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ClinicalTrials.gov public records Last synced Oct 14, 2026, 1:16 PM EDT

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Showing 265–288 of 1,212 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Osteoarthritis, Knee Clear all
Completed Phase 2 Interventional

Muscle Strengthening Device for Knee Osteoarthritis

NCT00007241
View directory record Official record
Conditions
Osteoarthritis
Interventions
Isometric exercise
Device
Lead sponsor
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
NIH
Eligibility
18 Years and older
Enrollment
92 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2002
U.S. locations
6
States / cities
Trumbull, Connecticut • Moorestown, New Jersey • Rochester, New York + 3 more
Source: ClinicalTrials.gov public record
Updated Jan 4, 2007 · Synced Oct 14, 2026, 1:16 PM EDT
Completed Phase 4 Interventional

Efficacy of Celecoxib vs Placebo to Prevent Pain in a Paced Walk

NCT00194090
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
celecoxib
Drug
Lead sponsor
University Hospitals Cleveland Medical Center
Other
Eligibility
45 Years to 85 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2005
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 26, 2022 · Synced Oct 14, 2026, 1:16 PM EDT
Withdrawn Not applicable Interventional

Knee Injections for the Clinical Management of Knee OsteoArthritis

NCT04595890
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
Arthrex Angel System used to prepare injection of Bone Marrow Concentrate (BMC), Saline injection
Device · Other
Lead sponsor
University of Delaware
Other
Eligibility
40 Years to 79 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Newark, Delaware
Source: ClinicalTrials.gov public record
Updated Oct 2, 2023 · Synced Oct 14, 2026, 1:16 PM EDT
Completed Phase 3 Interventional

A Multi-Center Actual-Use Study on the Safety of CL 108 for the Treatment of Moderate to Severe Acute Pain Associated With Osteoarthritis of the Knee or Hip

NCT02462850
View directory record Official record
Conditions
Pain, Nausea, Vomiting
Interventions
CL-108
Drug
Lead sponsor
Charleston Laboratories, Inc
Industry
Eligibility
18 Years and older
Enrollment
178 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 3, 2016 · Synced Oct 14, 2026, 1:16 PM EDT
Recruiting Not applicable Interventional

Fluoroscopic Versus Ultrasound Guidance for Cooled Radiofrequency Ablation of Geniculate Nerves in Knee Osteoarthritis: A Randomized Control Trial

NCT04472702
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
cRFA
Procedure
Lead sponsor
University of California, Davis
Other
Eligibility
35 Years to 99 Years
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
2
States / cities
Sacramento, California • Rochester, New York
Source: ClinicalTrials.gov public record
Updated Jun 16, 2026 · Synced Oct 14, 2026, 1:16 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Journey II Bi-Cruciate Stabilized (BCS) Total Knee System Retrospective Study

NCT03292003
View directory record Official record
Conditions
Total Knee Arthroplasty
Interventions
Journey II BCS Total Knee System
Device
Lead sponsor
Smith & Nephew, Inc.
Industry
Eligibility
Not listed
Enrollment
1,694 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2018
U.S. locations
9
States / cities
Aurora, Colorado • Gulf Breeze, Florida • Indianapolis, Indiana + 6 more
Source: ClinicalTrials.gov public record
Updated Mar 28, 2019 · Synced Oct 14, 2026, 1:16 PM EDT
Withdrawn Phase 4 Interventional

Exparel vs Exparel Plus ACB in TKAs

NCT02365727
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
Liposomal bupivacaine, Ropivacaine, Epinephrine, Clonidine, Saline
Drug
Lead sponsor
The Hawkins Foundation
Other
Eligibility
18 Years to 80 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015
U.S. locations
1
States / cities
Greenville, South Carolina
Source: ClinicalTrials.gov public record
Updated Jan 14, 2016 · Synced Oct 14, 2026, 1:16 PM EDT
Completed Phase 3 Interventional Results available

Study to Determine the Safety and the Efficacy of Fasinumab Compared to Placebo and Nonsteroidal Anti-inflammatory Drugs (NSAIDs) for Treatment of Adults With Pain From Osteoarthritis of the Knee or Hip

NCT03304379
View directory record Official record
Conditions
Osteoarthritis, Knee, Osteoarthritis, Hip
Interventions
Fasinumab, Diclofenac, Celecoxib, Matching placebo
Drug · Other
Lead sponsor
Regeneron Pharmaceuticals
Industry
Eligibility
18 Years and older
Enrollment
1,650 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
71
States / cities
Anniston, Alabama • Mobile, Alabama • Chandler, Arizona + 63 more
Source: ClinicalTrials.gov public record
Updated Feb 24, 2023 · Synced Oct 14, 2026, 1:16 PM EDT
Terminated Not applicable Interventional Results available

PEAK PlasmaBlade 4.0 Versus Traditional Electrosurgery in Total Knee Replacement.

NCT01081886
View directory record Official record
Conditions
Degenerative Joint Disease, Osteoarthritis
Interventions
PEAK PlasmaBlade 4.0, Traditional Electrosurgery with scalpel
Device
Lead sponsor
Medtronic Surgical Technologies
Industry
Eligibility
21 Years to 80 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
2
States / cities
Rochester Hills, Michigan • Arlington, Texas
Source: ClinicalTrials.gov public record
Updated Jan 8, 2013 · Synced Oct 14, 2026, 1:16 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

ROSA Robot Used in Total Knee Replacement Post Market Study

NCT03969654
View directory record Official record
Conditions
Knee Pain, Chronic Osteoarthritis, Avascular Necrosis of the Femoral Condyle, Moderate Varus, Valgus or Flexion Deformities, Rheumatoid Arthritis
Interventions
PERSONA Total Knee, Vanguard Total Knee, NexGen Total Knee
Device
Lead sponsor
Zimmer Biomet
Industry
Eligibility
18 Years and older
Enrollment
181 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
5
States / cities
Vail, Colorado • Westminster, Colorado • Springfield, Illinois + 2 more
Source: ClinicalTrials.gov public record
Updated May 3, 2024 · Synced Oct 14, 2026, 1:16 PM EDT
Completed Not applicable Interventional

ACP Max™ PRP System for Knee Osteoarthritis: A Feasibility Trial

NCT05765266
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
ACP Max™, Depo-Medrol®
Device
Lead sponsor
Arthrex, Inc.
Industry
Eligibility
18 Years to 75 Years
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
3
States / cities
Winston-Salem, North Carolina • Knoxville, Tennessee • Danville, Virginia
Source: ClinicalTrials.gov public record
Updated Feb 18, 2026 · Synced Oct 14, 2026, 1:16 PM EDT
Completed No phase listed Observational

Multicenter Orthopaedic Outcomes Network (MOON) ACL Reconstruction (ACLR): Onsite Follow-up

NCT00478894
View directory record Official record
Conditions
Rupture of Anterior Cruciate Ligament, Osteoarthritis
Interventions
Not listed
Lead sponsor
Vanderbilt University
Other
Eligibility
14 Years to 55 Years
Enrollment
432 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2025
U.S. locations
4
States / cities
St Louis, Missouri • Cleveland, Ohio • Columbus, Ohio + 1 more
Source: ClinicalTrials.gov public record
Updated Jan 27, 2026 · Synced Oct 14, 2026, 1:16 PM EDT
Terminated Phase 4 Interventional

ZYNRELEF for Pain Management in Total Knee Arthroplasty

NCT05644496
View directory record Official record
Conditions
Post Operative Pain, Osteoarthritis, Knee
Interventions
Bupivacaine-Meloxicam 400 Mg-12 Mg/14 mL Injectable Solution, Extended Release
Drug
Lead sponsor
Baptist Health South Florida
Other
Eligibility
35 Years to 70 Years
Enrollment
29 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated May 28, 2026 · Synced Oct 14, 2026, 1:16 PM EDT
Completed No phase listed Observational

Understanding the Differences in the Management of Patients With Arthritis of the Knee or Hip

NCT00105677
View directory record Official record
Conditions
Osteoarthritis, Arthritis, Degenerative, Osteoarthritis, Hip, Osteoarthritis, Knee
Interventions
Not listed
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
50 Years to 79 Years
Enrollment
980 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2006
U.S. locations
1
States / cities
Pittsburgh, Arizona
Source: ClinicalTrials.gov public record
Updated Apr 7, 2015 · Synced Oct 14, 2026, 1:16 PM EDT
Completed No phase listed Observational

How Variations in Pharmacogenomic Profiles Affect Pain and Narcotic Needs Following Total Knee Arthroplasty (TKA)

NCT04020471
View directory record Official record
Conditions
Knee Osteoarthritis, Total Knee Arthroplasty (TKA)
Interventions
Pain Scale/Medication Log
Other
Lead sponsor
Endeavor Health
Other
Eligibility
18 Years and older
Enrollment
375 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Skokie, Illinois
Source: ClinicalTrials.gov public record
Updated Apr 27, 2023 · Synced Oct 14, 2026, 1:16 PM EDT
Completed Early Phase 1 Interventional

Pilot Synovial Fluid Molecular/Stem Cell Response to PRP in Knee Osteoarthritis: Clinical & Imaging Outcome Correlation

NCT02468492
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
Platelet Rich Plasma, Normal Saline
Biological · Other
Lead sponsor
Hunter Holmes Mcguire Veteran Affairs Medical Center
Federal
Eligibility
40 Years and older
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Aug 16, 2017 · Synced Oct 14, 2026, 1:16 PM EDT
Completed Not applicable Interventional Results available

Subchondroplasty® Knee RCT

NCT03112200
View directory record Official record
Conditions
Bone Marrow Edema, Knee Pain Chronic, Knee Osteoarthritis, Osteoarthritis, Knee, Osteoarthritis
Interventions
Subchondroplasty with Arthroscopy, Arthroscopy Alone
Procedure
Lead sponsor
Zimmer Biomet
Industry
Eligibility
30 Years to 75 Years
Enrollment
131 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2023
U.S. locations
12
States / cities
Encinitas, California • Loma Linda, California • Stanford, California + 9 more
Source: ClinicalTrials.gov public record
Updated May 14, 2026 · Synced Oct 14, 2026, 1:16 PM EDT
Completed Phase 3 Interventional Results available

Phase 3 Adductor Canal Block With EXPAREL in Subjects Undergoing Primary Unilateral Total Knee Arthroplasty

NCT05139030
View directory record Official record
Conditions
Knee Osteoarthritis, Pain Management
Interventions
bupivacaine liposome injectable suspension, Bupivacaine Hydrochloride
Drug
Lead sponsor
Pacira Pharmaceuticals, Inc
Industry
Eligibility
18 Years and older
Enrollment
167 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022
U.S. locations
6
States / cities
Little Rock, Arkansas • Pasadena, California • Dayton, Ohio + 3 more
Source: ClinicalTrials.gov public record
Updated Oct 24, 2024 · Synced Oct 14, 2026, 1:16 PM EDT
Enrolling by invitation Not applicable Interventional

Rate of Allergic Contact Dermatitis and Cosmetic Outcomes

NCT06957444
View directory record Official record
Conditions
Allergic Contact Dermatitis, Osteoarthritis, Hip, Osteoarthritis, Knee
Interventions
Sylke Adhesive Dressing, Exofin Skin Glue, Suture Strip Plus
Procedure
Lead sponsor
West Virginia University
Other
Eligibility
18 Years to 80 Years
Enrollment
600 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Morgantown, West Virginia
Source: ClinicalTrials.gov public record
Updated May 12, 2026 · Synced Oct 14, 2026, 1:16 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Hyaluronic Acid vs Platelet Rich Plasma: Effects on Clinical Outcomes and Intra-articular Biology for the Treatment of Knee Osteoarthritis

NCT02588872
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
Platelet-rich Plasma (PRP), Hyaluronic Acid
Biological
Lead sponsor
Rush University Medical Center
Other
Eligibility
18 Years to 80 Years
Enrollment
111 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2015
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Mar 14, 2023 · Synced Oct 14, 2026, 1:16 PM EDT
Not listed Not applicable Interventional

The Effect of Adipose-Derived Stem Cells for Knee Osteoarthritis

NCT03014401
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
Arthroscopic debridement with stem cell transplantation, Arthroscopic debridement only
Procedure
Lead sponsor
University of Colorado, Denver
Other
Eligibility
35 Years to 70 Years
Enrollment
29 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2025
U.S. locations
3
States / cities
Santa Monica, California • Stanford, California • Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Apr 25, 2024 · Synced Oct 14, 2026, 1:16 PM EDT
Completed Phase 2 Interventional

Guided Imagery Response in Total Knee Replacement

NCT01491750
View directory record Official record
Conditions
Osteoarthritis
Interventions
GUIDED IMAGERY, PLACEBO
Behavioral
Lead sponsor
Kent State University
Other
Eligibility
18 Years and older
Enrollment
82 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
1
States / cities
Akron, Ohio
Source: ClinicalTrials.gov public record
Updated Jan 6, 2014 · Synced Oct 14, 2026, 1:16 PM EDT
Completed Phase 2 Interventional Results available

Randomized, Double-Blind, Placebo-Controlled, Phase 2 Study In Subjects With Osteoarthritic Pain Of The Knee

NCT00689273
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
PF-04136309, Placebo
Drug
Lead sponsor
Pfizer
Industry
Eligibility
18 Years to 75 Years
Enrollment
159 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008
U.S. locations
18
States / cities
DeLand, Florida • South Miami, Florida • Overland Park, Kansas + 10 more
Source: ClinicalTrials.gov public record
Updated Jul 13, 2021 · Synced Oct 14, 2026, 1:16 PM EDT
Active, not recruiting Not applicable Interventional

Conversations in Health Literacy Using AI Technology for Osteoarthritis Patients

NCT06778486
View directory record Official record
Conditions
Osteoarthritis, Osteoarthritis of the Hip or Knee
Interventions
Artificial Intelligence Chatbot
Other
Lead sponsor
University of California, Davis
Other
Eligibility
18 Years to 99 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated Sep 14, 2026 · Synced Oct 14, 2026, 1:16 PM EDT