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ClinicalTrials.gov public records Last synced Sep 19, 2026, 11:02 PM EDT

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Showing 25–38 of 14 matching trials from the live ClinicalTrials.gov search.

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Filters: Condition: Organ Dysfunction Syndrome, Multiple Clear all

Conditions: Severe Sepsis
Interventions: Drotrecogin alfa (activated); Drug
Lead sponsor: Eli Lilly and Company; Industry
Eligibility: 18 Years and older
Enrollment: 486 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2009
U.S. locations: 17
States / cities: Phoenix, Arizona • Scottsdale, Arizona • Fresno, California + 14 more

Conditions: Sepsis, Septic Shock, Sepsis With Acute Organ Dysfunction
Interventions: Not listed
Lead sponsor: Axis Shield Diagnostics Ltd; Industry
Eligibility: 18 Years and older
Enrollment: 571 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2019
U.S. locations: 5
States / cities: Philadelphia, Pennsylvania • York, Pennsylvania • Nashville, Tennessee + 1 more

Conditions: Critical Illness, Sepsis, Multiple Organ Failure
Interventions: Glutamine, Antioxidants, Glutamine + Antioxidants, Placebo; Other
Lead sponsor: Daren K. Heyland; Other
Eligibility: 18 Years and older
Enrollment: 1,223 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2005 – 2012
U.S. locations: 5
States / cities: Aurora, Colorado • Louisville, Kentucky • Dayton, Ohio + 2 more

Conditions: Sepsis, Severe Sepsis, Septic Shock, Multi-organ Failure
Interventions: Not listed
Lead sponsor: The University of Texas Health Science Center, Houston; Other
Eligibility: 18 Years and older
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Severe Hepatic Veno-Occlusive Disease
Interventions: Defibrotide; Drug
Lead sponsor: Jazz Pharmaceuticals; Industry
Eligibility: Not listed
Enrollment: 134 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2015
U.S. locations: 22
States / cities: Duarte, California • Palo Alto, California • Denver, Colorado + 19 more

Conditions: Congenital Disease
Interventions: Congenital Heart Disease Surgery; Procedure
Lead sponsor: University of Arizona; Other
Eligibility: 3 Days to 2 Years
Enrollment: 53 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2021
U.S. locations: 1
States / cities: Tucson, Arizona

Conditions: Sepsis, Burn Injury, Wound Healing, Critical Illness, Multiple Organ Dysfunction Syndrome
Interventions: Observational Cohort (No Intervention); Other
Lead sponsor: Henry M. Jackson Foundation for the Advancement of Military Medicine; Other
Eligibility: 18 Years to 80 Years
Enrollment: 80 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 3
States / cities: Tampa, Florida • Atlanta, Georgia • Houston, Texas

Conditions: Multi Organ Failure, Exocrine Pancreatic Insufficiency
Interventions: RELiZORB™, Placebo; Device · Other
Lead sponsor: Inova Health Care Services; Other
Eligibility: 18 Years to 89 Years
Enrollment: 32 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Falls Church, Virginia

Conditions: COVID-19, Post Acute Sequelae of COVID-19, Long COVID, Organ Dysfunction Syndrome, Multiple, Frailty Syndrome
Interventions: Blood and nasal swab sampling; Other
Lead sponsor: University of California, Los Angeles; Other
Eligibility: 18 Years and older
Enrollment: 600 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2026
U.S. locations: 7
States / cities: Los Angeles, California • Sylmar, California • Torrance, California + 3 more

Conditions: Respiratory Failure, Multiple Organ Failure
Interventions: PROOFcheck, Standard Care; Other
Lead sponsor: Albert Einstein College of Medicine; Other
Eligibility: 18 Years and older
Enrollment: 34,040 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2018
U.S. locations: 3
States / cities: Jacksonville, Florida • Rochester, Minnesota • The Bronx, New York

Conditions: Chronic Disease, Neoplasm Metastasis, Lung Neoplasm, Pulmonary Disease, Chronic Obstructive, Heart Failure, Congestive, Liver Cirrhosis, Kidney Failure, Chronic, Multiple Organ Failure, Health Care Quality, Access, and Evaluation, Intensive Care Units, Palliative Care, Health Services, Palliative Care, Patient Care, Lung Diseases, Cerebrovascular Disorders, Brain Injuries
Interventions: Facilitator-Based Intervention; Behavioral
Lead sponsor: University of Washington; Other
Eligibility: 18 Years and older
Enrollment: 977 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2024
U.S. locations: 3
States / cities: Seattle, Washington

Conditions: Hematopoietic Cell Transplantation
Interventions: Biorepository Trial; Other
Lead sponsor: Duke University; Other
Eligibility: 0 Years to 26 Years
Enrollment: 500 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2028
U.S. locations: 3
States / cities: Rochester, Minnesota • Durham, North Carolina • Houston, Texas

Conditions: Traumatic Complication of Injury
Interventions: Not listed
Lead sponsor: University of Alabama at Birmingham; Other
Eligibility: 19 Years and older
Enrollment: 90 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2010
U.S. locations: 1
States / cities: Birmingham, Alabama

Conditions: Pediatric Sepsis-induced MODS
Interventions: GM-CSF; Drug
Lead sponsor: Nationwide Children's Hospital; Other
Eligibility: Up to 17 Years
Enrollment: 75 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2023
U.S. locations: 8
States / cities: Los Angeles, California • San Francisco, California • Aurora, Colorado + 5 more

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Evaluate Protein C Levels in Severe Sepsis Patients on Drotrecogin Alfa (Activated)

Assessment of Heparin Binding Protein for the Prediction of Severe Sepsis

Trial of Glutamine and Antioxidant Supplementation in Critically Ill Patients

Alveolar Dead Space as Predictor of Organ Failure in Severe Sepsis

Defibrotide for the Treatment of Severe Hepatic Veno-Occlusive Disease in Hematopoetic Stem Cell Transplant Patients

Kids Intestinal Dysfunction in Congenital Heart Disease: the Kind Heart Study

TDAP in Burn Patients (Group 2)

Evaluating the Utility of RELiZORB™ for Treating Feeding Intolerance in Critically Ill Adults With Multi-Organ Failure

COVID-19 Outcome Prediction Algorithm

Prevention of Severe Acute Respiratory Failure in Patients With PROOFCheck

Facilitating Communication Study

A Prospective Registry of Pediatric Cellular Therapy Patients at Risk for Endothelial Dysfunction, Sinusoidal Obstruction Syndrome and/or Multi-Organ Dysfunction Syndrome (MODS).

Inflammatory Cytokine Variations in Traumatic Injury Responses

GM-CSF for Reversal of immunopAralysis in pediatriC sEpsis-induced MODS Study