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Showing 1–24 of 5,422 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Obesity/Overweight Clear all
Completed Phase 3 Interventional

A Study of LY3298176 (Tirzepatide) For the Maintenance of Body Weight Reduction in Participants Who Have Obesity or Overweight With Weight-Related Comorbidities

NCT06047548
View directory record Official record
Conditions
Overweight, Obesity
Interventions
Tirzepatide, Placebo
Drug
Lead sponsor
Eli Lilly and Company
Industry
Eligibility
18 Years and older
Enrollment
441 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
20
States / cities
Pelham, Alabama • Los Angeles, California • Santa Ana, California + 17 more
Source: ClinicalTrials.gov public record
Updated Mar 24, 2026 · Synced Jun 11, 2026, 2:12 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Timing of Sodium Intake and Nocturnal Sodium Excretion and Blood Pressure in Obese African Americans

NCT04021355
View directory record Official record
Conditions
Obesity, Hypertension, Circadian Dysregulation, Salt; Excess
Interventions
Oral sodium supplementation
Other
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
25 Years to 45 Years
Enrollment
53 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2025
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Dec 16, 2025 · Synced Jun 11, 2026, 2:12 AM EDT
Completed Phase 4 Interventional Results available

Use of Medication to Improve Weight Loss in Suboptimal Early Responders to Behavioral Treatment

NCT03779048
View directory record Official record
Conditions
Obesity
Interventions
Behavioral Treatment, Placebo, Phentermine 15 MG
Behavioral · Drug
Lead sponsor
University of Pennsylvania
Other
Eligibility
21 Years to 70 Years
Enrollment
147 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 10, 2025 · Synced Jun 11, 2026, 2:12 AM EDT
Completed Not applicable Interventional Results available

Impacts of Lentils on Metabolism and Inflammation

NCT04283448
View directory record Official record
Conditions
Hypertriglyceridemia, Inflammation, Waist, Hypertriglyceridemic
Interventions
Dietary Lentil, Control
Behavioral
Lead sponsor
Montana State University
Other
Eligibility
18 Years to 70 Years
Enrollment
38 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
Bozeman, Montana
Source: ClinicalTrials.gov public record
Updated Dec 12, 2024 · Synced Jun 11, 2026, 2:12 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Wellness Action Plan Trial Addressing Childhood Obesity

NCT02185248
View directory record Official record
Conditions
Childhood Obesity
Interventions
Wellness Action Plan
Behavioral
Lead sponsor
Roohi Kharofa, MD, MPH
Other
Eligibility
30 Months to 14 Years
Enrollment
181 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013
U.S. locations
1
States / cities
Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Mar 23, 2015 · Synced Jun 11, 2026, 2:12 AM EDT
Recruiting Phase 4 Interventional

A Study to Investigate Effectiveness of Tirzepatide Following Initiation of Ixekizumab in Participants With Active Psoriatic Arthritis and Overweight or Obesity in Clinical Practice (TOGETHER AMPLIFY-PsA)

NCT06864026
View directory record Official record
Conditions
Psoriatic Arthritis, Overweight or Obesity
Interventions
Tirzepatide
Drug
Lead sponsor
Eli Lilly and Company
Industry
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
53
States / cities
Avondale, Arizona • Chandler, Arizona • Flagstaff, Arizona + 48 more
Source: ClinicalTrials.gov public record
Updated Feb 9, 2026 · Synced Jun 11, 2026, 2:12 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Brief Physical Activity Program to Increase Physical Fitness in Elementary School Children

NCT02087774
View directory record Official record
Conditions
Childhood Obesity
Interventions
6 minutes activity
Behavioral
Lead sponsor
Marshall University
Other
Eligibility
Not listed
Enrollment
300 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2014
U.S. locations
1
States / cities
Huntington, West Virginia
Source: ClinicalTrials.gov public record
Updated Aug 14, 2014 · Synced Jun 11, 2026, 2:12 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Impact of Liraglutide 3.0 on Body Fat Distribution

NCT03038620
View directory record Official record
Conditions
Obesity, Visceral, Cardiovascular Diseases, Fat Disorder
Interventions
Liraglutide, Placebo
Drug
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
35 Years and older
Enrollment
235 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2020
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Nov 18, 2021 · Synced Jun 11, 2026, 2:12 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Leptin in Human Energy and Neuroendocrine Homeostasis

NCT00265980
View directory record Official record
Conditions
Obesity, Weight Loss
Interventions
Subcutaneous Placebo, Leptin
Drug
Lead sponsor
Columbia University
Other
Eligibility
19 Years to 45 Years
Enrollment
22 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2002 – 2013
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Sep 17, 2019 · Synced Jun 11, 2026, 2:12 AM EDT
Completed Not applicable Interventional

Response of the Gut Microbiome and Circulating Metabolome to Diet in Children: Ancillary Study to KIDFIT (NCT03405246)

NCT03612479
View directory record Official record
Conditions
Gastrointestinal Microbiome, Metabolome, Pediatric Obesity, Dietary Approaches to Stop Hypertension
Interventions
KIDFIT Healthy, KIDFIT Safe
Behavioral
Lead sponsor
Northwestern University
Other
Eligibility
3 Years to 5 Years
Enrollment
46 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jun 28, 2022 · Synced Jun 11, 2026, 2:12 AM EDT
Recruiting Phase 1 Interventional Accepts healthy volunteers

Human Models of Selective Insulin Resistance: Alpelisib, Part I

NCT06354088
View directory record Official record
Conditions
Insulin Resistance, Prediabetic State, Overweight and Obesity, Non-Alcoholic Fatty Liver Disease
Interventions
Alpelisib 300 mg, Placebo, [1-13C] sodium acetate, [6,6-2H2] D-glucose, Nestlé BOOST Plus
Drug · Dietary Supplement
Lead sponsor
Columbia University
Other
Eligibility
18 Years to 70 Years
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 8, 2026 · Synced Jun 11, 2026, 2:12 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Mothers and Others: Family-based Obesity Prevention for Infants and Toddlers

NCT01938118
View directory record Official record
Conditions
Obesity
Interventions
Obesity Prevention Group, Injury Prevention Group
Behavioral
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
Not listed
Enrollment
430 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2017
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 18, 2018 · Synced Jun 11, 2026, 2:12 AM EDT
Completed Not applicable Interventional Results available

Compression Stocking Use in Shoulder Arthroscopy in Beach Chair

NCT01996813
View directory record Official record
Conditions
Obesity, Shoulder Impingement
Interventions
Thigh-high compression stockings
Device
Lead sponsor
Loyola University
Other
Eligibility
18 Years and older
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
Maywood, Illinois
Source: ClinicalTrials.gov public record
Updated Aug 30, 2018 · Synced Jun 11, 2026, 2:12 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Impact of High Fiber Snacks on Adiposity, Glucose Regulation and Appetite

NCT02217124
View directory record Official record
Conditions
Obesity
Interventions
dried apples, muffin
Other
Lead sponsor
San Diego State University
Other
Eligibility
10 Years to 16 Years
Enrollment
45 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2016
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Aug 10, 2017 · Synced Jun 11, 2026, 2:12 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effect of ASEA on Energy Expenditure and Fat Oxidation in Humans

NCT01884727
View directory record Official record
Conditions
Obesity
Interventions
Salt Water, ASEA water
Dietary Supplement
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
50 Years to 65 Years · Female only
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2013
U.S. locations
1
States / cities
Kannapolis, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 23, 2013 · Synced Jun 11, 2026, 2:12 AM EDT
Not yet recruiting Phase 2 Interventional

Efficacy and Safety of GZR18 Every 2 Weeks Versus Tirzepatide and Placebo in Obese or Overweight Participants

NCT06737042
View directory record Official record
Conditions
Obesity and Overweight
Interventions
GZR18, Tirzepatide
Drug
Lead sponsor
Gan and Lee Pharmaceuticals, USA
Industry
Eligibility
18 Years to 75 Years
Enrollment
285 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
20
States / cities
Bessemer, Alabama • Centreville, Alabama • Little Rock, Arkansas + 16 more
Source: ClinicalTrials.gov public record
Updated Feb 3, 2025 · Synced Jun 11, 2026, 2:12 AM EDT
Withdrawn No phase listed Observational Accepts healthy volunteers

Leptin Signaling in Lean and Obese Humans

NCT01297426
View directory record Official record
Conditions
Obesity
Interventions
Not listed
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 65 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2015
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 23, 2015 · Synced Jun 11, 2026, 2:12 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Black Girls Move Physical Activity and Improving Dietary Intake Among Black Adolescent Daughters

NCT05433415
View directory record Official record
Conditions
Adolescent Obesity, Diabetes Mellitus
Interventions
Black Girls Move
Behavioral
Lead sponsor
Rush University Medical Center
Other
Eligibility
12 Years to 18 Years · Female only
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2026
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Mar 4, 2026 · Synced Jun 11, 2026, 2:12 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effect of Age and Weight Loss on Inflammation and Iron Homeostasis

NCT01636635
View directory record Official record
Conditions
Obesity, Aging
Interventions
Calorie Restriction
Other
Lead sponsor
Tufts University
Other
Eligibility
18 Years and older · Female only
Enrollment
44 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2013
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Nov 15, 2015 · Synced Jun 11, 2026, 2:12 AM EDT
Completed Not applicable Interventional

Telenutrition in Spinal Cord Injury

NCT03714217
View directory record Official record
Conditions
Spinal Cord Injury, Obesity
Interventions
Telenutrition Counseling
Behavioral
Lead sponsor
Santa Clara Valley Health & Hospital System
Other
Eligibility
18 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
San Jose, California
Source: ClinicalTrials.gov public record
Updated Sep 20, 2021 · Synced Jun 11, 2026, 2:12 AM EDT
Active, not recruiting Phase 1 Interventional Accepts healthy volunteers

ADRB3 Signaling Pathway in Human Adipose Tissue

NCT05634174
View directory record Official record
Conditions
Obesity, Prediabetes
Interventions
Mirabegron
Drug
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years to 70 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Oct 14, 2024 · Synced Jun 11, 2026, 2:12 AM EDT
Completed Not applicable Interventional Results available

Research Aimed at Improving Both Mood and Weight

NCT02246413
View directory record Official record
Conditions
Depression, Obesity
Interventions
RAINBOW Intervention Program
Behavioral
Lead sponsor
Palo Alto Medical Foundation
Other
Eligibility
18 Years and older
Enrollment
409 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2018
U.S. locations
2
States / cities
Palo Alto, California • Stanford, California
Source: ClinicalTrials.gov public record
Updated Apr 25, 2024 · Synced Jun 11, 2026, 2:12 AM EDT
Completed Not applicable Interventional Results available

The KP Personal Shopper: A Pilot to Improve the Impact of Dietary Advice

NCT01837524
View directory record Official record
Conditions
Overweight, Obesity
Interventions
KP Personal Shopper Visits, In-Office Dietitian Visits
Behavioral
Lead sponsor
Kaiser Permanente
Other
Eligibility
18 Years to 64 Years
Enrollment
55 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Apr 11, 2017 · Synced Jun 11, 2026, 2:12 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Metabolic Effects of Non-nutritive Sweeteners

NCT02413424
View directory record Official record
Conditions
Obesity
Interventions
Sucralose, Water, glucose load
Dietary Supplement · Other
Lead sponsor
University of Illinois at Urbana-Champaign
Other
Eligibility
18 Years to 40 Years
Enrollment
38 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2017
U.S. locations
1
States / cities
Urbana, Illinois
Source: ClinicalTrials.gov public record
Updated Sep 20, 2017 · Synced Jun 11, 2026, 2:12 AM EDT