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ClinicalTrials.gov public records Last synced Oct 25, 2026, 2:39 AM EDT

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Showing 889–912 of 1,870 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Neurocognitive Dysfunction Clear all
Completed Phase 2 Interventional

A Study to Evaluate KYN-5356 in Adults With Cognitive Impairment Associated With Schizophrenia

NCT07191483
View directory record Official record
Conditions
Cognitive Impairment Associated With Schizophrenia (CIAS)
Interventions
KYN-5356 low dose, Placebo, KYN-5356 Medium Dose, KYN-5356 High Dose
Drug · Other
Lead sponsor
Kynexis B.V.
Industry
Eligibility
18 Years to 55 Years
Enrollment
149 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
15
States / cities
Little Rock, Arkansas • Cerritos, California • Lemon Grove, California + 12 more
Source: ClinicalTrials.gov public record
Updated Oct 23, 2026 · Synced Oct 25, 2026, 2:39 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Safety, Tolerability, Pharmacokinetics of EVP-0962 and Effects of EVP-0962 on Cerebral Spinal Fluid Amyloid Concentrations in Healthy Subjects and in Subjects With Mild Cognitive Impairment or Early Alzheimer's Disease

NCT01661673
View directory record Official record
Conditions
Mild Cognitive Impairment, Alzheimer's Disease
Interventions
EVP-0962, Placebo
Drug
Lead sponsor
FORUM Pharmaceuticals Inc
Industry
Eligibility
45 Years to 85 Years
Enrollment
52 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
Started 2012
U.S. locations
1
States / cities
Glendale, California
Source: ClinicalTrials.gov public record
Updated Jan 13, 2014 · Synced Oct 25, 2026, 2:39 AM EDT
Completed Phase 1 Interventional

Care Partner-Assisted Diabetes Self-Management Through Linking Continuous Glucose Monitoring With Mobile Health: Improving Outcomes for Older Adults With Mild Cognitive Impairment

NCT05601583
View directory record Official record
Conditions
Type 2 Diabetes, Mild Cognitive Impairment
Interventions
Continuous Glucose Monitor (CGM)
Device
Lead sponsor
NYU Langone Health
Other
Eligibility
65 Years to 100 Years
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 27, 2026 · Synced Oct 25, 2026, 2:39 AM EDT
Suspended Phase 2 Interventional

Angiotensin (1-7) Treatment to Improve Cognitive Functioning in Heart Failure Patients

NCT03159988
View directory record Official record
Conditions
Chronic Heart Failure, Cognitive Impairment
Interventions
Angiotensin-(1-7), Memory Training
Drug · Behavioral
Lead sponsor
University of Arizona
Other
Eligibility
55 Years to 75 Years
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2026
U.S. locations
1
States / cities
Tucson, Arizona
Source: ClinicalTrials.gov public record
Updated Jun 4, 2025 · Synced Oct 25, 2026, 2:39 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Concurrent Aerobic Exercise and Cognitive Training to Prevent Alzheimer's in At-risk Older Adults (The Exergames Telerehabilitation Study)

NCT06340659
View directory record Official record
Conditions
At Risk for AD-dementia, With Subjective Cognitive Decline
Interventions
HbAEx, HbExergame
Behavioral
Lead sponsor
University of Minnesota
Other
Eligibility
65 Years to 99 Years
Enrollment
97 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Sep 1, 2026 · Synced Oct 25, 2026, 2:39 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Implementation of Multifaceted Patient-Centered Treatment Strategies for Intensive Blood Pressure Control in Minimize Cognitive Decline

NCT04797403
View directory record Official record
Conditions
Hypertension, Cognitive Decline
Interventions
Stepped-care protocol adapted from the SPRINT intensive-treatment algorithm
Behavioral
Lead sponsor
Tulane University
Other
Eligibility
40 Years and older
Enrollment
1,306 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2026
U.S. locations
1
States / cities
New Orleans, Louisiana
Source: ClinicalTrials.gov public record
Updated Oct 1, 2026 · Synced Oct 25, 2026, 2:39 AM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Autoimmune Features of Neurodegenerative Disorders

NCT04239079
View directory record Official record
Conditions
Parkinson Disease, Alzheimer Disease, Mild Cognitive Impairment
Interventions
Not listed
Lead sponsor
Columbia University
Other
Eligibility
55 Years to 90 Years
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2028
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 4, 2026 · Synced Oct 25, 2026, 2:39 AM EDT
Completed Not applicable Interventional

Optimal Medication Management in Alzheimer's Disease and Dementia

NCT03984396
View directory record Official record
Conditions
Dementia
Interventions
Educational Materials - Patient & Clinician
Other
Lead sponsor
Kaiser Permanente
Other
Eligibility
65 Years and older
Enrollment
7,398 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2024
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Feb 1, 2024 · Synced Oct 25, 2026, 2:39 AM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Circle Game Collaborative--Freddie the Frog

NCT05522946
View directory record Official record
Conditions
Cognitive Impairment, Physical Disability
Interventions
Gameplay between parent and child or adolescent with or without a disability
Other
Lead sponsor
Ohio State University
Other
Eligibility
5 Years and older
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Jun 15, 2023 · Synced Oct 25, 2026, 2:39 AM EDT
Enrolling by invitation Not applicable Interventional Accepts healthy volunteers

Application of the Modified Story Memory Technique (mSMT)© to Aging

NCT03370224
View directory record Official record
Conditions
Aging, Mild Cognitive Impairment
Interventions
Memory retraining exercises, Placebo control memory exercises
Behavioral
Lead sponsor
Kessler Foundation
Other
Eligibility
65 Years and older
Enrollment
33 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2026
U.S. locations
1
States / cities
East Hanover, New Jersey
Source: ClinicalTrials.gov public record
Updated Aug 11, 2025 · Synced Oct 25, 2026, 2:39 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Adapting a Behavioral Intervention to Accommodate Cognitive Dysfunction in People Who Inject Drugs

NCT05912374
View directory record Official record
Conditions
Cognitive Dysfunction
Interventions
standard Community-Friendly Health Recovery Program- Biobehavioral (CHRP-BB), enhanced Community-Friendly Health Recovery Program- Biobehavioral (CHRP-BB)
Behavioral
Lead sponsor
University of Connecticut
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jun 22, 2023 · Synced Oct 25, 2026, 2:39 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Cognitive Multi-Tasking Training in Healthy Older Adults

NCT04195230
View directory record Official record
Conditions
Age-related Cognitive Decline
Interventions
Multi-tasking Training
Behavioral
Lead sponsor
Columbia University
Other
Eligibility
60 Years to 75 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 28, 2022 · Synced Oct 25, 2026, 2:39 AM EDT
Completed Not applicable Interventional

Telehealth and Memory Study

NCT04586530
View directory record Official record
Conditions
Chemotherapy-related Cognitive Dysfunction
Interventions
Memory and Attention Adaptation Training (MAAT), Supportive Therapy (ST)
Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years and older
Enrollment
194 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
2
States / cities
Indianapolis, Indiana • Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 29, 2026 · Synced Oct 25, 2026, 2:39 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Patient-Centered NeuroRehabilitation (PCN)

NCT03036319
View directory record Official record
Conditions
Cognitive Deficit
Interventions
Active tDCS, Sham tDCS, Cognitively based intervention, Active tACS, Sham tACS, Active tRNS, Sham tRNS
Device · Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
50 Years and older
Enrollment
500 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2027
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Jan 14, 2026 · Synced Oct 25, 2026, 2:39 AM EDT
Completed Not applicable Interventional Results available

Cognitive Recovery After Electroconvulsive Therapy and General Anesthesia

NCT02761330
View directory record Official record
Conditions
Depression, Delirium, Seizures, Cognitive Disorders
Interventions
Ketamine, Electroconvulsive Therapy
Drug · Procedure
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years to 60 Years
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Jun 28, 2021 · Synced Oct 25, 2026, 2:39 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Aging and Cognitive Health Evaluation in Elders (ACHIEVE)

NCT03243422
View directory record Official record
Conditions
Aging, Cognitive Decline
Interventions
Successful aging health education intervention, Hearing intervention
Other
Lead sponsor
Johns Hopkins Bloomberg School of Public Health
Other
Eligibility
70 Years to 84 Years
Enrollment
977 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2023
U.S. locations
4
States / cities
Hagerstown, Maryland • Minneapolis, Minnesota • Jackson, Mississippi + 1 more
Source: ClinicalTrials.gov public record
Updated Feb 1, 2024 · Synced Oct 25, 2026, 2:39 AM EDT
Completed Not applicable Interventional

COgnitive Intervention to Restore Attention Using Nature Environment

NCT04485507
View directory record Official record
Conditions
Heart Failure, Cognitive Dysfunction
Interventions
Nature-VR, Urban-VR
Other
Lead sponsor
Indiana University
Other
Eligibility
21 Years and older
Enrollment
74 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Apr 17, 2024 · Synced Oct 25, 2026, 2:39 AM EDT
Completed No phase listed Observational

Imaging Dementia-Evidence for Amyloid Scanning (IDEAS) Study

NCT02420756
View directory record Official record
Conditions
Alzheimer's Disease, Dementia, Mild Cognitive Impairment
Interventions
PET Scan
Device
Lead sponsor
American College of Radiology
Other
Eligibility
65 Years and older
Enrollment
18,488 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
2
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 23, 2021 · Synced Oct 25, 2026, 2:39 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Changes in Cognition During a 24-h Simulated Military Operation

NCT04250480
View directory record Official record
Conditions
Cognitive Impairment
Interventions
beta-alanine, placebo
Dietary Supplement
Lead sponsor
University of Central Florida
Other
Eligibility
18 Years to 35 Years · Male only
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Orlando, Florida
Source: ClinicalTrials.gov public record
Updated Jan 31, 2020 · Synced Oct 25, 2026, 2:39 AM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

CEReBral AutorEgulation in Non-cardiac SuRgery and Relationship to Postoperative DeliriUm State

NCT06133842
View directory record Official record
Conditions
Perioperative/Postoperative Complications, Postoperative Cognitive Dysfunction, Postoperative Delirium, EEG With Periodic Abnormalities, Intraoperative Hypotension, Cerebral Hypoperfusion
Interventions
Intra-op EEG and CO data collection
Diagnostic Test
Lead sponsor
Beth Israel Deaconess Medical Center
Other
Eligibility
60 Years and older
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2027
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 30, 2026 · Synced Oct 25, 2026, 2:39 AM EDT
Not listed No phase listed Observational Accepts healthy volunteers

Longitudinal Innate Immunity and Aging Study

NCT03944603
View directory record Official record
Conditions
Healthy Older Adults Ages 60-89
Interventions
Not listed
Lead sponsor
University of Colorado, Denver
Other
Eligibility
60 Years to 89 Years
Enrollment
300 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2025
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Apr 2, 2024 · Synced Oct 25, 2026, 2:39 AM EDT
Enrolling by invitation Phase 2 Interventional Accepts healthy volunteers

Neuroimaging Study

NCT03618186
View directory record Official record
Conditions
Cognitive Impairment
Interventions
Tau PET scan
Combination Product
Lead sponsor
Mayo Clinic
Other
Eligibility
30 Years and older
Enrollment
240 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2030
U.S. locations
2
States / cities
Jacksonville, Florida • Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Jun 12, 2026 · Synced Oct 25, 2026, 2:39 AM EDT
Completed Phase 2 Interventional Results available

A Study to Assess the Safety and Efficacy of ASP4345 as Add-on Treatment for Cognitive Impairment in Subjects With Schizophrenia on Stable Doses of Antipsychotic Medication

NCT03557931
View directory record Official record
Conditions
Schizophrenia
Interventions
ASP4345, placebo, risperidone, quetiapine, olanzapine, ziprasidone, aripiprazole, brexpiprazole, paliperidone, lurasidone
Drug
Lead sponsor
Astellas Pharma Global Development, Inc.
Industry
Eligibility
18 Years to 55 Years
Enrollment
233 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
27
States / cities
Cerritos, California • Garden Grove, California • Lemon Grove, California + 19 more
Source: ClinicalTrials.gov public record
Updated Nov 12, 2024 · Synced Oct 25, 2026, 2:39 AM EDT
Terminated Phase 1 Interventional Accepts healthy volunteers Results available

A Study of LY2599666 in Healthy Participants and Participants With Mild Cognitive Impairment or Alzheimer's Disease (AD)

NCT02614131
View directory record Official record
Conditions
Healthy, Alzheimer's Disease, Mild Cognitive Impairment
Interventions
LY2599666, Solanezumab, Placebo SC, Placebo IV
Drug
Lead sponsor
Eli Lilly and Company
Industry
Eligibility
20 Years and older
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2016
U.S. locations
3
States / cities
Glendale, California • Marlton, New Jersey • Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Jun 17, 2020 · Synced Oct 25, 2026, 2:39 AM EDT