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ClinicalTrials.gov public records Last synced Oct 19, 2026, 1:37 AM EDT

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Showing 1–24 of 267 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Opioid Pain Medication Clear all
Completed No phase listed Observational Accepts healthy volunteers

A Strategy to Reduce Opioid Drug Prescribing by Clinicians

NCT03809507
View directory record Official record
Conditions
Analgesics Opioid
Interventions
Qualtrics survey questions
Other
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
25 Years to 70 Years
Enrollment
895 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 30, 2021 · Synced Oct 19, 2026, 1:37 AM EDT
Completed No phase listed Observational

Self Reported Deviations From Opioid Analgesic Prescription

NCT00907192
View directory record Official record
Conditions
Advanced Cancers
Interventions
Personal Interview, Questionnaire
Behavioral
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
18 Years and older
Enrollment
201 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jun 18, 2013 · Synced Oct 19, 2026, 1:37 AM EDT
Completed Phase 2 Interventional Results available

Prescription Opioid Abuse Among Pain Patients: Predictors of Relapse

NCT01967641
View directory record Official record
Conditions
Opioid Dependence
Interventions
buprenorphine/naloxone combination
Drug
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
18 Years to 65 Years
Enrollment
51 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2011
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 24, 2019 · Synced Oct 19, 2026, 1:37 AM EDT
Completed No phase listed Observational

Incidence and Predictors of Opioid Overdose and Death Among Long-Term Users of Opioid Analgesics

NCT02662153
View directory record Official record
Conditions
Opioid Overdose
Interventions
Observation only
Other
Lead sponsor
Member Companies of the Opioid PMR Consortium
Industry
Eligibility
18 Years to 79 Years
Enrollment
808,455 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
4
States / cities
Wilmington, Delaware • Boston, Massachusetts • Portland, Oregon + 1 more
Source: ClinicalTrials.gov public record
Updated Jul 14, 2022 · Synced Oct 19, 2026, 1:37 AM EDT
Completed Not applicable Interventional Results available

Liposomal Bupivacaine Versus Standard of Care in Total Knee Surgery

NCT02219087
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
Liposomal bupivacaine, Standard of Care
Drug
Lead sponsor
OhioHealth
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Jan 2, 2018 · Synced Oct 19, 2026, 1:37 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Analgesic Use and Effectiveness for Dental Procedures

NCT02929602
View directory record Official record
Conditions
Pain
Interventions
Not listed
Lead sponsor
Pearl Network
Network
Eligibility
Not listed
Enrollment
2,773 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2014
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Oct 11, 2016 · Synced Oct 19, 2026, 1:37 AM EDT
Completed Phase 1 Interventional

Buspirone for Opioid Tapering

NCT03521960
View directory record Official record
Conditions
Opioid-Related Disorders, Dependency (Psychology), Pain, Chronic, Opiate Withdrawal Syndrome
Interventions
Buspirone oral capsule, Placebo oral capsule
Drug
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years and older
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 23, 2020 · Synced Oct 19, 2026, 1:37 AM EDT
Completed Phase 2 Interventional Results available

A Study Evaluating Pain Relief and Safety of Orally Administered CR845 in Patients With Osteoarthritis of Hip or Knee

NCT02944448
View directory record Official record
Conditions
Osteoarthritis, Hip, Osteoarthritis, Knee, Arthritis, Joint Diseases, Musculoskeletal Diseases, Rheumatic Diseases
Interventions
CR845 tablet 1 mg, CR845 tablet 2.5 mg, CR845 tablet 5 mg, Placebo tablet
Drug
Lead sponsor
Cara Therapeutics, Inc.
Industry
Eligibility
25 Years and older
Enrollment
761 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
35
States / cities
Birmingham, Alabama • Peoria, Arizona • Phoenix, Arizona + 29 more
Source: ClinicalTrials.gov public record
Updated Oct 20, 2020 · Synced Oct 19, 2026, 1:37 AM EDT
Not listed Phase 2 Interventional Accepts healthy volunteers

Outcomes Mandate National Integration With Cannabis as Medicine

NCT03944447
View directory record Official record
Conditions
Chronic Pain, Chronic Pain Syndrome, Chronic Pain Due to Injury, Chronic Pain Due to Trauma, Fibromyalgia, Seizures, Hepatitis C, Cancer, Crohn Disease, HIV/AIDS, Multiple Sclerosis, Traumatic Brain Injury, Sickle Cell Disease, Post Traumatic Stress Disorder, Tourette Syndrome, Ulcerative Colitis, Glaucoma, Epilepsy, Inflammatory Bowel Diseases, Parkinson Disease, Amyotrophic Lateral Sclerosis, Chronic Traumatic Encephalopathy, Anxiety, Depression, Insomnia, Autism, Opioid-use Disorder, Bipolar Disorder, Covid19, SARS-CoV Infection, COVID-19, Corona Virus Infection, Coronavirus
Interventions
Cannabis, Medical, RYAH-Medtech Inhaler
Drug · Device
Lead sponsor
OMNI Medical Services, LLC
Network
Eligibility
7 Years and older
Enrollment
200,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2025
U.S. locations
17
States / cities
Boca Raton, Florida • Bradenton, Florida • Fort Lauderdale, Florida + 13 more
Source: ClinicalTrials.gov public record
Updated Jun 2, 2022 · Synced Oct 19, 2026, 1:37 AM EDT
Completed No phase listed Observational

Using a Narcotic to Enhance the Numbing Effect of the Local Anesthetic Lidocaine on Inflamed Molar Teeth

NCT00001952
View directory record Official record
Conditions
Healthy, Inflammation, Mouth Disease, Pain
Interventions
Not listed
Lead sponsor
National Institute of Dental and Craniofacial Research (NIDCR)
NIH
Eligibility
Not listed
Enrollment
275 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1999 – 2002
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 4, 2008 · Synced Oct 19, 2026, 1:37 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Integrative Psychosocial Group Treatment

NCT03648177
View directory record Official record
Conditions
Chronic Pain, Opioid Misuse
Interventions
IPGT, Treatment as Usual
Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years to 64 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 6, 2019 · Synced Oct 19, 2026, 1:37 AM EDT
Completed Not applicable Interventional

Evolution of Analgesic Tolerance With Opioids

NCT00275249
View directory record Official record
Conditions
Chronic Pain
Interventions
levorphanol
Drug
Lead sponsor
University of California, San Francisco
Other
Eligibility
21 Years to 80 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2005
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Apr 14, 2011 · Synced Oct 19, 2026, 1:37 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Ketamine to Improve Recovery After Cesarean Delivery - Part 1

NCT04037085
View directory record Official record
Conditions
Obstetric Pain, Postpartum Depression, Breastfeeding, Pain, Acute, Pain, Chronic, Obstetric Anesthesia Problems, Drug Effect, Opioid Use
Interventions
Ketamine
Drug
Lead sponsor
Grace Lim, MD, MS
Other
Eligibility
18 Years to 99 Years · Female only
Enrollment
8 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
2
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Dec 20, 2022 · Synced Oct 19, 2026, 1:37 AM EDT
Completed Not applicable Interventional Results available

Expectations and Pain Control Advancement In surgeRy: The REPAIR Trial

NCT03726476
View directory record Official record
Conditions
Abuses Over-The-Counter/Prescription Medications, Pain, Postoperative, Opioid Use, Physical Activity, Patient Dependence on
Interventions
Patient centered pre-op education, routine preop education
Behavioral
Lead sponsor
University of New Mexico
Other
Eligibility
18 Years and older · Female only
Enrollment
174 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
2
States / cities
Albuquerque, New Mexico • Rio Rancho, New Mexico
Source: ClinicalTrials.gov public record
Updated Jul 18, 2024 · Synced Oct 19, 2026, 1:37 AM EDT
Recruiting Phase 4 Interventional Accepts healthy volunteers

Medrol Dosepak for Outpatient Total Knee Arthroplasty

NCT05097976
View directory record Official record
Conditions
Total Knee Arthroplasty
Interventions
Methylprednisolone, Placebo
Drug
Lead sponsor
Rush University Medical Center
Other
Eligibility
18 Years and older
Enrollment
420 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2027
U.S. locations
1
States / cities
Oak Brook, Illinois
Source: ClinicalTrials.gov public record
Updated Jul 9, 2026 · Synced Oct 19, 2026, 1:37 AM EDT
Withdrawn Phase 3 Interventional

Pain Control Without Opioids

NCT04813991
View directory record Official record
Conditions
Perioperative Pain
Interventions
Ibuprofen 600 mg, OxyCODONE 5 Mg Oral Capsule
Drug
Lead sponsor
Hackensack Meridian Health
Other
Eligibility
18 Years to 90 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
Hackensack, New Jersey
Source: ClinicalTrials.gov public record
Updated Sep 10, 2022 · Synced Oct 19, 2026, 1:37 AM EDT
Completed Phase 3 Interventional

Re-Treatment Study of Probuphine in Opioid Addiction

NCT01262261
View directory record Official record
Conditions
Opioid Dependency
Interventions
Probuphine (buprenorphine implant)
Drug
Lead sponsor
Titan Pharmaceuticals
Industry
Eligibility
18 Years to 65 Years
Enrollment
85 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
18
States / cities
Los Angeles, California • National City, California • Oceanside, California + 15 more
Source: ClinicalTrials.gov public record
Updated Dec 31, 2018 · Synced Oct 19, 2026, 1:37 AM EDT
Completed Not applicable Interventional

Telehealth Delivered Physical Rehabilitation for an Ankle Sprain

NCT04520854
View directory record Official record
Conditions
Ankle Sprains, Telerehabilitation, Analgesic, Opioid, Analgesics, Non-narcotic, Anti-Inflammatory Agents, Non-Steroidal, Implementation Science, Acute Pain, Quality of Life
Interventions
Telehealth Protocol, Usual Care
Other
Lead sponsor
Kyle Kosik
Other
Eligibility
15 Years to 35 Years
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Jul 28, 2025 · Synced Oct 19, 2026, 1:37 AM EDT
Completed No phase listed Observational Results available

Medical Cannabis as an Opiate Alternative

NCT07194928
View directory record Official record
Conditions
Chronic Pain, Opioid Use
Interventions
We will monitor patient's response to medical marijuana as alternative to opioid for chronic pain.
Other
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
29 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 20, 2026 · Synced Oct 19, 2026, 1:37 AM EDT
Recruiting Phase 4 Interventional Accepts healthy volunteers

Better Options for Chronic Cancer Pain

NCT06574009
View directory record Official record
Conditions
Chronic Pain, Cancer Survivor, Opioid Dependence
Interventions
Multimodal pain care, Medication optimization, Buprenorphine rotation, Opioid tapering
Behavioral · Drug · Device + 1 more
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 99 Years
Enrollment
294 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2029
U.S. locations
2
States / cities
Indianapolis, Indiana • Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated May 11, 2026 · Synced Oct 19, 2026, 1:37 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Prospective Effect of Intravenous Ketorolac on Opioid Use, EBL and Complications Following Cesarean Delivery

NCT02509312
View directory record Official record
Conditions
Analgesia, Obstetrical, Postpartum Hemorrhage, Opioid Use, Nonsteroidals (NSAIDs)Toxicity, Coagulation Defect; Postpartum, Postoperative Pain, Ketorolac Adverse Reaction, Blood Loss, Postoperative
Interventions
Ketorolac, Placebo
Drug
Lead sponsor
University Hospitals Cleveland Medical Center
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
70 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jun 7, 2022 · Synced Oct 19, 2026, 1:37 AM EDT
Terminated Not applicable Interventional Results available

Intrathecal Morphine Compared to Conventional Medical Management for Pain Control and Opioid-related Side Effects

NCT01924182
View directory record Official record
Conditions
Chronic Pain
Interventions
SynchroMed Infusion System and Intrathecal Morphine Sulfate, Conventional Medicine
Device · Other
Lead sponsor
MedtronicNeuro
Industry
Eligibility
18 Years and older
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
6
States / cities
Homewood, Alabama • Napa, California • Walnut Creek, California + 3 more
Source: ClinicalTrials.gov public record
Updated Mar 29, 2018 · Synced Oct 19, 2026, 1:37 AM EDT
Completed Not applicable Interventional Results available

Patient Activation to Address Chronic Pain and Opioid Management in Primary Care

NCT02290223
View directory record Official record
Conditions
Chronic Pain
Interventions
Behavioral Based Treatment Model
Behavioral
Lead sponsor
Kaiser Permanente
Other
Eligibility
18 Years and older
Enrollment
376 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
2
States / cities
San Jose, California • Santa Clara, California
Source: ClinicalTrials.gov public record
Updated Oct 18, 2019 · Synced Oct 19, 2026, 1:37 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

The Use of Pecs Blocks in Combination With Exparel in Breast Reconstruction Surgery

NCT05171179
View directory record Official record
Conditions
Mammaplasty
Interventions
Breast Reconstruction (Mammaplasty), Pecs blocks, Exparel, Bupivacaine
Procedure · Device · Drug
Lead sponsor
Northwestern University
Other
Eligibility
18 Years and older · Female only
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2025
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Sep 24, 2025 · Synced Oct 19, 2026, 1:37 AM EDT