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Showing 1–24 of 91 matching trials from the live ClinicalTrials.gov search.
Local D1 index available.
Filters: Condition: Misoprostol Clear all
Completed Phase 2 Interventional Results available

Efficacy and Safety Study of the Misoprostol Vaginal Priming Insert (MVPI) Prior to Hysteroscopy

NCT00925938
View directory record Official record
Conditions
Cervical Priming
Interventions
misoprostol, placebo
Drug
Lead sponsor
Ferring Pharmaceuticals
Industry
Eligibility
18 Years to 80 Years · Female only
Enrollment
51 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010
U.S. locations
2
States / cities
Phoenix, Arizona • Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 12, 2014 · Synced Sep 6, 2026, 5:31 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Cervical Foley Plus Vaginal Misoprostol for Labor Induction

NCT01279343
View directory record Official record
Conditions
Induction of Labor
Interventions
Foley bulb
Device
Lead sponsor
Washington University School of Medicine
Other
Eligibility
16 Years to 45 Years · Female only
Enrollment
123 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2014
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated May 2, 2019 · Synced Sep 6, 2026, 5:31 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Misoprostol Dose and Timing Before Surgical Abortion at 13 to 16 Weeks' Gestation: a Randomized Trial

NCT02279914
View directory record Official record
Conditions
Abortion, Induced
Interventions
Misoprostol 400 mcg 3 hours prior to procedure, Misoprostol 600 mcg 90 minutes prior to procedure
Drug
Lead sponsor
Planned Parenthood of Greater New York
Other
Eligibility
18 Years and older · Female only
Enrollment
118 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2016
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 25, 2021 · Synced Sep 6, 2026, 5:31 AM EDT
Withdrawn Phase 4 Interventional

Misoprostol in Office Hysteroscopy and Endometrial Biopsy

NCT03547778
View directory record Official record
Conditions
Office Hysteroscopy and Endometrial Biopsy
Interventions
Misoprostol 50 mcg pesssary, Placebos
Drug
Lead sponsor
University of South Florida
Other
Eligibility
18 Years to 70 Years · Female only
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Jun 17, 2021 · Synced Sep 6, 2026, 5:31 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Mifepristone at Same Time Multicenter Study

NCT00269568
View directory record Official record
Conditions
Abortion Seekers
Interventions
mifepristone and misoprostol
Drug
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years to 55 Years · Female only
Enrollment
1,128 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2006
U.S. locations
4
States / cities
Los Angeles, California • Chicago, Illinois • Portland, Oregon + 1 more
Source: ClinicalTrials.gov public record
Updated Jan 28, 2016 · Synced Sep 6, 2026, 5:31 AM EDT
Completed Phase 3 Interventional Results available

Comparative Effectiveness of Pregnancy Failure Management Regimens

NCT02012491
View directory record Official record
Conditions
Spontaneous Abortion
Interventions
Misoprostol, Mifepristone
Drug
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older · Female only
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2019
U.S. locations
3
States / cities
Sacramento, California • The Bronx, New York • Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 17, 2019 · Synced Sep 6, 2026, 5:31 AM EDT
Completed Not applicable Interventional Results available

Foley Bulb With Oral Misoprostol for Induction of Labor

NCT03407625
View directory record Official record
Conditions
Pregnancy, Labor, Induced
Interventions
Foley bulb plus Oral Misoprostol, Oral Misoprostol
Other
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
10 Years and older · Female only
Enrollment
2,227 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Nov 3, 2020 · Synced Sep 6, 2026, 5:31 AM EDT
Completed No phase listed Observational

Labor Induction With Oral Versus Vaginal Misoprostol

NCT04755218
View directory record Official record
Conditions
Pregnancy, Labor, Induced
Interventions
Not listed
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
10 Years and older · Female only
Enrollment
2,546 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Apr 4, 2024 · Synced Sep 6, 2026, 5:31 AM EDT
Recruiting Early Phase 1 Interventional

Induction of Labor in Morbidly Obese Patients

NCT06199154
View directory record Official record
Conditions
Morbid Obesity, Pregnancy
Interventions
Misoprostol
Drug
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
18 Years and older · Female only
Enrollment
162 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 28, 2026 · Synced Sep 6, 2026, 5:31 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Randomized Trial Comparing Misoprostol and Foley Bulb for Pregnancy Termination in the Second Trimester

NCT00324519
View directory record Official record
Conditions
Pregnancy Trimester, Second, Induced Abortion
Interventions
Foley bulb, misoprostol
Device · Drug
Lead sponsor
University of Florida
Other
Eligibility
14 Years to 45 Years · Female only
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2007
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Mar 4, 2012 · Synced Sep 6, 2026, 5:31 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Cervical Ripening for Obese Women: A Randomized, Comparative Effectiveness Trial

NCT02639429
View directory record Official record
Conditions
Obesity, Labor Induction, Cesarean Delivery
Interventions
Vaginal Misoprostol, Foley Balloon + Vaginal Misoprostol
Drug · Device
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years and older · Female only
Enrollment
236 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2018
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Aug 25, 2019 · Synced Sep 6, 2026, 5:31 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Misoprostol Versus Dilapan-S for Cervical Preparation

NCT00835731
View directory record Official record
Conditions
Cervical Ripening
Interventions
misoprostol, Dilapan-S, vitamin B-12
Drug · Device
Lead sponsor
Planned Parenthood League of Massachusetts
Other
Eligibility
18 Years and older · Female only
Enrollment
125 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2011
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 22, 2017 · Synced Sep 6, 2026, 5:31 AM EDT
Recruiting Not applicable Interventional

Ripening Approaches for Prompt Induction and Delivery - Sequential Versus Concurrent Dilapan-S and Misoprostol to Achieve Vaginal Delivery (RAPID-DS)

NCT07717502
View directory record Official record
Conditions
Nulliparous Women Who Scheduled for Labor Induction, Pregnancy
Interventions
Sequential Cervical Ripening, Inpatient Combined Cervical Ripening
Combination Product
Lead sponsor
Ochsner Health System
Other
Eligibility
18 Years and older · Female only
Enrollment
260 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
New Orleans, Louisiana
Source: ClinicalTrials.gov public record
Updated Aug 23, 2026 · Synced Sep 6, 2026, 5:31 AM EDT
Completed No phase listed Observational

Misoprostol for Spinal Stenosis

NCT04611464
View directory record Official record
Conditions
Lumbar Spinal Stenosis, Low Back Pain
Interventions
Misoprostol
Drug
Lead sponsor
Dallas VA Medical Center
Federal
Eligibility
18 Years and older
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Nov 1, 2020 · Synced Sep 6, 2026, 5:31 AM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Immune Modulation by Misoprostol

NCT02259309
View directory record Official record
Conditions
Gynecological Infection
Interventions
Misoprostol - buccal, Misoprostol - vaginal
Drug
Lead sponsor
Vanderbilt University
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2015
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Jan 13, 2016 · Synced Sep 6, 2026, 5:31 AM EDT
Completed Phase 3 Interventional Results available

Safety/Efficacy Study Comparing the Misoprostol Vaginal Insert to Cervidil for Cervical Ripening and Induction of Labor

NCT00308711
View directory record Official record
Conditions
Cervical Ripening, Labor, Induced
Interventions
Misoprostol vaginal insert 100 mcg, Misoprostol vaginal insert 50 mcg, Dinoprostone vaginal insert (Cervidil)
Drug
Lead sponsor
Ferring Pharmaceuticals
Industry
Eligibility
18 Years and older · Female only
Enrollment
1,308 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2007
U.S. locations
49
States / cities
Birmingham, Alabama • Mesa, Arizona • Phoenix, Arizona + 43 more
Source: ClinicalTrials.gov public record
Updated Jun 24, 2012 · Synced Sep 6, 2026, 5:31 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

The Extended Gestational Age Medical Abortion Study

NCT00997347
View directory record Official record
Conditions
Medical Abortion
Interventions
Mifepristone and misoprostol
Drug
Lead sponsor
Gynuity Health Projects
Other
Eligibility
18 Years and older · Female only
Enrollment
1,400 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2012
U.S. locations
6
States / cities
West Palm Beach, Florida • Chicago, Illinois • Boston, Massachusetts + 3 more
Source: ClinicalTrials.gov public record
Updated Jul 1, 2012 · Synced Sep 6, 2026, 5:31 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Rectal Misoprostol as a Hemostatic Agent During Abdominal Myomectomy

NCT03064568
View directory record Official record
Conditions
Myomectomy; Surgical Blood Loss
Interventions
Misoprostol 200Mcg Tab, Placebo
Drug
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
20 Years to 50 Years · Female only
Enrollment
18 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2024
U.S. locations
3
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Jul 28, 2025 · Synced Sep 6, 2026, 5:31 AM EDT
Terminated Phase 2 Interventional Results available

PROCLAIM -- Misoprostol in the Prevention of Recurrent CDI Prevent Recurrence of Clostridium Difficile Infection With Misoprostol

NCT03617172
View directory record Official record
Conditions
Clostridium Difficile
Interventions
Misoprostol 100Mcg Tab, Placebo
Drug · Other
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
18 Years and older
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
3
States / cities
St Louis, Missouri • Chapel Hill, North Carolina • Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Nov 29, 2022 · Synced Sep 6, 2026, 5:31 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Cervical Preparation Before Dilation and Evacuation

NCT01751087
View directory record Official record
Conditions
Abortion, Induced
Interventions
Mifepristone, misoprostol, Osmotic dilators, placebo
Other · Drug · Device
Lead sponsor
Planned Parenthood League of Massachusetts
Other
Eligibility
18 Years and older · Female only
Enrollment
300 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2014
U.S. locations
7
States / cities
San Francisco, California • Chicago, Illinois • Boston, Massachusetts + 3 more
Source: ClinicalTrials.gov public record
Updated Feb 23, 2016 · Synced Sep 6, 2026, 5:31 AM EDT
Completed Phase 3 Interventional Results available

Misoprostol for Treatment of Fetal Death at 14-28 Weeks of Pregnancy

NCT00671060
View directory record Official record
Conditions
Intrauterine Fetal Demise
Interventions
Misoprostol
Drug
Lead sponsor
Gynuity Health Projects
Other
Eligibility
Female only
Enrollment
153 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2011
U.S. locations
4
States / cities
Palo Alto, California • Newark, Delaware • Chicago, Illinois + 1 more
Source: ClinicalTrials.gov public record
Updated May 7, 2013 · Synced Sep 6, 2026, 5:31 AM EDT
Withdrawn Not applicable Interventional

Mifepristone Versus Osmotic Dilators in Conjunction With Misoprostol for Cervical Preparation Prior to D&E at 14-19 Weeks

NCT02679092
View directory record Official record
Conditions
Legally Induced Abortion Without Mention of Complication
Interventions
Misoprostol, Mifepristone, Hygroscopic cervical dilators
Drug · Device
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older · Female only
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
1
States / cities
San Jose, California
Source: ClinicalTrials.gov public record
Updated Sep 18, 2019 · Synced Sep 6, 2026, 5:31 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Combined Vaginal Misoprostol and Perivascular Vasopressin

NCT03815344
View directory record Official record
Conditions
Leiomyoma, Laparoscopy, Uterine Myomectomy
Interventions
Standard, Standard-vaginal misoprostol
Drug
Lead sponsor
Antonios Likourezos
Other
Eligibility
18 Years to 55 Years · Female only
Enrollment
74 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
Brooklyn, New York
Source: ClinicalTrials.gov public record
Updated Jan 8, 2024 · Synced Sep 6, 2026, 5:31 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Mifepristone Versus Misoprostol for Cervical Preparation Prior to Surgical Abortion Between 11 to 15 Weeks

NCT01636063
View directory record Official record
Conditions
Induced Abortion, Abortion Techniques, Mifepristone, Misoprostol
Interventions
Mifepristone, Misoprostol
Drug
Lead sponsor
Boston University
Other
Eligibility
18 Years and older · Female only
Enrollment
42 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2014
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 21, 2017 · Synced Sep 6, 2026, 5:31 AM EDT