy (CTE) and Alzheimer's Disease (AD)

NCT04124029
View directory record Official record
Conditions
Mild Traumatic Brain Injury, Moderate Traumatic Brain Injury, Mild Cognitive Impairment
Interventions
No Intervention is used for this study but all subjects will be asked to complete electroencephalogram (EEG) testing and an MRI scan., No intervention is used for this study but all subjects will be asked to complete a venous blood draw procedure and a lumbar puncture procedure.
Device · Procedure
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
30 Years to 90 Years
Enrollment
800 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2026
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 1, 2026 · Synced Oct 30, 2026, 2:48 AM EDT
Completed Not applicable Interventional

Virtual Reality Based Balance Training in People With Mild Cognitive Impairment

NCT02214342
View directory record Official record
Conditions
Distorted; Balance, Motor Deficit, Cognitive Deficit
Interventions
Balance Training
Other
Lead sponsor
University of Arizona
Other
Eligibility
Not listed
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014
U.S. locations
1
States / cities
Sun City, Arizona
Source: ClinicalTrials.gov public record
Updated Dec 16, 2014 · Synced Oct 30, 2026, 2:48 AM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Development of a Database to Investigate Digital and Blood-Based Biomarkers and Their Relationship to Tau and Amyloid PET Imaging in Older Participants Who Are Cognitively Normal (CN), Have Mild Cognitive Impairment (MCI), or Have Mild-to-Moderate AD Dementia

NCT06584357
View directory record Official record
Conditions
Mild Cognitive Impairment, Alzheimer's Disease, Alzheimer's Disease, Early Onset, Memory Loss, Memory Disorders, Memory Impairment
Interventions
Biomarker Data Collection, MK6240
Other · Radiation
Lead sponsor
GAP Innovations, PBC
Industry
Eligibility
60 Years to 90 Years
Enrollment
1,200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2028
U.S. locations
22
States / cities
Atlantis, Florida • Aventura, Florida • Clermont, Florida + 19 more
Source: ClinicalTrials.gov public record
Updated Apr 15, 2026 · Synced Oct 30, 2026, 2:48 AM EDT
Not yet recruiting Not applicable Interventional

Sleep Interventions and Neurocognitive Outcomes

NCT05987007
View directory record Official record
Conditions
Sleep Disturbance, Amnestic Mild Cognitive Impairment
Interventions
Acoustic slow-wave activity enhancement, Cognitive behavioral therapy for insomnia
Device · Behavioral
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
60 Years to 85 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 3, 2026 · Synced Oct 30, 2026, 2:48 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Sound and Music for Mild Cognitive Impairment

NCT05064007
View directory record Official record
Conditions
Mild Cognitive Impairment
Interventions
A: 40 Hz music, B: 40 Hz sound, C: Preferred music
Behavioral
Lead sponsor
Johns Hopkins University
Other
Eligibility
50 Years to 95 Years
Enrollment
52 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2025
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Aug 29, 2025 · Synced Oct 30, 2026, 2:48 AM EDT
Completed Not applicable Interventional Results available

Home-Based Dual-Task Training for Older Adults

NCT05108246
View directory record Official record
Conditions
Mild Cognitive Impairment
Interventions
Dual-Task Exercise Training
Behavioral
Lead sponsor
State University of New York at Buffalo
Other
Eligibility
65 Years and older
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Sep 19, 2024 · Synced Oct 30, 2026, 2:48 AM EDT