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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Nitrates Clear all
Completed Phase 1 Interventional Accepts healthy volunteers

A Study of Oral Nitrate in Adults With Pulmonary Hypertension With Heart Failure and Preserved Ejection Fraction

NCT02980068
View directory record Official record
Conditions
Pulmonary; Hypertension, Heart Failure, Preserved Ejection Fraction
Interventions
15N Nitrate, 14N Nitrate
Drug
Lead sponsor
Gladwin, Mark, MD
Individual
Eligibility
18 Years and older
Enrollment
77 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2022
U.S. locations
2
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 21, 2022 · Synced Jul 22, 2026, 3:28 AM EDT
Completed Not applicable Interventional Results available

Safety and Effectiveness of a New Pleural Catheter for Symptomatic, Recurrent, MPEs Versus Approved Pleural Catheter

NCT02649894
View directory record Official record
Conditions
Malignant Pleural Effusion
Interventions
Active Comparator: Approved Uncoated PleurX Indwelling Pleural Catheter, Experimental: Silver Nitrate Coated Indwelling Pleural Catheter (SNCIPC)
Device
Lead sponsor
C. R. Bard
Industry
Eligibility
18 Years and older
Enrollment
119 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
16
States / cities
Huntsville, Alabama • Stanford, California • Tampa, Florida + 12 more
Source: ClinicalTrials.gov public record
Updated Dec 10, 2025 · Synced Jul 22, 2026, 3:28 AM EDT
Completed Not applicable Interventional

Dietary Nitrate Functional Gum Effect on Gingivitis and Heart Health

NCT06029283
View directory record Official record
Conditions
Gingivitis, Cardiovascular Diseases, Gingival Diseases, Gingival Bleeding, Periodontal Diseases
Interventions
dietary nitrate, Placebo chewing gum
Dietary Supplement · Other
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Sep 28, 2025 · Synced Jul 22, 2026, 3:28 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Nitrate and Exercise Performance in Middle to Older Aged Adults

NCT03371966
View directory record Official record
Conditions
Aging
Interventions
High Nitrate Beetroot Juice, Low Nitrate Beetroot Juice
Dietary Supplement
Lead sponsor
Wake Forest University
Other
Eligibility
40 Years to 65 Years
Enrollment
29 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated May 5, 2019 · Synced Jul 22, 2026, 3:28 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Effect of Dietary Nitrate on Immobilization-induced Changes in Skeletal Muscle in Young Healthy Men

NCT07161973
View directory record Official record
Conditions
Mitochondrial Energetics, Dietary Nitrate, Disuse Atrophy (Muscle) of Lower Leg
Interventions
Beetroot Juice - Active, Placebo Beetroot Juice Without Nitrate
Dietary Supplement
Lead sponsor
Indiana University
Other
Eligibility
18 Years to 44 Years · Male only
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Feb 22, 2026 · Synced Jul 22, 2026, 3:28 AM EDT
Recruiting Not applicable Interventional

Analysis of Coronary Reactivity Testing With and Without Intracoronary Nitrate Testing

NCT06896903
View directory record Official record
Conditions
ANOCA - Angina With Non-obstructive Coronary Arteries, INOCA (Ischemia With Non Obstructive Coronary Artery Disease)
Interventions
Coronary reactivity testing with and without nitrates
Diagnostic Test
Lead sponsor
Baylor Research Institute
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Plano, Texas
Source: ClinicalTrials.gov public record
Updated May 4, 2026 · Synced Jul 22, 2026, 3:28 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Determination of Variances in Exhaled Nitric Oxide Output in Normal Healthy Male Volunteers Consuming High and Low Nitrate/Nitrite Diets

NCT00027157
View directory record Official record
Conditions
Healthy
Interventions
Not listed
Lead sponsor
National Heart, Lung, and Blood Institute (NHLBI)
NIH
Eligibility
Male only
Enrollment
18 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2000 – 2003
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 3, 2008 · Synced Jul 22, 2026, 3:28 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Nitrate Supplementation and Muscle Blood Flow

NCT03459027
View directory record Official record
Conditions
Vasodilation, Blood Pressure, Active Hyperemia, Aging
Interventions
Super Beets, Beetroot powder
Dietary Supplement
Lead sponsor
University of Iowa
Other
Eligibility
60 Years to 80 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Jan 8, 2019 · Synced Jul 22, 2026, 3:28 AM EDT
Completed Not applicable Interventional

Acute Effects of Beetroot Juice on Locomotor Economy and Capacity in Chronic Stroke

NCT05720013
View directory record Official record
Conditions
Stroke, CVA
Interventions
Beetroot Juice supplement, Placebo supplement
Dietary Supplement
Lead sponsor
Indiana University
Other
Eligibility
18 Years to 89 Years
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated May 21, 2024 · Synced Jul 22, 2026, 3:28 AM EDT
Completed Phase 1 Interventional

Gallium Nitrate in Treating Children With Brain Tumor, Neuroblastoma, Rhabdomyosarcoma, Non-Hodgkin's Lymphoma, or Refractory Solid Tumors

NCT00002543
View directory record Official record
Conditions
Brain and Central Nervous System Tumors, Lymphoma, Neuroblastoma, Sarcoma, Unspecified Childhood Solid Tumor, Protocol Specific
Interventions
gallium nitrate
Drug
Lead sponsor
Medical College of Wisconsin
Other
Eligibility
Up to 21 Years
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1995 – 2004
U.S. locations
3
States / cities
Baltimore, Maryland • Boston, Massachusetts • Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Jul 17, 2013 · Synced Jul 22, 2026, 3:28 AM EDT
Completed Phase 2 Interventional

Nitrite Supplementation in Long COVID Patients

NCT05618574
View directory record Official record
Conditions
Long COVID, Cardiorespiratory Fitness
Interventions
140 ml per day of Beet-It nitrate beverage (James White Drinks Ltd., Ipswich, UK), 210 ml of nitrate-depleted placebo
Dietary Supplement
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 18, 2025 · Synced Jul 22, 2026, 3:28 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

An Open-label Study to Evaluate the Effects of Concurrent Administration of Vaginal Antimycotic Medication Miconazole Nitrate on the Pharmacokinetics of Nestorone and Ethinyl Estradiol Delivered by a Contraceptive Vaginal Ring in Normal Ovulating Women

NCT02215395
View directory record Official record
Conditions
Antifungal Drug Adverse Reaction
Interventions
NES/EE CVR
Drug
Lead sponsor
Population Council
Other
Eligibility
18 Years to 35 Years · Female only
Enrollment
45 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2015
U.S. locations
1
States / cities
Springfield, Missouri
Source: ClinicalTrials.gov public record
Updated Aug 14, 2017 · Synced Jul 22, 2026, 3:28 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of Beet Juice and Diet in Female Rowers

NCT06045845
View directory record Official record
Conditions
Dietary Habits, Nitrates, Exercise
Interventions
Beet Juice, Placebo
Dietary Supplement
Lead sponsor
University of Kansas Medical Center
Other
Eligibility
18 Years to 30 Years · Female only
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Lawrence, Kansas
Source: ClinicalTrials.gov public record
Updated Feb 1, 2024 · Synced Jul 22, 2026, 3:28 AM EDT
Withdrawn Phase 2 Interventional

Rituximab, Ifosfamide, Carboplatin, and Etoposide (RICE) Followed by Gallium Nitrate, Rituximab and Dexamethasone (GARD) for Relapsed or Refractory Diffuse Large B-Cell Lymphoma

NCT00836173
View directory record Official record
Conditions
Diffuse Large B-cell Lymphoma
Interventions
RICE, GaRD Treatment
Drug
Lead sponsor
Loyola University
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2012
U.S. locations
1
States / cities
Maywood, Illinois
Source: ClinicalTrials.gov public record
Updated Mar 15, 2016 · Synced Jul 22, 2026, 3:28 AM EDT
Completed Not applicable Interventional Results available

Dietary Nitrates and Vascular Function in Patients With Peripheral Artery Disease

NCT01983826
View directory record Official record
Conditions
Peripheral Artery Disease
Interventions
Sodium Nitrate, Placebo
Dietary Supplement · Other
Lead sponsor
University of Iowa
Other
Eligibility
50 Years to 85 Years
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Jun 2, 2019 · Synced Jul 22, 2026, 3:28 AM EDT
Completed Phase 2 Interventional

Phase II Gallium Nitrate in Relapsed or Refractory Non-Hodgkin's Lymphoma

NCT00054808
View directory record Official record
Conditions
Non-Hodgkin's Lymphoma, Relapsed Lymphoma, Refractory Lymphoma, Low-Grade Lymphoma, Intermediate-Grade Lymphoma
Interventions
gallium nitrate
Drug
Lead sponsor
Genta Incorporated
Industry
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2002
U.S. locations
1
States / cities
Berkeley Heights, New Jersey
Source: ClinicalTrials.gov public record
Updated Feb 7, 2006 · Synced Jul 22, 2026, 3:28 AM EDT
Completed Not applicable Interventional

The Effect of Dietary Nitrates on Physical Performance and Vascular Function in Chronic Kidney Disease

NCT04103736
View directory record Official record
Conditions
Kidney Disease, Chronic, Endothelial Dysfunction
Interventions
Beet It Sport Shot, Nitrate-depleted placebo
Dietary Supplement
Lead sponsor
University of Delaware
Other
Eligibility
18 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Newark, Delaware
Source: ClinicalTrials.gov public record
Updated Sep 24, 2019 · Synced Jul 22, 2026, 3:28 AM EDT
Completed Phase 4 Interventional Results available

Prospective Two-Year Study to Assess Miconazole Nitrate Resistance in Neonates and Infants

NCT00702507
View directory record Official record
Conditions
Diaper Rash
Interventions
0.25 % Miconazole Nitrate Ointment
Drug
Lead sponsor
Stiefel, a GSK Company
Industry
Eligibility
Up to 15 Months
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2010
U.S. locations
5
States / cities
San Diego, California • Coral Gables, Florida • Miami, Florida + 2 more
Source: ClinicalTrials.gov public record
Updated Mar 26, 2012 · Synced Jul 22, 2026, 3:28 AM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Medical Management of Caries in the Primary Dentition Using Silver Nitrate

NCT02604134
View directory record Official record
Conditions
Dental Caries
Interventions
Prophylaxis, Fluoride varnish, Silver Nitrate
Procedure · Drug
Lead sponsor
Arwa Owais
Other
Eligibility
2 Years to 11 Years
Enrollment
122 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2018
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Jul 10, 2019 · Synced Jul 22, 2026, 3:28 AM EDT
Completed Phase 3 Interventional

Safety and Efficacy of Econazole Nitrate Foam 1% and Foam Vehicle in Subjects With Tinea Pedis

NCT01358240
View directory record Official record
Conditions
Tinea Pedis, Athlete's Foot
Interventions
Econazole Nitrate Foam 1%, Vehicle Foam, Econazole Nitrate Cream 1%, Placebo Cream
Drug · Other
Lead sponsor
AmDerma
Industry
Eligibility
12 Years and older
Enrollment
336 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
12
States / cities
Fremont, California • Hockessin, Delaware • Boca Raton, Florida + 9 more
Source: ClinicalTrials.gov public record
Updated Sep 27, 2012 · Synced Jul 22, 2026, 3:28 AM EDT
Completed Phase 1 Interventional Results available

The Effects of Potassium Nitrate in Reducing Dentinal Hypersensitivity

NCT01587950
View directory record Official record
Conditions
Dentinal Hypersensitivity, Dental Pain
Interventions
Potassium Nitrate, Placebo
Drug
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
18 Years to 65 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009
U.S. locations
1
States / cities
Fort Wayne, Indiana
Source: ClinicalTrials.gov public record
Updated Apr 27, 2015 · Synced Jul 22, 2026, 3:28 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Dietary Nitrate and Muscle Power With Aging

NCT03513302
View directory record Official record
Conditions
Aging, Sarcopenia
Interventions
placebo, nitrate
Dietary Supplement
Lead sponsor
Indiana University
Other
Eligibility
65 Years to 79 Years
Enrollment
47 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2022
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Feb 18, 2025 · Synced Jul 22, 2026, 3:28 AM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Adjuvant Nitrate to Boost Exercise-induced Health Benefits in Older Adults

NCT07572266
View directory record Official record
Conditions
Aging, Aging Well, Healthy Aging
Interventions
Nitrate enriched beetroot juice, Nitrate depleted beetroot juice, 12 week of combined exercise training
Dietary Supplement · Other
Lead sponsor
Florida Institute for Human and Machine Cognition
Other
Eligibility
60 Years and older
Enrollment
226 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2031
U.S. locations
1
States / cities
Pensacola, Florida
Source: ClinicalTrials.gov public record
Updated Jul 9, 2026 · Synced Jul 22, 2026, 3:28 AM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers Results available

Inorganic Nitrate Supplementation on Cerebrovascular Aging and Arterial Stiffness Study

NCT03617302
View directory record Official record
Conditions
Aging, Arterial Stiffness, Endothelial Dysfunction, Hypertension, Cognitive Decline
Interventions
Experimental: Nitrate-containing, Placebo: Nitrate-depleted
Drug
Lead sponsor
Gary L. Pierce, PhD
Other
Eligibility
50 Years to 79 Years
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2024
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Mar 3, 2026 · Synced Jul 22, 2026, 3:28 AM EDT