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Conditions: Obesity, Smoking Cessation, Bariatric Surgery Patients
Interventions: Naltrexone Hydrochloride, Bupropion HCl Extended Release, Cognitive-Behavioral Therapy; Drug · Behavioral
Lead sponsor: Yale University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Heart Failure With Normal Ejection Fraction, Obesity
Interventions: Increasing daily unsaturated fatty acid consumption; Behavioral
Lead sponsor: Virginia Commonwealth University; Other
Eligibility: 18 Years and older
Enrollment: 16 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2018
U.S. locations: 1
States / cities: Richmond, Virginia

Conditions: Metabolic Dysfunction Associated Steatotic Liver Disease, Overweight (BMI > 25), Metabolic Syndrome
Interventions: Paso Program; Behavioral
Lead sponsor: Baylor College of Medicine; Other
Eligibility: 18 Years to 70 Years
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Houston, Texas

Conditions: GLP - 1, Obesity & Overweight, Muscle Loss, Exercise Intervention, Dietary Assessment
Interventions: Semaglutide, Dietary Counseling, Exercise; Drug · Behavioral
Lead sponsor: William Marsh Rice University; Other
Eligibility: 40 Years to 55 Years
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Overweight (BMI > 25), Obese But Otherwise Healthy Participants, Overweight or Obese, Obese Patients (BMI ≥ 30 kg/m²), Poor Sleep Quality, Healthy Participants, Physically Inactive
Interventions: Pistachio; Other
Lead sponsor: University of South Carolina; Other
Eligibility: 25 Years to 45 Years
Enrollment: 60 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Columbia, South Carolina

Conditions: GERD, Morbid Obesity
Interventions: Stretta, Radiofrequency (RF) Energy to the LES (Stretta Procedure); Device · Procedure
Lead sponsor: Montefiore Medical Center; Other
Eligibility: 18 Years to 80 Years
Enrollment: 5 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2019
U.S. locations: 13
States / cities: Los Angeles, California • Stanford, California • Norwalk, Connecticut + 8 more

Conditions: Obesity and Overweight
Interventions: Not listed
Lead sponsor: Texas Tech University; Other
Eligibility: 18 Years and older
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: Lubbock, Texas

Conditions: Metabolic Syndrome
Interventions: simvastatin, ezetimibe/simvastatin; Drug
Lead sponsor: University of Maryland, Baltimore; Other
Eligibility: 21 Years and older
Enrollment: 15 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2009 – 2011
U.S. locations: 3
States / cities: Baltimore, Maryland

Conditions: Morbid Obesity, Vitamin D Deficiency
Interventions: vitamin D3 (Replesta), vitamin D; Dietary Supplement
Lead sponsor: Texas Tech University; Other
Eligibility: 18 Years to 60 Years
Enrollment: 31 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2013
U.S. locations: 1
States / cities: Lubbock, Texas

Conditions: Type 2 Diabetes, High Blood Pressure, Arthritis, Obesity
Interventions: Metformin, Val, Cel and Met XR Low, Val, Cel and Met XR High; Drug
Lead sponsor: ARKAY Therapeutics; Industry
Eligibility: 18 Years to 70 Years
Enrollment: 115 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2029
U.S. locations: 1
States / cities: Albany, New York

Conditions: Obesity, Overweight, Craniopharyngioma
Interventions: Exenatide; Drug
Lead sponsor: Vanderbilt University Medical Center; Other
Eligibility: 18 Years to 40 Years
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2015
U.S. locations: 1
States / cities: Nashville, Tennessee

Conditions: Colon Cancer, Lung Cancer, Atrial Fibrillation, Diabetes Type 2, Obesity, Breast Cancer, Graves Disease, Osteoarthritis, Celiac Disease, Myocardial Infarction, Prostate Cancer
Interventions: SNP analysis; Genetic
Lead sponsor: Mayo Clinic; Other
Eligibility: 18 Years to 65 Years
Enrollment: 26 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2008 – 2010
U.S. locations: 1
States / cities: Rochester, Minnesota

Conditions: Surgical Wound Infection
Interventions: 80% oxygen, 30% oxygen; Other
Lead sponsor: The Cleveland Clinic; Other
Eligibility: 18 Years to 80 Years
Enrollment: 400 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2009
U.S. locations: 2
States / cities: Louisville, Kentucky • Cleveland, Ohio

Conditions: Pediatric Obesity
Interventions: Positive Reinforcement Text Message; Other
Lead sponsor: Marsha Ma; Other
Eligibility: 13 Years to 18 Years
Enrollment: 40 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2025
U.S. locations: 1
States / cities: Maywood, Illinois

Conditions: Obesity, Bariatric Surgery Candidate, Hypertension, Diabetes
Interventions: Magnetically Controlled Capsule Endoscopy (MCCE); Device
Lead sponsor: Jerry Dang; Other
Eligibility: 18 Years and older
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: Cleveland, Ohio

Conditions: Infection, Sepsis, Obesity
Interventions: IV vancomycin; Drug
Lead sponsor: CAMC Health System; Other
Eligibility: 18 Years to 99 Years
Enrollment: 128 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2021
U.S. locations: 1
States / cities: Charleston, West Virginia

Conditions: Sepsis, Septic Shock, Obesity
Interventions: Actual Body Weight Dosing, Adjusted Body Weight Dosing, Ideal Body Weight Dosing; Procedure
Lead sponsor: Wake Forest University Health Sciences; Other
Eligibility: 18 Years and older
Enrollment: 7 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: Charlotte, North Carolina

Conditions: Hypothalamic Obesity, Multiple Pituitary Hormone Deficiency Genetic Form, Septo-Optic Dysplasia, Optic Nerve Hypoplasia, Childhood-onset Combined Pituitary Hormone Deficiency, Pituitary Stalk Interruption Syndrome
Interventions: Setmelanotide, Placebo; Drug
Lead sponsor: Rhythm Pharmaceuticals, Inc.; Industry
Eligibility: 4 Years and older
Enrollment: 39 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2028
U.S. locations: 8
States / cities: Birmingham, Alabama • Aurora, Colorado • Chicago, Illinois + 5 more

Conditions: Morbid Obesity
Interventions: Laparoscopic Sleeve Gastrectomy, Laparoscopic Gastric Bypass; Procedure
Lead sponsor: Pennington Biomedical Research Center; Other
Eligibility: 18 Years and older
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2013
U.S. locations: 1
States / cities: Baton Rouge, Louisiana

Conditions: Morbid Obesity
Interventions: Not listed
Lead sponsor: Ethicon Endo-Surgery; Industry
Eligibility: 18 Years and older
Enrollment: 231 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2012
U.S. locations: 7
States / cities: Los Angeles, California • Celebration, Florida • Joliet, Illinois + 4 more

Conditions: Obesity
Interventions: Calorie-counting, MyPlate; Behavioral
Lead sponsor: University of California, Los Angeles; Other
Eligibility: 18 Years and older
Enrollment: 261 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2017
U.S. locations: 2
States / cities: Long Beach, California • Los Angeles, California

Conditions: Prediabetic State, PreDiabetes, Health Knowledge, Attitudes, Practice, Nutrition, Healthy, Acceptability of Health Care, Obesity Prevention
Interventions: One-arm feasibility pilot of a nutrition intervention to recruit, engage, and retain DPP participants in the safety-net setting in Los Angeles; Behavioral
Lead sponsor: Cedars-Sinai Medical Center; Other
Eligibility: 18 Years to 99 Years
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Obesity
Interventions: Transoral Suturing, Sham Endoscopy; Device · Other
Lead sponsor: C. R. Bard; Industry
Eligibility: 18 Years and older
Enrollment: 77 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2009
U.S. locations: 10
States / cities: Denver, Colorado • Baltimore, Maryland • Boston, Massachusetts + 7 more

Conditions: Inflammation, Prevention and Control, Colonic Neoplasms, Diet, Insulin
Interventions: LIFE; Dietary Supplement
Lead sponsor: National Cancer Institute (NCI); NIH
Eligibility: 35 Years to 75 Years · Male only
Enrollment: 65 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2005 – 2018
U.S. locations: 1
States / cities: University Park, Pennsylvania

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Development of a MHBC Intervention for Weight Loss and Smoking Cessation for Pre-Bariatric Surgery Patients

Unsaturated Fatty Acids Enriched-diet to Improve Cardiorespiratory Fitness, Metabolic Flexibility and Glucose Tolerance in Obese Patients

Feasibility of the Paso Program for Patients With Metabolic Dysfunction Associated Steatotic Liver Disease

Combatting Muscle Loss in Obese Adult Patients on GLP-1 Medications Through Dietary Counseling and Exercise During Treatment Evaluates Whether a 12-week Exercise and Individualized Nutrition Program Can Reduce Muscle and Bone Loss and Improve Strength, Fitness, and Function in Obese Adults on GLP-1

Pistachio Snacking and Metabolic Flexibility

Management of Reflux After Sleeve Using Stretta

Study of Patients Being Treated With Anti-obesity Medication

Simvastatin With or Without Ezetimibe and Atherothrombotic Biomarker Assessment

Effect of a Monthly High Dose of Vitamin D3 on Bariatric Surgery Patients

Evaluation of Superiority of Valsartan+Celecoxib+Metformin Over Metformin Alone in Type 2 Diabetes Patients

Weight Loss Study for Patients With Obesity Due to Craniopharyngioma or Other Brain Tumor

Predictive Genetic Risk Assessment Trial

Supplemental Postoperative Oxygen and Wound Infection in Morbidly Obese Patients

Text Messaging Pediatric Obese Patients

Preoperative Use of a Magnetically Controlled Capsule Endoscopy in Patients Undergoing Bariatric Surgery

Study of Obese Patients Comparing Two Vancomycin Loading Dose Regimens

Fluid Resuscitation in Septic Shock Patients With BMI Elevation

A Trial of Setmelanotide in Patients With Congenital Hypothalamic Obesity (Sub-study of NCT05774756)

Sleeve Gastrectomy Versus Gastric Bypass for Private Pay Patients Seeking Obesity Surgery

A Study of Clinical Outcomes of the REALIZE Adjustable Gastric Band-C

Is MyPlate Approach to Helping Overweight Patients Lose Weight More Patient-centered?

Feasibility of a Nutrition Intervention for Patients With Prediabetes at a Federally Qualified Health Center

Incisionless Treatment for Patients With Inadequate Weight Loss Following Roux-en-Y Gastric Bypass

Effect of High-Legume Diet on Colorectal Cancer Risk