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ClinicalTrials.gov public records Last synced Nov 15, 2026, 3:19 AM EST

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Showing 25–48 of 177 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Nicotine Dependence, Cigarettes Clear all

Conditions: Tobacco Use Disorder
Interventions: Cigarettes with varying nicotine content, E-Cigarettes; Other
Lead sponsor: University of Vermont; Other
Eligibility: 21 Years to 70 Years
Enrollment: 326 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2023
U.S. locations: 2
States / cities: Baltimore, Maryland • Burlington, Vermont

Conditions: Copd, Smoking Cessation, Nicotine Dependence, Tobacco Use, Cigarette Smoking
Interventions: Unified Protocol adapted for smoking cessation, American Lung Association self-management strategies for smoking cessation; Behavioral
Lead sponsor: Rush University Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 66 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2022
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Cigarette Smoking, Nicotine Dependence
Interventions: Internet Smoking Cessation Web Site; Behavioral
Lead sponsor: University of California, San Francisco; Other
Eligibility: 18 Years to 90 Years
Enrollment: 146 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2012 – 2016
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Nicotine Dependence
Interventions: Nicotine; Drug
Lead sponsor: Yale University; Other
Eligibility: 21 Years to 65 Years
Enrollment: 14 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2023
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Nicotine Dependence, Electronic Cigarette Use, Cigarette Smoking
Interventions: Nicotine, Juul e-cigarette, Reduction; Drug · Device · Behavioral
Lead sponsor: University of Vermont; Other
Eligibility: 21 Years and older
Enrollment: 77 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: Burlington, Vermont

Conditions: Tobacco Dependence
Interventions: Nicotine-Containing Electronic Cigarette, Non-Nicotine Electronic Cigarette; Other
Lead sponsor: Milton S. Hershey Medical Center; Other
Eligibility: 21 Years to 70 Years
Enrollment: 105 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2024
U.S. locations: 1
States / cities: Hershey, Pennsylvania

Conditions: Smoking, Nicotine Dependence
Interventions: Nicotine e-cigarette, Non-nicotine e-cigarette; Other
Lead sponsor: Yale University; Other
Eligibility: 18 Years and older
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2016
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Tobacco Dependence
Interventions: Reduced Nicotine Content Cigarettes, Same Nicotine Content Cigarettes; Drug
Lead sponsor: Milton S. Hershey Medical Center; Other
Eligibility: 18 Years to 65 Years
Enrollment: 280 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2018
U.S. locations: 2
States / cities: Washington D.C., District of Columbia • Hershey, Pennsylvania

Conditions: Nicotine Dependence, Major Depressive Disorder
Interventions: Varenicline, BASC, Standard treatment; Drug · Behavioral
Lead sponsor: Northwestern University; Other
Eligibility: 18 Years and older
Enrollment: 300 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2020
U.S. locations: 2
States / cities: Chicago, Illinois • Philadelphia, Pennsylvania

Conditions: Smoking, Cigarette, Smoking, Tobacco, Nicotine Dependence, Exposure to Toxic Agent
Interventions: Low wattage E cigarette device, High wattage E cigarette device, Usual brand cigarette; Behavioral
Lead sponsor: Ohio State University Comprehensive Cancer Center; Other
Eligibility: 18 Years to 99 Years
Enrollment: 372 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2022
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Substance Withdrawal Syndrome
Interventions: Abstinence from e-cigarettes; Behavioral
Lead sponsor: University of Vermont; Other
Eligibility: 18 Years and older
Enrollment: 147 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2018
U.S. locations: 2
States / cities: Baltimore, Maryland • Burlington, Vermont

Conditions: Nicotine Dependence
Interventions: Nicotine, behavioral counseling for smoking cessation; Drug · Behavioral
Lead sponsor: Brown University; Other
Eligibility: 18 Years to 75 Years
Enrollment: 250 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2021
U.S. locations: 1
States / cities: Providence, Rhode Island

Conditions: Nicotine Dependence, Tobacco-Related Carcinoma
Interventions: Smartphone app, Text Message, Survey Administration; Behavioral · Other
Lead sponsor: Fred Hutchinson Cancer Center; Other
Eligibility: 18 Years to 30 Years
Enrollment: 1,178 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Nicotine Dependence
Interventions: saline, Nicotine; Drug
Lead sponsor: Yale University; Other
Eligibility: 18 Years to 50 Years
Enrollment: 213 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2009 – 2016
U.S. locations: 1
States / cities: West Haven, Connecticut

Conditions: Nicotine Dependence, Cigarettes
Interventions: Motivational Text Messages, Control; Behavioral
Lead sponsor: Milton S. Hershey Medical Center; Other
Eligibility: 21 Years and older
Enrollment: 152 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015
U.S. locations: 1
States / cities: Hershey, Pennsylvania

Conditions: Nicotine Addiction, Smoking Cessation
Interventions: Nicotine polacrilex, STAM 1100mAh CE4 eGo Clearomizer; Drug · Other
Lead sponsor: Creighton University; Other
Eligibility: 19 Years and older
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013
U.S. locations: 1
States / cities: Omaha, Nebraska

Conditions: Nicotine Dependence
Interventions: lorcaserin, nicotine patch, placebo lorcaserin; Drug
Lead sponsor: Duke University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 97 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2018
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Smoking, Smoking Cessation, Craving, Addiction, Addiction Nicotine, Nicotine Dependence, Cigarette Smoking
Interventions: Real TBS to the vmPFC, Sham cTBS to the vmPFC; Device
Lead sponsor: Wake Forest University Health Sciences; Other
Eligibility: 18 Years to 75 Years
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2022
U.S. locations: 1
States / cities: Winston-Salem, North Carolina

Conditions: Nicotine Addiction, Cigarette Smoking
Interventions: Smoking research cigarettes with e-cigarette, Nicotine discrimination thresholds; Drug
Lead sponsor: Rose Research Center, LLC; Industry
Eligibility: 21 Years to 65 Years
Enrollment: 150 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2021
U.S. locations: 2
States / cities: Charlotte, North Carolina • Raleigh, North Carolina

Conditions: Nicotine Dependence
Interventions: Baclofen, placebo; Drug
Lead sponsor: University of Pennsylvania; Other
Eligibility: 18 Years to 60 Years
Enrollment: 44 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2013 – 2017
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Nicotine Dependence
Interventions: ECIG Session; Other
Lead sponsor: Virginia Commonwealth University; Other
Eligibility: 18 Years to 55 Years
Enrollment: 38 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018
U.S. locations: 1
States / cities: Richmond, Virginia

Conditions: Tobacco Dependence
Interventions: Varenicline, Nicotine patch, Placebo Patch, Placebo Pill; Drug · Other
Lead sponsor: University of Wisconsin, Madison; Other
Eligibility: 18 Years and older
Enrollment: 1,251 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2020
U.S. locations: 2
States / cities: Madison, Wisconsin • Milwaukee, Wisconsin

Conditions: Nicotine Dependence, Other Tobacco Product, Bladder Cancer, Lung Cancer, Cancer of Head and Neck
Interventions: HALO; Device
Lead sponsor: Dartmouth-Hitchcock Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 19 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2018
U.S. locations: 1
States / cities: Lebanon, New Hampshire

Conditions: Little Cigars and Cigarillos (LCC) Use
Interventions: FDA warnings + Image, FDA Warnings Text-Only, Surgeon General Text-Only Warnings; Behavioral
Lead sponsor: UNC Lineberger Comprehensive Cancer Center; Other
Eligibility: 15 Years to 20 Years
Enrollment: 928 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024
U.S. locations: 1
States / cities: Chapel Hill, North Carolina

Search by objective public record fields.

Low Nicotine Content Cigarettes in Vulnerable Populations: Opioid Use Disorder

Addressing Psychological Risk Factors Underlying Smoking Persistence in COPD Patients: The Fresh Start-II Study

Comparison of Internet Stop Smoking Intervention to Usual Care on Smoking Cessation at 6 Months

Effects of Menthol in E-cigarettes on Smoking Behaviors

E-cigarette Nicotine Study

Does Switching to Nicotine Containing Electronic Cigarettes Reduce Health Risk Markers

Short Term Effects of Electronic Cigarettes in Tobacco Dependent Adults

Reduced Nicotine Content Cigarettes in Smokers of Lower Socioeconomic Status

Behavioral Activation and Varenicline for Smoking Cessation in Depressed Smokers

Examination of Low Wattage and High Wattage E-Cigarettes

Does Abstinence From E-cigarettes Produce Withdrawal Symptoms?

Very Low-Nicotine Cigarettes in Smokers With SUD

A Digital Intervention (ACT on Vaping App) for Vaping Cessation in Young Adult E-Cigarette Users

Sensitivity to Intravenous Nicotine: Genetic Moderators

Penn State TXT2Quit Study

e-Cigarettes Versus NRT Gum for Smoking Cessation

Combination Nicotine Patch / Lorcaserin for Smoking Cessation

QuitFast: Evaluating Transcranial Magnetic Stimulation as a Tool to Reduce Smoking Directly Following a Quit Attempt

Abuse Liability of Reduced Nicotine Content Cigarettes in the Context of Concurrent E-Cigarette Use

Baclofen Effects in Cigarette Smokers

The Influence of Electronic (ECIG) Heater Resistance on ECIG Acute Effects

UW Quitting Using Intensive Treatment Study (QUITS)

Evaluation of Appeal and Impact of E-Cigarettes Among Chronic Smokers With Smoking-Related Cancers

Little Cigar and Cigarillo Warnings for Youth