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Showing 25–40 of 16 matching trials from the live ClinicalTrials.gov search.
Local D1 index available.
Filters: Condition: Neuropathic Back Pain Clear all
Completed Not applicable Interventional Accepts healthy volunteers Results available

Spinal Cord Stimulation vs. Medical Management for Low Back Pain (DISTINCT)

NCT04479787
View directory record Official record
Conditions
Chronic Low-Back Pain, Refractory Pain, Neuropathic Pain
Interventions
Spinal Cord Stimulation, Conventional Medical Management
Device · Other
Lead sponsor
Abbott Medical Devices
Industry
Eligibility
18 Years and older
Enrollment
270 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2024
U.S. locations
30
States / cities
Phoenix, Arizona • Tucson, Arizona • Camarillo, California + 27 more
Source: ClinicalTrials.gov public record
Updated Feb 2, 2025 · Synced Sep 22, 2026, 9:09 PM EDT
Not listed Not applicable Interventional

MC5-A Scrambler Therapy for the Treatment of Chronic Neuropathic Extremity Pain

NCT02701075
View directory record Official record
Conditions
Peripheral Neuropathy, Low Back Pain
Interventions
MC5-A Scrambler Therapy, MC5-A Scrambler Therapy Sham Device
Device
Lead sponsor
Brooke Army Medical Center
Federal
Eligibility
18 Years to 79 Years
Enrollment
58 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
1
States / cities
Fort Sam Houston, Texas
Source: ClinicalTrials.gov public record
Updated Feb 6, 2017 · Synced Sep 22, 2026, 9:09 PM EDT
Recruiting Phase 2 Interventional

A Master Protocol Study (LY900028) of Multiple Intervention-Specific-Appendices (ISAs) in Participants With Chronic Pain

NCT05986292
View directory record Official record
Conditions
Osteoarthritis, Knee, Diabetic Neuropathic Pain, Chronic Low-back Pain
Interventions
LY3016859 ISA, LY3556050 ISA, LY3526318 ISA, LY3857210 ISA, Placebo Oral, Placebo, LY4065967 ISA
Drug
Lead sponsor
Eli Lilly and Company
Industry
Eligibility
18 Years and older
Enrollment
10,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2027
U.S. locations
62
States / cities
Birmingham, Alabama • Glendale, Arizona • Phoenix, Arizona + 52 more
Source: ClinicalTrials.gov public record
Updated Sep 16, 2026 · Synced Sep 22, 2026, 9:09 PM EDT
Recruiting Not applicable Interventional

A Multicomponent Intervention for Patients With Lumbosacral Radiculopathy: Move-MORE

NCT07125027
View directory record Official record
Conditions
Lumbosacral Radiculopathy, Sciatica, Chronic Low Back Pain With a Neuropathic Component, Radiculopathy Lumbar, Chronic Pain (Back / Neck)
Interventions
Move-MORE
Behavioral
Lead sponsor
National University of Natural Medicine
Other
Eligibility
18 Years to 75 Years
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Aug 25, 2026 · Synced Sep 22, 2026, 9:09 PM EDT
Completed Phase 1 Interventional

Study of PIPE-791 for Subjects With Chronic Osteoarthritis Pain or Chronic Low Back Pain

NCT06810245
View directory record Official record
Conditions
Chronic Osteoarthritis Pain, Chronic Low Back Pain
Interventions
PIPE-791, Placebo
Drug
Lead sponsor
Contineum Therapeutics
Industry
Eligibility
18 Years to 70 Years
Enrollment
43 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
5
States / cities
Phoenix, Arizona • Marietta, Georgia • Hartsdale, New York + 2 more
Source: ClinicalTrials.gov public record
Updated Mar 17, 2026 · Synced Sep 22, 2026, 9:09 PM EDT
Completed Not applicable Interventional Results available

Intraoperative Neuromonitoring Recording With a Novel SCS Paddle

NCT05045625
View directory record Official record
Conditions
Chronic Pain, Neuropathic Pain, Failed Back Surgery Syndrome, Complex Regional Pain Syndromes
Interventions
HD Study Electrode
Device
Lead sponsor
Albany Medical College
Other
Eligibility
18 Years to 90 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Albany, New York
Source: ClinicalTrials.gov public record
Updated Feb 28, 2023 · Synced Sep 22, 2026, 9:09 PM EDT
Terminated Not applicable Interventional Results available

Spinal Cord Stimulation (SCS) for Neuropathic Pain of Back or Lower Extremity

NCT00399841
View directory record Official record
Conditions
Intractable Neuropathic Pain, Pain, Back Pain, Lower Extremity Pain
Interventions
Precision for Spinal Cord Stimulation
Device
Lead sponsor
Boston Scientific Corporation
Industry
Eligibility
18 Years and older
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2008
U.S. locations
1
States / cities
Belleville, Illinois
Source: ClinicalTrials.gov public record
Updated Dec 18, 2020 · Synced Sep 22, 2026, 9:09 PM EDT
Completed Phase 2 Interventional Results available

Trial of Dronabinol and Vaporized Cannabis in Chronic Low Back Pain

NCT02460692
View directory record Official record
Conditions
Cannabis, Low Back Pain, Neuropathic Pain
Interventions
Placebos, dronabinol, Vaporized Cannabis 3.7% THC/5.6% CBD
Drug
Lead sponsor
University of California, San Diego
Other
Eligibility
19 Years to 70 Years
Enrollment
131 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Sep 27, 2023 · Synced Sep 22, 2026, 9:09 PM EDT
Not yet recruiting No phase listed Observational

SERENITY Study of Chronic Pain Interference in Adults

NCT07820475
View directory record Official record
Conditions
Chronic Low Back Pain, Spinal Cord Injury, Neuropathic Pain, Chronic Pain, Pain Interference
Interventions
Not listed
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years and older
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2031
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Sep 14, 2026 · Synced Sep 22, 2026, 9:09 PM EDT
Terminated No phase listed Observational Accepts healthy volunteers

Sub-Sensory Intraspinal Neurostimulation Therapy

NCT01976598
View directory record Official record
Conditions
Back Pain, Back Pain With Radiation, Pain in Leg, Unspecified
Interventions
Sub-Sensory Stimulation
Other
Lead sponsor
Algos Clinical Development Thomas L. Yearwood, MD, PhD
Other
Eligibility
22 Years to 85 Years
Enrollment
1 participant
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2015
U.S. locations
1
States / cities
Pascagoula, Mississippi
Source: ClinicalTrials.gov public record
Updated Jan 18, 2015 · Synced Sep 22, 2026, 9:09 PM EDT
Terminated Not applicable Interventional

Measuring Evoked Potentials From the Spinal Cord and Dorsal Root Ganglion

NCT03976219
View directory record Official record
Conditions
Neuropathic Pain
Interventions
ECAPS Closed Loop SCS
Other
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 9, 2023 · Synced Sep 22, 2026, 9:09 PM EDT
Completed Phase 2 Interventional

Study to Evaluate the Efficacy and Safety of Oral Difelikefalin (CR845) for Moderate to Severe Pruritus in Subjects With Notalgia Paresthetica (KOMFORT)

NCT04706975
View directory record Official record
Conditions
Pruritus, Notalgia Paresthetica
Interventions
difelikefalin 2.0 mg, Placebo
Drug
Lead sponsor
Cara Therapeutics, Inc.
Industry
Eligibility
18 Years to 80 Years
Enrollment
126 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
26
States / cities
Fort Smith, Arkansas • Hot Springs, Arkansas • Rogers, Arkansas + 23 more
Source: ClinicalTrials.gov public record
Updated May 21, 2023 · Synced Sep 22, 2026, 9:09 PM EDT
Completed Phase 4 Interventional Results available

Lumbar Stenosis Outcomes Research (LUSTOR)

NCT00638443
View directory record Official record
Conditions
Lumbar Spinal Stenosis
Interventions
Pregabalin, Diphenhydramine
Drug
Lead sponsor
University of Rochester
Other
Eligibility
50 Years and older
Enrollment
29 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Jun 19, 2016 · Synced Sep 22, 2026, 9:09 PM EDT
Terminated Phase 2 Interventional Results available

Injecting Botulinum Toxin A Underneath the Skin to Treat Spinal Cord Pain in Patients With Spinal Cord Injury

NCT02736890
View directory record Official record
Conditions
Neuropathic Back Pain, Spinal Cord Injury
Interventions
Botulinum Toxin A, Placebo
Drug
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years to 80 Years
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 8, 2019 · Synced Sep 22, 2026, 9:09 PM EDT
Completed Not applicable Interventional Results available

Study to Evaluate Automated Intensity Management in Patients Undergoing a BSC SCS Temporary Trial

NCT04909593
View directory record Official record
Conditions
Chronic Pain, Intractable Pain, Low Back Pain, Pain, Neuropathic, Pain, Back
Interventions
Spinal Cord Stimulation
Device
Lead sponsor
Boston Scientific Corporation
Industry
Eligibility
18 Years and older
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Greenville, South Carolina
Source: ClinicalTrials.gov public record
Updated Dec 5, 2024 · Synced Sep 22, 2026, 9:09 PM EDT
Completed Phase 2 Interventional

Low-Dose Naltrexone and Acetaminophen Combination in the Treatment of Chronic Low Back Pain (ANODYNE-4)

NCT03201393
View directory record Official record
Conditions
Chronic Low Back Pain, Lumbar Radiculopathy
Interventions
Low-dose naltrexone and acetaminophen combination, Placebo
Drug
Lead sponsor
Allodynic Therapeutics, Inc
Industry
Eligibility
18 Years and older
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
North Miami, Florida
Source: ClinicalTrials.gov public record
Updated Apr 13, 2021 · Synced Sep 22, 2026, 9:09 PM EDT