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ClinicalTrials.gov public records Last synced Oct 21, 2026, 9:30 AM EDT

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Showing 1–24 of 91 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Misoprostol Clear all
Completed Not applicable Interventional Accepts healthy volunteers

A Randomized Trial of Buccal Compared to Oral Misoprostol Following Mifepristone for Medical Abortion up to 63 Days LMP

NCT00386867
View directory record Official record
Conditions
Abortion, Induced
Interventions
800 mcg misoprostol via oral or buccal administration
Drug
Lead sponsor
Gynuity Health Projects
Other
Eligibility
18 Years and older · Female only
Enrollment
1,200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2007
U.S. locations
8
States / cities
Chicago, Illinois • Boston, Massachusetts • New York, New York + 3 more
Source: ClinicalTrials.gov public record
Updated Jun 5, 2007 · Synced Oct 21, 2026, 9:30 AM EDT
Not listed Phase 3 Interventional Accepts healthy volunteers

Mifepristone and Misoprostol for Undesired Pregnancy of Unknown Location

NCT05839899
View directory record Official record
Conditions
Abortion
Interventions
Mifepristone plus one dose Misoprostol, Mifepristone plus two doses Misoprostol
Drug
Lead sponsor
Planned Parenthood League of Massachusetts
Other
Eligibility
18 Years and older · Female only
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 5, 2023 · Synced Oct 21, 2026, 9:30 AM EDT
Terminated Phase 3 Interventional Results available

Effect of Preoperative Buccal Misoprostol on Blood Loss in Second-trimester Dilation and Evacuation Abortion

NCT01436266
View directory record Official record
Conditions
Abortion, Blood Loss
Interventions
Misoprostol, Folic acid
Drug · Other
Lead sponsor
Boston University
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 30, 2017 · Synced Oct 21, 2026, 9:30 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Mifepristone at Same Time Multicenter Study

NCT00269568
View directory record Official record
Conditions
Abortion Seekers
Interventions
mifepristone and misoprostol
Drug
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years to 55 Years · Female only
Enrollment
1,128 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2006
U.S. locations
4
States / cities
Los Angeles, California • Chicago, Illinois • Portland, Oregon + 1 more
Source: ClinicalTrials.gov public record
Updated Jan 29, 2016 · Synced Oct 21, 2026, 9:30 AM EDT
Not listed No phase listed Observational Accepts healthy volunteers

Study of Effect of Vaginal ph and Acidification of Vaginal Misoprostol on Its Efficacy for Induction of Midtrimester Abortion

NCT01241045
View directory record Official record
Conditions
To Evaluate the Impact of the Vaginal Ph and Acidification of Vaginal Misoprostol on Its Efficacy in Facilitating Induction of Mid-trimester Abortion.
Interventions
Not listed
Lead sponsor
Ain Shams University
Other
Eligibility
15 Years to 45 Years · Female only
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010
U.S. locations
1
States / cities
Cairo, California
Source: ClinicalTrials.gov public record
Updated Nov 16, 2010 · Synced Oct 21, 2026, 9:30 AM EDT
Completed Phase 3 Interventional Results available

Misoprostol for Treatment of Fetal Death at 14-28 Weeks of Pregnancy

NCT00671060
View directory record Official record
Conditions
Intrauterine Fetal Demise
Interventions
Misoprostol
Drug
Lead sponsor
Gynuity Health Projects
Other
Eligibility
Female only
Enrollment
153 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2011
U.S. locations
4
States / cities
Palo Alto, California • Newark, Delaware • Chicago, Illinois + 1 more
Source: ClinicalTrials.gov public record
Updated May 8, 2013 · Synced Oct 21, 2026, 9:30 AM EDT
Terminated Phase 4 Interventional Accepts healthy volunteers

Mifepristone and Two Doses of Misoprostol for Abortion at 11&12 Weeks

NCT05119439
View directory record Official record
Conditions
Medical Abortion
Interventions
Mifepristone + 2 doses of misoprostol 800 mcg
Drug
Lead sponsor
Gynuity Health Projects
Other
Eligibility
11 Years to 55 Years · Female only
Enrollment
23 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
6
States / cities
Hilo, Hawaii • Honolulu, Hawaii • Saint Paul, Minnesota + 3 more
Source: ClinicalTrials.gov public record
Updated Jul 25, 2023 · Synced Oct 21, 2026, 9:30 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Comparison of Misoprostol Ripening Efficacy With Dilapan

NCT03670836
View directory record Official record
Conditions
Labor Onset and Length Abnormalities, Induced; Birth
Interventions
Dilapan, Misoprostol
Device · Drug
Lead sponsor
Columbia University
Other
Eligibility
18 Years and older · Female only
Enrollment
307 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2021
U.S. locations
2
States / cities
New York, New York • Galveston, Texas
Source: ClinicalTrials.gov public record
Updated Jul 19, 2024 · Synced Oct 21, 2026, 9:30 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

Misoprostol for Non-Viable Pregnancies

NCT00426491
View directory record Official record
Conditions
Abortifacient Agents, Nonsteroidal, Abortion, Incomplete, Misoprostol, Pregnancy
Interventions
Misoprostol
Drug
Lead sponsor
Madigan Army Medical Center
Federal
Eligibility
18 Years to 40 Years · Female only
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
1999 – 2006
U.S. locations
1
States / cities
Tacoma, Washington
Source: ClinicalTrials.gov public record
Updated Feb 8, 2008 · Synced Oct 21, 2026, 9:30 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Outpatient Medical Abortion With Mifepristone and Misoprostol Through 77 Days of Gestation

NCT02314754
View directory record Official record
Conditions
Medical Abortion
Interventions
Mifepristone followed by misoprostol 24-48 hours later
Drug
Lead sponsor
Gynuity Health Projects
Other
Eligibility
11 Years to 55 Years · Female only
Enrollment
719 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2016
U.S. locations
4
States / cities
Hartford, Connecticut • Atlanta, Georgia • Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jul 14, 2016 · Synced Oct 21, 2026, 9:30 AM EDT
Completed Phase 3 Interventional Results available

Comparative Effectiveness of Pregnancy Failure Management Regimens

NCT02012491
View directory record Official record
Conditions
Spontaneous Abortion
Interventions
Misoprostol, Mifepristone
Drug
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older · Female only
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2019
U.S. locations
3
States / cities
Sacramento, California • The Bronx, New York • Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 18, 2019 · Synced Oct 21, 2026, 9:30 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Intra Uterine Device Insertion in Nulliparous Women

NCT01422226
View directory record Official record
Conditions
Contraception
Interventions
Misoprostol, Placebo
Drug · Other
Lead sponsor
University of Colorado, Denver
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
3 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2012
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Feb 2, 2017 · Synced Oct 21, 2026, 9:30 AM EDT
Completed No phase listed Observational

Misoprostol for Spinal Stenosis

NCT04611464
View directory record Official record
Conditions
Lumbar Spinal Stenosis, Low Back Pain
Interventions
Misoprostol
Drug
Lead sponsor
Dallas VA Medical Center
Federal
Eligibility
18 Years and older
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Nov 2, 2020 · Synced Oct 21, 2026, 9:30 AM EDT
Completed Phase 2 Interventional

A Randomized, Control Trial for Preinduction Cervical Ripening

NCT00393731
View directory record Official record
Conditions
Labor, Induced
Interventions
Misoprostol, oxytocin
Drug
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
Female only
Enrollment
540 participants
Timeline
2004 – 2007
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jan 16, 2008 · Synced Oct 21, 2026, 9:30 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Cervical Ripening for Obese Women: A Randomized, Comparative Effectiveness Trial

NCT02639429
View directory record Official record
Conditions
Obesity, Labor Induction, Cesarean Delivery
Interventions
Vaginal Misoprostol, Foley Balloon + Vaginal Misoprostol
Drug · Device
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years and older · Female only
Enrollment
236 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2018
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Aug 26, 2019 · Synced Oct 21, 2026, 9:30 AM EDT
Recruiting Not applicable Interventional

Ripening Approaches for Prompt Induction and Delivery - Sequential Versus Concurrent Dilapan-S and Misoprostol to Achieve Vaginal Delivery (RAPID-DS)

NCT07717502
View directory record Official record
Conditions
Nulliparous Women Who Scheduled for Labor Induction, Pregnancy
Interventions
Sequential Cervical Ripening, Inpatient Combined Cervical Ripening
Combination Product
Lead sponsor
Ochsner Health System
Other
Eligibility
18 Years and older · Female only
Enrollment
260 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
New Orleans, Louisiana
Source: ClinicalTrials.gov public record
Updated Aug 24, 2026 · Synced Oct 21, 2026, 9:30 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Misoprostol With Intrauterine Device Insertion

NCT00613366
View directory record Official record
Conditions
Contraception
Interventions
Misoprostol, Magnesium Oxide
Drug · Dietary Supplement
Lead sponsor
Oregon Health and Science University
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2010
U.S. locations
2
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Mar 15, 2013 · Synced Oct 21, 2026, 9:30 AM EDT
Withdrawn Phase 4 Interventional

Misoprostol in Office Hysteroscopy and Endometrial Biopsy

NCT03547778
View directory record Official record
Conditions
Office Hysteroscopy and Endometrial Biopsy
Interventions
Misoprostol 50 mcg pesssary, Placebos
Drug
Lead sponsor
University of South Florida
Other
Eligibility
18 Years to 70 Years · Female only
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Jun 18, 2021 · Synced Oct 21, 2026, 9:30 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Letrozole and Misoprostol for Termination of Pregnancy up to 63 Days' Gestation

NCT05207644
View directory record Official record
Conditions
Pregnancy
Interventions
30 mg letrozole followed by 800 mcg misoprostol
Drug
Lead sponsor
Gynuity Health Projects
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Jun 15, 2022 · Synced Oct 21, 2026, 9:30 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Effect of Adjunctive Misoprostol Treatment on Blood Loss at Vaginal Delivery

NCT02411916
View directory record Official record
Conditions
Postpartum Hemorrhage
Interventions
misoprostol
Biological
Lead sponsor
New York City Health and Hospitals Corporation
Other
Eligibility
18 Years and older · Female only
Enrollment
143 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2019
U.S. locations
1
States / cities
Jamaica, New York
Source: ClinicalTrials.gov public record
Updated Sep 30, 2021 · Synced Oct 21, 2026, 9:30 AM EDT
Completed Phase 2 Interventional

Development of a Non-Invasive Treatment for Uterine Leiomyoma (Fibroids)

NCT00332033
View directory record Official record
Conditions
Uterine Leiomyoma, Fibroids
Interventions
Pirfenidone
Drug
Lead sponsor
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
NIH
Eligibility
35 Years to 50 Years · Female only
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2007
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 2, 2017 · Synced Oct 21, 2026, 9:30 AM EDT
Completed No phase listed Observational

Outpatient Cervical Ripening

NCT04041687
View directory record Official record
Conditions
Pregnancy
Interventions
Not listed
Lead sponsor
Prisma Health-Upstate
Other
Eligibility
Female only
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Greenville, South Carolina
Source: ClinicalTrials.gov public record
Updated Oct 30, 2024 · Synced Oct 21, 2026, 9:30 AM EDT
Completed Phase 4 Interventional Results available

Misoprostol Dosing in BMI Greater Than 30

NCT05262738
View directory record Official record
Conditions
Pregnancy Related, Obesity, Labor Onset and Length Abnormalities
Interventions
50 Micrograms Vaginal Misoprostol (Intervention), 25 Micrograms Vaginal Misoprostol (Control)
Drug
Lead sponsor
University of Texas at Austin
Other
Eligibility
18 Years and older · Female only
Enrollment
180 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Jul 3, 2024 · Synced Oct 21, 2026, 9:30 AM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Buccal Versus Vaginal Misoprostol In Combination With Foley Bulb

NCT03976037
View directory record Official record
Conditions
Induction of Labor
Interventions
Misoprostol
Drug
Lead sponsor
Christiana Care Health Services
Other
Eligibility
18 Years to 55 Years · Female only
Enrollment
216 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
Newark, Delaware
Source: ClinicalTrials.gov public record
Updated Feb 26, 2021 · Synced Oct 21, 2026, 9:30 AM EDT