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ClinicalTrials.gov public records Last synced Oct 22, 2026, 11:59 PM EDT

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Showing 1–24 of 51 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Mitral Valve Repair Clear all
Active, not recruiting Not applicable Interventional

MitraClip REPAIR MR Study

NCT04198870
View directory record Official record
Conditions
Mitral Valve Regurgitation
Interventions
MitraClip™ device implantation, Mitral Valve Repair Surgery
Device · Procedure
Lead sponsor
Abbott Medical Devices
Industry
Eligibility
18 Years and older
Enrollment
500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2035
U.S. locations
63
States / cities
Birmingham, Alabama • Mobile, Alabama • Phoenix, Arizona + 47 more
Source: ClinicalTrials.gov public record
Updated May 15, 2026 · Synced Oct 22, 2026, 11:59 PM EDT
Recruiting Not applicable Interventional

Transventricular Off-pump Mitral Valve Repair

NCT07726173
View directory record Official record
Conditions
Mitral Valve (MV) Regurgitation
Interventions
TRANSOM
Device
Lead sponsor
Johns Hopkins University
Other
Eligibility
21 Years and older
Enrollment
175 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 24, 2026 · Synced Oct 22, 2026, 11:59 PM EDT
Completed Not applicable Interventional Results available

Pleth Variability Index (PVI) as a Measure of Volume Status During Transcatheter Mitral Valve Repair

NCT03993938
View directory record Official record
Conditions
Mitral Regurgitation
Interventions
PVI measurement
Device
Lead sponsor
Henry Ford Health System
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Jun 24, 2022 · Synced Oct 22, 2026, 11:59 PM EDT
Recruiting Not applicable Interventional

Use of Force Feedback Instruments With the da Vinci Surgical System, Model IS5000 for Mitral Valve Repair

NCT07655505
View directory record Official record
Conditions
Mitral Regurgitation (MR)
Interventions
Mitral Valve Repair including the use of Force Feedback instruments
Device
Lead sponsor
Intuitive Surgical
Industry
Eligibility
22 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
3
States / cities
Atlanta, Georgia • New York, New York • Spokane, Washington
Source: ClinicalTrials.gov public record
Updated Sep 14, 2026 · Synced Oct 22, 2026, 11:59 PM EDT
Active, not recruiting Not applicable Interventional

Percutaneous or Surgical Repair In Mitral Prolapse And Regurgitation for ≥60 Year-olds (PRIMARY)

NCT05051033
View directory record Official record
Conditions
Mitral Valve Regurgitation
Interventions
Mitral valve repair, Transcatheter edge-to-edge repair
Procedure · Device
Lead sponsor
Annetine Gelijns
Other
Eligibility
60 Years and older
Enrollment
450 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2034
U.S. locations
29
States / cities
Los Angeles, California • San Francisco, California • Stanford, California + 19 more
Source: ClinicalTrials.gov public record
Updated Sep 30, 2026 · Synced Oct 22, 2026, 11:59 PM EDT
Recruiting No phase listed Observational

Transcatheter vs. Surgical Treatment of Degenerative Mitral Regurgitation

NCT07605715
View directory record Official record
Conditions
Degenerative Mitral Valve Disease
Interventions
Not listed
Lead sponsor
Cedars-Sinai Medical Center
Other
Eligibility
60 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated May 26, 2026 · Synced Oct 22, 2026, 11:59 PM EDT
Not listed No phase listed Observational

Primary Mitral Regurgitation Repair

NCT04067635
View directory record Official record
Conditions
Mitral Valve Insufficiency, Mitral Valve Prolapse, Chronic Mitral Disease, Mitral Regurgitation, Mitral Valve Disease, Degenerative Mitral Valve Disease, Myxomatous Mitral Valve Degeneration, Ventricular Remodeling
Interventions
Not listed
Lead sponsor
Eric Y. Yang, MD PhD
Other
Eligibility
18 Years and older
Enrollment
116 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Aug 28, 2019 · Synced Oct 22, 2026, 11:59 PM EDT
Terminated Not applicable Interventional Results available

Edwards Cardioband System ACTIVE Pivotal Clinical Trial (ACTIVE)

NCT03016975
View directory record Official record
Conditions
Functional Mitral Regurgitation, Mitral Regurgitation, Mitral Insufficiency
Interventions
Edwards Cardioband System, Guideline Directed Medical Therapy
Device · Drug
Lead sponsor
Edwards Lifesciences
Industry
Eligibility
18 Years and older
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2022
U.S. locations
24
States / cities
Los Angeles, California • Palo Alto, California • Aurora, Colorado + 18 more
Source: ClinicalTrials.gov public record
Updated Nov 30, 2023 · Synced Oct 22, 2026, 11:59 PM EDT
Completed Not applicable Interventional Results available

Suture Closure AFtEr VEIN Access for Cardiac Procedures (SAFE-VEIN) Trial

NCT04632641
View directory record Official record
Conditions
Atrial Fibrillation, Atrial Flutter, Heart Block, Pulmonary Embolism and Thrombosis, Mitral Valve Repair, Sinus Node Dysfunction, Bradycardia, Brady-tachy Syndrome
Interventions
Perclose ProGlide Suture-Mediated Closure System (SMC) - LARGE-BORE PROCEDURES, Figure 8 Suture - LARGE-BORE PROCEDURES
Device · Other
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older
Enrollment
107 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Oct 3, 2024 · Synced Oct 22, 2026, 11:59 PM EDT
Active, not recruiting No phase listed Observational

Long Term Follow Up for CTSN Mitral Valve Repair Studies

NCT03066050
View directory record Official record
Conditions
Mitral Valve Insufficiency, Coronary Artery Disease
Interventions
MV Repair, MV Replacement, CABG
Other
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years and older
Enrollment
368 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2027
U.S. locations
16
States / cities
Los Angeles, California • Atlanta, Georgia • Baltimore, Maryland + 13 more
Source: ClinicalTrials.gov public record
Updated Jul 16, 2025 · Synced Oct 22, 2026, 11:59 PM EDT
Not listed Not applicable Interventional

Erector Spinae Plane Block for Minimally Invasive Mitral Valve Surgery

NCT04770961
View directory record Official record
Conditions
Mitral Regurgitation, Mitral Valve Insufficiency, Mitral Valve Prolapse
Interventions
Erector spinae plane catheter with 0.5% Ropivacaine, Erector spinae plane catheter with saline
Procedure
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years to 75 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Mar 3, 2021 · Synced Oct 22, 2026, 11:59 PM EDT
Completed Not applicable Interventional

Mitral Loop Cerclage(MLC) for Reducing Functional Mitral Regurgitation

NCT02471664
View directory record Official record
Conditions
Functional Mitral Regurgitation, Heart Failure
Interventions
Mitral Loop Cerclage Annuloplasty
Device
Lead sponsor
Tau-MEDICAL Co., Ltd.
Industry
Eligibility
20 Years to 85 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Oct 13, 2017 · Synced Oct 22, 2026, 11:59 PM EDT
Recruiting Not applicable Interventional

Transcatheter Mitral Valve Repair for Inotrope Dependent Cardiogenic Shock

NCT05298124
View directory record Official record
Conditions
Cardiogenic Shock, Mitral Regurgitation
Interventions
Transcatheter edge-to-edge repair, Medical therapy
Device · Other
Lead sponsor
Ottawa Heart Institute Research Corporation
Other
Eligibility
18 Years and older
Enrollment
144 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2028
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated May 6, 2026 · Synced Oct 22, 2026, 11:59 PM EDT
Completed No phase listed Observational

Watchman for Patients With Atrial Fibrillation Undergoing Transcatheter Mitral Valve Repair (WATCH-TMVR)

NCT04494347
View directory record Official record
Conditions
Nonvalvular Atrial Fibrillation, Severe Degenerative Mitral Regurgitation
Interventions
MitraClip TMVR and Watchman LAAO
Procedure
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated May 1, 2026 · Synced Oct 22, 2026, 11:59 PM EDT
Completed Not applicable Interventional

Tricuspid Annuloplasty for Moderate Tricuspid Regurgitation Associated With Miral Operation

NCT01246947
View directory record Official record
Conditions
Cardiac Surgery, Tricuspid Valve Regurgitation
Interventions
Tricuspid valve repair, Mitral surgery alone
Procedure · Other
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
18 Years and older
Enrollment
57 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2017
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated May 8, 2023 · Synced Oct 22, 2026, 11:59 PM EDT
Recruiting No phase listed Observational

Assessment of Transcatheter Edge-to-Edge Repair in Atrial Functional Mitral Regurgitation (ATRIAL-MR)

NCT06911099
View directory record Official record
Conditions
Atrial Functional Mitral Regurgitation, Mitral Insufficiency
Interventions
Not listed
Lead sponsor
University Hospital of Cologne
Other
Eligibility
18 Years and older
Enrollment
1,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2035
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Apr 6, 2025 · Synced Oct 22, 2026, 11:59 PM EDT
Recruiting Not applicable Interventional

The CardioClip Study

NCT06241430
View directory record Official record
Conditions
Heart Failure With Reduced Ejection Fraction, Mitral Regurgitation
Interventions
CardioMEMS
Device
Lead sponsor
Columbia University
Other
Eligibility
18 Years to 90 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2030
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jun 29, 2026 · Synced Oct 22, 2026, 11:59 PM EDT
Active, not recruiting Not applicable Interventional

Randomized Trial of the Neochord DS1000 System Versus Open Surgical Repair

NCT02803957
View directory record Official record
Conditions
Mitral Valve Insufficiency
Interventions
NeoChord DS1000, Surgical Mitral Valve Repair
Device
Lead sponsor
NeoChord
Industry
Eligibility
21 Years and older
Enrollment
585 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2027
U.S. locations
14
States / cities
Sacramento, California • Stanford, California • Washington D.C., District of Columbia + 10 more
Source: ClinicalTrials.gov public record
Updated Apr 8, 2026 · Synced Oct 22, 2026, 11:59 PM EDT
Recruiting Not applicable Interventional

The EMPOWER Trial - The Carillon Mitral Contour System® in Treating Heart Failure With FMR

NCT03142152
View directory record Official record
Conditions
Functional Mitral Regurgitation, Heart Failure, Mitral Valve Insufficiency, Heart Diseases, Cardiovascular Diseases, Heart Valve Diseases
Interventions
Carillon Mitral Contour System, Guideline Directed Heart Failure Medication
Device · Other
Lead sponsor
Cardiac Dimensions, Inc.
Industry
Eligibility
18 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2030
U.S. locations
75
States / cities
Gilbert, Arizona • Phoenix, Arizona • Tucson, Arizona + 61 more
Source: ClinicalTrials.gov public record
Updated Apr 13, 2026 · Synced Oct 22, 2026, 11:59 PM EDT
Completed Not applicable Interventional Results available

Comparing the Effectiveness of a Mitral Valve Repair Procedure in Combination With Coronary Artery Bypass Grafting (CABG) Versus CABG Alone in People With Moderate Ischemic Mitral Regurgitation

NCT00806988
View directory record Official record
Conditions
Mitral Valve Insufficiency, Coronary Artery Disease
Interventions
Mitral Valve Repair, CABG
Procedure
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years and older
Enrollment
301 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2015
U.S. locations
19
States / cities
Los Angeles, California • Atlanta, Georgia • Marietta, Georgia + 16 more
Source: ClinicalTrials.gov public record
Updated Jun 26, 2017 · Synced Oct 22, 2026, 11:59 PM EDT
Withdrawn Not applicable Interventional

Effects of Mitral Valve Repair With the Geoform Ring on Cardiomyopathy

NCT00428103
View directory record Official record
Conditions
Mitral Valve Regurgitation, Congestive Heart Failure, Cardiomyopathy
Interventions
3 dimensional echocardiography
Procedure
Lead sponsor
Juan Crestanello, MD
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2012
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Feb 28, 2013 · Synced Oct 22, 2026, 11:59 PM EDT
Completed Not applicable Interventional Results available

EVEREST II Pivotal Study High Risk Registry (HRR)

NCT01940120
View directory record Official record
Conditions
Mitral Valve Insufficiency, Mitral Valve Regurgitation, Mitral Valve Incompetence, Mitral Regurgitation, Mitral Insufficiency
Interventions
Percutaneous mitral valve repair using MitraClip implant
Device
Lead sponsor
Abbott Medical Devices
Industry
Eligibility
18 Years and older
Enrollment
78 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2013
U.S. locations
2
States / cities
Evanston, Illinois • Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Nov 7, 2018 · Synced Oct 22, 2026, 11:59 PM EDT
Recruiting No phase listed Observational

Annuloplasty Rings and Band Post-Market Clinical Follow-Up Study

NCT04761120
View directory record Official record
Conditions
Mitral Regurgitation, Tricuspid Regurgitation, Valvular Heart Disease
Interventions
Abbott SJM Rigid Saddle Ring, Abbott SJM Séguin Ring, Abbott SJM Tailor Ring, Abbott SJM Tailor Band
Device
Lead sponsor
Abbott Medical Devices
Industry
Eligibility
18 Years and older
Enrollment
550 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2031
U.S. locations
2
States / cities
Durham, North Carolina • Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated May 18, 2026 · Synced Oct 22, 2026, 11:59 PM EDT
Terminated Not applicable Interventional

MitrAl ValvE RepaIr Clinical Trial (MAVERIC Trial) - United States

NCT03311295
View directory record Official record
Conditions
Mitral Valve Insufficiency
Interventions
ARTO System
Device
Lead sponsor
Mvrx, Inc.
Industry
Eligibility
21 Years to 85 Years
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated Apr 28, 2021 · Synced Oct 22, 2026, 11:59 PM EDT