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Showing 25–46 of 22 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Nasolabial Folds Clear all
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Belotero Post Approval Study

NCT01635855
View directory record Official record
Conditions
Nasolabial Folds
Interventions
Belotero®
Device
Lead sponsor
Merz North America, Inc.
Industry
Eligibility
18 Years to 75 Years
Enrollment
117 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012
U.S. locations
9
States / cities
Birmingham, Alabama • Los Angeles, California • San Francisco, California + 5 more
Source: ClinicalTrials.gov public record
Updated Jul 3, 2014 · Synced Jun 10, 2026, 8:50 PM EDT
Completed Phase 4 Interventional

A Post-Market Study to Evaluate Adverse Event Incidence Rates in Patients With Skin of Color Undergoing Correction of Nasolabial Folds With Hylaform, Hylaform Plus and Captique.

NCT00293163
View directory record Official record
Conditions
Facial Wrinkles
Interventions
Hylaform, Hylaform Plus (hylan B gel)
Device
Lead sponsor
Genzyme, a Sanofi Company
Industry
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006
U.S. locations
3
States / cities
Los Angeles, California • Warren, Michigan • Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 4, 2015 · Synced Jun 10, 2026, 8:50 PM EDT
Completed Phase 3 Interventional

A Study to Compare Subject Comfort During and After Injections With the Study Products and the Safety of the Non-FDA Approved Product for the Correction of Nasolabial Folds (NLFs)

NCT00417469
View directory record Official record
Conditions
Facial Wrinkles
Interventions
NADGL
Device
Lead sponsor
Genzyme, a Sanofi Company
Industry
Eligibility
18 Years and older
Enrollment
45 participants
Timeline
2007
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Mar 4, 2015 · Synced Jun 10, 2026, 8:50 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

RHA® 4 With New Anesthetic - Nasolabial Folds

NCT04087395
View directory record Official record
Conditions
Aging, Pain
Interventions
RHA®4 with new anesthetic agent, RHA®4-Lidocaine
Device
Lead sponsor
Teoxane SA
Industry
Eligibility
22 Years and older
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
3
States / cities
Beverly Hills, California • Coral Gables, Florida • Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jan 23, 2022 · Synced Jun 10, 2026, 8:50 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Safety Study of Cosmetic Tissue Augmentation in People of Color

NCT01147172
View directory record Official record
Conditions
Wrinkles
Interventions
Elevess
Device
Lead sponsor
Anika Therapeutics, Inc.
Industry
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2010
U.S. locations
9
States / cities
Los Angeles, California • Boca Raton, Florida • Coral Gables, Florida + 6 more
Source: ClinicalTrials.gov public record
Updated Oct 16, 2017 · Synced Jun 10, 2026, 8:50 PM EDT
Not listed Phase 2 Interventional

Phase 2 Study of TAT4 Gel for Reduction of Nasolabial Folds

NCT02607670
View directory record Official record
Conditions
Nasolabial Folds
Interventions
TAT4 Gel, Matching placebo
Drug
Lead sponsor
Topokine Therapeutics, Inc.
Industry
Eligibility
35 Years to 60 Years
Enrollment
111 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 4, 2016 · Synced Jun 10, 2026, 8:50 PM EDT
Completed Not applicable Interventional Results available

Safety and Effectiveness of Belotero® in Subjects With Fitzpatrick Phototypes IV Through VI

NCT00922623
View directory record Official record
Conditions
Facial Wrinkles
Interventions
Belotero®
Device
Lead sponsor
Merz North America, Inc.
Industry
Eligibility
18 Years to 75 Years
Enrollment
93 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
3
States / cities
Los Angeles, California • Mitchellville, Maryland • Montclair, New Jersey
Source: ClinicalTrials.gov public record
Updated Apr 25, 2013 · Synced Jun 10, 2026, 8:50 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Evaluation of the Safety and Efficacy of CosmetaLife™ for the Correction of Nasolabial Folds

NCT00414544
View directory record Official record
Conditions
Facial Wrinkles
Interventions
CosmetaLife, Restylane
Device
Lead sponsor
Cosmeta
Industry
Eligibility
18 Years and older
Enrollment
145 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2008
U.S. locations
5
States / cities
Tracy, California • Roswell, Georgia • Chestnut Hill, Massachusetts + 2 more
Source: ClinicalTrials.gov public record
Updated Jun 26, 2011 · Synced Jun 10, 2026, 8:50 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Multicenter Study of the Safety and Effectiveness of Dermal Filler, Belotero®.

NCT00876265
View directory record Official record
Conditions
Facial Wrinkles
Interventions
Belotero, Zyplast
Device
Lead sponsor
Merz North America, Inc.
Industry
Eligibility
18 Years to 75 Years
Enrollment
118 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2008
U.S. locations
6
States / cities
Birmingham, Alabama • Los Angeles, California • San Francisco, California + 3 more
Source: ClinicalTrials.gov public record
Updated Apr 25, 2013 · Synced Jun 10, 2026, 8:50 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

PREVELLE Shape (CX002) Dermal Filler Protocol

NCT00764257
View directory record Official record
Conditions
Correction of Nasolabial Folds and Lip Augmentation
Interventions
PREVELLE Shape, Restylane
Device
Lead sponsor
Mentor Worldwide, LLC
Industry
Eligibility
18 Years and older
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2007
U.S. locations
1
States / cities
Santa Barbara, California
Source: ClinicalTrials.gov public record
Updated Dec 19, 2011 · Synced Jun 10, 2026, 8:50 PM EDT
Completed Phase 3 Interventional

DL6049 Versus Cosmoplast in the Treatment of Nasolabial Fold Wrinkles, Long Term Follow-up

NCT00444353
View directory record Official record
Conditions
Nasolabial Fold Wrinkles
Interventions
DL6049 (injectable poly-L-lactic acid)
Device
Lead sponsor
Bausch Health Americas, Inc.
Industry
Eligibility
18 Years to 75 Years
Enrollment
240 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2007
U.S. locations
1
States / cities
Bridgewater, New Jersey
Source: ClinicalTrials.gov public record
Updated Sep 17, 2019 · Synced Jun 10, 2026, 8:50 PM EDT
Completed Not applicable Interventional Results available

Evaluation of Pain With Belotero® Balance With Integral Lidocaine for Correction of the Nasolabial Folds

NCT03319719
View directory record Official record
Conditions
Correction of Moderate to Severe Nasolabial Folds
Interventions
Belotero® Balance with integral lidocaine, Belotero® Balance
Device
Lead sponsor
Merz North America, Inc.
Industry
Eligibility
18 Years and older
Enrollment
52 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017
U.S. locations
3
States / cities
Washington D.C., District of Columbia • Nashville, Tennessee • Plano, Texas
Source: ClinicalTrials.gov public record
Updated Sep 30, 2019 · Synced Jun 10, 2026, 8:50 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Effect of Platelet-rich Fibrin Matrix on Skin Rejuvenation

NCT04128046
View directory record Official record
Conditions
Skin Rejuvenation, Skin Quality, Wrinkle, Nasolabial Fold
Interventions
PRFM injection, Saline injection
Procedure
Lead sponsor
New York Medical College
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Valhalla, New York
Source: ClinicalTrials.gov public record
Updated Oct 21, 2019 · Synced Jun 10, 2026, 8:50 PM EDT
Terminated Phase 4 Interventional Results available

Evaluate Efficacy, Safety & Subject Satisfaction of Pain Management With Pliaglis® Cream for Dermal Filler Injections

NCT00716443
View directory record Official record
Conditions
Nasolabial Folds
Interventions
tetracaine 7% / lidocaine 7% cream (Pliaglis® Cream), benzocaine 20% / lidocaine 6% / tetracaine 4% ointment
Drug
Lead sponsor
Galderma R&D
Industry
Eligibility
30 Years to 65 Years
Enrollment
51 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008
U.S. locations
4
States / cities
Aventura, Florida • West Palm Beach, Florida • New York, New York + 1 more
Source: ClinicalTrials.gov public record
Updated Aug 22, 2022 · Synced Jun 10, 2026, 8:50 PM EDT
Completed Not applicable Interventional Results available

A Safety and Effectiveness Study of JUVÉDERM VOLIFT® XC Versus Control for Moderate to Severe Nasolabial Folds

NCT01976663
View directory record Official record
Conditions
Moderate to Severe Nasolabial Folds
Interventions
JUVEDERM VOLIFT® XC, Control
Device
Lead sponsor
Allergan
Industry
Eligibility
18 Years and older
Enrollment
126 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
7
States / cities
Birmingham, Alabama • Los Angeles, California • San Francisco, California + 3 more
Source: ClinicalTrials.gov public record
Updated May 9, 2019 · Synced Jun 10, 2026, 8:50 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Safety and Effectiveness of JUVÉDERM™ Injectable Gel With Lidocaine

NCT00653861
View directory record Official record
Conditions
Nasolabial Folds
Interventions
JUVÉDERM™ Injectable Gel with Lidocaine, JUVÉDERM™ Injectable Gel
Device
Lead sponsor
Allergan Medical
Industry
Eligibility
18 Years and older
Enrollment
72 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008
U.S. locations
1
States / cities
Mount Kisco, New York
Source: ClinicalTrials.gov public record
Updated Oct 12, 2014 · Synced Jun 10, 2026, 8:50 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Radiesse® Injectable Dermal Filler for the Treatment of Nasolabial Folds in Persons of Color

NCT01012388
View directory record Official record
Conditions
Nasolabial Folds
Interventions
Radiesse® Injectable Dermal Filler
Device
Lead sponsor
Merz North America, Inc.
Industry
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2008
U.S. locations
5
States / cities
Los Angeles, California • Chevy Chase, Maryland • Ypsilanti, Michigan + 2 more
Source: ClinicalTrials.gov public record
Updated Apr 25, 2013 · Synced Jun 10, 2026, 8:50 PM EDT
Completed Phase 3 Interventional Results available

A Study to Compare the Safety and Effectiveness of a Non-FDA Approved Device Dermal Gel Extra (DGE) and an FDA Approved Device for the Correction of Nasolabial Folds (NLFs)

NCT00444626
View directory record Official record
Conditions
Facial Wrinkles at the Nasolabial Folds
Interventions
Dermal Gel Extra (DGE), Restylane, EMLA Cream
Device · Drug
Lead sponsor
Genzyme, a Sanofi Company
Industry
Eligibility
18 Years and older
Enrollment
140 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2008
U.S. locations
6
States / cities
Birmingham, Alabama • La Jolla, California • Miami Beach, Florida + 3 more
Source: ClinicalTrials.gov public record
Updated Apr 21, 2015 · Synced Jun 10, 2026, 8:50 PM EDT
Active, not recruiting Not applicable Interventional

Study to Evaluate the Safety and Effectiveness of GP0116

NCT05987163
View directory record Official record
Conditions
Skin Manifestations
Interventions
GP0116, Active Comparator: FDA approved dermal filler device (RHA 3)
Device
Lead sponsor
Galderma R&D
Industry
Eligibility
22 Years and older
Enrollment
186 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
18
States / cities
Santa Monica, California • Vista, California • Westport, Connecticut + 14 more
Source: ClinicalTrials.gov public record
Updated Jul 1, 2025 · Synced Jun 10, 2026, 8:50 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Phase 1 Study to Assess the Safety and Tolerability of TAT4 Gel in Healthy Volunteers

NCT02647853
View directory record Official record
Conditions
Nasolabial Folds, Lipoatrophy, Lipodystrophy
Interventions
TAT4 Gel concentration A, TAT4 Gel concentration B, Placebo
Drug
Lead sponsor
Topokine Therapeutics, Inc.
Industry
Eligibility
40 Years to 70 Years
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014
U.S. locations
1
States / cities
Cypress, California
Source: ClinicalTrials.gov public record
Updated Jan 5, 2016 · Synced Jun 10, 2026, 8:50 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Safety & Tolerability Study That Compares Restylane to Restylane With Lidocaine While Correcting Wrinkles in the Nasolabial Folds

NCT00797459
View directory record Official record
Conditions
Nasolabial Folds
Interventions
Restylane and Restylane-L
Device
Lead sponsor
Medicis Global Service Corporation
Industry
Eligibility
18 Years to 65 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2009
U.S. locations
3
States / cities
Coral Gables, Florida • Hunt Valley, Maryland • Mount Kisco, New York
Source: ClinicalTrials.gov public record
Updated Sep 5, 2013 · Synced Jun 10, 2026, 8:50 PM EDT
Completed Not applicable Interventional Results available

Effectiveness and Safety of Princess FILLER Lidocaine in Correction of Nasolabial Folds (NLF)

NCT03990883
View directory record Official record
Conditions
Dermatological Non-Disease
Interventions
Princess Filler Lidocaine
Device
Lead sponsor
Croma-Pharma GmbH
Industry
Eligibility
22 Years and older
Enrollment
295 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
11
States / cities
Birmingham, Alabama • Beverly Hills, California • San Diego, California + 8 more
Source: ClinicalTrials.gov public record
Updated Feb 3, 2025 · Synced Jun 10, 2026, 8:50 PM EDT