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ClinicalTrials.gov public records Last synced Oct 30, 2026, 10:49 PM EDT

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Showing 1–24 of 163 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Mitral Disease Clear all
Recruiting Not applicable Interventional

Cephea Early Feasibility Study

NCT05061004
View directory record Official record
Conditions
Mitral Regurgitation
Interventions
Cephea Mitral Valve System
Device
Lead sponsor
Abbott Medical Devices
Industry
Eligibility
18 Years and older
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2031
U.S. locations
20
States / cities
Phoenix, Arizona • Los Angeles, California • Sacramento, California + 15 more
Source: ClinicalTrials.gov public record
Updated Sep 11, 2026 · Synced Oct 30, 2026, 10:49 PM EDT
Active, not recruiting Not applicable Interventional

EFS of the CardioMech MVRS

NCT04820764
View directory record Official record
Conditions
Mitral Regurgitation
Interventions
CardioMech MVRS
Device
Lead sponsor
CardioMech AS
Industry
Eligibility
18 Years and older
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2031
U.S. locations
12
States / cities
Thousand Oaks, California • Evanston, Illinois • Wichita, Kansas + 9 more
Source: ClinicalTrials.gov public record
Updated Sep 25, 2026 · Synced Oct 30, 2026, 10:49 PM EDT
Completed Not applicable Interventional Results available

Feasibility Study of the Tendyne Mitral Valve System in Mitral Annular Calcification

NCT03539458
View directory record Official record
Conditions
Mitral Regurgitation, Mitral Insufficiency, Mitral Annular Calcification, Mitral Annulus Calcification, Cardiovascular Diseases, Valve Heart Disease, Heart Valve Diseases, Heart Valve Calcification, Mitral Valve Disease
Interventions
Tendyne Mitral Valve System
Device
Lead sponsor
Abbott Medical Devices
Industry
Eligibility
18 Years and older
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2024
U.S. locations
4
States / cities
Atlanta, Georgia • Wichita, Kansas • Minneapolis, Minnesota + 1 more
Source: ClinicalTrials.gov public record
Updated Nov 18, 2024 · Synced Oct 30, 2026, 10:49 PM EDT
Terminated Not applicable Interventional Results available

Cardiovalve Transfemoral Mitral Valve System

NCT03813524
View directory record Official record
Conditions
Mitral Regurgitation
Interventions
Cardiovalve Transfemoral Mitral Valve
Device
Lead sponsor
Cardiovalve Ltd.
Industry
Eligibility
18 Years to 84 Years
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
2
States / cities
Atlanta, Georgia • New York, New York
Source: ClinicalTrials.gov public record
Updated Jun 25, 2026 · Synced Oct 30, 2026, 10:49 PM EDT
Completed No phase listed Observational

Invasive Hemodynamic Response to Transcatheter Edge-to-Edge Mitral Valve Repair

NCT04200378
View directory record Official record
Conditions
Mitral Regurgitation
Interventions
Not listed
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2024
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated May 23, 2024 · Synced Oct 30, 2026, 10:49 PM EDT
Completed Not applicable Interventional

Physical and Functional Recovery From Cardiac Surgery in Hospitalized Patients: A Feasibility Pilot Study

NCT02375282
View directory record Official record
Conditions
Coronary Artery Disease, Mitral Valve Insufficiency, Aortic Valve Stenosis, Aortic Valve Regurgitation, Mitral Valve Stenosis, Coronary Artery Bypass Graft Triple Vessel
Interventions
Ambulation orderly
Procedure
Lead sponsor
Baystate Medical Center
Other
Eligibility
18 Years and older
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
Springfield, Massachusetts
Source: ClinicalTrials.gov public record
Updated Nov 6, 2017 · Synced Oct 30, 2026, 10:49 PM EDT
Completed Phase 3 Interventional Results available

Levosimendan in Patients With Left Ventricular Systolic Dysfunction Undergoing Cardiac Surgery On Cardiopulmonary Bypass

NCT02025621
View directory record Official record
Conditions
Coronary Artery Bypass Grafting, Mitral Valve Surgery, Low Cardiac Output Syndrome
Interventions
Levosimendan, Placebo
Drug
Lead sponsor
Tenax Therapeutics, Inc.
Industry
Eligibility
18 Years and older
Enrollment
882 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
49
States / cities
Burlington, Alabama • Huntsville, Alabama • Sacramento, California + 41 more
Source: ClinicalTrials.gov public record
Updated Jun 21, 2018 · Synced Oct 30, 2026, 10:49 PM EDT
Active, not recruiting No phase listed Observational

Genomic Investigation of Cardiovascular Diseases

NCT00722748
View directory record Official record
Conditions
Coronary Artery Disease, Myocardial Infarction, Atrial Fibrillation, Aortic Stenosis, Mitral Regurgitation, Idiopathic Cardiomyopathy
Interventions
Not listed
Lead sponsor
Scripps Translational Science Institute
Other
Eligibility
18 Years and older
Enrollment
15,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2030
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Jan 16, 2025 · Synced Oct 30, 2026, 10:49 PM EDT
Completed Phase 3 Interventional Results available

Rate Control Versus Rhythm Control For Postoperative Atrial Fibrillation

NCT02132767
View directory record Official record
Conditions
Postoperative Atrial Fibrillation
Interventions
Amiodarone, DC-cardioversion, Rate Control
Drug · Procedure
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years and older
Enrollment
523 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
17
States / cities
Los Angeles, California • Atlanta, Georgia • Baltimore, Maryland + 13 more
Source: ClinicalTrials.gov public record
Updated Mar 15, 2019 · Synced Oct 30, 2026, 10:49 PM EDT
Completed Phase 4 Interventional

A Randomized Clinical Trial of Metoprolol in Participants With Mitral Regurgitation.

NCT00166400
View directory record Official record
Conditions
Heart Valve Diseases
Interventions
metoprolol succinate
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
21 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2007
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Jul 24, 2008 · Synced Oct 30, 2026, 10:49 PM EDT
Completed Not applicable Interventional Results available

ProspeCtive, nOn-randoMized, MulticENter Clinical Evaluation of Edwards Pericardial Bioprostheses With a New Tissue Treatment Platform (COMMENCE)

NCT01757665
View directory record Official record
Conditions
Aortic Stenosis, Mitral Stenosis, Aortic Valve Insufficiency, Mitral Valve Insufficiency, Heart Failure
Interventions
Edwards Aortic and Mitral Bioprostheses Models 11000A and 11000M
Device
Lead sponsor
Edwards Lifesciences
Industry
Eligibility
18 Years and older
Enrollment
777 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2026
U.S. locations
29
States / cities
Birmingham, Alabama • Los Angeles, California • Sacramento, California + 20 more
Source: ClinicalTrials.gov public record
Updated May 7, 2026 · Synced Oct 30, 2026, 10:49 PM EDT
Completed Not applicable Interventional Results available

HALO: A Single Arm Prospective Investigation of the SJM™ Masters HP™ 15mm Rotatable Mechanical Heart Valve

NCT02097420
View directory record Official record
Conditions
Mitral Valve Disease, Damaged Mitral Valve, Malfunctioning Mitral Heart Valve, Mitral Valve Replacement
Interventions
Mitral valve replacement SJM™ Masters HP™ 15mm Rotatable Mechanical Heart Valve
Device
Lead sponsor
Abbott Medical Devices
Industry
Eligibility
Up to 5 Years
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2023
U.S. locations
24
States / cities
Birmingham, Alabama • Little Rock, Arkansas • Los Angeles, California + 20 more
Source: ClinicalTrials.gov public record
Updated Feb 11, 2025 · Synced Oct 30, 2026, 10:49 PM EDT
Not listed No phase listed Observational

Primary Mitral Regurgitation Repair

NCT04067635
View directory record Official record
Conditions
Mitral Valve Insufficiency, Mitral Valve Prolapse, Chronic Mitral Disease, Mitral Regurgitation, Mitral Valve Disease, Degenerative Mitral Valve Disease, Myxomatous Mitral Valve Degeneration, Ventricular Remodeling
Interventions
Not listed
Lead sponsor
Eric Y. Yang, MD PhD
Other
Eligibility
18 Years and older
Enrollment
116 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Aug 28, 2019 · Synced Oct 30, 2026, 10:49 PM EDT
Recruiting No phase listed Observational

Mosaic Mitral Valve: Long-Term Outcomes in Patients Under 65

NCT06917586
View directory record Official record
Conditions
Valve Disease, Heart, Valve Replacement, Valve Regurgitation, Mitral, Valve Heart Stenosis
Interventions
Not listed
Lead sponsor
Michael Moront
Other
Eligibility
18 Years to 65 Years
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Toledo, Ohio
Source: ClinicalTrials.gov public record
Updated Feb 20, 2026 · Synced Oct 30, 2026, 10:49 PM EDT
Completed No phase listed Observational

Molecular Mechanisms of Mitral Regurgitation-Aim 2

NCT01052532
View directory record Official record
Conditions
Mitral Regurgitation
Interventions
Not listed
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
21 Years and older
Enrollment
65 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2010
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Dec 2, 2010 · Synced Oct 30, 2026, 10:49 PM EDT
Active, not recruiting Not applicable Interventional

Edwards PASCAL CLASP IID/IIF Pivotal Clinical Trial

NCT03706833
View directory record Official record
Conditions
Degenerative Mitral Valve Disease, Mitral Regurgitation, Mitral Insufficiency, Functional Mitral Regurgitation
Interventions
Edwards PASCAL System, Abbott Mitraclip System
Device
Lead sponsor
Edwards Lifesciences
Industry
Eligibility
18 Years and older
Enrollment
1,247 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2031
U.S. locations
63
States / cities
Phoenix, Arizona • Tucson, Arizona • La Jolla, California + 50 more
Source: ClinicalTrials.gov public record
Updated Jul 8, 2026 · Synced Oct 30, 2026, 10:49 PM EDT
Completed Not applicable Interventional Results available

Early Feasibility Study of the Neovasc Tiara™ Mitral Valve System

NCT02276547
View directory record Official record
Conditions
Mitral Valve Regurgitation
Interventions
Mitral valve replacement
Device
Lead sponsor
Shockwave Medical, Inc.
Industry
Eligibility
18 Years and older
Enrollment
27 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2024
U.S. locations
6
States / cities
Los Angeles, California • Chicago, Illinois • Detroit, Michigan + 3 more
Source: ClinicalTrials.gov public record
Updated Jul 24, 2026 · Synced Oct 30, 2026, 10:49 PM EDT
Terminated Not applicable Interventional Results available

Artificial Valve Endocarditis Reduction Trial

NCT00590889
View directory record Official record
Conditions
Aortic Valve Disease, Mitral Valve Disease, Endocarditis
Interventions
Artificial Mechanical Heart Valve
Device
Lead sponsor
Abbott Medical Devices
Industry
Eligibility
Not listed
Enrollment
807 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1998 – 2014
U.S. locations
7
States / cities
Orlando, Florida • Boston, Massachusetts • Rochester, Minnesota + 3 more
Source: ClinicalTrials.gov public record
Updated Feb 27, 2019 · Synced Oct 30, 2026, 10:49 PM EDT
Not listed Not applicable Interventional

Caisson Transcatheter Mitral Valve Replacement (TMVR) System Early Feasibility Study

NCT02768402
View directory record Official record
Conditions
Mitral Valve Regurgitation
Interventions
Caisson TMVR System
Device
Lead sponsor
Caisson Interventional LLC
Industry
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2023
U.S. locations
13
States / cities
Los Angeles, California • Washington D.C., District of Columbia • Delray Beach, Florida + 9 more
Source: ClinicalTrials.gov public record
Updated Jan 28, 2020 · Synced Oct 30, 2026, 10:49 PM EDT
Completed Phase 2 Interventional

Safety and Efficacy of TP10, a Complement Inhibitor, in Adult Women Undergoing Cardiopulmonary Bypass Surgery

NCT00082121
View directory record Official record
Conditions
Myocardial Ischemia, Coronary Arteriosclerosis, Aortic Valve Insufficiency, Mitral Valve Insufficiency
Interventions
TP10
Drug
Lead sponsor
Avant Immunotherapeutics
Industry
Eligibility
18 Years and older · Female only
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2005
U.S. locations
18
States / cities
San Francisco, California • Washington D.C., District of Columbia • Gainesville, Florida + 15 more
Source: ClinicalTrials.gov public record
Updated Jul 20, 2007 · Synced Oct 30, 2026, 10:49 PM EDT
Completed No phase listed Observational

Development of an Algorithm to Differentiate Heart Murmurs Using Electronic Stethoscopes

NCT04400513
View directory record Official record
Conditions
Murmur, Heart, Aortic Valve Stenosis, Tricuspid Regurgitation, Mitral Regurgitation, Innocent Murmurs, Heart Murmurs
Interventions
Use of Eko CORE and Eko DUO electronic stethoscopes
Device
Lead sponsor
Eko Devices, Inc.
Industry
Eligibility
18 Years and older
Enrollment
1,145 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Springfield, Missouri
Source: ClinicalTrials.gov public record
Updated Feb 15, 2023 · Synced Oct 30, 2026, 10:49 PM EDT
Recruiting Not applicable Interventional

A Clinical Study of GeminiOne TEER System for the Treatment of Severe, Symptomatic MR.

NCT07086534
View directory record Official record
Conditions
Mitral Regurgitation
Interventions
GeminiOne Transcatheter Edge-to-Edge Repair (TEER) System
Device
Lead sponsor
Sierra Valve LLC
Industry
Eligibility
18 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2031
U.S. locations
1
States / cities
Thousand Oaks, California
Source: ClinicalTrials.gov public record
Updated Apr 24, 2026 · Synced Oct 30, 2026, 10:49 PM EDT
Not listed Phase 4 Interventional

Effect of Ranolazine on Valvular Disease in Patients With Pacemakers

NCT01979965
View directory record Official record
Conditions
Ischemic Mitral Regurgitation
Interventions
Ranolazine (Active drug), Placebo
Drug
Lead sponsor
University Cardiology
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
1
States / cities
Knoxville, Tennessee
Source: ClinicalTrials.gov public record
Updated Nov 8, 2013 · Synced Oct 30, 2026, 10:49 PM EDT
Completed Phase 2Phase 3 Interventional Accepts healthy volunteers Results available

Molecular Mechanisms of Volume Overload-Aim 1(SCCOR in Cardiac Dysfunction and Disease)

NCT01052428
View directory record Official record
Conditions
Mitral Regurgitation
Interventions
metoprolol succinate (Toprol XL), Placebo
Drug
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
19 Years to 70 Years
Enrollment
38 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2010
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Nov 22, 2012 · Synced Oct 30, 2026, 10:49 PM EDT