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ClinicalTrials.gov public records Last synced Oct 18, 2026, 7:27 AM EDT

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Showing 2065–2088 of 4,090 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Obstructive Clear all
Completed Phase 3 Interventional Results available

Pivotal Study to Assess the Efficacy, Safety and Tolerability of Dupilumab in Patients With Moderate-to-severe COPD With Type 2 Inflammation

NCT03930732
View directory record Official record
Conditions
Chronic Obstructive Pulmonary Disease
Interventions
Dupilumab SAR231893, Inhaled Corticosteroid, Inhaled Long-Acting Beta Agonist, Inhaled Long-Acting Muscarinic Antagonist, Placebo
Drug
Lead sponsor
Sanofi
Industry
Eligibility
40 Years to 80 Years
Enrollment
939 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
51
States / cities
Andalusia, Alabama • Birmingham, Alabama • Dothan, Alabama + 46 more
Source: ClinicalTrials.gov public record
Updated Feb 28, 2024 · Synced Oct 18, 2026, 7:27 AM EDT
Completed Not applicable Interventional Results available

Safety Study of Quickclot for Bleeding Control After Adenotonsillectomy

NCT01863563
View directory record Official record
Conditions
Sleep Apnea, Obstructive
Interventions
QuickClot
Device
Lead sponsor
Eastern Virginia Medical School
Other
Eligibility
2 Years to 17 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
1
States / cities
Norfolk, Virginia
Source: ClinicalTrials.gov public record
Updated Mar 26, 2019 · Synced Oct 18, 2026, 7:27 AM EDT
Recruiting Phase 2 Interventional

A Study of WIN378 in Participants With Moderate to Severe COPD (Sirius)

NCT07646587
View directory record Official record
Conditions
COPD (Chronic Obstructive Pulmonary Disease)
Interventions
WIN378, Placebo
Drug
Lead sponsor
Windward Bio
Industry
Eligibility
40 Years to 80 Years
Enrollment
105 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
8
States / cities
Los Angeles, California • Miami Lakes, Florida • North Dartmouth, Massachusetts + 5 more
Source: ClinicalTrials.gov public record
Updated Sep 15, 2026 · Synced Oct 18, 2026, 7:27 AM EDT
Terminated Phase 3 Interventional

A Study to Assess the Effect of Dexpramipexole in Adolescents and Adults With Severe Eosinophilic Asthma.

NCT05763121
View directory record Official record
Conditions
Eosinophilic Asthma, Asthma; Eosinophilic, Asthma
Interventions
Dexpramipexole Dihydrochloride, Placebo
Drug
Lead sponsor
Areteia Therapeutics
Industry
Eligibility
12 Years to 99 Years
Enrollment
1,061 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
89
States / cities
Bakersfield, California • La Palma, California • Newport Beach, California + 73 more
Source: ClinicalTrials.gov public record
Updated Dec 15, 2025 · Synced Oct 18, 2026, 7:27 AM EDT
Completed Phase 4 Interventional Results available

Study of Stapled Transanal Rectal Resection (STARR) Surgery in Refractory Constipation Associated With Obstructive Defecation Syndrome (ODS)

NCT00256984
View directory record Official record
Conditions
Obstructive Defecation Syndrome, Chronic Constipation, Rectocele, Intussusception
Interventions
Stapled Transanal Resection (STARR) with Transtar (PROXIMATE®) 33 mm Circular Stapler
Procedure
Lead sponsor
Ethicon Endo-Surgery
Industry
Eligibility
21 Years to 80 Years · Female only
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2008
U.S. locations
7
States / cities
Orlando, Florida • Burlington, Massachusetts • Minneapolis, Minnesota + 3 more
Source: ClinicalTrials.gov public record
Updated Jul 16, 2018 · Synced Oct 18, 2026, 7:27 AM EDT
Completed Phase 4 Interventional Results available

Patient Empowered Strategy to Reduce Asthma Morbidity in Highly Impacted Populations; PeRson EmPowered Asthma RElief

NCT02995733
View directory record Official record
Conditions
Asthma
Interventions
PARTICS using QVAR
Drug
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years to 75 Years
Enrollment
1,220 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
19
States / cities
Birmingham, Alabama • Los Angeles, California • Denver, Colorado + 14 more
Source: ClinicalTrials.gov public record
Updated Jan 19, 2023 · Synced Oct 18, 2026, 7:27 AM EDT
Completed Phase 1Phase 2 Interventional Results available

A Study to Evaluate Safety, Tolerability and Pharmacokinetics of Two Different Doses of Alpha1-Proteinase Inhibitor Subcutaneous (Human) 15% in Participants With Alpha1-Antitrypsin Deficiency

NCT04722887
View directory record Official record
Conditions
Alpha1-Antitrypsin Deficiency
Interventions
Alpha-1 15%, Liquid Alpha1-Proteinase Inhibitor (Human)
Biological
Lead sponsor
Grifols Therapeutics LLC
Industry
Eligibility
18 Years to 80 Years
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
5
States / cities
Los Angeles, California • Gainesville, Florida • Miami, Florida + 2 more
Source: ClinicalTrials.gov public record
Updated Oct 8, 2026 · Synced Oct 18, 2026, 7:27 AM EDT
Active, not recruiting Phase 1 Interventional

Leflunomide in Treating Patients With Steroid Dependent Chronic Graft Versus Host Disease

NCT04212416
View directory record Official record
Conditions
Chronic Graft Versus Host Disease, Steroid Refractory Graft Versus Host Disease
Interventions
Leflunomide
Drug
Lead sponsor
City of Hope Medical Center
Other
Eligibility
18 Years and older
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2027
U.S. locations
1
States / cities
Duarte, California
Source: ClinicalTrials.gov public record
Updated Jul 8, 2026 · Synced Oct 18, 2026, 7:27 AM EDT
Terminated Phase 4 Interventional Results available

Moderate to Persistent Asthma in the Obese Subject

NCT01016847
View directory record Official record
Conditions
Asthma
Interventions
Montelukast, Sugar pill
Drug · Other
Lead sponsor
Duke University
Other
Eligibility
18 Years to 65 Years
Enrollment
38 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Nov 17, 2014 · Synced Oct 18, 2026, 7:27 AM EDT
Completed Phase 2 Interventional Results available

Montelukast to Treat Bronchiolitis Obliterans

NCT00656058
View directory record Official record
Conditions
Bronchiolitis Obliterans, Chronic Graft Versus Host Disease, Leukotriene, Montelukast, Stem Cell Transplant
Interventions
Singulair (Montelukast Sodium)
Drug
Lead sponsor
National Cancer Institute (NCI)
NIH
Eligibility
6 Years to 80 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2018
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Apr 9, 2018 · Synced Oct 18, 2026, 7:27 AM EDT
Terminated No phase listed Observational Accepts healthy volunteers

Sub-Sensory Intraspinal Neurostimulation Therapy

NCT01976598
View directory record Official record
Conditions
Back Pain, Back Pain With Radiation, Pain in Leg, Unspecified
Interventions
Sub-Sensory Stimulation
Other
Lead sponsor
Algos Clinical Development Thomas L. Yearwood, MD, PhD
Other
Eligibility
22 Years to 85 Years
Enrollment
1 participant
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2015
U.S. locations
1
States / cities
Pascagoula, Mississippi
Source: ClinicalTrials.gov public record
Updated Jan 19, 2015 · Synced Oct 18, 2026, 7:27 AM EDT
Completed Phase 1Phase 2 Interventional Results available

DAW1033D in Obstructive Sleep Apnea

NCT03383887
View directory record Official record
Conditions
Obstructive Sleep Apnea (OSA)
Interventions
Placebo oral capsule, DAW1033D oral capsule
Drug
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
21 Years to 65 Years
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 25, 2020 · Synced Oct 18, 2026, 7:27 AM EDT
Completed No phase listed Observational

A Study to Evaluate Conceptual Saturation of Evaluating Respiratory Symptoms (E-RS) in Subjects With Asthma

NCT03344406
View directory record Official record
Conditions
Asthma
Interventions
Telephonic interviews, E-RS: COPD, Supplemental asthma items, Daily diary, Sociodemographic questionnaire, Clinical questionnaire
Other
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
18 Years and older
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 16, 2019 · Synced Oct 18, 2026, 7:27 AM EDT
Not listed No phase listed Observational

Adherence and Outcome of Upper Airway Stimulation (UAS) for OSA International Registry

NCT02907398
View directory record Official record
Conditions
Obstructive Sleep Apnea
Interventions
Inspire therapy, No intervention
Device · Other
Lead sponsor
Inspire Medical Systems, Inc.
Industry
Eligibility
Not listed
Enrollment
5,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2025
U.S. locations
53
States / cities
Birmingham, Alabama • Mesa, Arizona • Phoenix, Arizona + 43 more
Source: ClinicalTrials.gov public record
Updated Jun 19, 2025 · Synced Oct 18, 2026, 7:27 AM EDT
Completed Not applicable Interventional

Catheter-Based Treatment of Cardiovascular Disease

NCT00380016
View directory record Official record
Conditions
Obstructive Coronary Artery Disease, Obstructive Peripheral Artery Disease, Structural Heart Disease
Interventions
Percutaneous Transluminal Angioplasty
Procedure
Lead sponsor
National Heart, Lung, and Blood Institute (NHLBI)
NIH
Eligibility
18 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2009
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 2, 2017 · Synced Oct 18, 2026, 7:27 AM EDT
Completed Not applicable Interventional Results available

Inhaled Corticosteroids After a Pediatric Emergency Visit for Asthma

NCT00294398
View directory record Official record
Conditions
Asthma
Interventions
ICS Prescription + Standard Asthma ED Discharge Therapy, Standard Asthma ED Discharge Therapy
Other
Lead sponsor
Children's Hospital of Philadelphia
Other
Eligibility
1 Year to 18 Years
Enrollment
152 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2009
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 13, 2015 · Synced Oct 18, 2026, 7:27 AM EDT
Completed No phase listed Observational Results available

Exacerbation Risk in Asthma

NCT05501639
View directory record Official record
Conditions
Asthma
Interventions
tiotropium, long-acting β2-agonists (LABA), inhaled corticosteroids (ICS)
Drug
Lead sponsor
Boehringer Ingelheim
Industry
Eligibility
12 Years and older
Enrollment
1,899 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021
U.S. locations
1
States / cities
White Plains, New York
Source: ClinicalTrials.gov public record
Updated Apr 1, 2024 · Synced Oct 18, 2026, 7:27 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Redesigning Ambulatory Care Delivery to Enhance Asthma Control in Children

NCT02409277
View directory record Official record
Conditions
Asthma
Interventions
Experimental: Standard vs Intensive e-AT Intervention
Other
Lead sponsor
University of Utah
Other
Eligibility
2 Years to 17 Years
Enrollment
926 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2016
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Feb 5, 2020 · Synced Oct 18, 2026, 7:27 AM EDT
Completed Not applicable Interventional Results available

Remote Diagnosis and Management of Obstructive Sleep Apnea

NCT03007745
View directory record Official record
Conditions
Sleep Apnea - Obstructive, Cost Effectiveness, Telemedicine
Interventions
autoadjusting continuous positive airway pressure
Device
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
435 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
3
States / cities
San Diego, California • Decatur, Georgia • Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 20, 2025 · Synced Oct 18, 2026, 7:27 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Risk Factors for Post-Operative Respiratory Complications in Patients at Risk for OSA

NCT02729077
View directory record Official record
Conditions
Respiratory Complications
Interventions
Pulse Oximetry
Device
Lead sponsor
Ohio State University
Other
Eligibility
18 Years to 75 Years
Enrollment
324 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2021
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Feb 24, 2021 · Synced Oct 18, 2026, 7:27 AM EDT
Withdrawn Phase 1Phase 2 Interventional

Endoscopic Pancreatic Duct Stenting for Relief of Obstructive Pain in Patients With Pancreatic Cancer

NCT01895790
View directory record Official record
Conditions
Pancreatic Cancer
Interventions
Pancreatic Duct Stent Placement
Device
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 80 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 6, 2017 · Synced Oct 18, 2026, 7:27 AM EDT
Completed Phase 2 Interventional

Nurse Managed Upper Body Strength Training in Chronic Obstructive Pulmonary Disease (COPD)

NCT01057797
View directory record Official record
Conditions
Chronic Obstructive Pulmonary Disease
Interventions
Exercise-specific self-efficacy, Gentle chair exercise, upper body strength training
Behavioral
Lead sponsor
University of Illinois at Chicago
Other
Eligibility
45 Years and older
Enrollment
208 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2009
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jan 27, 2010 · Synced Oct 18, 2026, 7:27 AM EDT
Completed No phase listed Observational

Feasibility and Acceptability of the Propeller Monitoring System in Children With Persistent Asthma

NCT03648450
View directory record Official record
Conditions
Asthma
Interventions
Propeller EMD
Other
Lead sponsor
Connecticut Children's Medical Center
Other
Eligibility
10 Years to 18 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
Hartford, Connecticut
Source: ClinicalTrials.gov public record
Updated Sep 18, 2023 · Synced Oct 18, 2026, 7:27 AM EDT
Completed No phase listed Observational

Mechanisms Underlying Asthma Exacerbations Prevented and Persistent With Immune-Based Therapy

NCT02502890
View directory record Official record
Conditions
Asthma
Interventions
Not listed
Lead sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
NIH
Eligibility
6 Years to 17 Years
Enrollment
208 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
9
States / cities
Aurora, Colorado • Washington D.C., District of Columbia • Chicago, Illinois + 6 more
Source: ClinicalTrials.gov public record
Updated Feb 20, 2018 · Synced Oct 18, 2026, 7:27 AM EDT