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ClinicalTrials.gov public records Last synced Nov 4, 2026, 2:56 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1–24 of 241 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Mitral Valve Insufficiency Clear all

Conditions: Mitral Valve Insufficiency, Mitral Valve Regurgitation, Mitral Valve Incompetence, Mitral Regurgitation, Mitral Insufficiency
Interventions: Percutaneous mitral valve repair (MitraClip Implant); Device
Lead sponsor: Abbott Medical Devices; Industry
Eligibility: 18 Years and older
Enrollment: 55 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2003 – 2011
U.S. locations: 1
States / cities: Evanston, Illinois

Conditions: Glioma
Interventions: Deuterated Glucose, Magnetic Resonance Imaging (MRI), Blood Sample, MR spectroscopy (MRS); Drug · Procedure
Lead sponsor: University of California, San Francisco; Other
Eligibility: 18 Years and older
Enrollment: 80 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2027
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Ischemic Stroke
Interventions: intravenous (IV) recombinant human tissue plasminogen activator (rtPA), Penumbra System; Drug · Device
Lead sponsor: Penumbra Inc.; Industry
Eligibility: 18 Years to 85 Years
Enrollment: 108 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2016
U.S. locations: 4
States / cities: Denver, Colorado • Gainesville, Florida • Chicago, Illinois + 1 more

Conditions: Hepatic Encephalopathy, Liver Cirrhosis
Interventions: Flumazenil, Placebo; Drug
Lead sponsor: Yale University; Other
Eligibility: 18 Years to 99 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2017
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Bipolar I Disorder, Schizoaffective Disorder, Psychosis
Interventions: Ketogenic diet; Other
Lead sponsor: Mclean Hospital; Other
Eligibility: 18 Years to 45 Years
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2027
U.S. locations: 1
States / cities: Belmont, Massachusetts

Conditions: Mitral Valve Regurgitation, Congestive Heart Failure, Cardiomyopathy
Interventions: 3 dimensional echocardiography; Procedure
Lead sponsor: Juan Crestanello, MD; Other
Eligibility: 18 Years and older
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2012
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Mitral Regurgitation
Interventions: Not listed
Lead sponsor: Mayo Clinic; Other
Eligibility: 18 Years and older
Enrollment: 22 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2024
U.S. locations: 1
States / cities: Rochester, Minnesota

Conditions: Ischemic Stroke, Acute Stroke
Interventions: Zoom System; Device
Lead sponsor: Imperative Care, Inc.; Industry
Eligibility: 18 Years and older
Enrollment: 750 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2030
U.S. locations: 25
States / cities: Huntsville, Alabama • Walnut Creek, California • Tampa, Florida + 20 more

Conditions: Malignant Gliomas, Oligodendrogliomas, Astrocytomas
Interventions: 3 Tesla scanning; Device
Lead sponsor: University of Texas Southwestern Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 142 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2021
U.S. locations: 1
States / cities: Dallas, Texas

Conditions: Bipolar Disorder, Bipolar Depression, Bipolar I Disorder, Bipolar II Disorder
Interventions: Low Field Magnetic Stimulation; Device
Lead sponsor: Mclean Hospital; Other
Eligibility: 50 Years and older
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2026
U.S. locations: 1
States / cities: Belmont, Massachusetts

Conditions: Alcoholism
Interventions: Ketogenic Diet (KD), Standard American (SA) Meals and Shakes; Other
Lead sponsor: National Institute on Alcohol Abuse and Alcoholism (NIAAA); NIH
Eligibility: 18 Years and older
Enrollment: 53 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2023
U.S. locations: 1
States / cities: Bethesda, Maryland

Conditions: Mitral Regurgitation, Mitral Valve Regurgitation
Interventions: MitraClip® NT System; Device
Lead sponsor: Abbott Medical Devices; Industry
Eligibility: 18 Years and older
Enrollment: 162 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2024
U.S. locations: 32
States / cities: La Jolla, California • Los Angeles, California • Mountain View, California + 25 more

Conditions: Lumbar Disc Disease
Interventions: NOCISCAN-LS Disc MR Spectroscopy; Other
Lead sponsor: Nocimed, LLC; Other
Eligibility: 18 Years to 70 Years
Enrollment: 240 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2025
U.S. locations: 1
States / cities: Plano, Texas

Conditions: Prostate Cancer
Interventions: Diagnostic Imaging: C11 choline PET; C11 acetate PET; and MRI Spectroscopy; Device
Lead sponsor: Mayo Clinic; Other
Eligibility: 18 Years and older · Male only
Enrollment: 8 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2003 – 2009
U.S. locations: 1
States / cities: Rochester, Minnesota

Conditions: Breast Cancer
Interventions: Magnetic Resonance Imaging (MRI), Magnetic Resonance Spectroscopy (MRS); Procedure
Lead sponsor: M.D. Anderson Cancer Center; Other
Eligibility: 18 Years and older
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2022
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Mitral Regurgitation
Interventions: Candesartan, atacand, Placebo; Drug
Lead sponsor: Mayo Clinic; Other
Eligibility: 18 Years and older
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 1998 – 2001
U.S. locations: 1
States / cities: Rochester, Minnesota

Conditions: Mitral Regurgitation
Interventions: Mydfrin; Drug
Lead sponsor: Montefiore Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 35 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2026
U.S. locations: 1
States / cities: New York, New York

Conditions: HIV Associated Neurocognitive Disorder
Interventions: Fluconazole, Paroxetine, Paroxetine and Fluconazole, Placebo; Drug
Lead sponsor: Johns Hopkins University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 45 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2016
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Mitral Regurgitation Functional, Mitral Valve Disease, Cardiovascular Diseases
Interventions: Millipede Transcatheter Annuloplasty Ring System (Millipede System); Device
Lead sponsor: Boston Scientific Corporation; Industry
Eligibility: 18 Years and older
Enrollment: 4 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2026
U.S. locations: 3
States / cities: Tucson, Arizona • New York, New York • The Bronx, New York

Conditions: Glioblastoma Multiforme
Interventions: Novo-TTF; Device
Lead sponsor: Abramson Cancer Center at Penn Medicine; Other
Eligibility: 18 Years and older
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2023
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Depression, Involutional, Healthy
Interventions: Not listed
Lead sponsor: National Institute of Mental Health (NIMH); NIH
Eligibility: 18 Years to 60 Years
Enrollment: 450 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2002 – 2005
U.S. locations: 1
States / cities: Bethesda, Maryland

Conditions: Mitral Regurgitation, Mitral Disease
Interventions: Edwards SAPIEN M3 System; Device
Lead sponsor: Edwards Lifesciences; Industry
Eligibility: 18 Years and older
Enrollment: 72 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2026
U.S. locations: 8
States / cities: Los Angeles, California • San Francisco, California • Atlanta, Georgia + 5 more

Conditions: Heart Failure, Mitral Regurgitation
Interventions: V-Wave Shunt Placement; Device
Lead sponsor: samir kapadia; Other
Eligibility: 18 Years and older
Enrollment: 16 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2030
U.S. locations: 1
States / cities: Cleveland, Ohio

Conditions: Head and Neck Cancer
Interventions: DCE-MRI, DW-MRI and MRS; Other
Lead sponsor: OHSU Knight Cancer Institute; Other
Eligibility: 18 Years and older
Enrollment: 10 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2011 – 2015
U.S. locations: 1
States / cities: Portland, Oregon

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Feasibility Study of a Percutaneous Mitral Valve Repair System.

Assessing Brain Metabolism Using MRS With Deuterated Glucose

Assess the Penumbra System in the Treatment of Acute Stroke

Treatment of Hepatic Encephalopathy With Flumazenil and Change in Cortical GABA Levels in MRS

Open Label Extension Study of NCT06221852

Effects of Mitral Valve Repair With the Geoform Ring on Cardiomyopathy

Invasive Hemodynamic Response to Transcatheter Edge-to-Edge Mitral Valve Repair

Continuous Dual Aspiration Technique With Zoom System for Stroke

Clinical Development of Cancer-Specific MRS Biomarkers in Malignant Gliomas

Low Field Magnetic Stimulation: Imaging Biomarkers in Geriatric Bipolar Depression

Ketogenic Diet (KD) in Alcoholism

Cardiovascular Outcomes Assessment of the MitraClip Percutaneous Therapy for Heart Failure Patients With Functional MR

NOCISCAN-Lumbar Spine (LS) Clinical Evaluation Study

Novel PET/CT Agents and MRS/MRI in Prostate CA and High Risk Prostate Cancer: An Inter-SPORE Collaboration

Non-Invasive Magnetic Resonance Imaging (MRI) and Magnetic Resonance Spectroscopy Techniques (MRS) for Assessing Neoadjuvant Chemotherapy in Locally Advanced Breast Cancer

Angiotensin-II Blockade in Mitral Regurgitation

Use of Phenylephrine for Assessment of Mitral Regurgitation Severity

Study of Paroxetine and Fluconazole for the Treatment of HIV Associated Neurocognitive Disorder

A Feasibility Study of the Millipede Transcatheter Annuloplasty Ring System in Patients With Functional Mitral Regurgitation

Evaluating Therapeutic Response to Novo-TTF

Serotonin Function During Depression

SAPIEN M3 EFS: Early Feasibility Study of the Edwards SAPIEN M3 System for the Treatment of Mitral Regurgitation

Implantation of a Permanent Interatrial Shunt to Reduce Left Atrial Filling Pressures Following MitraClip

Magnetic Resonance Imaging (MRI) in the Assessment of Head and Neck Squamous Cell Carcinoma (HNSCC) Response