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ClinicalTrials.gov public records Last synced Oct 26, 2026, 11:49 PM EDT

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Showing 49–72 of 824 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Obstructive Apnea Clear all
Completed Phase 4 Interventional Results available

Solriamfetol's Effect on Cognitive Health in Apnea Participants During a Randomized Placebo-controlled Study

NCT04789174
View directory record Official record
Conditions
Excessive Daytime Sleepiness, Obstructive Sleep Apnea, Impaired Cognitive Function
Interventions
Solriamfetol, Placebo
Drug
Lead sponsor
Axsome Therapeutics, Inc.
Industry
Eligibility
18 Years to 65 Years
Enrollment
59 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
15
States / cities
Los Angeles, California • Santa Ana, California • Jacksonville, Florida + 11 more
Source: ClinicalTrials.gov public record
Updated Jan 26, 2026 · Synced Oct 26, 2026, 11:49 PM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Mandibular Advancement Device (MAD) in Pregnant Women With Obstructive Sleep Apnea (OSA)

NCT06256640
View directory record Official record
Conditions
Obstructive Sleep Apnea of Adult, Pregnancy Related
Interventions
Mandibular advancement Device
Device
Lead sponsor
Henry Ford Health System
Other
Eligibility
18 Years to 40 Years · Female only
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Jan 29, 2025 · Synced Oct 26, 2026, 11:49 PM EDT
Completed Not applicable Interventional

The POSAtive Study: Study for the Treatment of Positional Obstructive Sleep Apnea

NCT03061071
View directory record Official record
Conditions
Sleep Apnea Syndromes
Interventions
NightBalance Sleep Position Trainer (SPT), Automated Adjusting Positive Airway Pressure (APAP)
Device
Lead sponsor
NightBalance
Industry
Eligibility
20 Years to 80 Years
Enrollment
117 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
11
States / cities
Birmingham, Alabama • Glendale, Arizona • Gainesville, Florida + 8 more
Source: ClinicalTrials.gov public record
Updated Aug 21, 2018 · Synced Oct 26, 2026, 11:49 PM EDT
Recruiting Phase 1 Interventional

Benefits of Oxytocin in Obstructive Sleep Apnea (OSA) Patients Using Continuous Positive Airway Pressure (CPAP) Machine

NCT03860233
View directory record Official record
Conditions
Sleep Apnea, Sleep Apnea, Obstructive
Interventions
Oxytocin, Placebo
Drug
Lead sponsor
Vivek Jain
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2026
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated May 4, 2026 · Synced Oct 26, 2026, 11:49 PM EDT
Not listed No phase listed Observational Accepts healthy volunteers

Analysis of the Prevalence and Characteristics of Concomitant Sleep and Headache Disorders, and the Efficacy of CPAP Treatment for Headache Among Those Patients Diagnosed With Obstructive Sleep Apnea

NCT00520156
View directory record Official record
Conditions
Headache Disorder, Sleep Disorder, Obstructive Sleep Apnea
Interventions
Continuous positive airway pressure (CPAP)
Device
Lead sponsor
Walter Reed Army Medical Center
Federal
Eligibility
18 Years to 80 Years
Enrollment
600 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2008
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Aug 23, 2007 · Synced Oct 26, 2026, 11:49 PM EDT
Recruiting Phase 3 Interventional

AMAZE 3: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Obstructive Sleep Apnoea Not Treated With Positive Airway Pressure Lose Weight and Improve Sleep Apnoea

NCT07571005
View directory record Official record
Conditions
Obesity, Overweight, Obstructive Sleep Apnoea
Interventions
NNC0487-0111, Placebo (matched to NNC0487-0111)
Drug
Lead sponsor
Novo Nordisk A/S
Industry
Eligibility
18 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
17
States / cities
San Diego, California • Miami, Florida • Naples, Florida + 13 more
Source: ClinicalTrials.gov public record
Updated Sep 11, 2026 · Synced Oct 26, 2026, 11:49 PM EDT
Completed Not applicable Interventional

"Reversibility of Cardiovascular Injury With CPAP Use: Mechanisms Involved"

NCT01317329
View directory record Official record
Conditions
Sleep Apnea, Obstructive, Hypoxia, Hypercapnia, Sleep Disorders, Obesity, Hypertension, Coronary Artery Vasospasm, Right Ventricular Overload, Left Ventricular Function Systolic Dysfunction, Ventricular Hypertrophy
Interventions
Clinically prescribed CPAP therapy
Other
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
21 Years to 50 Years
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Mar 6, 2020 · Synced Oct 26, 2026, 11:49 PM EDT
Terminated Not applicable Interventional

Clinical Study for the BONGO NASAL Expiratory Positive Airway Pressure (EPAP) Device in the Treatment of Obstructive Sleep Apnea (OSA)

NCT02590159
View directory record Official record
Conditions
Obstructive Sleep Apnea
Interventions
BONGO NASAL EPAP
Device
Lead sponsor
InnoMed Healthscience Inc.
Industry
Eligibility
21 Years and older
Enrollment
9 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Aug 21, 2017 · Synced Oct 26, 2026, 11:49 PM EDT
Active, not recruiting Not applicable Interventional

MCI: CPAP Treatment of OSA (Memories2)

NCT03113461
View directory record Official record
Conditions
Mild Cognitive Impairment, Sleep Apnea, Obstructive
Interventions
CPAP
Device
Lead sponsor
University of Pennsylvania
Other
Eligibility
55 Years to 85 Years
Enrollment
327 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2025
U.S. locations
4
States / cities
St Louis, Missouri • Philadelphia, Pennsylvania • Austin, Texas + 1 more
Source: ClinicalTrials.gov public record
Updated Apr 12, 2023 · Synced Oct 26, 2026, 11:49 PM EDT
Recruiting Not applicable Interventional

Obstructive Sleep Apnea Non-PAP Outcomes and Viable Alternatives

NCT07074288
View directory record Official record
Conditions
Obstructive Sleep Apnea
Interventions
MAD, HGNS
Device
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Apr 14, 2026 · Synced Oct 26, 2026, 11:49 PM EDT
Completed Not applicable Interventional Results available

Auto-PAP Therapy For Improved Fetal Growth

NCT03318003
View directory record Official record
Conditions
Obstructive Sleep Apnea, Pregnancy
Interventions
Auto-PAP
Device
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older · Female only
Enrollment
43 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Nov 18, 2022 · Synced Oct 26, 2026, 11:49 PM EDT
Recruiting Phase 4 Interventional

Effect of Oxymetazoline Hydrochloride in Combination With Fluticasone Propionate on the Apnea Hypopnea Index (AHI) in Subject With Persistent Nasal Congestion and Mild Obstructive Sleep Apnea

NCT02630121
View directory record Official record
Conditions
Sleep Apnea, Chronic Nasal Congestion
Interventions
Oxymetazoline Hydrochloride, Placebo
Drug
Lead sponsor
University of South Florida
Other
Eligibility
18 Years to 65 Years
Enrollment
52 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Jan 24, 2025 · Synced Oct 26, 2026, 11:49 PM EDT
Completed Phase 3 Interventional

Investigation of a Novel Positive Pressure Therapy to Rescue Patients Failing to Tolerate CPAP During an Initial Encounter

NCT00635206
View directory record Official record
Conditions
Obstructive Sleep Apnea
Interventions
BiPap auto with Fi Flex, Standard CPAP
Device
Lead sponsor
Clayton Sleep Insititute
Industry
Eligibility
21 Years to 75 Years
Enrollment
51 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2009
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Jul 14, 2009 · Synced Oct 26, 2026, 11:49 PM EDT
Completed Not applicable Interventional

Weekly Phone Calls Versus Brief Patient Education to Improve CPAP (Continuous Positive Airway Pressure) Compliance

NCT00945776
View directory record Official record
Conditions
Obstructive Sleep Apnea (OSA)
Interventions
Weekly phone calls, Frequently asked questions, Usual care
Behavioral
Lead sponsor
CAMC Health System
Other
Eligibility
18 Years and older
Enrollment
128 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2009
U.S. locations
1
States / cities
Charleston, West Virginia
Source: ClinicalTrials.gov public record
Updated Sep 10, 2026 · Synced Oct 26, 2026, 11:49 PM EDT
Completed Not applicable Interventional

Whitsundays (Nasal) Mask Take Home Study (90 Days)

NCT06036329
View directory record Official record
Conditions
Obstructive Sleep Apnea
Interventions
Group A : provided with 1 Whitsundays Nasal mask without a spare mask cushion, Group B : provided with 1 Whitsundays Nasal mask with 2 spare mask cushions
Device
Lead sponsor
ResMed
Industry
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023
U.S. locations
2
States / cities
San Diego, California • St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Feb 29, 2024 · Synced Oct 26, 2026, 11:49 PM EDT
Completed Phase 1Phase 2 Interventional

Combination Pharmacological Interventions for Multiple Mechanisms of Obstructive Sleep Apnea

NCT03892772
View directory record Official record
Conditions
Sleep Apnea
Interventions
SAS0421a, SAS0421b, SAS0421c, placebo
Drug
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years to 79 Years
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 2, 2022 · Synced Oct 26, 2026, 11:49 PM EDT
Recruiting Not applicable Interventional

Impact of Positive Airway Pressure Therapy on Clinical Outcomes in Older Veterans With Chronic Obstructive Pulmonary Disease and Comorbid Obstructive Sleep Apnea (Overlap Syndrome)

NCT04179981
View directory record Official record
Conditions
Sleep Apnea Syndrome, Obstructive Sleep Apnea, COPD, Overlap Syndrome, Quality of Life, Neurocognitive Function, Sleepiness, Elderly, Positive Airway Pressure
Interventions
Positive airway pressure, Conservative care (control arm)
Device · Other
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
60 Years and older
Enrollment
668 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2027
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Jun 5, 2026 · Synced Oct 26, 2026, 11:49 PM EDT
Completed Not applicable Interventional Results available

Titration Pressures in Sleep Apnea Patients Using ThermoSmart® Versus Conventional Humidification

NCT00681083
View directory record Official record
Conditions
Sleep Apnea, Obstructive
Interventions
Heated breathing tube (CPAP with ThermoSmart), Non heated breathing tube (CPAP with conventional humidification)
Device
Lead sponsor
Fisher and Paykel Healthcare
Industry
Eligibility
18 Years and older
Enrollment
26 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008
U.S. locations
2
States / cities
Tulsa, Oklahoma
Source: ClinicalTrials.gov public record
Updated Jun 12, 2019 · Synced Oct 26, 2026, 11:49 PM EDT
Recruiting Not applicable Interventional

Severe Label Expansion for EVO Products Trial

NCT07090395
View directory record Official record
Conditions
Obstructive Sleep Apnea
Interventions
EVO Sleep and Snore Device
Device
Lead sponsor
ProSomnus Sleep Technologies
Industry
Eligibility
18 Years to 80 Years
Enrollment
49 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
2
States / cities
New York, New York • Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Mar 17, 2026 · Synced Oct 26, 2026, 11:49 PM EDT
Completed No phase listed Observational

Use of Blood Biomarkers and Biomarker Index to Aid in the Diagnosis of Obstructive Sleep Apnea (OSA)

NCT03122483
View directory record Official record
Conditions
Obstructive Sleep Apnea
Interventions
blood biomarker
Diagnostic Test
Lead sponsor
Beckman Coulter, Inc.
Industry
Eligibility
18 Years to 70 Years · Male only
Enrollment
250 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
3
States / cities
Irvine, California • Boston, Massachusetts • Columbia, South Carolina
Source: ClinicalTrials.gov public record
Updated Aug 18, 2017 · Synced Oct 26, 2026, 11:49 PM EDT
Completed Not applicable Interventional

Motor Plasticity, Intermittent Hypoxia and Sleep Apnea

NCT04017767
View directory record Official record
Conditions
Sleep Apnea, Obstructive, Spinal Cord Injuries, Hypoxia
Interventions
Induced Acute Intermittent Hypoxia (AIH), AIH mask
Procedure · Device
Lead sponsor
University of Miami
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Sep 8, 2025 · Synced Oct 26, 2026, 11:49 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Study to Determine the Effectiveness of Pillar Palatal Implants to Treat Obstructive Sleep Apnea

NCT00307957
View directory record Official record
Conditions
Obstructive Sleep Apnea
Interventions
Pillar Palatal Implants
Device
Lead sponsor
University of Cincinnati
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2006
U.S. locations
3
States / cities
Indianapolis, Indiana • Cincinnati, Ohio • Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Dec 12, 2007 · Synced Oct 26, 2026, 11:49 PM EDT
Active, not recruiting No phase listed Observational

Obstructive Sleep Apnea in Survivors of Hodgkin Lymphoma Treated With Thoracic Radiation

NCT03361020
View directory record Official record
Conditions
Obstructive Sleep Apnea, Hodgkin Lymphoma
Interventions
Not listed
Lead sponsor
St. Jude Children's Research Hospital
Other
Eligibility
18 Years and older
Enrollment
434 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2028
U.S. locations
1
States / cities
Memphis, Tennessee
Source: ClinicalTrials.gov public record
Updated Jun 17, 2026 · Synced Oct 26, 2026, 11:49 PM EDT
Completed No phase listed Observational

Pre and Post Orthopedic Surgery Sleep and Cardiac Testing (PROSPECT)

NCT00785070
View directory record Official record
Conditions
Obstructive Sleep Apnea
Interventions
Not listed
Lead sponsor
Memorial Health System
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2009
U.S. locations
1
States / cities
Colorado Springs, Colorado
Source: ClinicalTrials.gov public record
Updated Feb 9, 2009 · Synced Oct 26, 2026, 11:49 PM EDT