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ClinicalTrials.gov public records Last synced Nov 10, 2026, 5:48 PM EST

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Showing 1–24 of 245 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Mitral Valve Regurgitation Clear all
Recruiting Phase 4 Interventional

International Care Bundle Evaluation in Cerebral Hemorrhage Research

NCT06429332
View directory record Official record
Conditions
Intracerebral Hemorrhage, Intracerebral Haemorrhage, Intraventricular Hemorrhage, Stroke, Cerebrovascular Disease
Interventions
Reversal of Oral anticoagulation within 30 minutes, Early intensive blood pressure lowering, Treatment of pyrexia, Hyperglycemia treatment, Do-not-resuscitate (DNR) or withdrawal of care, Referral to Intensive Care, Referral to Neurosurgery, Repeat brain imaging, Standard care
Other · Diagnostic Test
Lead sponsor
Region Skane
Other
Eligibility
18 Years and older
Enrollment
3,500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Oklahoma City, Oklahoma
Source: ClinicalTrials.gov public record
Updated May 22, 2026 · Synced Nov 10, 2026, 5:48 PM EST
Active, not recruiting No phase listed Observational

Genomic Investigation of Cardiovascular Diseases

NCT00722748
View directory record Official record
Conditions
Coronary Artery Disease, Myocardial Infarction, Atrial Fibrillation, Aortic Stenosis, Mitral Regurgitation, Idiopathic Cardiomyopathy
Interventions
Not listed
Lead sponsor
Scripps Translational Science Institute
Other
Eligibility
18 Years and older
Enrollment
15,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2030
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Jan 16, 2025 · Synced Nov 10, 2026, 5:48 PM EST
Recruiting Not applicable Interventional

Ketogenic and Nutritional Interventions for First Episode Bipolar Disorder

NCT06221852
View directory record Official record
Conditions
Bipolar I Disorder, Psychosis, Schizoaffective Disorder
Interventions
Ketogenic diet, Dietary Guidelines for Americans
Other
Lead sponsor
Mclean Hospital
Other
Eligibility
18 Years to 45 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Belmont, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 17, 2026 · Synced Nov 10, 2026, 5:48 PM EST
Completed No phase listed Observational Accepts healthy volunteers

7T MRS in Parkinson's Disease

NCT01237210
View directory record Official record
Conditions
Parkinson's Disease
Interventions
Not listed
Lead sponsor
University of Minnesota
Other
Eligibility
45 Years to 75 Years
Enrollment
78 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2019
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Nov 1, 2019 · Synced Nov 10, 2026, 5:48 PM EST
Not listed No phase listed Observational Accepts healthy volunteers

NOCISCAN-Lumbar Spine (LS) Clinical Evaluation Study

NCT04015791
View directory record Official record
Conditions
Lumbar Disc Disease
Interventions
NOCISCAN-LS Disc MR Spectroscopy
Other
Lead sponsor
Nocimed, LLC
Other
Eligibility
18 Years to 70 Years
Enrollment
240 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Plano, Texas
Source: ClinicalTrials.gov public record
Updated Jul 29, 2022 · Synced Nov 10, 2026, 5:48 PM EST
Recruiting Not applicable Interventional

Reduction or Elimination of Mitral Regurgitation With the SATURN TMVR System (CASSINI-US)

NCT07130994
View directory record Official record
Conditions
Mitral Regurgitation, Heart Disease
Interventions
Mitral Valve Replacement
Device
Lead sponsor
InnovHeart
Industry
Eligibility
18 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2032
U.S. locations
5
States / cities
Los Angeles, California • Sacramento, California • Thousand Oaks, California + 2 more
Source: ClinicalTrials.gov public record
Updated Aug 10, 2026 · Synced Nov 10, 2026, 5:48 PM EST
Not listed Not applicable Interventional Results available

Cardiovascular Outcomes Assessment of the MitraClip Percutaneous Therapy for Heart Failure Patients With Functional Mitral Regurgitation (The COAPT Trial) and COAPT CAS

NCT01626079
View directory record Official record
Conditions
Mitral Regurgitation, Mitral Valve Regurgitation, Treatment of Functional Mitral Regurgitation in Symptomatic Heart Failure Subjects, Heart Failure
Interventions
MitraClip System
Device
Lead sponsor
Abbott Medical Devices
Industry
Eligibility
18 Years and older
Enrollment
776 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2024
U.S. locations
81
States / cities
Birmingham, Alabama • Phoenix, Arizona • Scottsdale, Arizona + 65 more
Source: ClinicalTrials.gov public record
Updated Nov 27, 2023 · Synced Nov 10, 2026, 5:48 PM EST
Recruiting No phase listed Observational Accepts healthy volunteers

Assessing Brain Metabolism Using MRS With Deuterated Glucose

NCT06594315
View directory record Official record
Conditions
Glioma
Interventions
Deuterated Glucose, Magnetic Resonance Imaging (MRI), Blood Sample, MR spectroscopy (MRS)
Drug · Procedure
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2027
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Sep 2, 2026 · Synced Nov 10, 2026, 5:48 PM EST
Completed Not applicable Interventional Accepts healthy volunteers

Use of 31P MRS to Assess Brain NAD+ in Healthy Current and Former Collegiate Athletes

NCT02721537
View directory record Official record
Conditions
Concussion, Mild
Interventions
Nicotinamide Riboside, Matching placebo
Dietary Supplement · Other
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2022
U.S. locations
2
States / cities
Minneapolis, Minnesota • Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Aug 3, 2022 · Synced Nov 10, 2026, 5:48 PM EST
Completed No phase listed Observational

Molecular Mechanisms of Mitral Regurgitation-Aim 2

NCT01052532
View directory record Official record
Conditions
Mitral Regurgitation
Interventions
Not listed
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
21 Years and older
Enrollment
65 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2010
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Dec 2, 2010 · Synced Nov 10, 2026, 5:48 PM EST
Recruiting Phase 1Phase 2 Interventional

Use of Phenylephrine for Assessment of Mitral Regurgitation Severity

NCT04500899
View directory record Official record
Conditions
Mitral Regurgitation
Interventions
Mydfrin
Drug
Lead sponsor
Montefiore Medical Center
Other
Eligibility
18 Years and older
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2026
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 20, 2025 · Synced Nov 10, 2026, 5:48 PM EST
Active, not recruiting Not applicable Interventional

Edwards PASCAL CLASP IID/IIF Pivotal Clinical Trial

NCT03706833
View directory record Official record
Conditions
Degenerative Mitral Valve Disease, Mitral Regurgitation, Mitral Insufficiency, Functional Mitral Regurgitation
Interventions
Edwards PASCAL System, Abbott Mitraclip System
Device
Lead sponsor
Edwards Lifesciences
Industry
Eligibility
18 Years and older
Enrollment
1,247 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2031
U.S. locations
63
States / cities
Phoenix, Arizona • Tucson, Arizona • La Jolla, California + 50 more
Source: ClinicalTrials.gov public record
Updated Jul 8, 2026 · Synced Nov 10, 2026, 5:48 PM EST
Completed No phase listed Observational Accepts healthy volunteers

Phono- and Electrocardiogram Assisted Detection of Valvular Disease

NCT03458806
View directory record Official record
Conditions
Aortic Valve Stenosis, Mitral Regurgitation, Heart Murmurs, Valvular Heart Disease
Interventions
AS Algorithm 1, AS Algorithm 2, MR Algorithm 1, MR Algorithm 2
Diagnostic Test
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
156 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jul 2, 2021 · Synced Nov 10, 2026, 5:48 PM EST
Completed No phase listed Observational

Invasive Hemodynamic Response to Transcatheter Edge-to-Edge Mitral Valve Repair

NCT04200378
View directory record Official record
Conditions
Mitral Regurgitation
Interventions
Not listed
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2024
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated May 23, 2024 · Synced Nov 10, 2026, 5:48 PM EST
Recruiting No phase listed Observational

Transcatheter vs. Surgical Treatment of Degenerative Mitral Regurgitation

NCT07605715
View directory record Official record
Conditions
Degenerative Mitral Valve Disease
Interventions
Not listed
Lead sponsor
Cedars-Sinai Medical Center
Other
Eligibility
60 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated May 26, 2026 · Synced Nov 10, 2026, 5:48 PM EST
Not listed Not applicable Interventional

Caisson Transcatheter Mitral Valve Replacement (TMVR) System Early Feasibility Study

NCT02768402
View directory record Official record
Conditions
Mitral Valve Regurgitation
Interventions
Caisson TMVR System
Device
Lead sponsor
Caisson Interventional LLC
Industry
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2023
U.S. locations
13
States / cities
Los Angeles, California • Washington D.C., District of Columbia • Delray Beach, Florida + 9 more
Source: ClinicalTrials.gov public record
Updated Jan 28, 2020 · Synced Nov 10, 2026, 5:48 PM EST
Active, not recruiting Not applicable Interventional Results available

Implantation of a Permanent Interatrial Shunt to Reduce Left Atrial Filling Pressures Following MitraClip

NCT04729933
View directory record Official record
Conditions
Heart Failure, Mitral Regurgitation
Interventions
V-Wave Shunt Placement
Device
Lead sponsor
samir kapadia
Other
Eligibility
18 Years and older
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2030
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 5, 2026 · Synced Nov 10, 2026, 5:48 PM EST
Completed No phase listed Observational Accepts healthy volunteers

Magnetic Resonance Spectroscopy (MRS) in Midlife Depression

NCT02567110
View directory record Official record
Conditions
Depression, Depression Bipolar
Interventions
Not listed
Lead sponsor
Emory University
Other
Eligibility
35 Years to 65 Years
Enrollment
169 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2022
U.S. locations
3
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Feb 3, 2023 · Synced Nov 10, 2026, 5:48 PM EST
Completed Phase 4 Interventional

Janssen Asperger's MRS (Magnetic Resonance Spectroscopy Risperidone Study

NCT00352196
View directory record Official record
Conditions
Asperger's Disorder
Interventions
Risperidone, Magnetic Resonance Spectroscopy
Drug · Other
Lead sponsor
Augusta University
Other
Eligibility
6 Years and older
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2007
U.S. locations
1
States / cities
Augusta, Georgia
Source: ClinicalTrials.gov public record
Updated Jan 14, 2015 · Synced Nov 10, 2026, 5:48 PM EST
Completed No phase listed Observational Accepts healthy volunteers

Glutamate Probes in Adolescent Depression

NCT02307617
View directory record Official record
Conditions
Major Depressive Disorder, Major Depressive Disorder, Recurrent, Major Depressive Disorder, Remitted
Interventions
Not listed
Lead sponsor
Mayo Clinic
Other
Eligibility
13 Years to 21 Years
Enrollment
57 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2017
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Apr 23, 2021 · Synced Nov 10, 2026, 5:48 PM EST
Completed Not applicable Interventional Results available

The CLASP Study Edwards PASCAL TrAnScatheter Mitral Valve RePair System Study

NCT03170349
View directory record Official record
Conditions
Mitral Valve Regurgitation
Interventions
Mitral Valve Repair
Device
Lead sponsor
Edwards Lifesciences
Industry
Eligibility
18 Years and older
Enrollment
124 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2025
U.S. locations
8
States / cities
Los Angeles, California • Aurora, Colorado • Evanston, Illinois + 5 more
Source: ClinicalTrials.gov public record
Updated Feb 5, 2026 · Synced Nov 10, 2026, 5:48 PM EST
Recruiting Not applicable Interventional Accepts healthy volunteers

Investigating Brain Function in People With and Without Visual Snow Syndrome Using Adaptation to Visual Stimuli

NCT06961864
View directory record Official record
Conditions
Visual Snow Syndrome, Migraine, Healthy
Interventions
Visual Adaptation, Assessments and Questionnaires, Functional Magnetic Resonance Imaging (fMRI), Magnetic Resonance Imaging (MRS)
Behavioral · Device
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years to 60 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2030
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Jan 14, 2026 · Synced Nov 10, 2026, 5:48 PM EST
Completed No phase listed Observational Accepts healthy volunteers

Clinical Development of MR Spectroscopy and Imaging in Brain Cancers

NCT02731521
View directory record Official record
Conditions
Malignant Gliomas, Astrocytomas, Oligodendrogliomas
Interventions
3 Tesla Scanning, 7 Tesla Scanning
Device
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years and older
Enrollment
112 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2021
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Feb 3, 2022 · Synced Nov 10, 2026, 5:48 PM EST
Active, not recruiting No phase listed Observational Accepts healthy volunteers

Age and Sex-Specific PREValence of AcqUirEd VALVular Heart DiseasE

NCT05357404
View directory record Official record
Conditions
Valvular Heart Disease
Interventions
Not listed
Lead sponsor
Cardiovascular Research Foundation, New York
Other
Eligibility
65 Years to 85 Years
Enrollment
2,870 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2025
U.S. locations
1
States / cities
Walnut Creek, California
Source: ClinicalTrials.gov public record
Updated Feb 7, 2025 · Synced Nov 10, 2026, 5:48 PM EST