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ClinicalTrials.gov public records Last synced Oct 17, 2026, 2:39 AM EDT

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Showing 25–48 of 182 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Muscle Hypertonia Clear all
Completed Not applicable Interventional

Extracorporeal Shockwave Therapy for Spasticity in People With Spinal Cord Injury

NCT05432999
View directory record Official record
Conditions
Spinal Cord Injuries, Spasticity, Muscle, Spastic Paraplegia, Spastic Quadriplegia, Spastic Tetraplegia, Paraplegia, Tetraplegia
Interventions
Extracorporeal Shockwave Therapy
Device
Lead sponsor
Kessler Foundation
Other
Eligibility
18 Years and older
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
West Orange, New Jersey
Source: ClinicalTrials.gov public record
Updated Mar 25, 2026 · Synced Oct 17, 2026, 2:39 AM EDT
Active, not recruiting Phase 2 Interventional

Peripheral Modulation of Muscle Stiffness and Spasticity

NCT03306615
View directory record Official record
Conditions
Muscle Spasticity
Interventions
Hyaluronidase, Placebo
Drug
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years and older
Enrollment
56 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2027
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jun 30, 2026 · Synced Oct 17, 2026, 2:39 AM EDT
Completed Phase 3 Interventional Results available

Efficacy and Safety of SPARC0921 in Subjects With Spasticity

NCT01457352
View directory record Official record
Conditions
Spasticity
Interventions
SPARC0921, Placebo0921
Drug
Lead sponsor
Sun Pharma Advanced Research Company Limited
Industry
Eligibility
18 Years and older
Enrollment
392 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2017
U.S. locations
56
States / cities
Gilbert, Arizona • Phoenix, Arizona • Costa Mesa, California + 50 more
Source: ClinicalTrials.gov public record
Updated Jun 18, 2019 · Synced Oct 17, 2026, 2:39 AM EDT
Completed Not applicable Interventional Results available

Spinal Cord Stimulation to Augment Activity Based Therapy

NCT03240601
View directory record Official record
Conditions
Transcutaneous Spinal Stimulation, Walking, Spasticity, Human, Spinal Cord Injuries
Interventions
Transcutaneous spinal stimulation
Device
Lead sponsor
Shepherd Center, Atlanta GA
Other
Eligibility
18 Years to 65 Years
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Jan 25, 2022 · Synced Oct 17, 2026, 2:39 AM EDT
Recruiting Not applicable Interventional

Leg Stretching Using an Exoskeleton on Demand for People With Spasticity

NCT05926596
View directory record Official record
Conditions
Spasticity, Movement Disorders, Spinal Cord Injury
Interventions
Wearable Robotic Exoskeleton
Device
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Syracuse, New York
Source: ClinicalTrials.gov public record
Updated Oct 2, 2026 · Synced Oct 17, 2026, 2:39 AM EDT
Not yet recruiting Not applicable Interventional

Vibrotactile Coordinated Reset for Spasticity After Spinal Cord Injury

NCT06290609
View directory record Official record
Conditions
Spasticity, Muscle, Spinal Cord Injuries
Interventions
Vibrotactile Coordinated Reset
Device
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated May 15, 2025 · Synced Oct 17, 2026, 2:39 AM EDT
Terminated Not applicable Interventional

Transcutaneous Spinal and Peripheral Stimulation and Wrist Robotic Therapy for Patients With Spastic Stroke

NCT04113525
View directory record Official record
Conditions
Spasticity as Sequela of Stroke, Stroke, Stroke Sequelae, Hemiplegia, Spastic, Hemiparesis, Upper Limb Hypertonia, CVA
Interventions
MyoRegulator™ System
Device
Lead sponsor
Northwell Health
Other
Eligibility
18 Years and older
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Manhasset, New York
Source: ClinicalTrials.gov public record
Updated Apr 14, 2022 · Synced Oct 17, 2026, 2:39 AM EDT
Recruiting Phase 1 Interventional

Shockwave for Elbow and Wrist Spasticity in People With Spinal Cord Injury

NCT07501429
View directory record Official record
Conditions
Spinal Cord Injury, Spasticity, Shockwave Therapy
Interventions
Focused extracorporeal shockwave therapy
Device
Lead sponsor
Kessler Foundation
Other
Eligibility
18 Years and older
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
West Orange, New Jersey
Source: ClinicalTrials.gov public record
Updated Mar 30, 2026 · Synced Oct 17, 2026, 2:39 AM EDT
Completed Phase 4 Interventional Results available

Imaging of 3D Innervation Zone Distribution in Spastic Muscles From High-density Surface EMG Recordings

NCT03302741
View directory record Official record
Conditions
Spasticity
Interventions
Botulinum neurotoxin (BTX), Physical Therapy, Standard BTX injection (ultrasound guided), 3-dimensional innervation zone (3DIZ) guided injection
Drug · Other · Device
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
21 Years to 75 Years
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Nov 5, 2020 · Synced Oct 17, 2026, 2:39 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

MyoSense- Automated Muscle Hypertonicity Classification System

NCT02076581
View directory record Official record
Conditions
Stroke, Dystonia, Cerebral Palsy
Interventions
Not listed
Lead sponsor
Great Lakes NeuroTechnologies Inc.
Industry
Eligibility
5 Years and older
Enrollment
53 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2015
U.S. locations
1
States / cities
Valley View, Ohio
Source: ClinicalTrials.gov public record
Updated Jun 1, 2015 · Synced Oct 17, 2026, 2:39 AM EDT
Recruiting Early Phase 1 Interventional Accepts healthy volunteers

Effect of Neural Constraints on Movement in Stroke

NCT06666673
View directory record Official record
Conditions
Stroke
Interventions
Tizanidine, Placebo
Drug
Lead sponsor
Northwestern University
Other
Eligibility
18 Years to 80 Years
Enrollment
64 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2029
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Oct 5, 2026 · Synced Oct 17, 2026, 2:39 AM EDT
Completed Phase 2 Interventional

Levetiracetam for Cramps, Spasticity and Neuroprotection in Motor Neuron Disease

NCT00324454
View directory record Official record
Conditions
Motor Neuron Disease, Amyotrophic Lateral Sclerosis, Primary Lateral Sclerosis, Progressive Muscular Atrophy
Interventions
Levetiracetam
Biological
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2008
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 19, 2013 · Synced Oct 17, 2026, 2:39 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Spinal Cord Stimulation for Children With Cerebral Palsy

NCT07516067
View directory record Official record
Conditions
Cerebral Palsy, Spasticity
Interventions
Transcutaneous Spinal Cord Stimulation (tSCS)
Device
Lead sponsor
Martin Piazza
Other
Eligibility
5 Years to 17 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 7, 2026 · Synced Oct 17, 2026, 2:39 AM EDT
Completed No phase listed Observational

Muscle Ultrasound Measures as Biomarkers of Upper Motor Neuron Function

NCT02408900
View directory record Official record
Conditions
Muscle Spasticity
Interventions
Not listed
Lead sponsor
National Institute of Neurological Disorders and Stroke (NINDS)
NIH
Eligibility
18 Years to 75 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Dec 17, 2019 · Synced Oct 17, 2026, 2:39 AM EDT
Recruiting Not applicable Interventional

Radiosurgery Treatment for Spasticity Associated With Stroke, SCI & Cerebral Palsy

NCT06070233
View directory record Official record
Conditions
Spasticity as Sequela of Stroke, Spastic Cerebral Palsy, Spasticity, Muscle
Interventions
stereotactic radiosurgery (SRS) dorsal root rhizotomy radiomodulation, Sham
Radiation · Other
Lead sponsor
Ohio State University
Other
Eligibility
16 Years and older
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
2
States / cities
Winter Park, Florida • Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Dec 19, 2025 · Synced Oct 17, 2026, 2:39 AM EDT
Completed Phase 3 Interventional Results available

Safety and Efficacy of Oral Fampridine-Sustained Release (SR) for the Treatment of Spasticity Resulting From Spinal Cord Injury

NCT01683838
View directory record Official record
Conditions
Spinal Cord Injury, Muscle Spasticity
Interventions
Fampridine-SR, Placebo
Drug
Lead sponsor
Acorda Therapeutics
Industry
Eligibility
18 Years to 70 Years
Enrollment
204 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2004
U.S. locations
27
States / cities
Birmingham, Alabama • Long Beach, California • Sacramento, California + 23 more
Source: ClinicalTrials.gov public record
Updated Aug 25, 2017 · Synced Oct 17, 2026, 2:39 AM EDT
Not listed Phase 3 Interventional

" Treating MS Patients With Lower Extremity Spasticity Using Dysport"

NCT03585569
View directory record Official record
Conditions
Multiple Sclerosis, Spasticity, Muscle
Interventions
Abobotulinumtoxin A
Biological
Lead sponsor
Neurology Center of New England P.C.
Other
Eligibility
Not listed
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Foxborough, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 13, 2018 · Synced Oct 17, 2026, 2:39 AM EDT
Recruiting Not applicable Interventional

Dorsal Root Electrical Stimulation in Children With Cerebral Palsy

NCT07715006
View directory record Official record
Conditions
Cerebral Palsy (CP), Cerebral Palsy, Spasticity, Spasticity Due to Cerebral Palsy
Interventions
Constant Current Stimulator, Cadwell Guardian System
Device
Lead sponsor
Martin Piazza
Other
Eligibility
3 Years to 14 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 11, 2026 · Synced Oct 17, 2026, 2:39 AM EDT
Not listed No phase listed Observational Accepts healthy volunteers

A Prospective Study of Spasticity in Individuals With Multiple Sclerosis

NCT01111435
View directory record Official record
Conditions
Spasticity
Interventions
Not listed
Lead sponsor
Fraser, Cira, Ph.D., RN, ACNS-BC
Individual
Eligibility
18 Years and older
Enrollment
110 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2012
U.S. locations
1
States / cities
Kansas City, Missouri
Source: ClinicalTrials.gov public record
Updated Mar 5, 2012 · Synced Oct 17, 2026, 2:39 AM EDT
Recruiting Phase 1Phase 2 Interventional

Virtual tES Device Treatment for Parkinson's Disease Motor Symptoms

NCT07182058
View directory record Official record
Conditions
PARKINSON DISEASE (Disorder)
Interventions
Transcranial Electrical Stimulation Device
Device
Lead sponsor
U: The Mind Company
Industry
Eligibility
18 Years to 80 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jan 27, 2026 · Synced Oct 17, 2026, 2:39 AM EDT
Completed Phase 2 Interventional Results available

Safety Study of Botulinum Toxin Type A in Post-Upper Limb Stroke Patients With Reduced Lung Function

NCT00076687
View directory record Official record
Conditions
Stroke, Muscle Spasticity, Motor Neuron Disease
Interventions
botulinum toxin Type A, saline
Biological · Drug
Lead sponsor
Allergan
Industry
Eligibility
18 Years and older
Enrollment
155 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2009
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Oct 3, 2011 · Synced Oct 17, 2026, 2:39 AM EDT
No Longer Available No phase listed Expanded access

Individual Patient Expanded Access IND of Hope Biosciences Autologous Adipose-derived Mesenchymal Stem Cells for the Treatment of Cerebral Palsy

NCT04029896
View directory record Official record
Conditions
Cerebral Palsy
Interventions
HB-adMSCs
Biological
Lead sponsor
Hope Biosciences Research Foundation
Industry
Eligibility
3 Years and older · Male only
U.S. locations
1
States / cities
Sugar Land, Texas
Source: ClinicalTrials.gov public record
Updated Sep 29, 2025 · Synced Oct 17, 2026, 2:39 AM EDT
Completed No phase listed Observational

Use of Surface Electromyography Biofeedback to Improve Reaching in Children With Cerebral Palsy

NCT00473161
View directory record Official record
Conditions
Cerebral Palsy, Weakness, Hypertonia
Interventions
surface EMG biofeedback
Device
Lead sponsor
University of Southern California
Other
Eligibility
1 Month to 21 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2007
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated May 23, 2014 · Synced Oct 17, 2026, 2:39 AM EDT
Recruiting Not applicable Interventional

Intrathecal Baclofen and Pediatric Dystonia

NCT06606574
View directory record Official record
Conditions
Dystonic Cerebral Palsy
Interventions
Titration protocol
Other
Lead sponsor
Baylor College of Medicine
Other
Eligibility
Up to 17 Years
Enrollment
65 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2029
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jul 30, 2025 · Synced Oct 17, 2026, 2:39 AM EDT