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ClinicalTrials.gov public records Last synced Nov 14, 2026, 7:07 PM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 121–144 of 206 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: NAC Clear all

Conditions: Cocaine Dependence
Interventions: N-acetylcysteine, Placebo; Dietary Supplement · Other
Lead sponsor: Yale University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 21 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2020
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Parkinson Disease
Interventions: N-acetylcysteine, Placebo; Drug
Lead sponsor: Weill Medical College of Cornell University; Other
Eligibility: 50 Years to 75 Years
Enrollment: 50 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2012 – 2016
U.S. locations: 1
States / cities: New York, New York

Conditions: Methamphetamine Abuse, Methamphetamine Dependence, Substance Abuse
Interventions: Placebo, N-acetylcysteine; Drug
Lead sponsor: Baylor College of Medicine; Other
Eligibility: 18 Years to 55 Years
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2011
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Diabetes, Proteinuria
Interventions: N-acetylcysteine(Mucomyst); Drug
Lead sponsor: US Department of Veterans Affairs; Federal
Eligibility: 18 Years to 80 Years
Enrollment: 15 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2007
U.S. locations: 1
States / cities: Dayton, Ohio

Conditions: Ovarian Carcinoma, Stage 3 or 4, Epithelial Ovarian Carcinoma, Primary Peritoneal Carcinoma
Interventions: Paclitaxel, N-acetylcysteine, Cisplatin; Drug
Lead sponsor: OHSU Knight Cancer Institute; Other
Eligibility: 18 Years to 75 Years · Female only
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2014
U.S. locations: 1
States / cities: Portland, Oregon

Conditions: Autism Spectrum Disorder
Interventions: N-acetylcysteine, Placebo; Drug
Lead sponsor: Emory University; Other
Eligibility: 5 Years to 12 Years
Enrollment: 8 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2019
U.S. locations: 1
States / cities: Atlanta, Georgia

Conditions: Cocaine Abuse, Cocaine Dependence
Interventions: Cocaine, n-Acetylcysteine, Placebo; Drug
Lead sponsor: University of Kentucky; Other
Eligibility: 18 Years to 55 Years
Enrollment: 15 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2014 – 2016
U.S. locations: 1
States / cities: Lexington, Kentucky

Conditions: Trichotillomania
Interventions: Placebo, N-Acetyl Cysteine; Drug
Lead sponsor: University of Chicago; Other
Eligibility: 18 Years to 65 Years
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2008
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Acute Ischemic Stroke
Interventions: Acetylcysteine, Dextrose in Water; Drug
Lead sponsor: Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 4 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2024
U.S. locations: 1
States / cities: Torrance, California

Conditions: Non-verbal Learning Disorder, Autism Spectrum Disorder, Autism
Interventions: Open-label Treatment with Omega-3 Fatty Acids + Inositol, Open-label Treatment with N-acetylcysteine; Drug
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 5 Years to 17 Years
Enrollment: 54 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2024
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Bronchiolitis Acute
Interventions: N-Acetyl Cysteine; Drug
Lead sponsor: Carilion Clinic; Other
Eligibility: 1 Week to 2 Years
Enrollment: 106 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2020
U.S. locations: 1
States / cities: Roanoke, Virginia

Conditions: Ovarian Cancer, Cognitive Impairment
Interventions: N-Acetyl-Cysteine, Placebo; Drug · Other
Lead sponsor: University of California, Irvine; Other
Eligibility: 18 Years and older · Female only
Enrollment: 102 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Orange, California

Conditions: Purpura, Thrombotic Thrombocytopenic, TTP
Interventions: N-Acetylcysteine; Drug
Lead sponsor: Bloodworks; Other
Eligibility: 18 Years and older
Enrollment: 3 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2017
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: HER2 Negative Breast Cancer
Interventions: Response monitoring (no intervention); Other
Lead sponsor: New Mexico Cancer Research Alliance; Other
Eligibility: 18 Years and older · Female only
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2027
U.S. locations: 1
States / cities: Albuquerque, New Mexico

Conditions: Cocaine-Related Disorders
Interventions: N-Acetylcysteine, Placebo; Drug
Lead sponsor: National Institute on Drug Abuse (NIDA); NIH
Eligibility: 18 Years to 45 Years
Enrollment: 17 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2003 – 2005
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Emotional Dysregulation
Interventions: N-Acetyl Cysteine (NAC), Placebo; Drug
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 6 Years to 12 Years
Enrollment: 120 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2027 – 2030
U.S. locations: 2
States / cities: Boston, Massachusetts • Cambridge, Massachusetts

Conditions: Autistic Disorder, Asperger Syndrome, Child Development Disorders, Pervasive
Interventions: N-acetylcysteine, Placebo; Drug
Lead sponsor: Indiana University; Other
Eligibility: 4 Years to 12 Years
Enrollment: 31 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2009
U.S. locations: 1
States / cities: Indianapolis, Indiana

Conditions: Progressive Multiple Sclerosis, Fatigue
Interventions: N-acetyl cysteine, Placebo; Drug
Lead sponsor: University of California, San Francisco; Other
Eligibility: 18 Years to 75 Years
Enrollment: 15 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2018
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Anosmia
Interventions: N-acetyl cysteine (NAC); Drug
Lead sponsor: University of Miami; Other
Eligibility: 18 Years and older
Enrollment: 29 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2017
U.S. locations: 1
States / cities: Miami, Florida

Conditions: Obesity, Nonalcoholic Fatty Liver Disease, Cardiovascular Disease
Interventions: N-acetyl cysteine 600 mg once/day, N-acetyl cysteine 600mg twice/day, Placebo twice/day; Dietary Supplement · Other
Lead sponsor: Nemours Children's Clinic; Other
Eligibility: 7 Years to 18 Years
Enrollment: 14 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2020
U.S. locations: 1
States / cities: Jacksonville, Florida

Conditions: Pulmonary Fibrosis
Interventions: N-acetylcysteine (NAC), Placebo; Drug
Lead sponsor: Duke University; Other
Eligibility: 35 Years to 85 Years
Enrollment: 264 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2014
U.S. locations: 26
States / cities: Birmingham, Alabama • Los Angeles, California • San Francisco, California + 20 more

Conditions: Cocaine Abuse or Dependence, Cocaine Related Disorders
Interventions: Not listed
Lead sponsor: Wayne State University; Other
Eligibility: 18 Years to 55 Years
Enrollment: 16 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2017
U.S. locations: 1
States / cities: Detroit, Michigan

Conditions: Insulin Resistance, Metabolic Syndrome x
Interventions: N-acetylcysteine 20% 4ml, N-acetylcysteine 20% in 4 ml; Drug
Lead sponsor: Midwest Biomedical Research; Other
Eligibility: 18 Years and older
Enrollment: 121 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2005 – 2013
U.S. locations: 1
States / cities: Kansas City, Missouri

Conditions: Pathological Gambling
Interventions: N-Acetyl Cysteine; Drug
Lead sponsor: University of Minnesota; Other
Eligibility: 18 Years to 65 Years
Enrollment: 36 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2006
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Search by objective public record fields.

Functional Magnetic Resonance Imaging of N-acetylcysteine in Cocaine Dependence

N-Acetylcysteine for Neuroprotection in Parkinson's Disease

NAC as a Potential Treatment for Methamphetamine Dependence

Use of Mucomyst to Ameliorate Oxidant Stress in Diabetics With Proteinuria

N-acetylcysteine Given IV With Cisplatin and Paclitaxel in Patients With Ovarian Cancer

A Feasibility Study of N-acetylcysteine for Self-injurious Behavior in Children With Autism Spectrum Disorder

n-Acetylcysteine and Cocaine

N-Acetyl Cysteine in Trichotillomania

Intravenous N-Acetylcysteine for the Treatment of Acute Ischemic Stroke

Natural Treatments for the Management of Emotional Dysregulation in Youth With Non-verbal Learning Disability (NVLD) and/or Autism Spectrum Disorders (ASD)

Nebulized N-Acetyl Cysteine for Bronchiolitis in Inpatient Hospital Use

Effect of NAC on Preventing Chemo-Related Cognitive Impairments in Ovarian Ca Pts Treated W/ PBT

A Pilot Study of N-acetylcysteine in Thrombotic Thrombocytopenia Purpura

Monitoring Response to Neoadjuvant Chemotherapy in HER2 Negative Breast Cancer Using High-speed MR Spectroscopic Imaging

Effectiveness of N-acetylcysteine in Treating Cocaine Dependent Individuals - 1

The MIND Study: The MGH/MIT Investigation of NAC on Dysregulation

A Study of Oral N-Acetylcysteine in Children With Autism Spectrum Disorders

A Study of Oxidative Pathways in MS Fatigue

NAC Trial for Anosmia

Fatty Liver Disease in Obese Children

Evaluating the Effectiveness of Prednisone, Azathioprine, and N-acetylcysteine in Patients With IPF

Effects of N-acetylcysteine on Brain Chemistry and Behavior in Cocaine Abusers (NAC)

Insulin Resistance Study

An Open-Label Study of N-Acetyl Cysteine in Pathological Gambling