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ClinicalTrials.gov public records Last synced Oct 15, 2026, 1:05 AM EDT

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Showing 433–456 of 1,212 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Osteoarthritis, Knee Clear all
Completed Not applicable Interventional

Strengthening Exercise and Quadriceps Force During Walking

NCT01538407
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
Strength Training
Other
Lead sponsor
Frederiksberg University Hospital
Other
Eligibility
18 Years to 70 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
1
States / cities
Greenville, North Carolina
Source: ClinicalTrials.gov public record
Updated Jan 22, 2014 · Synced Oct 15, 2026, 1:05 AM EDT
Completed Phase 3 Interventional

Open Label Safety and Tolerability Study of COV155 in Subjects With Osteoarthritis (OA) or Chronic Low Back Pain (CLBP)

NCT01722864
View directory record Official record
Conditions
Osteoarthritis, Knee, Osteoarthritis, Hip, Chronic Low Back Pain
Interventions
COV155
Drug
Lead sponsor
Mallinckrodt
Industry
Eligibility
18 Years and older
Enrollment
153 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
34
States / cities
Anaheim, California • Lomita, California • Santa Ana, California + 24 more
Source: ClinicalTrials.gov public record
Updated Oct 19, 2016 · Synced Oct 15, 2026, 1:05 AM EDT
Recruiting Not applicable Interventional

Daily Knee Sleeve Use Versus No Use in Older Adults With Chronic Knee Pain

NCT07674901
View directory record Official record
Conditions
Knee Arthritis, Osteoarthritis
Interventions
Knee sleeve
Device
Lead sponsor
Margaret L Gourlay, MD, MPH
Other
Eligibility
50 Years to 64 Years
Enrollment
235 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2032
U.S. locations
1
States / cities
Springfield, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 8, 2026 · Synced Oct 15, 2026, 1:05 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Effectiveness of a Knee Brace When Combined With Viscosupplementation in the Treatment of Knee Osteoarthritis

NCT01478386
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
Orthovisc, DonJoy HA lite knee brace, Orthovisc injections and DonJoy HA lite knee brace
Other · Device
Lead sponsor
OAD Orthopaedics
Other
Eligibility
18 Years and older
Enrollment
11 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2013
U.S. locations
1
States / cities
Warrenville, Illinois
Source: ClinicalTrials.gov public record
Updated Jul 23, 2013 · Synced Oct 15, 2026, 1:05 AM EDT
Terminated Not applicable Interventional

Study to Evaluate Iovera®° in Adult Patients Undergoing Total Knee Arthroplasty

NCT04191031
View directory record Official record
Conditions
Post-Operative Pain Management
Interventions
ioveraº, ioveraº sham
Device
Lead sponsor
Pacira Pharmaceuticals, Inc
Industry
Eligibility
22 Years and older
Enrollment
79 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
7
States / cities
Fremont, California • Pasadena, California • Tamarac, Florida + 4 more
Source: ClinicalTrials.gov public record
Updated Jan 25, 2023 · Synced Oct 15, 2026, 1:05 AM EDT
Not listed Not applicable Interventional

Wearable Sensor-based Balance Training for Patients With Knee Osteoarthritis

NCT02620462
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
Wearable sensor-based exercise training
Device
Lead sponsor
University of Arizona
Other
Eligibility
18 Years to 90 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Tucson, Arizona
Source: ClinicalTrials.gov public record
Updated May 17, 2016 · Synced Oct 15, 2026, 1:05 AM EDT
Recruiting Not applicable Interventional

Outcomes of Low-Impact Exercise Program for People With Ankle, Knee, and/or Hip Pain

NCT03711773
View directory record Official record
Conditions
Osteoarthritis, Osteoarthritis, Knee, Osteoarthritis, Hip, Osteoarthritis Ankle
Interventions
Group Physical Therapy Classes
Other
Lead sponsor
University of Missouri-Columbia
Other
Eligibility
18 Years and older
Enrollment
10,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2030
U.S. locations
1
States / cities
Columbia, Missouri
Source: ClinicalTrials.gov public record
Updated Feb 2, 2026 · Synced Oct 15, 2026, 1:05 AM EDT
Recruiting Phase 4 Interventional

Systemic Oral Glucocorticoids for the Treatment of Acute Osteoarthritis Pain in the Emergency Department

NCT06603662
View directory record Official record
Conditions
Osteoarthritis, Osteoarthritis (OA) of the Knee, Osteoarthritis (OA) of the Shoulder, Osteoarthritis (OA) of the Hip
Interventions
Prednisone, Dexamethasone, Placebo
Drug
Lead sponsor
WellSpan Health
Other
Eligibility
18 Years and older
Enrollment
192 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
York, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 19, 2026 · Synced Oct 15, 2026, 1:05 AM EDT
Terminated Not applicable Interventional Results available

Efficacy of AposTherapy® in Knee OA

NCT03153956
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
Calibrated AposTherapy®, Non-Calibrated Sham Apos Therapy Device
Device
Lead sponsor
NYU Langone Health
Other
Eligibility
45 Years to 75 Years
Enrollment
77 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Mar 24, 2020 · Synced Oct 15, 2026, 1:05 AM EDT
Completed Not applicable Interventional Results available

Immediate Effects of rTMS on Excitability of the Quadriceps With Knee Osteoarthritis

NCT02881775
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
rTMS and exercise, Sham rTMS and exercise
Device
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
40 Years to 75 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 11, 2019 · Synced Oct 15, 2026, 1:05 AM EDT
Terminated No phase listed Observational Accepts healthy volunteers

Osteoarthritis and Body Composition: Evaluation of Systematic Mediators

NCT00771082
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
Not listed
Lead sponsor
National Institute on Aging (NIA)
NIH
Eligibility
20 Years and older
Enrollment
1,033 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2003 – 2012
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jun 6, 2012 · Synced Oct 15, 2026, 1:05 AM EDT
Completed Not applicable Interventional Results available

Improving Function After Knee Arthroplasty With Weight-Bearing Biofeedback

NCT01333189
View directory record Official record
Conditions
Arthropathy of Knee Joint
Interventions
Weight-bearing biofeedback exercise, Standard of care exercise
Other
Lead sponsor
University of Colorado, Denver
Other
Eligibility
50 Years to 85 Years
Enrollment
26 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Apr 23, 2019 · Synced Oct 15, 2026, 1:05 AM EDT
Completed Phase 1Phase 2 Interventional Accepts healthy volunteers

Autologous Alpha-2 Macroglobulin Rich Plasma, Safety and Efficacy in Symptomatic Moderate Knee Osteoarthritis

NCT06329492
View directory record Official record
Conditions
Osteoarthritis, OA, Knee Osteoarthritis
Interventions
Autologous Alpha-2 Macroglobulin Rich Plasma (A2MRP)
Biological
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 65 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Feb 12, 2026 · Synced Oct 15, 2026, 1:05 AM EDT
Active, not recruiting No phase listed Observational Accepts healthy volunteers

Performance of MOTO Medial® Unicompartmental Knee Arthroplasty

NCT03211663
View directory record Official record
Conditions
Knee Osteoarthritis, Knee Arthritis, Knee Pain Chronic
Interventions
MOTO Medial® UKA
Device
Lead sponsor
Medacta USA
Industry
Eligibility
18 Years and older
Enrollment
269 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2025
U.S. locations
5
States / cities
Lady Lake, Florida • Louisville, Kentucky • Billings, Montana + 2 more
Source: ClinicalTrials.gov public record
Updated Sep 25, 2025 · Synced Oct 15, 2026, 1:05 AM EDT
Withdrawn Phase 4 Interventional

A Comparison of Exparel Local Anesthetic in Total Knee Arthroplasty (TKA) Patients

NCT02765815
View directory record Official record
Conditions
Osteoarthritis, Knee, Arthroplasty, Replacement, Knee
Interventions
Liposomal bupivacaine, 266mg, Bupivacaine 0.5 % with Epinephrine, Ketorolac 30mg, Morphine 10mg, Bupivacaine 0.25% with Epinephrine
Drug
Lead sponsor
Holy Cross Hospital, Florida
Other
Eligibility
18 Years to 88 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Fort Lauderdale, Florida
Source: ClinicalTrials.gov public record
Updated Aug 9, 2017 · Synced Oct 15, 2026, 1:05 AM EDT
Recruiting Not applicable Interventional

Steps Towards Osteoarthritis Prevention

NCT06193343
View directory record Official record
Conditions
Anterior Cruciate Ligament Injuries
Interventions
Adaptive Daily Step Promotion
Behavioral
Lead sponsor
University of Georgia
Other
Eligibility
16 Years to 40 Years
Enrollment
56 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
1
States / cities
Athens, Georgia
Source: ClinicalTrials.gov public record
Updated Apr 29, 2026 · Synced Oct 15, 2026, 1:05 AM EDT
Enrolling by invitation No phase listed Observational Accepts healthy volunteers

MOON Onsite MRI 10 Years After ACL Reconstruction

NCT04660955
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
No Intervention - Observational study with MRI
Other
Lead sponsor
The Cleveland Clinic
Other
Eligibility
22 Years to 45 Years
Enrollment
219 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2030
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 24, 2026 · Synced Oct 15, 2026, 1:05 AM EDT
Terminated Not applicable Interventional

DexCom Hospital Study-CGM Directed Insulin Delivery

NCT05504785
View directory record Official record
Conditions
Type 2 Diabetes, Hip Osteoarthritis, Knee Osteoarthritis
Interventions
DexCom G6 continuous glucose monitor
Device
Lead sponsor
Thomas Jefferson University
Other
Eligibility
30 Years to 80 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 17, 2022 · Synced Oct 15, 2026, 1:05 AM EDT
Completed Phase 2 Interventional

Lyophilized and Micronized Particulate Human Amniotic and Umbilical Cord (TTAX03) for KL Grade 3-4 Knee OA

NCT05079035
View directory record Official record
Conditions
Knee Osteoarthritis, Knee Pain Chronic, Knee Arthritis
Interventions
TTAX03, Saline
Biological
Lead sponsor
BioTissue Holdings, Inc
Industry
Eligibility
35 Years to 85 Years
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
10
States / cities
Birmingham, Alabama • Tucson, Arizona • La Mesa, California + 6 more
Source: ClinicalTrials.gov public record
Updated Sep 19, 2025 · Synced Oct 15, 2026, 1:05 AM EDT
Terminated Phase 3 Interventional

Prospective Assessment of the Efficacy of Hyaluronate Knee Injections in Patients With Osteoarthritis

NCT00323778
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
Hyalgan
Drug
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
45 Years to 90 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2006
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 6, 2008 · Synced Oct 15, 2026, 1:05 AM EDT
Not yet recruiting Phase 2 Interventional

Inulin Supplementation for Reducing Inflammation and Knee Pain in Older Adults With Osteoarthritis

NCT07189585
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
inulin, Maltodextrin (Placebo)
Drug
Lead sponsor
Yale University
Other
Eligibility
40 Years and older
Enrollment
84 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
West Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jul 7, 2026 · Synced Oct 15, 2026, 1:05 AM EDT
Terminated Not applicable Interventional Results available

LEGION™ Primary Safety and Efficacy

NCT04040985
View directory record Official record
Conditions
Osteo Arthritis Knee, Total Knee Replacement
Interventions
Total Knee Arthroplasty using LEGION™ Total Knee System
Procedure
Lead sponsor
Smith & Nephew, Inc.
Industry
Eligibility
18 Years and older
Enrollment
128 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2020
U.S. locations
5
States / cities
Vero Beach, Florida • Des Moines, Iowa • Louisville, Kentucky + 2 more
Source: ClinicalTrials.gov public record
Updated Oct 10, 2024 · Synced Oct 15, 2026, 1:05 AM EDT
Completed Not applicable Interventional Results available

Ultrasound Guided Knee Injections in Musculoskeletal Medicine

NCT03293238
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
Joint line ultrasound, Joint line landmark, Suprapatellar ultrasound guided, Suprapatellar Landmark
Procedure
Lead sponsor
Andrews Research & Education Foundation
Other
Eligibility
18 Years to 90 Years
Enrollment
63 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2018
U.S. locations
1
States / cities
Gulf Breeze, Florida
Source: ClinicalTrials.gov public record
Updated Aug 8, 2022 · Synced Oct 15, 2026, 1:05 AM EDT
Recruiting Not applicable Interventional

Mechanical Alignment vs Kalipered Kinematic Alignment Total Knee Arthroplasty

NCT06617871
View directory record Official record
Conditions
Knee Osteoarthritis, Knee Arthropathy
Interventions
Mechanical Alignment (MA), Kinematic Alignment (KA) Interventions:
Procedure
Lead sponsor
Northwestern University
Other
Eligibility
21 Years to 79 Years
Enrollment
95 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Mar 24, 2026 · Synced Oct 15, 2026, 1:05 AM EDT